LOCUS       NM_001009178            1388 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus POU class 5 homeobox 1 (Pou5f1), mRNA.
ACCESSION   NM_001009178 XM_228354
VERSION     NM_001009178.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1388)
  AUTHORS   Yaglova NV, Obernikhin SS, Nazimova SV, Timokhina EP and Yaglov VV.
  TITLE     Changes in the Expression of Transcription Factor Oct4 during
            Postnatal Development of Adrenal Medulla
  JOURNAL   Bull Exp Biol Med 173 (6), 783-786 (2022)
   PUBMED   36322318
  REMARK    GeneRIF: Changes in the Expression of Transcription Factor Oct4
            during Postnatal Development of Adrenal Medulla.
REFERENCE   2  (bases 1 to 1388)
  AUTHORS   Spade DJ, Hall SJ, Wortzel JD, Reyes G and Boekelheide K.
  TITLE     All-trans Retinoic Acid Disrupts Development in Ex Vivo Cultured
            Fetal Rat Testes. II: Modulation of Mono-(2-ethylhexyl) Phthalate
            Toxicity
  JOURNAL   Toxicol Sci 168 (1), 149-159 (2019)
   PUBMED   30476341
REFERENCE   3  (bases 1 to 1388)
  AUTHORS   Spade DJ, Dere E, Hall SJ, Schorl C, Freiman RN and Boekelheide K.
  TITLE     All-Trans Retinoic Acid Disrupts Development in Ex Vivo Cultured
            Fetal Rat Testes. I: Altered Seminiferous Cord Maturation and
            Testicular Cell Fate
  JOURNAL   Toxicol Sci 167 (2), 546-558 (2019)
   PUBMED   30329139
REFERENCE   4  (bases 1 to 1388)
  AUTHORS   Doffou M, Adams G, Bowen WC, Paranjpe S, Parihar HS, Nguyen H,
            Michalopoulos GK and Bhave VS.
  TITLE     Oct4 Is Crucial for Transdifferentiation of Hepatocytes to Biliary
            Epithelial Cells in an In Vitro Organoid Culture Model
  JOURNAL   Gene Expr 18 (1), 51-62 (2018)
   PUBMED   29212575
  REMARK    GeneRIF: OCt4 is essential for hepatocyte to cholangiocyte
            transdifferentiation in an in vitro organoid culture.
REFERENCE   5  (bases 1 to 1388)
  AUTHORS   Bae KB, Yu DH, Lee KY, Yao K, Ryu J, Lim DY, Zykova TA, Kim MO,
            Bode AM and Dong Z.
  TITLE     Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4
            Protein Stability in Mouse Embryonic Stem Cells
  JOURNAL   Stem Cell Reports 9 (6), 2050-2064 (2017)
   PUBMED   29153991
REFERENCE   6  (bases 1 to 1388)
  AUTHORS   Yuan H, Corbi N, Basilico C and Dailey L.
  TITLE     Developmental-specific activity of the FGF-4 enhancer requires the
            synergistic action of Sox2 and Oct-3
  JOURNAL   Genes Dev 9 (21), 2635-2645 (1995)
   PUBMED   7590241
REFERENCE   7  (bases 1 to 1388)
  AUTHORS   Scholer HR, Dressler GR, Balling R, Rohdewohld H and Gruss P.
  TITLE     Oct-4: a germline-specific transcription factor mapping to the
            mouse t-complex
  JOURNAL   EMBO J 9 (7), 2185-2195 (1990)
   PUBMED   2357966
REFERENCE   8  (bases 1 to 1388)
  AUTHORS   Rosner MH, Vigano MA, Ozato K, Timmons PM, Poirier F, Rigby PW and
            Staudt LM.
  TITLE     A POU-domain transcription factor in early stem cells and germ
            cells of the mammalian embryo
  JOURNAL   Nature 345 (6277), 686-692 (1990)
   PUBMED   1972777
REFERENCE   9  (bases 1 to 1388)
  AUTHORS   Scholer HR, Ruppert S, Suzuki N, Chowdhury K and Gruss P.
  TITLE     New type of POU domain in germ line-specific protein Oct-4
  JOURNAL   Nature 344 (6265), 435-439 (1990)
   PUBMED   1690859
REFERENCE   10 (bases 1 to 1388)
  AUTHORS   Okamoto K, Okazawa H, Okuda A, Sakai M, Muramatsu M and Hamada H.
  TITLE     A novel octamer binding transcription factor is differentially
            expressed in mouse embryonic cells
  JOURNAL   Cell 60 (3), 461-472 (1990)
   PUBMED   1967980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC158566.1.
            
            On Oct 2, 2009 this sequence version replaced NM_001009178.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158566.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132266,
                                           SAMD00132284 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1388
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1388
                     /gene="Pou5f1"
                     /note="POU class 5 homeobox 1"
                     /db_xref="GeneID:294562"
                     /db_xref="RGD:1359491"
     exon            1..464
                     /gene="Pou5f1"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1139
                     /gene="Pou5f1"
                     /codon_start=1
                     /product="POU domain, class 5, transcription factor 1"
                     /protein_id="NP_001009178.1"
                     /db_xref="GeneID:294562"
                     /db_xref="RGD:1359491"
                     /translation="MAGHLASDFAFSPPPGGGDGSAGLEPGWVDPRTWLSFQGPPSGP
                     GIGPGSEVLGISPCPPAYEFCGGMAYCGPQVGLGLVPQVGVETLQPEGQAGARVESNS
                     EGASSGPCTARPSAVKLEKVEPSPEESQDMKALQKELEQFAKLLKQKRITLGYTQADV
                     GLTLGVLFGKVFSQTTICRFEALQLSLKNMCKLRPLLEKWVEEADNNENLQEICKSET
                     LVQARKRKRTSIENRVRWNLENMFLQCPKPSLQQITSIAKQLGLERDVVRVWFCNRRQ
                     KGKRSSIEYSQREEYEAAGKPFPGGAVSFPLPPGPHFGAPGYGSPHFTTLYSVPFPEG
                     EAFPSVPVTALGSPMHSN"
     exon            465..585
                     /gene="Pou5f1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..716
                     /gene="Pou5f1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..875
                     /gene="Pou5f1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1363
                     /gene="Pou5f1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggagggag agaggtgcaa acagtcccta ggtgagtcgt ccttccacca ggcccccggc
       61 tcggggagcc caccttcccc atggctggac acctggcttc agacttcgcc ttctcacccc
      121 cacctggtgg gggtgatggg tcagcagggc tggagccggg ctgggtggac cctcgaacct
      181 ggctaagctt ccaggggcct ccaagtgggc ctggaatcgg accaggttca gaggtgctgg
      241 ggatctcccc gtgtccccca gcatacgagt tctgtggagg gatggcatac tgtggacctc
      301 aggttggact gggcctagtc ccccaagttg gcgtggagac tctgcagccc gagggccagg
      361 caggagcacg agtggagagc aactcggagg gagcctcctc tgggccctgt actgcccgcc
      421 ccagcgccgt gaagttggag aaggtggaac ctagtcccga ggagtcccag gatatgaaag
      481 ccctgcagaa ggagctagag cagtttgcca agctgctgaa acagaagagg atcaccttgg
      541 ggtacaccca ggccgacgtg gggctcaccc tgggcgttct ctttggaaag gtgttcagcc
      601 agacaaccat ctgccgcttc gaggccctgc agctcagcct taagaacatg tgtaagctgc
      661 ggcccctgct ggagaagtgg gtggaggaag ctgacaacaa cgagaacctt caggagatat
      721 gcaaatcgga gaccctggtg caggcccgga agagaaagcg gactagcatt gagaaccgtg
      781 tgaggtggaa cctggagaac atgtttctgc agtgcccgaa gccctccctg cagcagatca
      841 ctagcattgc caagcagctt gggctggaga gggatgtggt tcgagtgtgg ttctgtaacc
      901 ggcgccagaa ggggaaaaga tcgagcattg aatattccca acgagaagag tatgaggccg
      961 cggggaaacc tttcccaggg ggggctgtgt cctttcctct gcccccaggc ccccactttg
     1021 gtgctccagg ctatgggagc ccccatttca ccacactcta ctcggtccct tttcctgagg
     1081 gcgaggcctt tccctctgtt cctgtcactg ctctgggctc tcccatgcat tcaaactgag
     1141 gcaccagccc tccctgggga tgaggtgagc caaggcaagg aagggaggta gacaaagaga
     1201 acctgaagct ttggggccta gattctttta ctggggagga attgaaagca caaacagggg
     1261 tggttggggg ggcggggggg gagagatgaa gttcagtgac gctgttgatc aggaacccgt
     1321 ccgaagttct taagttctta aataaagtct gggatacaca gtaaaaaaaa aaaaaaaaaa
     1381 aaaaaaaa
//
