LOCUS       NM_138837               3127 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus POU class 3 homeobox 3 (Pou3f3), mRNA.
ACCESSION   NM_138837
VERSION     NM_138837.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3127)
  AUTHORS   Snijders Blok,L., Kleefstra,T., Venselaar,H., Maas,S., Kroes,H.Y.,
            Lachmeijer,A.M.A., van Gassen,K.L.I., Firth,H.V., Tomkins,S.,
            Bodek,S., Ounap,K., Wojcik,M.H., Cunniff,C., Bergstrom,K.,
            Powis,Z., Tang,S., Shinde,D.N., Au,C., Iglesias,A.D., Izumi,K.,
            Leonard,J., Abou Tayoun,A., Baker,S.W., Tartaglia,M., Niceta,M.,
            Dentici,M.L., Okamoto,N., Miyake,N., Matsumoto,N., Vitobello,A.,
            Faivre,L., Philippe,C., Gilissen,C., Wiel,L., Pfundt,R.,
            Deriziotis,P., Brunner,H.G. and Fisher,S.E.
  CONSRTM   DDD Study
  TITLE     De Novo Variants Disturbing the Transactivation Capacity of POU3F3
            Cause a Characteristic Neurodevelopmental Disorder
  JOURNAL   Am J Hum Genet 105 (2), 403-412 (2019)
   PUBMED   31303265
REFERENCE   2  (bases 1 to 3127)
  AUTHORS   Mutai,H., Nagashima,R., Sugitani,Y., Noda,T., Fujii,M. and
            Matsunaga,T.
  TITLE     Expression of Pou3f3/Brn-1 and its genomic methylation in
            developing auditory epithelium
  JOURNAL   Dev Neurobiol 69 (14), 913-930 (2009)
   PUBMED   19743445
  REMARK    GeneRIF: Pou3f3 may be important for the maintenance or functional
            development of the postnatal cochlea. This is the first report to
            study involvement of an epigenetic regulatory mechanism in the
            developing mammalian auditory epithelium.
REFERENCE   3  (bases 1 to 3127)
  AUTHORS   Kim,D.K., Han,S.B., Hong,S.T., Choi,Y.J., Sun,W., Geum,D. and
            Kim,H.
  TITLE     Expression of Sox11 and Brn transcription factors during
            development and following transient forebrain ischemia in the rat
  JOURNAL   Neurosci Lett 433 (3), 259-264 (2008)
   PUBMED   18261853
  REMARK    GeneRIF: Collectively, overall results suggest that the expression
            of Sox11 and Brn1 may be modulated by the cell-type specific
            machinery.
REFERENCE   4  (bases 1 to 3127)
  AUTHORS   Aigner,B., Rathkolb,B., Herbach,N., Kemter,E., Schessl,C.,
            Klaften,M., Klempt,M., de Angelis,M.H., Wanke,R. and Wolf,E.
  TITLE     Screening for increased plasma urea levels in a large-scale ENU
            mouse mutagenesis project reveals kidney disease models
  JOURNAL   Am J Physiol Renal Physiol 292 (5), F1560-F1567 (2007)
   PUBMED   17264314
REFERENCE   5  (bases 1 to 3127)
  AUTHORS   Castro,D.S., Skowronska-Krawczyk,D., Armant,O., Donaldson,I.J.,
            Parras,C., Hunt,C., Critchley,J.A., Nguyen,L., Gossler,A.,
            Gottgens,B., Matter,J.M. and Guillemot,F.
  TITLE     Proneural bHLH and Brn proteins coregulate a neurogenic program
            through cooperative binding to a conserved DNA motif
  JOURNAL   Dev Cell 11 (6), 831-844 (2006)
   PUBMED   17141158
REFERENCE   6  (bases 1 to 3127)
  AUTHORS   Kuhlbrodt,K., Herbarth,B., Sock,E., Enderich,J.,
            Hermans-Borgmeyer,I. and Wegner,M.
  TITLE     Cooperative function of POU proteins and SOX proteins in glial
            cells
  JOURNAL   J Biol Chem 273 (26), 16050-16057 (1998)
   PUBMED   9632656
REFERENCE   7  (bases 1 to 3127)
  AUTHORS   Schreiber,J., Enderich,J., Sock,E., Schmidt,C.,
            Richter-Landsberg,C. and Wegner,M.
  TITLE     Redundancy of class III POU proteins in the oligodendrocyte lineage
  JOURNAL   J Biol Chem 272 (51), 32286-32293 (1997)
   PUBMED   9405434
REFERENCE   8  (bases 1 to 3127)
  AUTHORS   Malik,K.F., Jaffe,H., Brady,J. and Young,W.S. 3rd.
  TITLE     The class III POU factor Brn-4 interacts with other class III POU
            factors and the heterogeneous nuclear ribonucleoprotein U
  JOURNAL   Brain Res Mol Brain Res 45 (1), 99-107 (1997)
   PUBMED   9105675
REFERENCE   9  (bases 1 to 3127)
  AUTHORS   Sock,E., Enderich,J., Rosenfeld,M.G. and Wegner,M.
  TITLE     Identification of the nuclear localization signal of the POU domain
            protein Tst-1/Oct6
  JOURNAL   J Biol Chem 271 (29), 17512-17518 (1996)
   PUBMED   8663425
REFERENCE   10 (bases 1 to 3127)
  AUTHORS   Le Moine,C. and Young,W.S. 3rd.
  TITLE     RHS2, a POU domain-containing gene, and its expression in
            developing and adult rat
  JOURNAL   Proc Natl Acad Sci U S A 89 (8), 3285-3289 (1992)
   PUBMED   1348858
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            On Mar 18, 2021 this sequence version replaced NM_138837.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3127              JAXUCZ010000009.1  52438026-52441152
FEATURES             Location/Qualifiers
     source          1..3127
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q22"
     gene            1..3127
                     /gene="Pou3f3"
                     /gene_synonym="Brn1; RHS1"
                     /note="POU class 3 homeobox 3"
                     /db_xref="GeneID:192109"
                     /db_xref="RGD:619768"
     exon            1..3127
                     /gene="Pou3f3"
                     /gene_synonym="Brn1; RHS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1560
                     /gene="Pou3f3"
                     /gene_synonym="Brn1; RHS1"
                     /function="transcription factor"
                     /note="class III POU protein POU-domain; brain-1; brn-1
                     protein; brain-specific homeobox/POU domain protein 1"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 3"
                     /protein_id="NP_620192.2"
                     /db_xref="GeneID:192109"
                     /db_xref="RGD:619768"
                     /translation="MATAASNPYLPGNSLLAAGSIVHSDAAGAGGGGGGGGGGGGGAG
                     GGGGGMQPGSAAVTSGAYRGDPSSVKMVQSDFMQGAMAASNGGHMLSHAHQWVTALPH
                     AAAAAAAAAAAAVEASSPWSGSAVGMAGSPQQPPQPPPPPPQGPDVKGGAGREDLHAG
                     TALHHRGPPHLGPPPPPPHQGHPGGWGAAAAAAAAAAAAAAAAHLPSMAGGQQPPPQS
                     LLYSQPGGFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHH
                     AHPHPPHPHHAQGPPHHGGGGAGPGLNSHDPHSDEDTPTSDDLEQFAKQFKQRRIKLG
                     FTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSSTGSPT
                     SIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITNLADSLQLEKEVVRVW
                     FCNRRQKEKRMTPPGIQQQTPDDVYSQVGTVSADTPPPHHGLQTSVQ"
ORIGIN      
        1 gcggccgcgg ctgctgctgc ggcggcggcg gtggtggcgg cggtggggtg gcgggagcgg
       61 agcggcatgg ccacggcggc ttctaacccc tacctgccgg ggaacagcct gctcgcggcc
      121 ggatccattg tgcactcgga cgcggccggg gcgggcggcg gcggaggggg cggcggcggt
      181 ggcggcggcg gggcgggggg cggcggcggc ggcatgcagc cgggaagcgc cgccgtgacc
      241 tcgggcgcct accgggggga tccgtcctcc gtcaagatgg tccagagtga cttcatgcag
      301 ggggccatgg ccgccagcaa cggcggccat atgctgagcc acgcgcacca gtgggtcacc
      361 gccctgcccc acgctgccgc cgctgccgcc gctgctgccg ccgccgccgt ggaagccagc
      421 tctccgtggt cgggcagcgc ggtgggcatg gccggcagcc cccagcagcc accacagccg
      481 ccgccgccgc cgccgcaggg ccccgacgtg aagggaggcg ctggacgcga agacctgcac
      541 gccggcacag cgctgcacca ccgcggaccg ccgcacctcg ggcccccgcc accgccccct
      601 caccagggac accctggagg ctggggggcc gcagccgccg ctgccgctgc cgccgccgcc
      661 gccgctgccg ccgctcacct cccgtccatg gcgggcggcc agcagccgcc gccgcagagt
      721 ctgctgtact cgcagcccgg aggcttcacg gtgaacggca tgctgagcgc gcccccgggg
      781 ccaggcggtg gcggcggcgg agcgggcggt ggagcccaaa gcctggttca cccggggtta
      841 gtgcgcgggg acacgcccga gctggcggag catcatcacc accatcacca ccacgcgcac
      901 ccgcacccgc cgcacccgca ccacgcgcag ggacccccac atcacggtgg cggcggagcg
      961 gggccaggac tcaacagcca cgacccgcac tcggacgagg acacgccgac gtctgacgac
     1021 ctggagcagt tcgctaagca gttcaagcag cggcgcatca agctgggctt cacccaggcg
     1081 gacgtggggc tggctctggg cactctgtat ggcaatgtgt tctcgcagac caccatctgc
     1141 cgcttcgagg ccctgcagct cagtttcaag aacatgtgca agctcaagcc gctgctgaac
     1201 aagtggctgg aggaggccga ctcgagcacc ggcagcccca ccagcattga caagatcgca
     1261 gcacagggcc gcaagcgcaa gaagcggacc tccatcgagg ttagcgtcaa aggcgcgctg
     1321 gagagccact tcctcaagtg ccctaaaccc tcggcgcagg agatcaccaa cttggccgac
     1381 agcctgcagc tggaaaagga ggtcgtgcgg gtctggttct gcaaccgacg ccaaaaggaa
     1441 aaacgcatga cgccccctgg catccagcag cagacgccgg acgatgtcta ctcgcaggtg
     1501 gggaccgtga gcgctgacac accgccaccg caccacgggc tgcagaccag cgtgcagtga
     1561 atgccggggc gcagcgcgaa gtgggccgcc gccaccacct ccgcagccgc tgtcagcacc
     1621 gccacggtca ccgccgctgc cgtctctgag cggccgccga gaaccaccgc cgccgctgct
     1681 gccgctgctg ccgccgccgc cgccgccgcc gccgccgccg ctgccgccgc gcagacccaa
     1741 cacctggcca gtgccagggt gaccaggcct cctcccctcc gcccaaagac aggcgagcca
     1801 tggccctagg aggggggaga acagctggag accgatgaga ctctttctga agtccaagga
     1861 aggagggacc aaaaacaaat ttttaagcat aataaatacc aagactgttt tatatgcata
     1921 tataacaaac aaaaccggaa gaggaaaagg gaggaacaag gacatctcgt ttatactgtg
     1981 gtggtgtttt gttcctgttt tgaaagaagg gtgaagatgc ctaacgcacc aaaactacac
     2041 acgaggtact gtccacaccg agatgtcctg ctcggcgaca gtggagaaca cctgcctctg
     2101 agataagaga gaccccctcc ccgttcttcc acttcttcca aaagggctgc ctaaaagatc
     2161 catggaaact ttctttactg ggagcgacct gaaaagaaag acgcaccagg tttcctgcag
     2221 gtctgactct gctcctcgac agtgtttttc ttggccatat tcaagtcttt ggggaacaaa
     2281 taaatcaact aagaaatggg aaggaaggag aaacagagtc tgggggggga gggaagattc
     2341 acagcttctg aagttaacag actgaacagg aaagccaaaa gaaagcatcc ttgccgtaaa
     2401 cttgggaata aaagcatcgc gaaagagcca aggctgggcg aggctgaagg gtaggtatgt
     2461 ccagccgcaa tccgccagcg gagagggcac aacagcgggg ccagggccca gcctttgaga
     2521 ccgcccagaa gggccaggtc tcccccacgc cactgaaccc gggctttgcc gactgccgct
     2581 cggggtggac catgcctaaa gattccgccg ctaatatttt ttttattaac attttttatt
     2641 ttttatttct ggactgactc cgataaaagg gtgtggaaag acagcaccaa ccgcgcactt
     2701 cccttgactt ctgccctcga tccgttgcca actttgattg aatgggtgct gcggatgtga
     2761 ttatgtaata ctgccatttc caagcagtgt ttttggtagg ttttaataaa cagacttttc
     2821 aaatgacggc aatatagaat cgttagatcc gttgttgatc taaaaatatt tgctttatat
     2881 tttcattaaa tgacttcttt taatatttta ttcaaaatac ttatgaactg ctgcaaaacg
     2941 gtaatttatt tttccccaga tcttgtatta cgtgtttttt tcagacgagc acaaatcaaa
     3001 atgaaatgaa aatatggaca gttgttaggt aataagggta tcttttgatg tgatcatttg
     3061 attgtaattt aatttgagta gtgattccgt aagagctgat tgagaaaata aatttgttag
     3121 aatgaaa
//
