LOCUS       NM_017252               1278 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus POU class 3 homeobox 4 (Pou3f4), mRNA.
ACCESSION   NM_017252
VERSION     NM_017252.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1278)
  AUTHORS   Zhang,L., Zhang,X., Zhang,Y., Xu,N., Wang,J., Zhu,Y. and Xia,C.
  TITLE     Brn4 promotes the differentiation of radial glial cells into
            neurons by inhibiting CtBP2
  JOURNAL   Life Sci 254, 116866 (2020)
   PUBMED   31518606
  REMARK    GeneRIF: results indicated that Brn4 promoted the neuronal
            differentiation of neural stem cells via inhibition of CtBP2 and is
            a potential tool for generating neurons in cell replacement therapy
            of neurodegenerative diseases and brain injury
REFERENCE   2  (bases 1 to 1278)
  AUTHORS   Uetsuka,S., Ogata,G., Nagamori,S., Isozumi,N., Nin,F., Yoshida,T.,
            Komune,S., Kitahara,T., Kikkawa,Y., Inohara,H., Kanai,Y. and
            Hibino,H.
  TITLE     Molecular architecture of the stria vascularis membrane transport
            system, which is essential for physiological functions of the
            mammalian cochlea
  JOURNAL   Eur J Neurosci 42 (3), 1984-2002 (2015)
   PUBMED   26060893
REFERENCE   3  (bases 1 to 1278)
  AUTHORS   Tan,X.F., Jin,G.H., Tian,M.L., Qin,J.B., Zhang,L., Zhu,H.X. and
            Li,H.M.
  TITLE     The co-transduction of Nurr1 and Brn4 genes induces the
            differentiation of neural stem cells into dopaminergic neurons
  JOURNAL   Cell Biol Int 35 (12), 1217-1223 (2011)
   PUBMED   21663595
  REMARK    GeneRIF: The co-transduction of Nurr1 and Brn4 genes induces cell
            differentiation of neural stem cells
REFERENCE   4  (bases 1 to 1278)
  AUTHORS   Shi,J., Jin,G., Zhu,H., Tian,M., Zhang,X., Qin,J. and Tan,X.
  TITLE     The role of Brn-4 in the regulation of neural stem cell
            differentiation into neurons
  JOURNAL   Neurosci Res 67 (1), 8-17 (2010)
   PUBMED   20105446
  REMARK    GeneRIF: Brn-4 expression is required both for neuronal
            differentiation of NSCs and maturation of newborn neurons, and that
            there may be some regulatory factors in deafferented hippocampus
            that can regulate Brn-4 expression in neuronal progenitors.
REFERENCE   5  (bases 1 to 1278)
  AUTHORS   Zhang,X., Jin,G., Wang,L., Hu,W., Tian,M., Qin,J. and Huang,H.
  TITLE     Brn-4 is upregulated in the deafferented hippocampus and promotes
            neuronal differentiation of neural progenitors in vitro
  JOURNAL   Hippocampus 19 (2), 176-186 (2009)
   PUBMED   18831054
  REMARK    GeneRIF: study showed after fimbria-fornix lesion, Brn-4 in
            deafferented hippocampus was upregulated & might play a role in
            inducing local progenitors to differentiate into neurons, which may
            compensate for loss of cholinergic afferent fibers or other
            dysfunctions
REFERENCE   6  (bases 1 to 1278)
  AUTHORS   Malik,K.F., Jaffe,H., Brady,J. and Young,W.S. 3rd.
  TITLE     The class III POU factor Brn-4 interacts with other class III POU
            factors and the heterogeneous nuclear ribonucleoprotein U
  JOURNAL   Brain Res Mol Brain Res 45 (1), 99-107 (1997)
   PUBMED   9105675
REFERENCE   7  (bases 1 to 1278)
  AUTHORS   de Kok,Y.J., Cremers,C.W., Ropers,H.H. and Cremers,F.P.
  TITLE     The molecular basis of X-linked deafness type 3 (DFN3) in two
            sporadic cases: identification of a somatic mosaicism for a POU3F4
            missense mutation
  JOURNAL   Hum Mutat 10 (3), 207-211 (1997)
   PUBMED   9298820
REFERENCE   8  (bases 1 to 1278)
  AUTHORS   de Kok,Y.J., van der Maarel,S.M., Bitner-Glindzicz,M., Huber,I.,
            Monaco,A.P., Malcolm,S., Pembrey,M.E., Ropers,H.H. and Cremers,F.P.
  TITLE     Association between X-linked mixed deafness and mutations in the
            POU domain gene POU3F4
  JOURNAL   Science 267 (5198), 685-688 (1995)
   PUBMED   7839145
REFERENCE   9  (bases 1 to 1278)
  AUTHORS   Mathis,J.M., Simmons,D.M., He,X., Swanson,L.W. and Rosenfeld,M.G.
  TITLE     Brain 4: a novel mammalian POU domain transcription factor
            exhibiting restricted brain-specific expression
  JOURNAL   EMBO J 11 (7), 2551-2561 (1992)
   PUBMED   1628619
REFERENCE   10 (bases 1 to 1278)
  AUTHORS   Le Moine,C. and Young,W.S. 3rd.
  TITLE     RHS2, a POU domain-containing gene, and its expression in
            developing and adult rat
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3285-3289 (1992)
   PUBMED   1348858
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M84645.1 and Z11834.1.
            
            On Nov 23, 2005 this sequence version replaced NM_017252.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1162              M84645.1           1-1162
            1163-1278           Z11834.1           1135-1250
FEATURES             Location/Qualifiers
     source          1..1278
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq31"
     gene            1..1278
                     /gene="Pou3f4"
                     /gene_synonym="RHS2"
                     /note="POU class 3 homeobox 4"
                     /db_xref="GeneID:29589"
                     /db_xref="RGD:61947"
     exon            1..1278
                     /gene="Pou3f4"
                     /gene_synonym="RHS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..1118
                     /gene="Pou3f4"
                     /gene_synonym="RHS2"
                     /note="brn-4; brain-4; RHS2 class III POU protein;
                     brain-specific homeobox/POU domain protein 4; OTF-9;
                     oct-9; octamer-binding protein 9; octamer-binding
                     transcription factor 9"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 4"
                     /protein_id="NP_058948.1"
                     /db_xref="GeneID:29589"
                     /db_xref="RGD:61947"
                     /translation="MATAASNPYSILSSSSLVHADSAGMQQGSPFRNPQKLLQSDYLQ
                     GVPSNGHPLGHHWVTSLSDGGPWSSTLATSPLDQQDVKPGREDLQLGAIIHHRSPHVA
                     HHSPHTNHPNAWGASPAPNSSITSSGQPLNVYSQPGFTVSGMLEHGGLTPPPAAASTQ
                     SLHPVLREPPDHGELGSHHCQDHSDEETPTSDELEQFAKQFKQRRIKLGFTQADVGLA
                     LGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPTSIDKIAAQG
                     RKRKKRTSIEVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEK
                     RMTPPGDQQPHEVYSHTVKTDASCHDL"
ORIGIN      
        1 acattataac tagtagagga tcctcatcga ccatggccac agctgcctcg aatccctaca
       61 gcattctcag ttccagctcc ctcgtccatg cggactctgc gggcatgcag cagggaagtc
      121 ctttccgcaa tcctcagaaa cttctccaaa gtgactactt gcagggagtt cccagcaatg
      181 ggcatcccct cgggcatcac tgggtgacca gtctgagcga cgggggcccg tggtcctcca
      241 cattggccac cagccccctg gaccagcagg acgtgaagcc gggacgtgaa gatctgcaac
      301 tgggagcaat catccatcac cgctcgcctc acgtagccca ccactcgccc cacactaacc
      361 atccgaacgc ctggggagcg agcccggctc caaactcgtc catcacgtcc agcggccaac
      421 ctctcaatgt gtactcgcag ccaggcttca cggtgagtgg tatgctagag cacgggggac
      481 tcactccacc accagctgct gcctccacac agagcctgca tccagtgctc cgggagcctc
      541 cagaccatgg tgagctgggc tcgcaccact gccaggacca ctcggatgaa gagactccaa
      601 cctctgatga gttggaacag ttcgccaaac aattcaaaca aagaagaatc aagttgggtt
      661 tcacgcaagc cgacgtgggg ctggcattgg gcacactgta tggcaacgtg ttctcgcaga
      721 ctaccatctg caggttcgag gccttgcaac tgagcttcaa gaacatgtgc aagctgaaac
      781 cactgctaaa taagtggctg gaggaggctg attcatccac aggaagcccg accagcattg
      841 acaagatcgc cgctcagggc cgtaaacgca agaagcgaac ctccattgag gtgagtgtca
      901 agggcgtact ggaaacgcat ttcctcaagt gtcccaagcc tgcagcacag gagatctcct
      961 cgctggcaga cagtctccag ttggagaaag aagtggtacg tgtctggttc tgtaatagaa
     1021 gacaaaaaga aaaaagaatg actccgccag gggatcagca gccacacgag gtttattcgc
     1081 acacggtgaa aacagatgcg tcctgccacg atctctgact ggaggaagca aggaggtggc
     1141 ccgctgcact gggagcagtg ctgatacaat tctctcttta ccttcctttc agcattacat
     1201 tctttattat tgctatctct ctagcttgct agctcttcct ttctttcaca ggggtttcta
     1261 acttcttatg acttatgt
//
