LOCUS       NM_134355               3210 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus POU class 4 homeobox 2 (Pou4f2), mRNA.
ACCESSION   NM_134355 XM_001074669 XM_344756
VERSION     NM_134355.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3210)
  AUTHORS   Mele,L., Maskell,L.J., Stuckey,D.J., Clark,J.E., Heads,R.J. and
            Budhram-Mahadeo,V.S.
  TITLE     The POU4F2/Brn-3b transcription factor is required for the
            hypertrophic response to angiotensin II in the heart
  JOURNAL   Cell Death Dis 10 (8), 621 (2019)
   PUBMED   31413277
  REMARK    GeneRIF: hearts from male Brn-3b KO mutant mice display contractile
            dysfunction at baseline but also attenuated hypertrophic responses
            to AngII treatment. Hearts from AngII-treated male Brn-3b KO mice
            develop further contractile dysfunction linked to extensive
            fibrosis/remodelling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3210)
  AUTHORS   Maskell,L.J., Qamar,K., Babakr,A.A., Hawkins,T.A., Heads,R.J. and
            Budhram-Mahadeo,V.S.
  TITLE     Essential but partially redundant roles for POU4F1/Brn-3a and
            POU4F2/Brn-3b transcription factors in the developing heart
  JOURNAL   Cell Death Dis 8 (6), e2861 (2017)
   PUBMED   28594399
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3210)
  AUTHORS   Bitsi,S., Ali,H., Maskell,L., Ounzain,S., Mohamed-Ali,V. and
            Budhram-Mahadeo,V.S.
  TITLE     Profound hyperglycemia in knockout mutant mice identifies novel
            function for POU4F2/Brn-3b in regulating metabolic processes
  JOURNAL   Am J Physiol Endocrinol Metab 310 (5), E303-E312 (2016)
   PUBMED   26670484
REFERENCE   4  (bases 1 to 3210)
  AUTHORS   Phatak,N.R., Stankowska,D.L. and Krishnamoorthy,R.R.
  TITLE     Transcription Factor Brn-3b Overexpression Enhances Neurite
            Outgrowth in PC12 Cells Under Condition of Hypoxia
  JOURNAL   Cell Mol Neurobiol 35 (6), 769-783 (2015)
   PUBMED   25786379
  REMARK    GeneRIF: A potential role for Brn-3b in neurodegenerative diseases
            in which hypoxia/ischemia contribute to pathophysiology of the
            disease.
REFERENCE   5  (bases 1 to 3210)
  AUTHORS   Wu,F., Kaczynski,T.J., Sethuramanujam,S., Li,R., Jain,V.,
            Slaughter,M. and Mu,X.
  TITLE     Two transcription factors, Pou4f2 and Isl1, are sufficient to
            specify the retinal ganglion cell fate
  JOURNAL   Proc Natl Acad Sci U S A 112 (13), E1559-E1568 (2015)
   PUBMED   25775587
REFERENCE   6  (bases 1 to 3210)
  AUTHORS   Xiang,M., Zhou,L., Macke,J.P., Yoshioka,T., Hendry,S.H., Eddy,R.L.,
            Shows,T.B. and Nathans,J.
  TITLE     The Brn-3 family of POU-domain factors: primary structure, binding
            specificity, and expression in subsets of retinal ganglion cells
            and somatosensory neurons
  JOURNAL   J Neurosci 15 (7 Pt 1), 4762-4785 (1995)
   PUBMED   7623109
REFERENCE   7  (bases 1 to 3210)
  AUTHORS   Morris,P.J., Theil,T., Ring,C.J., Lillycrop,K.A., Moroy,T. and
            Latchman,D.S.
  TITLE     The opposite and antagonistic effects of the closely related POU
            family transcription factors Brn-3a and Brn-3b on the activity of a
            target promoter are dependent on differences in the POU domain
  JOURNAL   Mol Cell Biol 14 (10), 6907-6914 (1994)
   PUBMED   7935408
REFERENCE   8  (bases 1 to 3210)
  AUTHORS   Turner,E.E., Jenne,K.J. and Rosenfeld,M.G.
  TITLE     Brn-3.2: a Brn-3-related transcription factor with distinctive
            central nervous system expression and regulation by retinoic acid
  JOURNAL   Neuron 12 (1), 205-218 (1994)
   PUBMED   7904822
REFERENCE   9  (bases 1 to 3210)
  AUTHORS   Theil,T., McLean-Hunter,S., Zornig,M. and Moroy,T.
  TITLE     Mouse Brn-3 family of POU transcription factors: a new
            aminoterminal domain is crucial for the oncogenic activity of
            Brn-3a
  JOURNAL   Nucleic Acids Res 21 (25), 5921-5929 (1993)
   PUBMED   8290353
REFERENCE   10 (bases 1 to 3210)
  AUTHORS   Xiang,M., Zhou,L., Peng,Y.W., Eddy,R.L., Shows,T.B. and Nathans,J.
  TITLE     Brn-3b: a POU domain gene expressed in a subset of retinal ganglion
            cells
  JOURNAL   Neuron 11 (4), 689-701 (1993)
   PUBMED   7691107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000019.1.
            
            On or before Dec 20, 2009 this sequence version replaced
            XM_001074669.1, XM_344756.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN12840115,
                              SAMN13663594 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-537               JAXUCZ010000019.1  46390958-46391494
            538-3210            JAXUCZ010000019.1  46391927-46394599
FEATURES             Location/Qualifiers
     source          1..3210
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q11"
     gene            1..3210
                     /gene="Pou4f2"
                     /gene_synonym="Brn-3.2; Brn-3B; Brn3b"
                     /note="POU class 4 homeobox 2"
                     /db_xref="GeneID:171355"
                     /db_xref="RGD:620075"
     exon            1..537
                     /gene="Pou4f2"
                     /gene_synonym="Brn-3.2; Brn-3B; Brn3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1479
                     /gene="Pou4f2"
                     /gene_synonym="Brn-3.2; Brn-3B; Brn3b"
                     /note="brain-3B; brain-specific homeobox/POU domain
                     protein 3B"
                     /codon_start=1
                     /product="POU domain, class 4, transcription factor 2"
                     /protein_id="NP_599182.1"
                     /db_xref="GeneID:171355"
                     /db_xref="RGD:620075"
                     /translation="MMMMSLNSKQAFSMPHAGSLHVEPKYSALHSASPGSSAPAAPSA
                     SSPSSSSNAGSGGGGGGGGGGGGGGRSSSSSSSGSGGGGGGGSEAMRRACLPTPPSNI
                     FGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSS
                     SVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGTVVST
                     PAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLG
                     VTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHR
                     EKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVV
                     RVWFCNQRQKQKRMKYSAGI"
     exon            538..3210
                     /gene="Pou4f2"
                     /gene_synonym="Brn-3.2; Brn-3B; Brn3b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcacttt ggggcgctga ggtctgaagc cagcgccacc cggagcaggg caacagcttg
       61 agcagaccca gcaggcgaca cagaagcgga gccagactgg gagagccgag cctggaagcg
      121 gtggccgctg agcacaactt tgccgtgttg ttccctctgc tgctcccgcc gggtacttct
      181 ccggagggtc ggtagctggg accagagtga gccagcgacg agcgcgccgc gcaaggaaag
      241 atgatgatga tgtccctgaa tagcaagcag gcgttcagca tgcctcatgc cggcagcctg
      301 catgtggagc ccaagtactc ggcgctgcac agtgcctccc cgggttcctc tgcgcccgcg
      361 gcgccctcgg ccagttcccc tagcagctcc agcaacgctg gcagcggcgg cggcggcggc
      421 ggcggcggcg gcggtggtgg cggaggccgg agcagcagtt ccagcagcag tggcagcggc
      481 ggcggcggcg gcgggggctc ggaggcgatg cggagagctt gtcttccaac cccaccgagc
      541 aatatattcg gcggtctgga tgagagtctg ctggcccgtg ccgaggctct ggccgccgtg
      601 gacatcgtct cccagagtaa gagccaccac caccatccgc cccaccacag ccccttcaag
      661 ccggacgcca cttaccacac catgaacacc atcccgtgca cgtctgccgc ttcctcttca
      721 tccgtgccca tctcgcaccc gtccgctctg gctggcaccc accaccatca ccaccaccac
      781 catcaccacc accaccagcc acatcaggct ctggagggcg agctgctgga gcacctgagc
      841 cccgggctgg ccctgggagc catggcgggc cccgacggca cggtggtgtc cactccggct
      901 cacgcaccgc acatggccac catgaacccc atgcaccaag cagccctgag catggcccac
      961 gcgcacggtc tgccctcgca catgggctgc atgagcgacg tggatgcaga cccgcgggac
     1021 ctggaggcgt tcgccgagcg cttcaagcag cgacgcatca agctgggagt gacccaggcg
     1081 gatgtgggtt cggcgctggc caacctcaag ataccgggcg taggctcgct cagccagagc
     1141 accatctgca ggtttgagtc cctcacgctg tcgcacaaca acatgatcgc gctcaagccc
     1201 atcctgcagg cgtggctgga ggaagcagag aaatcccacc gcgagaagct caccaagccc
     1261 gagctcttca atggcgcgga gaagaagcgc aagcgcacgt ccatcgcggc gcccgagaag
     1321 cgctcactgg aagcctactt cgccatccag ccaaggccct cctcggagaa gatcgcggcc
     1381 atcgccgaga agctggatct caagaaaaac gtagtgcgcg tctggttctg caaccagagg
     1441 cagaaacaga agagaatgaa atactcagcc ggcatttagg gacccttctc cagggatggc
     1501 cctttccctt cgccctctct tttctaaccc ccctcttgtc tctcctgcct cttttctttc
     1561 tactttggct atcagaaaca attccggtaa atgtgaaccc agaccaagtc aggagcaaag
     1621 aaacaagcag ctgagcccaa atcagaaaga ttgtgaattg atttcgcaaa gtgaagaaaa
     1681 aacaaaatca caaacacacc acaaaaggaa tttgtcacgt tgtaacagag ctgtcccttt
     1741 taagcgcacc tcgactgctc agcttcatca gaggaagtgt ggagctggtt gtcaacagga
     1801 agacagaggg acaagcttct gaaaaccccg caagaatgag caagtaagat ttgtttttat
     1861 tcttacagac gtcaccttgt tcacgtttaa aagtacactt tgcagctatt tttcagaaat
     1921 agaaattgat tcaggactga aactcgaagc tagagttgat gcttaatgtg acacgataga
     1981 gacgcctcta aagtattttg aattaaaaaa agatggcaga ttttctgcat ttacactgta
     2041 tattatatat atatttttat tgtggttctt atcgctttct tccttctcta aagtgttaat
     2101 acttacgaag gagttgcgcc tgctgtgttc actgatcttg acaactatta ttagattatt
     2161 gccgtacaac cttctgtaaa ttattaattt atctctctgg caacttaatt ttgtgcacat
     2221 cctaactaac taaacttctt tagtctgaaa aataaaaccg gcggatacat ataggtagtg
     2281 atgctcaaat gttctttttt ctttttccgt ctgatgagtt ccctggagtt tcacagcttt
     2341 cccgcttaga ctgtgttctc ttcggcctag ttgtatattc tcactttgaa tgaagattgt
     2401 ttcctccctt tgtttttaac tggtagcgtt ctaatttgtg agctgacact tgataatgga
     2461 tgtcttaatc gtgtagatct gattcactgt ccgaagtctt gtttacttcc ttccatattt
     2521 aatggggatt cccacattgt cccccgcagc acacgtgctc tctcactcac tttacaagcc
     2581 tacacacaga cacacagtac acgtctctaa cagaagagaa ggggcagttg gaggtacgac
     2641 tgataaccag tgtatccttt tccagcctag gtgcgttctc cacttggtgc ttactctgct
     2701 ggactcaaag atttcaccca ggtatttcaa tctcccagct tttagttgct ttgtggctac
     2761 atttgacctt tataggatcc ttcagttttt ccttttagga tgtttgtttg taggggaaaa
     2821 ttttggaact ataagaaaga cagtgcactg cctgtaaatt cacagtgttt ggtagaatcc
     2881 ttttggagca cacacacaag aataggtaca cagcgactgg taccttctct attgtaaata
     2941 tttcattcaa aatgatgcac atataaatat attcttacag aatttgctgt aattgttgat
     3001 ccatttgagg ctctccaaag ttctgagttc tgtatatgac ctcgttcctt gtttttgtta
     3061 atgaattatt tactatagta atgtattaag ttattttggg tgttgtttca ttgtctttca
     3121 tcgaagagat gattttaatg ttttattggc aaagtatgct acttttttca ttaaaatatg
     3181 ctattaatat taaatgactt ttaaaacgtg
//
