LOCUS       NM_001395152            2672 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protection of telomeres 1 (Pot1), mRNA.
ACCESSION   NM_001395152 XM_006236160
VERSION     NM_001395152.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2672)
  AUTHORS   Yin,H., Hardikar,S., Lindstroem,S., Hsu,L., Anderson,K.E.,
            Banbury,B.L., Berndt,S.I., Chan,A.T., Giovanucci,E.L.,
            Harrison,T.A., Joshi,A.D., Nan,H., Potter,J.D., Sakoda,L.C.,
            Slattery,M.L., Schoen,R.E., White,E., Peters,U. and Newcomb,P.A.
  TITLE     Telomere Maintenance Variants and Survival after Colorectal Cancer:
            Smoking- and Sex-Specific Associations
  JOURNAL   Cancer Epidemiol Biomarkers Prev 29 (9), 1817-1824 (2020)
   PUBMED   32586834
REFERENCE   2  (bases 1 to 2672)
  AUTHORS   Ishigaki,K., Akiyama,M., Kanai,M., Takahashi,A., Kawakami,E.,
            Sugishita,H., Sakaue,S., Matoba,N., Low,S.K., Okada,Y., Terao,C.,
            Amariuta,T., Gazal,S., Kochi,Y., Horikoshi,M., Suzuki,K., Ito,K.,
            Koyama,S., Ozaki,K., Niida,S., Sakata,Y., Sakata,Y., Kohno,T.,
            Shiraishi,K., Momozawa,Y., Hirata,M., Matsuda,K., Ikeda,M.,
            Iwata,N., Ikegawa,S., Kou,I., Tanaka,T., Nakagawa,H., Suzuki,A.,
            Hirota,T., Tamari,M., Chayama,K., Miki,D., Mori,M., Nagayama,S.,
            Daigo,Y., Miki,Y., Katagiri,T., Ogawa,O., Obara,W., Ito,H.,
            Yoshida,T., Imoto,I., Takahashi,T., Tanikawa,C., Suzuki,T.,
            Sinozaki,N., Minami,S., Yamaguchi,H., Asai,S., Takahashi,Y.,
            Yamaji,K., Takahashi,K., Fujioka,T., Takata,R., Yanai,H.,
            Masumoto,A., Koretsune,Y., Kutsumi,H., Higashiyama,M., Murayama,S.,
            Minegishi,N., Suzuki,K., Tanno,K., Shimizu,A., Yamaji,T.,
            Iwasaki,M., Sawada,N., Uemura,H., Tanaka,K., Naito,M., Sasaki,M.,
            Wakai,K., Tsugane,S., Yamamoto,M., Yamamoto,K., Murakami,Y.,
            Nakamura,Y., Raychaudhuri,S., Inazawa,J., Yamauchi,T., Kadowaki,T.,
            Kubo,M. and Kamatani,Y.
  TITLE     Large-scale genome-wide association study in a Japanese population
            identifies novel susceptibility loci across different diseases
  JOURNAL   Nat Genet 52 (7), 669-679 (2020)
   PUBMED   32514122
REFERENCE   3  (bases 1 to 2672)
  AUTHORS   Yu,Y., Tan,R., Ren,Q., Gao,B., Sheng,Z., Zhang,J., Zheng,X.,
            Jiang,Y., Lan,L. and Mao,Z.
  TITLE     POT1 inhibits the efficiency but promotes the fidelity of
            nonhomologous end joining at non-telomeric DNA regions
  JOURNAL   Aging (Albany NY) 9 (12), 2529-2543 (2017)
   PUBMED   29227966
REFERENCE   4  (bases 1 to 2672)
  AUTHORS   Poojary,S.S., Mishra,G., Singh,T.D., Gupta,S., Shrivastav,B.R. and
            Tiwari,P.K.
  TITLE     Telomere length variation and expression analysis of shelterin
            complex genes during gallbladder carcinogenesis
  JOURNAL   J Cancer Res Ther 13 (2), 235-239 (2017)
   PUBMED   28643740
REFERENCE   5  (bases 1 to 2672)
  AUTHORS   Karami,S., Han,Y., Pande,M., Cheng,I., Rudd,J., Pierce,B.L.,
            Nutter,E.L., Schumacher,F.R., Kote-Jarai,Z., Lindstrom,S.,
            Witte,J.S., Fang,S., Han,J., Kraft,P., Hunter,D.J., Song,F.,
            Hung,R.J., McKay,J., Gruber,S.B., Chanock,S.J., Risch,A., Shen,H.,
            Haiman,C.A., Boardman,L., Ulrich,C.M., Casey,G., Peters,U., Amin Al
            Olama,A., Berchuck,A., Berndt,S.I., Bezieau,S., Brennan,P.,
            Brenner,H., Brinton,L., Caporaso,N., Chan,A.T., Chang-Claude,J.,
            Christiani,D.C., Cunningham,J.M., Easton,D., Eeles,R.A., Eisen,T.,
            Gala,M., Gallinger,S.J., Gayther,S.A., Goode,E.L., Gronberg,H.,
            Henderson,B.E., Houlston,R., Joshi,A.D., Kury,S., Landi,M.T., Le
            Marchand,L., Muir,K., Newcomb,P.A., Permuth-Wey,J., Pharoah,P.,
            Phelan,C., Potter,J.D., Ramus,S.J., Risch,H., Schildkraut,J.,
            Slattery,M.L., Song,H., Wentzensen,N., White,E., Wiklund,F.,
            Zanke,B.W., Sellers,T.A., Zheng,W., Chatterjee,N., Amos,C.I. and
            Doherty,J.A.
  CONSRTM   GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and
            TRICL
  TITLE     Telomere structure and maintenance gene variants and risk of five
            cancer types
  JOURNAL   Int J Cancer 139 (12), 2655-2670 (2016)
   PUBMED   27459707
REFERENCE   6  (bases 1 to 2672)
  AUTHORS   Kelleher,C., Kurth,I. and Lingner,J.
  TITLE     Human protection of telomeres 1 (POT1) is a negative regulator of
            telomerase activity in vitro
  JOURNAL   Mol Cell Biol 25 (2), 808-818 (2005)
   PUBMED   15632080
REFERENCE   7  (bases 1 to 2672)
  AUTHORS   Liu,D., O'Connor,M.S., Qin,J. and Songyang,Z.
  TITLE     Telosome, a mammalian telomere-associated complex formed by
            multiple telomeric proteins
  JOURNAL   J Biol Chem 279 (49), 51338-51342 (2004)
   PUBMED   15383534
REFERENCE   8  (bases 1 to 2672)
  AUTHORS   Liu,D., Safari,A., O'Connor,M.S., Chan,D.W., Laegeler,A., Qin,J.
            and Songyang,Z.
  TITLE     PTOP interacts with POT1 and regulates its localization to
            telomeres
  JOURNAL   Nat Cell Biol 6 (7), 673-680 (2004)
   PUBMED   15181449
REFERENCE   9  (bases 1 to 2672)
  AUTHORS   Loayza,D. and De Lange,T.
  TITLE     POT1 as a terminal transducer of TRF1 telomere length control
  JOURNAL   Nature 423 (6943), 1013-1018 (2003)
   PUBMED   12768206
REFERENCE   10 (bases 1 to 2672)
  AUTHORS   Colgin,L.M., Baran,K., Baumann,P., Cech,T.R. and Reddel,R.R.
  TITLE     Human POT1 facilitates telomere elongation by telomerase
  JOURNAL   Curr Biol 13 (11), 942-946 (2003)
   PUBMED   12781132
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Jun 4, 2021 this sequence version replaced XM_006236160.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643291.11953.1,
                                           SRR26360186.1455042.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                JAXUCZ010000004.1  55228501-55228543   c
            44-109              JAXUCZ010000004.1  55225282-55225347   c
            110-156             JAXUCZ010000004.1  55217874-55217920   c
            157-271             JAXUCZ010000004.1  55212898-55213012   c
            272-402             JAXUCZ010000004.1  55199614-55199744   c
            403-693             JAXUCZ010000004.1  55196339-55196629   c
            694-849             JAXUCZ010000004.1  55192964-55193119   c
            850-1019            JAXUCZ010000004.1  55187448-55187617   c
            1020-1105           JAXUCZ010000004.1  55184334-55184419   c
            1106-1168           JAXUCZ010000004.1  55183125-55183187   c
            1169-1325           JAXUCZ010000004.1  55180469-55180625   c
            1326-1531           JAXUCZ010000004.1  55178709-55178914   c
            1532-1667           JAXUCZ010000004.1  55177899-55178034   c
            1668-1756           JAXUCZ010000004.1  55175863-55175951   c
            1757-1848           JAXUCZ010000004.1  55174201-55174292   c
            1849-1954           JAXUCZ010000004.1  55172488-55172593   c
            1955-2672           JAXUCZ010000004.1  55170821-55171538   c
FEATURES             Location/Qualifiers
     source          1..2672
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2672
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /note="protection of telomeres 1"
                     /db_xref="GeneID:500054"
                     /db_xref="RGD:1562696"
     exon            1..43
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            44..109
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            110..156
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2064
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /note="protection of telomeres 1A; protection of telomeres
                     1 homolog"
                     /codon_start=1
                     /product="protection of telomeres protein 1"
                     /protein_id="NP_001382081.1"
                     /db_xref="GeneID:500054"
                     /db_xref="RGD:1562696"
                     /translation="MSLVPVTPYTYTPLNLLKEGAVANVYGVVKFFKPPYLSKGTDYC
                     SVVTIVDPTNVKLTCMLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINSSGFA
                     SLTFEGTLGTPVTARTSSKVFSFTSQDQKMVEALRVWASKHIAASSSLVQLCDAQPLQ
                     YYDLTCQLLGKAEVDGTAFLLKVWDGTRTMFPSWRVSIQNLTFEGDLSHIQRLQSLVI
                     DILVYDNHVQVAKSLKIGSFIRIYSLHTKLQSVDSETSKSLLRLEFHLHGGTSYGRGI
                     RVLPDESSCVDQLKKDLECADSAVTQPSNGICQSKNEDSFVLSSSASGSVSLYEEERC
                     QQVSSTILTDHQHLEKTPLCAVLKQKAPQQYRVRAKLRSYLPRRLPQSVKLICPQCHS
                     LQEVPHEDSLDKLLQDAATKAPDIRLQGTSLYESKIWTTEGQGGRQVAVHFVKKDGVL
                     PLSSECLILIEGGRLCEVSKLSSKFHSVIPVRSGPEDLELLDISAPFLIQGKLHHYGC
                     KQCSSLKPIQNLNSLLNKGPWIPSSVAKVLGIVPLQYVFVMTFTLDDGTGVLDTYLKD
                     SENFFKIPASEVLTDDNLQRNLEAIMDMICPPGIKVDAYPWLECLIKSYNVTIGTEQR
                     ICYQIFDTTVAEDV"
     exon            157..271
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            272..402
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            403..693
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            694..849
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1019
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1105
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1168
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1325
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1531
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1667
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1756
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1848
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1954
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2672
                     /gene="Pot1"
                     /gene_synonym="Pot1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgggcgcgtc aatgcagacc ttagttgtcc gcgggtcttg ctgggaaaac tcagttgttc
       61 ttaatgcctt gcggaagtaa aacagctgtt ttgaagatta gactttgagg tttgtgataa
      121 atctatgaga ggatttccca tcaaacaatg tctttggttc cggtaactcc ctatacatat
      181 acacccctga atctacttaa ggaaggtgca gttgccaatg tctatggtgt tgtgaaattc
      241 tttaagcctc catatctcag caaaggaact gattattgct cagttgtaac aattgtggac
      301 ccaacaaatg tgaagttaac gtgcatgctc tttagtggaa actatgaagc ccttccgatc
      361 atttacaaag ttggagacat tgttcgcttc cataggctga agatccaagt atataaaaat
      421 gagcttcagg gaatcaacag ctctgggttc gcgtctttga catttgaagg aacattaggg
      481 acacctgtca cagcacgtac ttcaagcaaa gtttttagct tcacttctca ggaccaaaaa
      541 atggtagaag ctttgcgagt ttgggcatcc aagcacattg cagcttcttc aagtttagtg
      601 cagctgtgtg acgctcagcc cctgcaatat tatgacctga cctgtcagct tctgggtaaa
      661 gcagaagtgg atggaacagc ctttcttcta aaggtatggg acggaaccag gactatgttt
      721 ccctcttgga gagtctccat acaaaatctt acctttgaag gtgacttgag tcacattcag
      781 cggctacaga gtctggtgat agacattcta gtctatgaca atcatgttca agtggcaaaa
      841 tccctcaaga ttggaagctt tattcgaatc tatagcctcc ataccaaact tcagtctgtt
      901 gattcagaaa ccagcaagtc attgttaagg ctggagtttc atctccatgg agggaccagt
      961 tatggtcggg ggattagggt tttgccagat gaaagctcgt gtgtggatca gctgaaaaaa
     1021 gatttagaat gtgcagattc ggcagtcact caaccctcaa atggtatctg tcaatcaaaa
     1081 aatgaggata gctttgtact ttcaagctct gcatcaggct cagtatccct gtatgaggaa
     1141 gaacgatgtc agcaagtctc ttctacaata ctcacagatc accagcactt agagaaaact
     1201 ccattgtgtg ccgttttgaa gcaaaaggct ccgcagcaat atcgggtccg tgccaagctg
     1261 aggtcgtatt tgcccaggag acttccccag tctgttaaac tgatctgtcc gcagtgccat
     1321 tcactacaag aagttccaca tgaggacagt ttggataaac ttttgcaaga tgctgcaact
     1381 aaagcgccag acatcaggct gcaaggtaca tctttgtatg aatcaaagat ctggaccacc
     1441 gaaggccagg gaggacggca ggtcgctgtt cactttgtga agaaggatgg tgttctccca
     1501 ctttcaagtg aatgtctaat tttgatagaa ggaggaagac tctgtgaagt gtccaagctg
     1561 tccagcaagt tccacagtgt gatccctgtg aggtccggcc ctgaggatct ggagctcctc
     1621 gacatttcag ccccattcct catacaggga aagctgcatc actatggatg taaacagtgt
     1681 tcaagcttga aacctataca aaacctaaat tcccttctta ataaaggacc atggattcct
     1741 tcctccgtgg caaaagtcct gggcattgtg cctctgcagt atgtgtttgt tatgacgttc
     1801 actctggatg atggaacagg agtgttggac acttacctca aggattctga aaactttttc
     1861 aagatcccag catctgaagt cctcactgat gacaaccttc agaggaatct ggaagcgatc
     1921 atggatatga tatgccctcc tggaataaaa gttgatgcat acccgtggct tgagtgcctc
     1981 atcaagtcct acaatgtcac cattggaaca gaacaacgaa tttgctacca gatttttgac
     2041 accacggttg cagaagatgt ctagtgctgc cattcagtgc agtgtgtatg gattttacaa
     2101 ttttagaaaa ggtcatgact ctgagattct cagaagacac ttggctattg tcaaaagtat
     2161 tgtatccatt ttcactgtag ttcttttgta cagaaaacta ttttgttatt tatgccatct
     2221 tgtgaacatg tcagaaatcc cttgctgctc atcatgtccc agggagtata aaatgagaca
     2281 gcactggttg gggagaatgc ccactctcat ttttaaaaca ctggtagcaa cttctccttc
     2341 tgtgctgttt gattcttttt tttttttttt ttttgtacag aagaatctgc ttagcaactt
     2401 ctgaaagaat tctccctcta cttccacaca tgagtatcag gttaactgag tgcttgttga
     2461 acagatgccg tctcaccaag cggggatata ctaaaaggag ggtttccttt cagaagacat
     2521 ggctttgttt gggtgctctt gatgcccatt tcaggataaa tgtatctctt tgaaccaaat
     2581 agtatgcgtg actttctgct tctctctgga atactagaag ctatttaatt tcataccaac
     2641 taataaagtg ataggattta tattttcatg aa
//
