LOCUS       NM_001100834            1368 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus inorganic pyrophosphatase 1 (Ppa1), mRNA.
ACCESSION   NM_001100834 XM_001055932 XM_215416
VERSION     NM_001100834.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1368)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   2  (bases 1 to 1368)
  AUTHORS   Panda,H., Pandey,R.S., Debata,P.R. and Supakar,P.C.
  TITLE     Age-dependent differential expression and activity of rat liver
            cytosolic inorganic pyrophosphatase gene
  JOURNAL   Biogerontology 8 (5), 517-525 (2007)
   PUBMED   17415680
  REMARK    GeneRIF: There is an age-associated increase (approximately 2-fold)
            in the expression of rat liver cytosolic iPPase gene by
            differential display PCR and northern blot analysis.
REFERENCE   3  (bases 1 to 1368)
  AUTHORS   Panda,H., Pandey,R.S., Debata,P.R. and Supakar,P.C.
  TITLE     Cloning, expression, and functional analysis of rat liver cytosolic
            inorganic pyrophosphatase gene and characterization of its
            functional promoter
  JOURNAL   Gene Expr 14 (1), 13-22 (2007)
   PUBMED   17933215
  REMARK    GeneRIF: Cloning, expression, and functional analysis of rat liver
            cytosolic Pyp gene and characterization of its functional promoter
            are reported.
REFERENCE   4  (bases 1 to 1368)
  AUTHORS   Yasue,M., Serikawa,T. and Yamada,J.
  TITLE     Chromosomal assignments of 23 biochemical loci of the rat by using
            rat x mouse somatic cell hybrids
  JOURNAL   Cytogenet Cell Genet 57 (2-3), 142-148 (1991)
   PUBMED   1914521
REFERENCE   5  (bases 1 to 1368)
  AUTHORS   Thuillier,L.
  TITLE     Purification and kinetic properties of human erythrocyte
            Mg2+-dependent inorganic pyrophosphatase
  JOURNAL   Biochim Biophys Acta 524 (1), 198-206 (1978)
   PUBMED   656444
REFERENCE   6  (bases 1 to 1368)
  AUTHORS   Fisher,R.A., Turner,B.M., Dorkin,H.L. and Harris,H.
  TITLE     Studies on human erythrocyte inorganic pyrophosphatase
  JOURNAL   Ann Hum Genet 37 (3), 341-353 (1974)
   PUBMED   4130389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC099794.1.
            
            On or before Nov 23, 2008 this sequence version replaced
            XM_215416.4, XM_001055932.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099794.1, CF111033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1368              BC099794.1         1-1368
FEATURES             Location/Qualifiers
     source          1..1368
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..1368
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /note="inorganic pyrophosphatase 1"
                     /db_xref="GeneID:294504"
                     /db_xref="RGD:1589773"
     exon            1..192
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..998
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /EC_number="3.6.1.1"
                     /note="pyrophosphatase 1; pyrophosphatase (inorganic) 1"
                     /codon_start=1
                     /product="inorganic pyrophosphatase"
                     /protein_id="NP_001094304.1"
                     /db_xref="GeneID:294504"
                     /db_xref="RGD:1589773"
                     /translation="MSSFSSEERAAPFTLEYRVFIKNEKGQYISPFHDVPIYADKDVF
                     HMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWE
                     DPGHSDEHTGCCGDNDPIDVCEIGSKVCARGEIIRVKVLGILAMIDEGETDWKVIAIN
                     VDDPDAANYHDISDVERLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKNKEFAVD
                     IIKNTHDYWKALVTKKTDGKGISCMNTTVSESPFKCDPDAAKAIVDALPPPCESACAL
                     PMDVDKWFHHQKN"
     exon            193..251
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            252..305
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            306..425
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            426..512
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            513..639
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            640..767
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            768..853
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            854..923
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            924..966
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1313
                     /gene="Ppa1"
                     /gene_synonym="Pp; Pyp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaccagcggg ccagctcgtg gtgcgcaggc gcgagcttcc tccacggtac aaccgctccg
       61 aggctgggct gtgtggttgt gtagctgtgc agcggcggcg acggcggcac aggcacatct
      121 cggacaccat gagcagcttc agcagcgagg agcgcgcagc gcccttcacc ctggagtacc
      181 gcgtcttcat caaaaatgag aaagggcagt atatttctcc atttcatgat gttccaattt
      241 acgcagacaa ggatgtgttc cacatggtgg ttgaggttcc acgctggtca aatgcaaaaa
      301 tggagattgc tacaaaggac cctttaaacc cgattaagca agacgtgaag aagggaaagc
      361 tccgctatgt ggccaatctg ttcccttaca aaggctacat ctggaactat ggcgccatcc
      421 cccagacttg ggaagaccca ggacacagtg acgagcacac tggctgctgt ggtgacaacg
      481 acccaattga cgtttgtgaa attggaagca aggtatgtgc cagaggtgag ataatcaggg
      541 tgaaggtcct gggcatactg gccatgatcg acgagggtga gaccgactgg aaggtcattg
      601 ccattaatgt ggacgatcca gacgcagcca attaccatga tatttctgat gtggaacggc
      661 tgaaacccgg ctacttagaa gctaccgttg actggtttag aaggtataag gttcctgatg
      721 ggaaaccaga aaatgagttt gcattcaacg cagaatttaa aaataaggag tttgcagttg
      781 acattattaa aaacacccac gattattgga aggcattagt gactaagaag acagatggga
      841 aagggatcag ttgcatgaac accacagtgt ctgagagccc cttcaagtgt gatcctgatg
      901 cagccaaagc cattgtggat gctttaccac caccatgtga gtctgcctgc gcactaccaa
      961 tggacgtgga taaatggttc catcatcaga aaaactgatg cgattccttg ggagtgcagg
     1021 ctgatacggc tgtatcctgt tcatctggaa gcattagaca cagaagtgta gtaacttctc
     1081 catgctctga atttctatgc tcacctaatg gggtagattc cgctgtgact ggtccaatat
     1141 gttcagaagg ttagccatct agacacctca catcccaacc aagacaactt ttactaaatg
     1201 ttagctctca aagctgaggg gacatggaag tcatttgtgg atagatgtgt aaggtgggca
     1261 cctattggat gtatatgttt atcatgttag gaaataaagt tattttactg aaaaaaaaaa
     1321 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
