LOCUS       NM_172085               5909 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus POU class 3 homeobox 2 (Pou3f2), mRNA.
ACCESSION   NM_172085 XM_001059735 XM_345510
VERSION     NM_172085.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5909)
  AUTHORS   Wapinski OL, Vierbuchen T, Qu K, Lee QY, Chanda S, Fuentes DR,
            Giresi PG, Ng YH, Marro S, Neff NF, Drechsel D, Martynoga B, Castro
            DS, Webb AE, Sudhof TC, Brunet A, Guillemot F, Chang HY and Wernig
            M.
  TITLE     Hierarchical mechanisms for direct reprogramming of fibroblasts to
            neurons
  JOURNAL   Cell 155 (3), 621-635 (2013)
   PUBMED   24243019
REFERENCE   2  (bases 1 to 5909)
  AUTHORS   Ellmann L, Joshi MB, Resink TJ, Bosserhoff AK and Kuphal S.
  TITLE     BRN2 is a transcriptional repressor of CDH13 (T-cadherin) in
            melanoma cells
  JOURNAL   Lab Invest 92 (12), 1788-1800 (2012)
   PUBMED   23069940
REFERENCE   3  (bases 1 to 5909)
  AUTHORS   Arnold SJ, Huang GJ, Cheung AF, Era T, Nishikawa S, Bikoff EK,
            Molnar Z, Robertson EJ and Groszer M.
  TITLE     The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in
            the cortical subventricular zone
  JOURNAL   Genes Dev 22 (18), 2479-2484 (2008)
   PUBMED   18794345
REFERENCE   4  (bases 1 to 5909)
  AUTHORS   Hoser M, Potzner MR, Koch JM, Bosl MR, Wegner M and Sock E.
  TITLE     Sox12 deletion in the mouse reveals nonreciprocal redundancy with
            the related Sox4 and Sox11 transcription factors
  JOURNAL   Mol Cell Biol 28 (15), 4675-4687 (2008)
   PUBMED   18505825
REFERENCE   5  (bases 1 to 5909)
  AUTHORS   Dy P, Penzo-Mendez A, Wang H, Pedraza CE, Macklin WB and Lefebvre
            V.
  TITLE     The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping
            expression patterns and molecular properties
  JOURNAL   Nucleic Acids Res 36 (9), 3101-3117 (2008)
   PUBMED   18403418
REFERENCE   6  (bases 1 to 5909)
  AUTHORS   Malik KF, Jaffe H, Brady J and Young WS 3rd.
  TITLE     The class III POU factor Brn-4 interacts with other class III POU
            factors and the heterogeneous nuclear ribonucleoprotein U
  JOURNAL   Brain Res Mol Brain Res 45 (1), 99-107 (1997)
   PUBMED   9105675
REFERENCE   7  (bases 1 to 5909)
  AUTHORS   Brunekreef GA, van Genesen ST and Lubsen NH.
  TITLE     Sp1- and octamer-consensus sequence binding proteins during lens
            fibre differentiation
  JOURNAL   Exp Eye Res 64 (3), 295-299 (1997)
   PUBMED   9196379
REFERENCE   8  (bases 1 to 5909)
  AUTHORS   Suzuki T, Kim HS, Kurabayashi M, Hamada H, Fujii H, Aikawa M,
            Watanabe M, Watanabe N, Sakomura Y, Yazaki Y and Nagai R.
  TITLE     Preferential differentiation of P19 mouse embryonal carcinoma cells
            into smooth muscle cells. Use of retinoic acid and antisense
            against the central nervous system-specific POU transcription
            factor Brn-2
  JOURNAL   Circ Res 78 (3), 395-404 (1996)
   PUBMED   8593698
REFERENCE   9  (bases 1 to 5909)
  AUTHORS   Schonemann MD, Ryan AK, McEvilly RJ, O'Connell SM, Arias CA, Kalla
            KA, Li P, Sawchenko PE and Rosenfeld MG.
  TITLE     Development and survival of the endocrine hypothalamus and
            posterior pituitary gland requires the neuronal POU domain factor
            Brn-2
  JOURNAL   Genes Dev 9 (24), 3122-3135 (1995)
   PUBMED   8543156
REFERENCE   10 (bases 1 to 5909)
  AUTHORS   Li P, He X, Gerrero MR, Mok M, Aggarwal A and Rosenfeld MG.
  TITLE     Spacing and orientation of bipartite DNA-binding motifs as
            potential functional determinants for POU domain factors
  JOURNAL   Genes Dev 7 (12B), 2483-2496 (1993)
   PUBMED   8276233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000161.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_172085.4.
            
            On Feb 10, 2021 this sequence version replaced NM_172085.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: L27663.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5909              JACYVU010000161.1  11502059-11507967   c
FEATURES             Location/Qualifiers
     source          1..5909
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..5909
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="POU class 3 homeobox 2"
                     /db_xref="GeneID:29588"
                     /db_xref="RGD:61946"
     exon            1..5909
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1408
                     /gene="Pou3f2"
                     /gene_synonym="Brn-2; oct-7; OTF-7"
                     /note="nervous system-specific octamer-binding
                     transcription factor N-Oct-3; brain-specific homeobox/POU
                     domain protein 2; brain-2; protein Brn-2; octamer-binding
                     protein 7; octamer-binding transcription factor 7"
                     /codon_start=1
                     /product="POU domain, class 3, transcription factor 2"
                     /protein_id="NP_742082.2"
                     /db_xref="GeneID:29588"
                     /db_xref="RGD:61946"
                     /translation="MATAASNHYSLLTSSASIVHAEPPGGMQQGAGGYREAQSLVQGD
                     YGALQSNGHPLSHAHQWITALSHGGSGGGGGGGGGGGGGGGGGGDGSPWSTSPLGQPD
                     IKPSVVVQQGGRGDELHGPGALQQQHQQQQQQQQQQQQQQQQQQQQQQQRPPHLVHHA
                     ANHHPGPGAWRSAAAAAHLPPSMGASNGGLLYSQPSFTVNGMLGAGGQPAGLHHHGLR
                     DAHDEPHHADHHPHPHSHPHQQPPPPPPPQGPPGHPGAHHDPHSDEDTPTSDDLEQFA
                     KQFKQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWL
                     EEADSSSGSPTSIDKIAAQGRKRKKRTSIEVSVKGALESHFLKCPKPSAQEITSLADS
                     LQLEKEVVRVWFCNRRQKEKRMTPPGGTLPGAEDVYGGSRDTPPHHGVQTPVQ"
ORIGIN      
        1 ccaaggcaga aaagtaactg tcaaatgcgc ggctccttta accagagcgc ccagtccggc
       61 tccgagagtc atggcgaccg cagcgtctaa ccactacagc ctgctcacct ccagcgcctc
      121 catcgtgcac gccgagccgc ctggcggcat gcagcagggc gcggggggct accgcgaggc
      181 acagagcctg gtgcagggcg actacggtgc gctgcagagc aacgggcacc cgctcagcca
      241 cgctcaccag tggatcaccg cgctgtccca cggcggcagc ggcgggggcg gcggcggtgg
      301 tggaggaggc gggggaggcg gcgggggagg cggcgacggc tccccgtggt ccaccagccc
      361 cctaggccag ccggacatca agccctcggt ggtggtacag cagggtggcc gaggcgacga
      421 gctgcacggg ccaggagcgc tgcagcagca gcaccaacag caacagcagc agcagcaaca
      481 gcaacagcag caacaacagc aacagcagca gcagcaacaa cagcgaccgc cacatctggt
      541 gcaccacgct gccaaccacc atcccgggcc cggggcatgg cggagtgcgg cggctgcagc
      601 tcaccttcct ccctccatgg gagcttccaa cggtggtttg ctctattcgc agcccagctt
      661 cacggtgaac ggcatgctgg gcgcaggagg gcagccggct gggctgcacc accacggcct
      721 gagggacgcc cacgatgagc cccatcatgc agaccaccac ccgcatccgc actctcaccc
      781 gcaccagcaa ccgcccccgc cacctccccc acaaggccca ccgggccacc caggcgcgca
      841 ccacgacccg cactcggacg aggacacgcc gacctcagac gacctggagc agttcgccaa
      901 gcaattcaag cagaggcgga tcaaactagg atttactcaa gcagacgtgg ggctggcgct
      961 tggcaccctg tacggcaacg tcttctcgca gaccaccatc tgcaggtttg aggccctgca
     1021 gctgagcttc aagaacatgt gcaagctgaa gcctttgttg aacaagtggt tggaagaggc
     1081 agactcatcc tcgggcagcc ccaccagcat agacaagatc gctgcgcaag ggcgcaaacg
     1141 gaaaaagcgg acctccatcg aggtgagcgt caagggggct ctggagagcc atttcctcaa
     1201 atgccctaag ccctcggccc aggagatcac ctccctcgcg gacagcttac agctggagaa
     1261 ggaggtggtg agagtttggt tttgtaacag gagacagaaa gagaaaagga tgacccctcc
     1321 cggagggact ctgccgggcg ccgaggatgt gtatgggggg agtagggaca cgccaccaca
     1381 ccacggggtg cagacgcccg tccagtgaac tcaagcaggg gaggggcaga gcttggggct
     1441 cccctcccct ttggtccaca gtcttaactg ggacctctgt tccccctgta acttctgatt
     1501 gttttttttt ttttaattat tattttcccg gtcccttaaa aagagaaaaa aatagagaaa
     1561 ttaaggagaa aggaaagtaa aagtaaaaca ctggactaac ctatagcagg tagcaggtgt
     1621 attcatgggt tttgaccttt gcaagcgagt acccaggcaa tgaagtagaa tgtctcctag
     1681 taagagtgaa gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtctgt
     1741 gtgtgagaga gagagagaga gagagagaga gagagagaga gagagagaga gagagaggga
     1801 gggaggagtc ctggtaaaac taaataaatt accaaaaaga aaaaaaatcc accaaaccgt
     1861 acacaacaca aaactgcagc ttcccatgct caaagttgac acgtgctgct gtgtttattt
     1921 aatatggtcc ccatcaggaa agagggaaaa atacactttt taaaactatt ggcaaaattt
     1981 aagcacacga atttgcactg caagaaaatt gaagtttaca ttgacaagtt caaccctttt
     2041 tttttttttc tcttaatacc cactgttaaa tttgaagctg tcctttgggt tctgttctgt
     2101 tctgccttat ccagtggaga ggacagaagc cagctcctgg ccaccctcca ttccagcgtt
     2161 ctgatgcccc ttgttcttat tgcttgtaaa ctttgttttc ttcaacgccc cagacctggt
     2221 gtaacactta ttggctcttt tcaccaaagc gaaatgattg gcttcacaca aaataaataa
     2281 atgtttgcat tcaggaaatg tgtatggttt gcccgcttta tgcaaggcag gaatatcgtt
     2341 ggaaatacaa atataagtgt tgagcactgt tttttgtttg gttggttttt tttgtttttt
     2401 tttgtttttg tttttgtttt tgtttttgta aaccacacag taaacttcat cttcaggcag
     2461 tatttctggg taggagagaa aaaggaaaat caatagtgag tgatcagtca cttcattttt
     2521 ttcaggcagg gctattgtga aagaactaaa aaaacaaaca gaaaaaaacc tgtgaggtta
     2581 aatatattgt ccaacagaca gaaattaagg actctgagaa cttggaaaca cactgggttc
     2641 tctgcctttg ggtttaataa cttaattata agggattagt tgtgatgaca gcagtggtta
     2701 aactttgttc ctctactagg ttttattttt taacataaag aaaataaccc aggaactcga
     2761 tatatcatat gcacactgtg tttcttaaca cagaaatgca tatactataa tgcatatata
     2821 tatatatata tatatattgg atagacaggt ttttgtaccc aacagttcaa ttgtttatga
     2881 agtcatattt tgggctttac accatcttcc cccataagtt attgcagaaa aacatcagtt
     2941 cagattggac aaaattcccc ccactttcat taaaacagac aaatgaaggg gagggggcat
     3001 tttcaatgat ttctttctcc ccctttgtta ataaattttc agtgcatttt tttttacctt
     3061 gtctaaatgg gaaatggttt acacccaaca caatagaata ttctggaagg tgtaggtaag
     3121 aaaacaaaaa cagaaaaggc tatggctaaa ctgaaattaa caccattaaa actgtgatca
     3181 gtttaaaaaa ttaaatagtt atcagcacaa aagggcgcta aaagggaaaa aaaccttaaa
     3241 tagttggggt tttatttctt tgttaggtat cagataaatg ttatgttaaa aaagtaaatt
     3301 ctcactacca taaattgatg gctcagcatc ggattagcat tgcactccgt agttaaggtt
     3361 ttaggtaata tgctttatca agtattgtct ttagaaactc ctgtgattgt ttcattttcg
     3421 atgtttttac aagataaatg gtgacttata atgggcatat ttatttgcct gtatttcatt
     3481 tcccccaatg aatgtcacag gagatgccat agagctattt caggttatat cacactgctt
     3541 cttcctgatg tgtggggact ggccttcagt aaagcaaccc agaggagggc agatggccaa
     3601 tggtaaaagg aggaaatgaa tttgcagata cttattacca agtaggtaag gtcaggaagc
     3661 tggggttccg gggatgtgcc tacatcttct cttgctctct taggcttaca aatatgaaag
     3721 ttaccactga accttaccat atgtatatat gtttaatatc tgtcttttga aatgcagaaa
     3781 tagtttaaat gtttctttgt ctatttttcc ttttgttttt aatgctaccc agggaaatat
     3841 tttcatatcg ttttacgtgg cctgcctcaa tgtatattta tttctttgga gaaaaaaaaa
     3901 ggttctgaaa actggttttc tgtagcttta aatgagtagg tagcaagatc tatatgggat
     3961 gtcatttttt tgttcagttt ctttaaaaaa atgctttgtt ttgatacatt tggttgtgct
     4021 tgtggggaaa ataaaagcgc agagatcctt atatatttat gttaaagtaa tattttatta
     4081 ttacataaaa cagaaatgca caataccttc atagtttgtt ctaattattg aaatatcttt
     4141 attttatttt taaagatagt gccaagttct aagaggtgag gaagccctac ctagacctta
     4201 tactgactga gctgtgtata aaatacttcc cttcctttat acgtcataaa gttttggaat
     4261 aaattttatg catatattgc cagctttcat gtttataact tccagaggca ttttcttagt
     4321 tttttttttt taaagaggag tgttcagact tttctttgca gaaactacca tggggcccaa
     4381 atattgtctt cactgccttg tagaattcaa tcaaatcagt cattgggttt cagctccaat
     4441 ttgttggcca tttcctgaac aaacgaaaaa aaaatacttg ccttgtaaat acatgcccag
     4501 gtccctacac cttccctcca ggttagctgc tctttgccaa tggattgtta aggatagcat
     4561 cagtgggact agatggacct taacctctgc cacatgtcct taggtaaact ggtaccttca
     4621 gaaaagtgag gcttagacag aaattattat tcattattaa caaatatccc tcaacaacaa
     4681 aaactcttaa cgatatgcaa tatatatgtt taccaactga ttaaaagtag ataccacaca
     4741 ttagtcctct taggtttaca ggggaaagat acttttttta caacagtgta tctctctcac
     4801 caggcaaaca aacaaacaaa ccacatcaag atctacatta aaagaagagg gaaagaatgt
     4861 attggagaga tacaagccat ggtttgtttc agaaggtttt agataaagca ctgcacttaa
     4921 aacaacagca aacaagcaaa aagatagtct ttaatgttgg tgaagtgttt atatatttgt
     4981 tggtgtattt aaagtcctcc ttggaacact gacttaaaat ataaatgtcc atttaggaaa
     5041 ggagtttctg ggcttattac ttctgatcat cttttctaat tcctagtcaa tattacatgg
     5101 gtcccaaaca gattctgcca aatgatctta tcaatagtct gaacaagaag tgacagaaag
     5161 aagaagtgtt ttgtgaccac agacatgctg atgggtaaaa tgtttaagct aggtatagat
     5221 ttgagttctg ggtcaatatc cctcctctga aggaggaaag cgagcctcat ctgccctctg
     5281 cagggcgttt cagtggaccc tgagaaggca tttttttttc ctttcctcag gcactgtgaa
     5341 cagacctgga aacatcatat attaaacaga cacactatgt tcctgacttg tgttggtcac
     5401 tggggtcctc aagctgctct ggtagcttcc atgccagtct tagaatgtat tcccacttaa
     5461 aaaaaaaaaa gactgcagag tcattaatac aaatctgtgg ggacaattgt cagatatcga
     5521 caagccatct ctatcctaaa ggcaaaaatg cagtgtttgt gtttgctcaa aacatgccat
     5581 attttagatt tttatatata cagacatact ggggaagaaa agattgtata tgaaagagta
     5641 tgtgaaggtc ataaggatgg aatggccaca actaatatta tgcttggtgt gtgtggtttt
     5701 ttttaaacat tcttagttcc cctgaagaaa tgtcctttat gtttcagata gtaccagtaa
     5761 aacagctgtc ctcgttcctc tccctcctgc tcttacagag aaggccacac gctgtcagaa
     5821 ttttctggtg aaatgttttt aattaaggca cttgtctctc tatcttattc cttcaaaaat
     5881 aaaaaccaat aaaacaacat aacagcaaa
//
