LOCUS       NM_001105746            2231 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus POU class 6 homeobox 1 (Pou6f1), mRNA.
ACCESSION   NM_001105746 XM_001064836 XM_343334
VERSION     NM_001105746.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2231)
  AUTHORS   Li,W.Y., Li,Z.G., Fu,X.M., Wang,X.Y., Lv,Z.X., Sun,P., Zhu,X.F. and
            Wang,Y.
  TITLE     Transgenic Schwann cells overexpressing POU6F1 promote sciatic
            nerve regeneration within acellular nerve allografts
  JOURNAL   J Neural Eng 19 (6) (2022)
   PUBMED   36317259
  REMARK    GeneRIF: Transgenic Schwann cells overexpressing POU6F1 promote
            sciatic nerve regeneration within acellular nerve allografts.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2231)
  AUTHORS   Toda,K., Yamamoto,D., Fumoto,M., Ikeshita,N., Herningtyas,E.H.,
            Iida,K., Takahashi,Y., Kaji,H., Chihara,K. and Okimura,Y.
  TITLE     Involvement of mPOU (Brn-5), a class VI POU protein, in the gene
            expression of Pit-1 as well as PRL
  JOURNAL   Mol Cell Endocrinol 280 (1-2), 20-29 (2008)
   PUBMED   17933456
  REMARK    GeneRIF: Brn-5 enhances prolactin gene expression directly in
            association with Pit-1 and CREB-binding protein, and indirectly via
            the activation of Pit-1 gene expression.
REFERENCE   3  (bases 1 to 2231)
  AUTHORS   Molinari,S., Relaix,F., Lemonnier,M., Kirschbaum,B., Schafer,B. and
            Buckingham,M.
  TITLE     A novel complex regulates cardiac actin gene expression through
            interaction of Emb, a class VI POU domain protein, MEF2D, and the
            histone transacetylase p300
  JOURNAL   Mol Cell Biol 24 (7), 2944-2957 (2004)
   PUBMED   15024082
REFERENCE   4  (bases 1 to 2231)
  AUTHORS   Cui,H. and Bulleit,R.F.
  TITLE     Expression of the POU transcription factor Brn-5 is an early event
            in the terminal differentiation of CNS neurons
  JOURNAL   J Neurosci Res 52 (6), 625-632 (1998)
   PUBMED   9669311
REFERENCE   5  (bases 1 to 2231)
  AUTHORS   Wey,E. and Schafer,B.W.
  TITLE     Identification of novel DNA binding sites recognized by the
            transcription factor mPOU (POU6F1)
  JOURNAL   Biochem Biophys Res Commun 220 (2), 274-279 (1996)
   PUBMED   8645295
REFERENCE   6  (bases 1 to 2231)
  AUTHORS   Wey,E., Lyons,G.E. and Schafer,B.W.
  TITLE     A human POU domain gene, mPOU, is expressed in developing brain and
            specific adult tissues
  JOURNAL   Eur J Biochem 220 (3), 753-762 (1994)
   PUBMED   7908264
REFERENCE   7  (bases 1 to 2231)
  AUTHORS   Andersen,B., Schonemann,M.D., Pearse,R.V. 2nd, Jenne,K.,
            Sugarman,J. and Rosenfeld,M.G.
  TITLE     Brn-5 is a divergent POU domain factor highly expressed in layer IV
            of the neocortex
  JOURNAL   J Biol Chem 268 (31), 23390-23398 (1993)
   PUBMED   7901208
REFERENCE   8  (bases 1 to 2231)
  AUTHORS   Okamoto,K., Wakamiya,M., Noji,S., Koyama,E., Taniguchi,S.,
            Takemura,R., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Muramatsu,M. et al.
  TITLE     A novel class of murine POU gene predominantly expressed in central
            nervous system
  JOURNAL   J Biol Chem 268 (10), 7449-7457 (1993)
   PUBMED   8463278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH474035.2.
            
            On or before Oct 3, 2007 this sequence version replaced
            XM_343334.3, XM_001064836.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L23204.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132265, SAMD00132285
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2231
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..2231
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /note="POU class 6 homeobox 1"
                     /db_xref="GeneID:116545"
                     /db_xref="RGD:620615"
     exon            1..845
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     CDS             801..1706
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /note="brain-5; brn-5 protein; brain-specific homeobox/POU
                     domain protein 5"
                     /codon_start=1
                     /product="POU domain, class 6, transcription factor 1"
                     /protein_id="NP_001099216.1"
                     /db_xref="GeneID:116545"
                     /db_xref="RGD:620615"
                     /translation="MPGISSPILTNAQGQVIGALPWVVNSASVATPAPAQSLQVQAVT
                     PQLLLNAQGQVIATLASSPLPQPVAVRKPSTPESPAKSEVQPIQPTQAVPPPAVILTS
                     PAPALKPSASAPIPITCSETPTVSQLVSKPHTPSLDEDGINLEEIREFAKNFKIRRLS
                     LGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLNEAELRNQE
                     GQQNLMEFVGGEPSKKRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDRE
                     VVRVWFCNRRQTLKNTSKLNVFQIP"
     exon            846..1049
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1191
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1360
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..2231
                     /gene="Pou6f1"
                     /gene_synonym="Brn5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaaagatt tctgcagcag tgctcccctt ccctgtgact gtgctcccct tccctgtgac
       61 tgtgctcccc tcccctatga ctatgctctt cctcccctgt gactgtgctc cccttcccca
      121 agactgtgct ccctttcttt caactgtatt tcccctcctg tgactgtgct ccccttccca
      181 gagactgtgc tctcctgtga ctgtgctcct cttctctgag actgtgctcc cttcccccaa
      241 gactatgttc cccttcccag agactgtgtt cccctcccct atcactgtgt tcccctcccc
      301 tgttactgtg ctcccttccc ctgtgactct gctctcctcc cctgtgactg tgctcccctt
      361 ccccatgact gtgctcccct tccccgtgac tgtgctcccc ttccccatga ctgtgctccc
      421 cttccccgtg actgtgctcc cctcccccgt cactatgctc tcctcccccg tgactgtgct
      481 ccccttcccc gtgactgtgc tccccttccc cgtgactgtg ctccccttcc ccgtgactgt
      541 gctccccttc cccgtgactg tgctcccctt ccctgctatc cccctgtact tgtctcccta
      601 gtcttgagta ccagccagtg gactagagcc tgcagcccag taccctcagc cctcttccct
      661 ctctgtgccc tttcttgcct ctcggtctct gagcaaggct cttcctccac ccacagatca
      721 gtgccgcgtc ccttggggga cagacgcaaa tcctgggctc cctcactaca gctccagtta
      781 ttaccaacac cattcccagc atgcccggga tcagcagtcc gatcctcacc aatgctcagg
      841 gacaggttat tggagcactt ccatgggtag tgaactcagc cagtgtggcc acaccagcac
      901 cagcacagag cctgcaggtc caagctgtga ctccccagct cttgttgaat gcccagggcc
      961 aggtgatcgc aacactagcc agcagccccc tgcctcaacc tgtggctgtc cggaagccaa
     1021 gcacaccgga gtcccctgca aagagtgagg tgcaacccat ccagccgaca caagccgtgc
     1081 ccccacctgc tgtaatcctc accagcccag ctccagcact caagccatca gcctcagctc
     1141 ccatcccaat cacctgctca gagacaccta cagtcagtca gttggtatca aaaccgcaca
     1201 ctccgagtct ggatgaggac gggatcaact tagaagagat ccgggagttt gccaagaatt
     1261 ttaagatccg gaggctctcc ctgggtctga cacagaccca ggtgggccag gctctgaccg
     1321 caacagaggg gccagcctac agccaatcag ccatctgcag gttcgagaag ttagacatca
     1381 cacccaagag tgcccagaag ctgaagccgg ttttggaaaa gtggttgaac gaggcagagc
     1441 tccggaacca ggaaggccag cagaatctga tggagtttgt gggcggcgag ccctccaaga
     1501 aacgcaagcg gcgtacttcc ttcacaccac aggccataga ggctctcaat gcctactttg
     1561 agaaaaaccc cctgcccacc ggccaggaga tcaccgagat cgctaaggag ctcaactatg
     1621 accgtgaggt ggtgagggtc tggttctgta atcgacgcca gacactcaag aacaccagca
     1681 agctgaatgt ctttcagatc ccctagggct cggggtcagc gtgttccttg tgcgaatccc
     1741 tcagcagtca gctgaagtca ctgagtggca gtactgtggg cagctgtgct tgccctcggt
     1801 catgagactc cacctgtgca tgtgtgtcaa tgcctgcctc ttctgcccac atatgtcaca
     1861 ccctggggag gcccgagggg ctgcatgaga gccctaggct ctgggctggg catgtggaag
     1921 gagggggttg gtggggtcct tagaaaagca ctttgccgag gtggtttctg aagggtgaat
     1981 tctggttgag aaccaggaag gctctgtctt tggggcaggg ccgtagcaac tcttggggac
     2041 aactgtgtag tggctcttgg ttttggtgac gtcctttccc ccttcccctc actcctctgt
     2101 ggctgtgccg gtgtgacaac acaccgggtg gaactgcagc ctcacactgc ctcccttcct
     2161 ctgaatatgg gcacactgaa ccccctgaaa ggactgagga atccagagag tcgtggtgtg
     2221 ctgctcagac c
//
