LOCUS       NM_001419538            5634 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus POU class 4 homeobox 1 (Pou4f1), mRNA.
ACCESSION   NM_001419538 XM_008770931
VERSION     NM_001419538.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5634)
  AUTHORS   Maskell,L.J., Qamar,K., Babakr,A.A., Hawkins,T.A., Heads,R.J. and
            Budhram-Mahadeo,V.S.
  TITLE     Essential but partially redundant roles for POU4F1/Brn-3a and
            POU4F2/Brn-3b transcription factors in the developing heart
  JOURNAL   Cell Death Dis 8 (6), e2861 (2017)
   PUBMED   28594399
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5634)
  AUTHORS   Garcia-Ayuso,D., Di Pierdomenico,J., Esquiva,G.,
            Nadal-Nicolas,F.M., Pinilla,I., Cuenca,N., Vidal-Sanz,M.,
            Agudo-Barriuso,M. and Villegas-Perez,M.P.
  TITLE     Inherited Photoreceptor Degeneration Causes the Death of
            Melanopsin-Positive Retinal Ganglion Cells and Increases Their
            Coexpression of Brn3a
  JOURNAL   Invest Ophthalmol Vis Sci 56 (8), 4592-4604 (2015)
   PUBMED   26200499
  REMARK    GeneRIF: phenotypic and molecular changes that may represent an
            effort to resist degeneration and/or preferential survival of
            m+RGCs capable of synthesizing Brn3a.
REFERENCE   3  (bases 1 to 5634)
  AUTHORS   Zhang,L., Wahlin,K., Li,Y., Masuda,T., Yang,Z., Zack,D.J. and
            Esumi,N.
  TITLE     RIT2, a neuron-specific small guanosine triphosphatase, is
            expressed in retinal neuronal cells and its promoter is modulated
            by the POU4 transcription factors
  JOURNAL   Mol Vis 19, 1371-1386 (2013)
   PUBMED   23805044
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5634)
  AUTHORS   Dykes,I.M., Tempest,L., Lee,S.I. and Turner,E.E.
  TITLE     Brn3a and Islet1 act epistatically to regulate the gene expression
            program of sensory differentiation
  JOURNAL   J Neurosci 31 (27), 9789-9799 (2011)
   PUBMED   21734270
REFERENCE   5  (bases 1 to 5634)
  AUTHORS   Sanchez-Migallon,M.C., Nadal-Nicolas,F.M., Jimenez-Lopez,M.,
            Sobrado-Calvo,P., Vidal-Sanz,M. and Agudo-Barriuso,M.
  TITLE     Brain derived neurotrophic factor maintains Brn3a expression in
            axotomized rat retinal ganglion cells
  JOURNAL   Exp Eye Res 92 (4), 260-267 (2011)
   PUBMED   21315070
  REMARK    GeneRIF: Brn3a is a reliable retinal ganglion cell marker that can
            be used to accurately measure the potential effect of a given
            neuroprotective therapy.
REFERENCE   6  (bases 1 to 5634)
  AUTHORS   Xiang,M., Zhou,L., Macke,J.P., Yoshioka,T., Hendry,S.H., Eddy,R.L.,
            Shows,T.B. and Nathans,J.
  TITLE     The Brn-3 family of POU-domain factors: primary structure, binding
            specificity, and expression in subsets of retinal ganglion cells
            and somatosensory neurons
  JOURNAL   J Neurosci 15 (7 Pt 1), 4762-4785 (1995)
   PUBMED   7623109
REFERENCE   7  (bases 1 to 5634)
  AUTHORS   Morris,P.J., Theil,T., Ring,C.J., Lillycrop,K.A., Moroy,T. and
            Latchman,D.S.
  TITLE     The opposite and antagonistic effects of the closely related POU
            family transcription factors Brn-3a and Brn-3b on the activity of a
            target promoter are dependent on differences in the POU domain
  JOURNAL   Mol Cell Biol 14 (10), 6907-6914 (1994)
   PUBMED   7935408
REFERENCE   8  (bases 1 to 5634)
  AUTHORS   Theil,T., McLean-Hunter,S., Zornig,M. and Moroy,T.
  TITLE     Mouse Brn-3 family of POU transcription factors: a new
            aminoterminal domain is crucial for the oncogenic activity of
            Brn-3a
  JOURNAL   Nucleic Acids Res 21 (25), 5921-5929 (1993)
   PUBMED   8290353
REFERENCE   9  (bases 1 to 5634)
  AUTHORS   Lillycrop,K.A., Budrahan,V.S., Lakin,N.D., Terrenghi,G., Wood,J.N.,
            Polak,J.M. and Latchman,D.S.
  TITLE     A novel POU family transcription factor is closely related to Brn-3
            but has a distinct expression pattern in neuronal cells
  JOURNAL   Nucleic Acids Res 20 (19), 5093-5096 (1992)
   PUBMED   1383937
REFERENCE   10 (bases 1 to 5634)
  AUTHORS   He,X., Treacy,M.N., Simmons,D.M., Ingraham,H.A., Swanson,L.W. and
            Rosenfeld,M.G.
  TITLE     Expression of a large family of POU-domain regulatory genes in
            mammalian brain development
  JOURNAL   Nature 340 (6228), 35-41 (1989)
   PUBMED   2739723
  REMARK    Erratum:[Nature 1989 Aug 24;340(6235):662]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On Apr 7, 2023 this sequence version replaced XM_008770931.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-424               JAXUCZ010000015.1  87674220-87674643   c
            425-5634            JAXUCZ010000015.1  87668328-87673537   c
FEATURES             Location/Qualifiers
     source          1..5634
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q22"
     gene            1..5634
                     /gene="Pou4f1"
                     /gene_synonym="brn-3A; Brn3a"
                     /note="POU class 4 homeobox 1"
                     /db_xref="GeneID:114503"
                     /db_xref="RGD:620074"
     exon            1..424
                     /gene="Pou4f1"
                     /gene_synonym="brn-3A; Brn3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..1567
                     /gene="Pou4f1"
                     /gene_synonym="brn-3A; Brn3a"
                     /note="brain-specific homeobox/POU domain protein 3A;
                     brain-3A"
                     /codon_start=1
                     /product="POU domain, class 4, transcription factor 1"
                     /protein_id="NP_001406467.1"
                     /db_xref="GeneID:114503"
                     /db_xref="RGD:620074"
                     /translation="MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQS
                     NLFASLDETLLARAEALAAVDIAVSQGKSHPFKPDATYHTMNSVPCTSTSTVPLAHHH
                     HHHHHHQALEPGDLLDHISSPSLALMAGAGGAGAAGGGGGAHDGPGGAGGPGGGGGPG
                     GGGPGGGGGGGGPGGGGGGPGGGLLGGSAHPHPHMHGLGHLSHPAAAAAMNMPSGLPH
                     PGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAER
                     FKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAW
                     LEEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAE
                     KLDLKKNVVRVWFCNQRQKQKRMKFSATY"
     exon            425..5634
                     /gene="Pou4f1"
                     /gene_synonym="brn-3A; Brn3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagaggagcg cagcccgtcg gcgcgccggg ctagagctct cggagaagcg ggatcgcggg
       61 acctgcgcgc gggcgggcgc tctgcgcggt ccgaggcagc gggccgcgct ccccggcgca
      121 gcagcagcag tagcagcagc agtagcagca gcagcagccc ccgcccgcgg cgagaccgag
      181 gcgagccgcc gagccgagcg tagcctcggg acagaggccg ggcgagcggg cgagcgggcg
      241 agcgtacttt gccgcggact ttgcgagtgt tttgtggatt tttacatgcc aagccgccaa
      301 gatgatgtcc atgaacagca agcagcctca ctttgccatg catcccaccc tccctgagca
      361 caagtacccg tcgctgcact ccagctccga ggccatccgg cgggcctgcc tgcccacgcc
      421 gccgctgcag agcaacctct tcgctagcct ggacgagacg ctcctggcgc gggccgaggc
      481 gctggcggcc gtggacatcg cggtgtccca gggcaagagc caccctttca agccggacgc
      541 cacgtaccac acgatgaata gcgtgccctg cacgtccacg tccactgtgc cgctggcgca
      601 ccaccaccac caccaccatc accaccaggc gctcgagccc ggtgacctgc tggaccacat
      661 ctcgtcgccg tcgctcgcgc tcatggccgg cgcggggggt gcgggcgcgg cgggcggcgg
      721 cggcggcgcc cacgacggcc ccgggggcgc aggcggcccg gggggcggcg gtggcccggg
      781 cggcggcggc cccgggggtg gcggcggcgg cggtggcccg ggcggcggcg gcggcggccc
      841 gggcggcggg ctcttgggcg gctcggcgca tccgcacccg cacatgcacg gcctgggcca
      901 cctgtcgcac cccgcggccg cggccgccat gaacatgccg tccgggctgc cgcatcccgg
      961 gctcgtggcc gcggcggcgc accacggcgc ggcggcggca gcggcggcgg cggcggccgg
     1021 gcaggtggca gcggcgtcgg cggcggctgc ggtggtgggc gcggcgggcc tggcgtccat
     1081 ctgcgactcg gacacggacc cgcgcgagct cgaggcgttc gccgagcgct tcaagcagcg
     1141 gcgcatcaag ctgggcgtga cgcaggccga cgtgggctcg gcgctggcca acctcaagat
     1201 cccgggcgtg ggctcgctca gccagagcac catctgcagg ttcgagtcgc tcacgttgtc
     1261 gcacaacaac atgatcgcgc tcaagcccat cctgcaggcg tggctggagg aggccgaggg
     1321 cgcgcagcgt gagaaaatga acaagccgga gctcttcaac ggcggcgaga agaagcgcaa
     1381 gcggacttcc atcgccgcgc ccgagaagcg ctccctcgag gcctattttg ccgtacaacc
     1441 ccggccctcc tcggagaaga tcgccgccat cgccgagaaa ctggacctca aaaagaacgt
     1501 ggtgcgggtg tggttttgca accagagaca gaagcagaag cggatgaaat tctctgccac
     1561 ttactgagga gggtgtgaga cgccgggtgg ggcacactgg ggagctgagg ggtgcgtttc
     1621 tggggttctc tctggcctac ttcccctcat ttagagtgtc tgttatcctg cctgcatttg
     1681 gggagttcct ttacttgcct ttccctcagc cccacactgc accctgccct tactgtcccc
     1741 cagcctagag aagggtgtgg gtgtggagaa agtttgcgac ggcagaagga gagaatgggg
     1801 ggcgtttagg tgagcagggc gtgggggtga agaaaagcaa agactagagc tgggggtttt
     1861 gagaagcagg atggttctgg ggactagggt gggacgggaa gatgggggaa gaactgggga
     1921 tagacagata tcttgaccag agacacttac aaaaatcatc tggggaccaa ggaactatgt
     1981 acaaagacaa aactaccaac catcaccaaa aaacaaagca taaaacccta gacaaataaa
     2041 gaggggggtg ggagacaaag aaggaggctt taggaattta actcctggga gcagtattct
     2101 gcagcttcgt ttatccccaa ggaagagaaa acagcaatac cattactacc accactccaa
     2161 cttcccaagc acaagtgagt cctacaggaa aaccaaacaa cccggacctt gagcttctgg
     2221 ggaggaaggt agttgttctg tgtttaactc tcccttctaa aatcctacac cgtatgtgcg
     2281 ctctttgatt catttcctct tttccaaaga gactccaagg cttcagccca gcagctggac
     2341 cttagcttac atgcgctttg ggaagctgcc tggtcattca caccgaatct tcactttcca
     2401 ggagccaatg gccacagcct tgtggcctgg tcttggtcag gtgagggtct ttaggccatg
     2461 agagcccaaa agacagaaat taggttctct gaaaaaaata tttgttctgg gataattaaa
     2521 cgatcttaac acctacagta gggttttact tttatatatt tgttcatgca tccatgaaca
     2581 aatctgaaac gttttttttc cttccaccct acttacagaa ctttaccttc atgtgcctgc
     2641 cctgttttcc ggattcaaac tctactgaca cttattaatt tagattgaat gatagggtgg
     2701 gagatcatag ggaggaaact tccttccagt tccacttttc tccactgaat acaatctcac
     2761 ttttctaggt ccctgtctcc ctcccttgga gaacatgaag ttgttgaaaa gctgagaagt
     2821 ttctgctttc atttgggggc aggagtccca tgtaagaaaa atcacctaaa atcccagaag
     2881 aaaggaagag atttaaagat ttaaagcccc tcccaccctg ttcgtttcaa ataggtctgc
     2941 acttatccgg gaaagcagaa gtgtttccct gttgttcttg tgttgttcaa ggatcattta
     3001 ttaccaggga taaacgctga gttgcagaaa cttcaatttg cactatgagt ttccaaaata
     3061 gaaaatcatg tatggtatct catactaata atccaaactg ctgatagatt ttttttaaat
     3121 gagaaagaca gtttgagaaa ggaaaaaaaa aaaaacaaga aatgtggtct agtgaaatgc
     3181 ctgctttgtt gtgtatacga tactgtttgg atctcatgtg gagatggttt cttactatca
     3241 tgtaaccaca accgaagagg aaaatggaag agatgagggg gggagcactg tctaggaaga
     3301 ctgaaatcat gcatggtctg aaaggtgcag aaggaagtac gattaggtct cactctgggt
     3361 aggcgttgtt gtttatttaa ttatgtcgta tgtcattgtt tgcagcacaa aacattctat
     3421 gcatttgaaa ctgagcacta aactgggcta gctttctgat agaccgtttt gtggatagtg
     3481 tgatctcaca gtctacttac tgcctgtttc cactgaaaac acaacattat tgtaaatatt
     3541 ttctttcatg cacaggctca cacagtggtt acaaactgcc agtgttaatc ctgaaatgtc
     3601 tcaccgactg gtcctcctcc tgtccatgtt gtgtctgcag agctttctcc ttggttatgt
     3661 ctttgctcta ttgccccccc caccccaccc caccccatca gaaccatttc tgtgcgccaa
     3721 catacaacag ggaggtgtgt cccagcacac ttccaaataa aacgtgactg aaagaagaac
     3781 aattttatga tctgggtgca tttttgtgtt tacattgagc caagtcctgg tagagccggt
     3841 caacaaatga gacaaccaaa acaaaccaaa acaaaccaaa aaacaaaaca aagcaaaaaa
     3901 aaaaaaaaaa aacaaaaccc acatcaaaca gacagccgca aacaaacatt aaaatcaaag
     3961 aagaagggga aagggggagt cagcaggaat gaaagggtga gatttattta tttttttcta
     4021 catgagagtt cagtttcaga taactcctgt aagatgaatt gcttgtccat ttcctcaaac
     4081 ttttaatctt aattccagaa gctcttaagc cactgcaccc tgttcagagc ggtgagggaa
     4141 agctgtaaat aatcaggcac ctgaaagaca tttaagtcat ggtcagggac acaggcatct
     4201 aaggtttgaa tgtgctgttc tactctaaaa acacttctaa aaactgttgt aactaaacga
     4261 cttttcctta gcagttaata cattttaaaa gtattctttg atctgcccca ataacttatc
     4321 aaatgcttct ctttatttag aacattttgc ataccaccta ttgcttcaga ttgacaagag
     4381 attttctttc ttccttcctt ttctttcctt ccttccttcc ttcctttctt cttttctttt
     4441 ttcttttctt tcttttttct ttttttgtga cctggaacta gatcaaatgc caaatgtaca
     4501 aactttctta atagttggga ctatatcctc tgaagtcatc ttattttagc taaatctttt
     4561 taacttcacc ggcatatctg tgaaagaaaa gtgatgttca gaaaagaata gtacatttta
     4621 aaaaggtgtg attttaaaac agttgttaat attttaaaaa gcactagagg tatttttaaa
     4681 aatagatctc ttccatcaaa attggtttgt ttctgttatt gacttgaaat atcatcagag
     4741 tttctaataa aatacatttg taaaaacaca ttattttata gaaaagtatg accagatttc
     4801 attgttggag atccaggaat gaacaaataa aaagattaac gaaggttgtt tttctaataa
     4861 tctgctcaaa cagaaatgtt gcaggcaaat acatttgtat tatataataa tggataatgt
     4921 atgtattaag aatttaagca tttgttttgt attaagtaaa tccttgccca gtacttaaaa
     4981 aagagtatta tgctaataaa acatcatgaa aatgcattgc tttgcagggt ttcctatttt
     5041 atgtagtagg aaactgtgca aaacttaaaa aaaaaagttt tgctttctag taagttggat
     5101 gtgtacagaa caggaaggaa tggtagagct cttttaagac tcctttagcc ggcagccgat
     5161 ggcaaatttt aaaaggaaag ccctgaagag aaggcaatgg tttgctgctc tgtggtagtt
     5221 tagcctttcc aagttctctg gttccaaaag tcgggaaaac acgcggaatg gactgcctcc
     5281 catatctact aatcggtggg gggaaaatgt gtgagtctga agtcctctaa ataacacacg
     5341 tttcaaaagg taggggaact agggtccgat tctgttttag tctcttaaga cacacaggag
     5401 caaaatagga aagcggaaaa agaaaaatat atgccttgcc accgaaatgc tacctttctc
     5461 ttaaaactgc tttctgaact cttcacggga ttctgctttt tctgtagttc ttaagaaagg
     5521 atgtccccag catccgtcag ctagcttctg gatagatttt tgtctaatgc gtgttcttaa
     5581 attattctga acttcagtta taaactgtta aataaacagt aggcacccac cgca
//
