LOCUS       NM_013008               2545 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus POU class 1 homeobox 1 (Pou1f1), mRNA.
ACCESSION   NM_013008
VERSION     NM_013008.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2545)
  AUTHORS   Du,Q., Hoover,A.R., Dozmorov,I., Raj,P., Khan,S., Molina,E.,
            Chang,T.C., de la Morena,M.T., Cleaver,O.B., Mendell,J.T. and van
            Oers,N.S.C.
  TITLE     MIR205HG Is a Long Noncoding RNA that Regulates Growth Hormone and
            Prolactin Production in the Anterior Pituitary
  JOURNAL   Dev Cell 49 (4), 618-631 (2019)
   PUBMED   30982661
REFERENCE   2  (bases 1 to 2545)
  AUTHORS   Masumoto,A., Sonou,T., Ohya,M., Yashiro,M., Nakashima,Y., Okuda,K.,
            Iwashita,Y., Mima,T., Negi,S. and Shigematsu,T.
  TITLE     Calcium Overload Accelerates Phosphate-Induced Vascular
            Calcification Via Pit-1, but not the Calcium-Sensing Receptor
  JOURNAL   J Atheroscler Thromb 24 (7), 716-724 (2017)
   PUBMED   27840385
  REMARK    GeneRIF: Upregulation of Pit-1 protein is associated with Vascular
            Calcification.
REFERENCE   3  (bases 1 to 2545)
  AUTHORS   Bose,S., Ganguly,S., Kumar,S. and Boockfor,F.R.
  TITLE     A Pit-1 Binding Site Adjacent to E-box133 in the Rat PRL Promoter
            is Necessary for Pulsatile Gene Expression Activity
  JOURNAL   Neurochem Res 41 (6), 1390-1400 (2016)
   PUBMED   26875730
  REMARK    GeneRIF: Down-regulation of Pit-1 reduced prolactin levels during
            pulse periods.
REFERENCE   4  (bases 1 to 2545)
  AUTHORS   Sobrier,M.L., Tsai,Y.C., Perez,C., Leheup,B., Bouceba,T.,
            Duquesnoy,P., Copin,B., Sizova,D., Penzo,A., Stanger,B.Z.,
            Cooke,N.E., Liebhaber,S.A. and Amselem,S.
  TITLE     Functional characterization of a human POU1F1 mutation associated
            with isolated growth hormone deficiency: a novel etiology for IGHD
  JOURNAL   Hum Mol Genet 25 (3), 472-483 (2016)
   PUBMED   26612202
REFERENCE   5  (bases 1 to 2545)
  AUTHORS   Jullien,N., Roche,C., Brue,T., Figarella-Branger,D., Graillon,T.,
            Barlier,A. and Herman,J.P.
  TITLE     Dose-dependent dual role of PIT-1 (POU1F1) in somatolactotroph cell
            proliferation and apoptosis
  JOURNAL   PLoS One 10 (3), e0120010 (2015)
   PUBMED   25822178
  REMARK    GeneRIF: Blocking expression of endogenous PIT-1 induced a marked
            decrease of cell proliferation in somatolactotroph cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2545)
  AUTHORS   Lin,C., Lin,S.C., Chang,C.P. and Rosenfeld,M.G.
  TITLE     Pit-1-dependent expression of the receptor for growth hormone
            releasing factor mediates pituitary cell growth
  JOURNAL   Nature 360 (6406), 765-768 (1992)
   PUBMED   1334535
REFERENCE   7  (bases 1 to 2545)
  AUTHORS   Theill,L.E., Hattori,K., Lazzaro,D., Castrillo,J.L. and Karin,M.
  TITLE     Differential splicing of the GHF1 primary transcript gives rise to
            two functionally distinct homeodomain proteins
  JOURNAL   EMBO J 11 (6), 2261-2269 (1992)
   PUBMED   1600947
REFERENCE   8  (bases 1 to 2545)
  AUTHORS   Tatsumi,K., Miyai,K., Notomi,T., Kaibe,K., Amino,N., Mizuno,Y. and
            Kohno,H.
  TITLE     Cretinism with combined hormone deficiency caused by a mutation in
            the PIT1 gene
  JOURNAL   Nat Genet 1 (1), 56-58 (1992)
   PUBMED   1302000
REFERENCE   9  (bases 1 to 2545)
  AUTHORS   Morris,A.E., Kloss,B., McChesney,R.E., Bancroft,C. and Chasin,L.A.
  TITLE     An alternatively spliced Pit-1 isoform altered in its ability to
            trans-activate
  JOURNAL   Nucleic Acids Res 20 (6), 1355-1361 (1992)
   PUBMED   1561093
REFERENCE   10 (bases 1 to 2545)
  AUTHORS   Konzak,K.E. and Moore,D.D.
  TITLE     Functional isoforms of Pit-1 generated by alternative messenger RNA
            splicing
  JOURNAL   Mol Endocrinol 6 (2), 241-247 (1992)
   PUBMED   1569967
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061563.1.
            
            On Aug 31, 2012 this sequence version replaced NM_013008.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061563.1, L01506.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2545              BC061563.1         5-2549
FEATURES             Location/Qualifiers
     source          1..2545
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11p12"
     gene            1..2545
                     /gene="Pou1f1"
                     /gene_synonym="GHF1; GHF1A; Pit1; PIT1Z"
                     /note="POU class 1 homeobox 1"
                     /db_xref="GeneID:25517"
                     /db_xref="RGD:3367"
     exon            1..258
                     /gene="Pou1f1"
                     /gene_synonym="GHF1; GHF1A; Pit1; PIT1Z"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..992
                     /gene="Pou1f1"
                     /gene_synonym="GHF1; GHF1A; Pit1; PIT1Z"
                     /note="GHF-1; pit-1; growth hormone factor 1; POU domain,
                     class 1, transcription factor 1; Pituary specific
                     transcription factor 1 (growth hormone factor 1);
                     homeodomain protein for Growth Hormone (GH)"
                     /codon_start=1
                     /product="pituitary-specific positive transcription factor
                     1"
                     /protein_id="NP_037140.2"
                     /db_xref="GeneID:25517"
                     /db_xref="RGD:3367"
                     /translation="MSCQPFTSADTFIPLNSDASAALPLRMHHNAAEGLPASNHATNV
                     MSTATGLHYSVPSCHYGNQPSTYGVMAGTLTPCLYKFPDHTLSHGFPPLHQPLLAEDP
                     TASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAV
                     HGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRR
                     TTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSL
                     NQSLFSISKEHLECR"
     exon            259..330
                     /gene="Pou1f1"
                     /gene_synonym="GHF1; GHF1A; Pit1; PIT1Z"
                     /inference="alignment:Splign:2.1.0"
     exon            331..555
                     /gene="Pou1f1"
                     /gene_synonym="GHF1; GHF1A; Pit1; PIT1Z"
                     /inference="alignment:Splign:2.1.0"
     exon            556..720
                     /gene="Pou1f1"
                     /gene_synonym="GHF1; GHF1A; Pit1; PIT1Z"
                     /inference="alignment:Splign:2.1.0"
     exon            721..781
                     /gene="Pou1f1"
                     /gene_synonym="GHF1; GHF1A; Pit1; PIT1Z"
                     /inference="alignment:Splign:2.1.0"
     exon            782..2358
                     /gene="Pou1f1"
                     /gene_synonym="GHF1; GHF1A; Pit1; PIT1Z"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagccgccc tgatgtatat atgcaatagg gagccgtgaa tcggcccttt gatacagtaa
       61 tataataaaa gcggactggc aagcggtgcg tcttagttct ctactctctt gtgggaatga
      121 gttgccaacc tttcacctcg gctgatacct ttatacctct gaattctgac gcttctgctg
      181 ccctgcctct gagaatgcac cacaatgccg ctgagggtct cccagcctcc aaccacgcca
      241 ccaacgtgat gtccacagcg acaggacttc attattctgt gccttcctgt cattatggaa
      301 accagccatc cacctacgga gtgatggcag gcactttaac cccttgtctt tacaagtttc
      361 cagaccacac cctgagtcat gggtttcctc ccctgcacca acctctgctg gcggaggacc
      421 caacagcctc tgaatttaag caggaactca ggcggaaaag taaattggtg gaagagccaa
      481 tagacatgga ctccccggaa atccgagaac tggagcagtt tgccaacgaa tttaaagtga
      541 gaagaattaa gttaggatac acccagacaa acgtgggcga agctctggcc gctgtccacg
      601 gctccgaatt cagtcaaaca accatctgcc gatttgaaaa cttgcagctc agtttcaaaa
      661 atgcttgcaa actgaaagca attttatcca agtggctgga ggaagctgag caggtcggag
      721 ctttgtacaa tgaaaaagtg ggagcaaacg aaaggaagag gaaacggagg acaactatca
      781 gtatcgccgc taaggatgct ttggagagac actttggaga gcacagcaaa ccttcttcgc
      841 aggagatcat gcggatggct gaagaattga atctcgagaa agaagtagta agagtgtggt
      901 tttgcaaccg aaggcagaga gaaaaacggg tgaaaacgag tctcaatcaa agtctgttct
      961 ctatttcaaa ggagcatctt gagtgcagat aagacttgcc tgtggtagcc atgtgtggta
     1021 gcctttccat tcctttctga tttcaagaaa aatcagaagt tacttagctt cataaactag
     1081 attaaatcag caacccctgc agtttttgtt tcactttctt tctttccttt ttagatccaa
     1141 tgatttaaaa caagacgttt tatttagttg ttctcagaat tcatagcatt gcctttactc
     1201 ctaaatcatc accaagaatg ctcacaatac ctcttccaat tctgccttta tacctaatac
     1261 acagagaggt ggggataact gggagagagg ccatcatata tgcgaatatt ttgagtttaa
     1321 aattaccttt tgtaagtcaa tttattgttc tttaaatttt aatcagtaag gacaaatatt
     1381 taccgactat taaccaggga tggctcaagt tgataatcta ttgacttggc cagagagatg
     1441 tctcagtggt taagagcatc tgttgctctt ccagaggatg tgggttccat cacctataca
     1501 gctcacaact gtctgtcaca ctatttccag aggaaatcca aggagtctcc tgggttccat
     1561 tgacacttgg cctgaaaatg gagcacagac atacatgtag acaaaatact catacatata
     1621 cagtaaaaat aataaatcta taaacaaaaa gaaaatatat tggtttatac tcagtatgcc
     1681 cctagcacta tgttttgttt tgttttgttt tgttttggag taaggtttga caatccagag
     1741 gtgactagag acaactaaga attttattaa ttgccttcag aaataatctt cagtcagaat
     1801 ctattgatat ctttgacatt aacacttagg acgcgttttt tgaacaattt gtaggagcat
     1861 ttaggcatga catctgggcg tattctttta tacacattag ctttctgagg ctctgctaca
     1921 gaaaacatgt gagctgcaag ctaaacttgc tgacacaata atccttcagt tttggctttg
     1981 ttttgttttg tttggtagtg agttcaatcc tgagcacaag tgaaatttaa aaatgaaaaa
     2041 tatggtttag ggatccctaa cctatatcat aaatctgtgt ggaagctgca ctagggcgag
     2101 gctacgtggc ttacttgctg ttatgtttcc agtgactgaa aaagcactcg ctcctagtag
     2161 gtatgtatag accatgctaa aggaatgggc ccaatggtga acaaccgcta caaatatgaa
     2221 gggtaccagg caacctgaaa aatctaactt gtttttgaag tctcattgta gaaactcacc
     2281 tgaggttcct taacaaagtg tcaattttgg tctcactggt cacattttga tttattaata
     2341 aaaattggaa atatggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2401 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2521 aaaaaaaaaa aaaaaaaaaa aaaaa
//
