LOCUS       NM_001271204            1875 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus POU class 2 homeobox 2 (Pou2f2), mRNA.
ACCESSION   NM_001271204 XM_001077129 XM_003748785 XM_003748786 XM_003748787
            XM_003748788 XM_341802
VERSION     NM_001271204.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1875)
  AUTHORS   Yang,T.C., Lu,M.H., Wang,W.J. and Chen,J.Y.
  TITLE     CEBPB/POU2F2 modulates endothelin 1 expression in prehypertensive
            SHR vascular smooth muscle cells
  JOURNAL   J Mol Endocrinol 71 (1), e220178 (2023)
   PUBMED   36942826
  REMARK    GeneRIF: CEBPB/POU2F2 modulates endothelin 1 expression in
            prehypertensive SHR vascular smooth muscle cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1875)
  AUTHORS   Camos,S., Gubern,C., Sobrado,M., Rodriguez,R., Romera,V.G.,
            Moro,M.A., Lizasoain,I., Serena,J., Mallolas,J. and Castellanos,M.
  TITLE     Oct-2 transcription factor binding activity and expression
            up-regulation in rat cerebral ischaemia is associated with a
            diminution of neuronal damage in vitro
  JOURNAL   Neuromolecular Med 16 (2), 332-349 (2014)
   PUBMED   24282026
  REMARK    GeneRIF: Oct-2 expression and binding activity increase in the late
            phase of cerebral ischaemia. It is involved in reducing
            ischaemic-mediated neuronal injury.
REFERENCE   3  (bases 1 to 1875)
  AUTHORS   Castro,D.S., Skowronska-Krawczyk,D., Armant,O., Donaldson,I.J.,
            Parras,C., Hunt,C., Critchley,J.A., Nguyen,L., Gossler,A.,
            Gottgens,B., Matter,J.M. and Guillemot,F.
  TITLE     Proneural bHLH and Brn proteins coregulate a neurogenic program
            through cooperative binding to a conserved DNA motif
  JOURNAL   Dev Cell 11 (6), 831-844 (2006)
   PUBMED   17141158
REFERENCE   4  (bases 1 to 1875)
  AUTHORS   Dees,W.L., Srivastava,V.K. and Hiney,J.K.
  TITLE     Alcohol alters insulin-like growth factor-1 activated oct 2 POU
            domain gene expression in the immature female hypothalamus
  JOURNAL   J Stud Alcohol 66 (1), 35-45 (2005)
   PUBMED   15830901
  REMARK    GeneRIF: Oct 2 POU gene is a likely target by which alcohol can
            interfere with glial-neuronal interactions and interrupt LHRH
            secretion during prepubertal development.
REFERENCE   5  (bases 1 to 1875)
  AUTHORS   Corcoran,L.M., Koentgen,F., Dietrich,W., Veale,M. and Humbert,P.O.
  TITLE     All known in vivo functions of the Oct-2 transcription factor
            require the C-terminal protein domain
  JOURNAL   J Immunol 172 (5), 2962-2969 (2004)
   PUBMED   14978099
REFERENCE   6  (bases 1 to 1875)
  AUTHORS   Zwilling,S., Konig,H. and Wirth,T.
  TITLE     High mobility group protein 2 functionally interacts with the POU
            domains of octamer transcription factors
  JOURNAL   EMBO J 14 (6), 1198-1208 (1995)
   PUBMED   7720710
REFERENCE   7  (bases 1 to 1875)
  AUTHORS   Andersen,B., Pearse,R.V. 2nd, Schlegel,P.N., Cichon,Z.,
            Schonemann,M.D., Bardin,C.W. and Rosenfeld,M.G.
  TITLE     Sperm 1: a POU-domain gene transiently expressed immediately before
            meiosis I in the male germ cell
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11084-11088 (1993)
   PUBMED   7902581
REFERENCE   8  (bases 1 to 1875)
  AUTHORS   Corcoran,L.M., Karvelas,M., Nossal,G.J., Ye,Z.S., Jacks,T. and
            Baltimore,D.
  TITLE     Oct-2, although not required for early B-cell development, is
            critical for later B-cell maturation and for postnatal survival
  JOURNAL   Genes Dev 7 (4), 570-582 (1993)
   PUBMED   8096198
REFERENCE   9  (bases 1 to 1875)
  AUTHORS   Wirth,T., Priess,A., Annweiler,A., Zwilling,S. and Oeler,B.
  TITLE     Multiple Oct2 isoforms are generated by alternative splicing
  JOURNAL   Nucleic Acids Res 19 (1), 43-51 (1991)
   PUBMED   2011512
REFERENCE   10 (bases 1 to 1875)
  AUTHORS   Scheidereit,C., Cromlish,J.A., Gerster,T., Kawakami,K.,
            Balmaceda,C.G., Currie,R.A. and Roeder,R.G.
  TITLE     A human lymphoid-specific transcription factor that activates
            immunoglobulin genes is a homoeobox protein
  JOURNAL   Nature 336 (6199), 551-557 (1988)
   PUBMED   2904654
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            L25863.1 and FQ225995.1.
            
            On Oct 8, 2014 this sequence version replaced NM_001271204.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132261, SAMD00132262
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1388              L25863.1           1-1388
            1389-1875           FQ225995.1         807-1293
FEATURES             Location/Qualifiers
     source          1..1875
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..1875
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /note="POU class 2 homeobox 2"
                     /db_xref="GeneID:117058"
                     /db_xref="RGD:621690"
     CDS             1..1392
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /codon_start=1
                     /product="POU domain, class 2, transcription factor 2"
                     /protein_id="NP_001258133.2"
                     /db_xref="GeneID:117058"
                     /db_xref="RGD:621690"
                     /translation="MVHSSMGAPEIRMSKPLEAEKQSLDSPSEHTDTERNGPDINHQN
                     PQNKASPFSVSPTGPSTKIKAEDPSGDSAPAAPPPPQPAQPHLPQAQLMLTGSQLAGD
                     IQQLLQLQQLVLVPGHHLQPPAQFLLPQAQQSQPGLLPTPNLFQLPQQTQGALLTSQP
                     RAGLPTQPSKCLEPPSHPEEPSDLEELEQFARTFKQRRIKLGFTQGDVGLAMGKLYGN
                     DFSQTTISRFEALNLSFKNMCKLKPLLEKWLNDAETMSVDSSLPSPNQLSSPSLGFDG
                     LPGRRRKKRTSIETNVRFALEKSFLANQKPTSEEILLIAEQLHMEKEVIRVWFCNRRQ
                     KEKRINPCSAAPMLPSPGKPTSYSPHLVTPQGGAGTLPLSQASSSLSTTVTTLSSAVG
                     TLHPSRTAGGGGGGGGAAPPLNSIPSVTPPPPATTNSTNPSPQGSHSAIGLTGLNPSA
                     GPGLWWNPAPYQP"
     exon            1..28
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            29..94
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            95..129
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            130..186
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            187..303
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            304..409
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            410..501
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            502..615
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            616..757
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..906
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1083
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1150
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1352
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1875
                     /gene="Pou2f2"
                     /gene_synonym="2-Oct; Oct2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggttcact ccagcatggg ggctccagaa ataagaatgt ctaagcccct ggaggccgag
       61 aagcaaagtc tggactcccc gtcagagcac acagacactg aaagaaatgg acccgacatt
      121 aaccatcaga acccccagaa caaagcgtcc ccattctctg tgtccccaac tggccccagc
      181 accaagatca aggctgaaga ccccagtggt gattcagccc cagcagcacc cccgcccccc
      241 cagccggctc agcctcatct gccccaggcc caactcatgt tgacgggcag ccagctagct
      301 ggggacatac agcaactcct ccagctccaa cagctggtgc ttgtccccgg ccaccacctc
      361 cagccacctg ctcagttcct gctgccacaa gcgcagcaga gtcagccagg gctgctacca
      421 acgccaaatc tattccagct acctcagcaa acccagggag ctctcctgac ctcccagccc
      481 cgggctgggc ttcctacaca gccctcgaaa tgcttggagc caccatccca cccggaggag
      541 cccagtgatc tggaggagct ggaacagttc gctcgcacct tcaagcaacg ccgcatcaag
      601 ctgggcttca cacagggtga tgtgggcctg gccatgggca agctctatgg caacgacttc
      661 agccaaacga ccatttcccg cttcgaggcc cttaacctga gcttcaagaa catgtgtaaa
      721 ctcaagcccc tcctggagaa gtggctcaac gacgcagaga ctatgtctgt ggattcaagc
      781 ctacccagcc caaaccagct gagcagcccc agcctgggtt tcgacgggct gccggggcgg
      841 agacgcaaga agaggaccag catcgagacg aatgtccgct tcgccttaga gaagagtttc
      901 ctagcgaacc agaagcctac ctcagaggag atcctgctga ttgcagagca gctgcacatg
      961 gaaaaggaag tgatccgcgt ctggttctgc aaccggcgcc agaaggagaa acgcatcaac
     1021 ccttgcagtg cggcccccat gctgcccagc ccgggaaagc cgaccagtta cagcccgcac
     1081 ctggtcacac cccaaggggg cgcaggaacc ttaccattgt cccaagcttc tagcagtctg
     1141 agcacaacag ttactacctt atcctcagct gtggggacac tccaccccag ccggacagca
     1201 ggagggggtg gcggtggggg cggagccgcg ccccccctca attccatccc ctctgtcact
     1261 cccccacccc cggccaccac caacagcaca aacccgagcc ctcaaggcag ccactcggct
     1321 atcggcttga cgggcctgaa ccccagcgca ggccctggcc tctggtggaa ccctgcccct
     1381 taccagcctt gatagcagcg ggaacctggt gctgggggca gccggtgcgg ccccagggag
     1441 ccccagccta gtaacctcgc ctctcttctt gaaccacacc gggctgcccc tgctcagtgc
     1501 cccaccaggc gtgggtctgg tctcagcagc ggctgcagct gtggcagcga ccatctccag
     1561 caagtctcct ggcctctcct cttcgtcttc atcctcctcc tcctcctcca cttgcagtga
     1621 agtggcagcg cagacctctg gaggcccggg gggacccgag gcagggtcca aggccgagtg
     1681 agagcccacc atgcctcccc tcctactcct ctgagtcccc tgaccttggt cccctgccca
     1741 agagagggtg aggaggctgg tgggggatac agtggatcct cggagcagga gtgacgaagg
     1801 aggaaaagac caaaaatcca accaaaaaca aaaacaaaca aacaaacaaa caaaaggaaa
     1861 ccaaccaaca aaaaa
//
