LOCUS       NM_001108550            3177 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus periostin (Postn), mRNA.
ACCESSION   NM_001108550 XM_001055327 XM_342245
VERSION     NM_001108550.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3177)
  AUTHORS   Zhu,D., Chen,S., Sheng,P., Wang,Z., Li,Y. and Kang,X.
  TITLE     POSTN promotes nucleus pulposus cell senescence and extracellular
            matrix metabolism via activing Wnt/beta-catenin and NF-kappaB
            signal pathway in intervertebral disc degeneration
  JOURNAL   Cell Signal 121, 111277 (2024)
   PUBMED   38944256
  REMARK    GeneRIF: POSTN promotes nucleus pulposus cell senescence and
            extracellular matrix metabolism via activing Wnt/beta-catenin and
            NF-kappaB signal pathway in intervertebral disc degeneration.
REFERENCE   2  (bases 1 to 3177)
  AUTHORS   Wu,J., Chen,Y., Liao,Z., Liu,H., Zhang,S., Zhong,D., Qiu,X.,
            Chen,T., Su,D., Ke,X., Wan,Y., Zhou,T. and Su,P.
  TITLE     Self-amplifying loop of NF-kappaB and periostin initiated by PIEZO1
            accelerates mechano-induced senescence of nucleus pulposus cells
            and intervertebral disc degeneration
  JOURNAL   Mol Ther 30 (10), 3241-3256 (2022)
   PUBMED   35619555
  REMARK    GeneRIF: Self-amplifying loop of NF-kappaB and periostin initiated
            by PIEZO1 accelerates mechano-induced senescence of nucleus
            pulposus cells and intervertebral disc degeneration.
REFERENCE   3  (bases 1 to 3177)
  AUTHORS   Zheng,Y., Zeng,L., Dong,X., Du,Q. and Gao,Y.
  TITLE     Periostin aggravates the early phase of traumatic brain injury via
            the MAPK/ERK pathway
  JOURNAL   Neurol Res 44 (6), 560-569 (2022)
   PUBMED   35001858
  REMARK    GeneRIF: Periostin aggravates the early phase of traumatic brain
            injury via the MAPK/ERK pathway.
REFERENCE   4  (bases 1 to 3177)
  AUTHORS   Sun,X.J., Ma,W.Q., Zhu,Y. and Liu,N.F.
  TITLE     POSTN promotes diabetic vascular calcification by interfering with
            autophagic flux
  JOURNAL   Cell Signal 83, 109983 (2021)
   PUBMED   33744420
  REMARK    GeneRIF: POSTN promotes diabetic vascular calcification by
            interfering with autophagic flux.
REFERENCE   5  (bases 1 to 3177)
  AUTHORS   Zhu,Y., Ji,J.J., Wang,X.D., Sun,X.J., Li,M., Wei,Q., Ren,L.Q. and
            Liu,N.F.
  TITLE     Periostin promotes arterial calcification through PPARgamma-related
            glucose metabolism reprogramming
  JOURNAL   Am J Physiol Heart Circ Physiol 320 (6), H2222-H2239 (2021)
   PUBMED   33834866
  REMARK    GeneRIF: Periostin promotes arterial calcification through
            PPARgamma-related glucose metabolism reprogramming.
REFERENCE   6  (bases 1 to 3177)
  AUTHORS   Li,P., Oparil,S., Feng,W. and Chen,Y.F.
  TITLE     Hypoxia-responsive growth factors upregulate periostin and
            osteopontin expression via distinct signaling pathways in rat
            pulmonary arterial smooth muscle cells
  JOURNAL   J Appl Physiol (1985) 97 (4), 1550-8 (2004)
   PUBMED   15121739
  REMARK    GeneRIF: This study demonstrates that growth factor-induced
            expression of PN in PASMCs is mediated through PI3K/p70S6K,
            Ras/MEK1/2, and Ras/p38MAPK signaling pathways, whereas the
            expression of OPN is mediated through Ras/MEK1/2 and Ras/JNK
            signaling pathways.
REFERENCE   7  (bases 1 to 3177)
  AUTHORS   Katsuragi,N., Morishita,R., Nakamura,N., Ochiai,T., Taniyama,Y.,
            Hasegawa,Y., Kawashima,K., Kaneda,Y., Ogihara,T. and Sugimura,K.
  TITLE     Periostin as a novel factor responsible for ventricular dilation
  JOURNAL   Circulation 110 (13), 1806-1813 (2004)
   PUBMED   15381649
  REMARK    GeneRIF: Overexpression of the periostin gene led to cardiac
            dysfunction. Periostin contributes to cardiac dilation.
REFERENCE   8  (bases 1 to 3177)
  AUTHORS   Gillan,L., Matei,D., Fishman,D.A., Gerbin,C.S., Karlan,B.Y. and
            Chang,D.D.
  TITLE     Periostin secreted by epithelial ovarian carcinoma is a ligand for
            alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell
            motility
  JOURNAL   Cancer Res 62 (18), 5358-5364 (2002)
   PUBMED   12235007
REFERENCE   9  (bases 1 to 3177)
  AUTHORS   Horiuchi,K., Amizuka,N., Takeshita,S., Takamatsu,H., Katsuura,M.,
            Ozawa,H., Toyama,Y., Bonewald,L.F. and Kudo,A.
  TITLE     Identification and characterization of a novel protein, periostin,
            with restricted expression to periosteum and periodontal ligament
            and increased expression by transforming growth factor beta
  JOURNAL   J Bone Miner Res 14 (7), 1239-1249 (1999)
   PUBMED   10404027
REFERENCE   10 (bases 1 to 3177)
  AUTHORS   Sugiura,T., Takamatsu,H., Kudo,A. and Amann,E.
  TITLE     Expression and characterization of murine osteoblast-specific
            factor 2 (OSF-2) in a baculovirus expression system
  JOURNAL   Protein Expr Purif 6 (3), 305-311 (1995)
   PUBMED   7663166
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474003.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342245.3, XM_001055327.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760384,
                              SAMEA5760386 [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3177
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..3177
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /note="periostin"
                     /db_xref="GeneID:361945"
                     /db_xref="RGD:1305285"
     exon            1..143
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2451
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /note="periostin-like factor; periostin, osteoblast
                     specific factor"
                     /codon_start=1
                     /product="periostin precursor"
                     /protein_id="NP_001102020.1"
                     /db_xref="GeneID:361945"
                     /db_xref="RGD:1305285"
                     /translation="MVPLLPLSALLLLFLCDVDPANANSYYDKVLAHSRIRGRDQGPN
                     VCALQQILGTKKKYFSSCKNWYQGAICGKKTTVLYECCPGYMRMEGMKGCPAVMPIDH
                     VYGTLGIVGATTTQHYSDVSKLREEIEGKGSYTYFAPSNEAWDNLDSDIRRGLENNVN
                     VELLNALHSHMVNKRMLTKDLKHGMVIPSMYNNLGLFINHYPNGVVTVNCARVIHGNQ
                     IATNGVVHVIDRVLTQIGTSIQDFIEAEDELSSFRAAAITSDLLESLGRDGHFTLFAP
                     TNEAFEKLPRGVLERIMGDKVASEALMKYHILNTLQCSEAITGGAVFETMEGNTIEIG
                     CEGDSISINGIKMVNKKDIVTKNGVIHLIDEVLIPDSAKQVIELAGKQQTTFTDLVAQ
                     LGLASSLKPDGEYTLLAPVNNAFSDDTLSMDQRLLKLILQNHILKVKVGLSDLYNGQI
                     LETIGGKQLRVFVYRTAICIENSCMVRGSKQGRNGAIHIFREIIQPAEKSLHEKLRQD
                     KRFSIFLSLLEAADLKDLLTQPGDWTLFAPTNDAFKGMTNEEREILIGDKNALQNIIL
                     YHLTPGVYIGKGFEPGVTNILKTTQGSKIYVKGVNETLLVNELKSKESDIMTTNGVIH
                     VVDKLLYPADIPVGNDQLLELLNKLIKYIQIKFVRGSTFKEIPMTVYTTKIITKLVEP
                     KIKVIQGSLQPIIKTEGPAMTKIHIEGEPDFRLIKEGETVTEVIHGEPVIKKYTKIID
                     GVPVEITEKETREERIITGPEIKYTRISTGGGETEETLQKFLQKDTPAKKIQANKRVQ
                     GSRRRSREGRSQ"
     exon            144..242
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            243..307
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            308..465
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            466..630
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            631..777
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            778..919
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1132
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1267
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1416
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1553
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1684
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1815
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1918
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..1986
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            1987..2032
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2113
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2203
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            2204..2293
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2371
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2413
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..3177
                     /gene="Postn"
                     /gene_synonym="Plf"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagctcag ggctgaagat ggttcctctc ctgcccttat ctgctctgct gctgctgttc
       61 ctgtgtgacg ttgaccccgc aaatgccaac agttactatg acaaggtcct agctcacagc
      121 cgcatcaggg gtcgggatca gggcccaaat gtctgtgccc tccagcagat tctgggcacc
      181 aaaaagaaat acttcagctc ctgtaagaac tggtatcaag gtgctatctg cgggaagaaa
      241 accactgtgc tatatgaatg ctgccccggc tatatgagaa tggaagggat gaaaggctgc
      301 ccagcagtga tgcccattga ccatgtttat ggcacgctgg gcatcgtggg agccacgacc
      361 actcaacact attctgatgt ctcgaagctc agggaagaga ttgaaggaaa agggtcctac
      421 acatacttcg cgccgagtaa cgaagcttgg gacaacctgg attccgacat ccgcagagga
      481 ctagagaaca atgtcaatgt tgagttactg aacgctttac acagccacat ggttaataag
      541 agaatgctaa ccaaggacct gaaacacggc atggttattc cttcaatgta caacaatctg
      601 gggcttttta tcaatcatta tcccaatggg gttgtcactg tgaactgtgc tcgagtaatc
      661 cacgggaacc agattgccac aaatggtgtt gtccatgtca tcgaccgtgt cctgacacaa
      721 attggcacct ccatccaaga cttcattgaa gcagaagatg agctttcatc attcagagcg
      781 gctgccatca cttctgacct tttggagtcc cttggaagag acggtcactt cacactcttt
      841 gctcccacca atgaggcttt cgagaaactc ccacgaggag tcctagaaag gatcatggga
      901 gacaaagtgg cttctgaagc tctcatgaag taccacatcc tgaataccct ccagtgctct
      961 gaggctatca caggaggagc ggtgtttgag accatggaag gaaacactat tgaaataggg
     1021 tgtgagggag acagcatctc cattaacgga atcaagatgg tgaacaagaa agacattgtg
     1081 acgaagaatg gtgtcatcca cctgattgat gaagtcctca ttcctgattc tgctaaacaa
     1141 gttattgagc tggctggaaa acagcaaacc actttcacgg acctggtagc ccagttaggg
     1201 ttggcgtctt ctctgaagcc ggatggagag tacacgctgt tagcgcctgt gaacaatgcg
     1261 ttctctgatg acactctgag catggaccag cgccttctta agctaattct gcaaaatcac
     1321 atattgaaag taaaagtcgg ccttagtgat ctctacaatg gacagattct ggagaccatt
     1381 ggaggcaaac aactccgtgt cttcgtgtat cggacggcta tctgcataga aaactcatgc
     1441 atggtgagag gaagcaagca ggggaggaac ggtgccattc acatattccg agagatcatc
     1501 caaccggcgg agaagtccct gcacgaaaaa ctgcgccaag ataagcgctt cagcatcttc
     1561 ctcagcctcc tcgaagctgc agatctgaaa gatcttctga cacagcccgg agattggacc
     1621 ttgtttgcac caaccaatga tgccttcaag ggaatgacta atgaagaaag ggagattctg
     1681 attggggata aaaatgctct ccaaaacatc attctttacc acctgacccc aggggtttat
     1741 attggaaagg gatttgaacc cggagtcacc aacatcctga agaccacaca gggaagcaaa
     1801 atctatgtga aaggagtcaa tgagacgctt ttggtgaatg agttgaagtc caaagaatct
     1861 gacatcatga caacaaacgg cgtcattcac gttgtggaca aactcctcta tccagcagac
     1921 attccggttg gaaatgatca gctcttggaa ttactgaaca aactgataaa atacatccaa
     1981 attaagttcg ttcgtggcag caccttcaaa gaaatcccca tgactgtcta tacaactaaa
     2041 attataacca aactcgtgga accaaaaatt aaagtcattc aaggcagtct tcagcctatt
     2101 atcaaaacag aaggacctgc aatgacgaag atccacattg aaggcgagcc tgacttcagg
     2161 ctgattaaag aaggtgaaac agtgacagaa gtgatccacg gagaaccagt cattaaaaag
     2221 tacaccaaaa tcatagacgg ggttcctgtt gaaataactg aaaaagagac ccgggaagaa
     2281 cgcatcatca caggtcctga gataaaatac actaggattt ccacaggagg tggggaaaca
     2341 gaagagaccc tgcagaaatt cttgcaaaaa gacacacctg caaagaagat acaagccaac
     2401 aaaagggttc aagggtctag aaggcgatca agagaaggcc gttctcagtg aaaattcaaa
     2461 ggccagacaa cagagtttat ataatcctaa atcaacaatc tgatttttaa gggaaattat
     2521 aagagcccca ttgacttcgg aatctgaaat ggcaacaaac agaagctaat tgtcaagcaa
     2581 atctgaacgc agagttaatt tgtttctgaa tgagaaacat aggaaaatga tagtctcctg
     2641 tggggtagga actgaaggaa atataggacc atgcagggat tttatctcaa tgagagaagt
     2701 tctgattata ttaggaatcc accaaagacc atcattgtga ctggatccac acagctaagt
     2761 ctttgctcag tgaacatggt caagaagagg ctggaaaaac ccaaagcaca cagttacctt
     2821 tccatgggag gctaagctat caaaagcggt gttcagttat acaacaagca agccaagcca
     2881 ccaaattaca aacagtggtg ttacatattt ctcgtgcaat gtgggtttcc tgctaaattt
     2941 tgttgttttt acacttgatt tatatcctcg agatgattgt catatgcttt ttgcagtaca
     3001 aatgtttctc tcaaacattt caataaaaac attcttcagg tataaagaga attacttcag
     3061 acttggtaat tcagaaaact caaggtttaa gttaaaagtg agtttagact ttggaatagg
     3121 acttcatacc tttttttatt gttaacaagt actcaataaa ggaatctgaa taacata
//
