LOCUS       NM_001130550            3369 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Rattus norvegicus POP1 homolog, ribonuclease P/MRP subunit (Pop1),
            transcript variant 2, mRNA.
ACCESSION   NM_001130550 XM_001058648 XM_235391
VERSION     NM_001130550.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3369)
  AUTHORS   Wu,J., Niu,S., Tan,M., Huang,C., Li,M., Song,Y., Wang,Q., Chen,J.,
            Shi,S., Lan,P. and Lei,M.
  TITLE     Cryo-EM Structure of the Human Ribonuclease P Holoenzyme
  JOURNAL   Cell 175 (5), 1393-1404 (2018)
   PUBMED   30454648
REFERENCE   2  (bases 1 to 3369)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   3  (bases 1 to 3369)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 3369)
  AUTHORS   Lai,L.B., Vioque,A., Kirsebom,L.A. and Gopalan,V.
  TITLE     Unexpected diversity of RNase P, an ancient tRNA processing enzyme:
            challenges and prospects
  JOURNAL   FEBS Lett 584 (2), 287-296 (2010)
   PUBMED   19931535
  REMARK    Review article
REFERENCE   5  (bases 1 to 3369)
  AUTHORS   Welting,T.J., Kikkert,B.J., van Venrooij,W.J. and Pruijn,G.J.
  TITLE     Differential association of protein subunits with the human RNase
            MRP and RNase P complexes
  JOURNAL   RNA 12 (7), 1373-1382 (2006)
   PUBMED   16723659
REFERENCE   6  (bases 1 to 3369)
  AUTHORS   Lygerou,Z., Pluk,H., van Venrooij,W.J. and Seraphin,B.
  TITLE     hPop1: an autoantigenic protein subunit shared by the human RNase P
            and RNase MRP ribonucleoproteins
  JOURNAL   EMBO J 15 (21), 5936-5948 (1996)
   PUBMED   8918471
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CH473950.2.
            
            On or before Jul 28, 2008 this sequence version replaced
            XM_001058648.1, XM_235391.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN06621351
                              [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3369
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q22"
     gene            1..3369
                     /gene="Pop1"
                     /note="POP1 homolog, ribonuclease P/MRP subunit"
                     /db_xref="GeneID:315045"
                     /db_xref="RGD:1308609"
     exon            1..92
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            93..233
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..3229
                     /gene="Pop1"
                     /EC_number="3.1.26.5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ribonucleases P/MRP protein subunit POP1; processing of
                     precursor 1, ribonuclease P/MRP subunit"
                     /codon_start=1
                     /product="ribonucleases P/MRP protein subunit POP1 isoform
                     2"
                     /protein_id="NP_001124022.1"
                     /db_xref="GeneID:315045"
                     /db_xref="RGD:1308609"
                     /translation="MSNAKERKHAKKMRSQPSNVTLSSGFVTERDGKRHFGGKPSQSQ
                     KQELHSGTSRQWQIKMSPHLLPESDANEQTSSKTMFKKKGGWKAGPEGTSQEIPKYIT
                     ASTFAQARAAEISAMLKAVTQKSSNSLVFQTLPRHMRRRAMSHNVKRLPRRLQEMAKK
                     EAEKAAHQKKEHSKNKCHKARRCHINRTLEFNRRQQKNIWLETHIWHAKRFHMVKRWG
                     YCLGERPTAKSHRACYRAMTDLCLLQDLSYYCCLELKGKEEEILKALSQMCSIDTGLT
                     FAAVHCLSGKRQGSLMLYRANKYPRDMLGPVTFIWKSRETPGDASEERQLWIWLHPTL
                     KLAVLEEIKTTCQCSEPVKPSVCVPAPLLTPAQEDIQAGLADDKIGKKRKRRDDGENA
                     RRAKKTIGDGTGDPCQPRSWLSPTTGIVVSDLTMEMNRFRLVGPLSHCILTSALRAAP
                     VHRGEEDAEETPHGWWTDTCRSPHGLSLHQRQEAVFQLLGGISSPAEIPAGTILGLTV
                     RDPRVNLPPQRCRALPDPERYHVSEFICEEGMCTSSWSCAHWKPLSDHTDDPDNEQVK
                     QLLLEGVPVECAHSFIWNQDICQSVTENKIVDQDLNRMRSELLVPGSQLVLGARESKI
                     PILLIQQPGKVTGEDRLGWGSGWDILLPKGWGMAFWIPFIYRGARVGGLKEAAVHSQY
                     KRSPNVPGDFPDCRAGVLFAEDQAKDLLEKYQRRPPAKRPNYVKLGTLAPFCCPWEQL
                     TRDWESRIQTQEAAVIDSVPGAQETDPRRLGVPCVPKETCQLSNEASIAENQPRKPEV
                     TGCQAQAGTEVALEQNASEDHAAATGSQLCVVRSRKLLKQLSSWCGPSSEVRRAPCRG
                     QQELTRKACLSILADFPRALVWVSLSLLKKGSPEPHTMICVPSKEDLFQLSQDQCYHG
                     PCESRHSDPFKSLILKEKEKKKKEKRQDGEQGASKGQAAGAPTAGQEARIQGLWSGPL
                     PGLTSHCSRPLLGFVTHGDFSMAVGCGEALGFVSVTGLLEMLSSQSAAMRGLVLLRPP
                     TSLQYRFARVTIEV"
     exon            234..401
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            402..577
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..826
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..914
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1102
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1359
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1453
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1565
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1685
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1775
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1891
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2083
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2238
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            2239..2586
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..3369
                     /gene="Pop1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcagttca cttgctcgcc cgccgtggtg ggatcttcca ggggtttcag aaccttgtca
       61 ctgaccggcg aagccctcgg agcatttggc agaaatgtct aacgcaaagg agagaaaaca
      121 tgctaagaaa atgagaagcc agcccagtaa tgtgactctg tcctccggct ttgtgactga
      181 gagagatgga aagcgccatt ttggggggaa accttcccaa tctcagaaac aagagcttca
      241 ttctggaacc tcacggcagt ggcagatcaa gatgagcccc cacttacttc ctgagtctga
      301 tgcgaatgag cagacttcct ccaaaaccat gtttaagaaa aagggaggct ggaaagcagg
      361 tcctgagggc acttctcagg agatccccaa atatataacc gcttctacct ttgctcaagc
      421 acgagctgcc gagatcagtg ccatgttaaa agctgtgacc cagaagtcct ccaattccct
      481 ggttttccag actcttccac ggcacatgcg gcgaagagcc atgagccaca acgtcaaacg
      541 ccttcctaga aggttgcagg agatggccaa aaaggaggct gagaaagccg ctcatcagaa
      601 aaaagaacat tcgaaaaata aatgccacaa agcccgaaga tgtcacataa accggaccct
      661 ggagtttaac cgcagacaac agaagaatat atggttagag actcatatct ggcatgccaa
      721 acggtttcat atggtgaaga ggtggggtta ctgtctcggg gagaggccca cggccaagag
      781 ccaccgagcc tgctatcgag ctatgacaga cctctgcctc ctacaggatt tatcatatta
      841 ctgttgtttg gagttgaagg gcaaagagga agaaatactg aaggcacttt ctcaaatgtg
      901 cagcatagac acaggactga cttttgctgc agttcactgc ttgtctggga agcggcaagg
      961 gagcctcatg ctttaccggg caaataagta tcccagagac atgcttgggc cggttacctt
     1021 catctggaag tctagggaga ccccagggga cgcctctgag gaaaggcagc tgtggatctg
     1081 gcttcaccca actcttaaac tggctgtcct agaggaaata aaaacaacgt gccagtgttc
     1141 agaacccgtc aagccaagtg tctgtgtgcc tgccccactc ctgacaccag cccaggaaga
     1201 cattcaggca ggactagctg atgacaaaat cggcaagaaa agaaaaagga gagatgatgg
     1261 ggaaaatgct agacgagcga agaagaccat tggtgacggg acaggagatc cctgccagcc
     1321 acggtcgtgg ctctctccca ctacagggat cgtagtcagt gacttgacca tggagatgaa
     1381 caggttccgg ctggtcggac ctctttcgca ctgtatcctg acctcagcac tgagggctgc
     1441 tcctgtacac agaggtgagg aggatgcaga ggagacaccg catggctggt ggactgacac
     1501 gtgcaggagt cctcatggcc tttctcttca ccagagacaa gaagcagtgt ttcagttgtt
     1561 gggagggata tcgtcaccgg cagaaattcc agcaggtact attctgggat tgacagtcag
     1621 ggacccgaga gtaaatttgc ctccacagcg gtgcagagct ttgcctgatc cagaacgata
     1681 ccacgtttca gaatttatct gtgaggaagg gatgtgcacc agcagctggt cttgtgctca
     1741 ttggaagcct ctgtctgacc atacagatga tccagacaat gagcaagtta agcagctgct
     1801 tctggagggt gtgcctgtgg agtgtgcaca cagcttcatc tggaaccagg atatctgcca
     1861 gagcgttaca gagaataaaa tcgtggacca ggatttaaac cgcatgagaa gcgaattgct
     1921 ggtgcccgga tcacagcttg ttttaggggc tcgtgaatcc aagataccta tacttctgat
     1981 tcagcagccg ggaaaagtga ctggcgaaga ccgactgggc tggggcagtg gctgggacat
     2041 cctccttccc aagggctggg gcatggcctt ttggattcca tttatctacc gaggtgcaag
     2101 ggttggtgga ttaaaagagg ctgcagtaca ctctcagtac aaacggtcac ctaatgtccc
     2161 aggcgacttc ccagactgtc gtgctggcgt tctcttcgct gaagaccaag ctaaggacct
     2221 tctagagaag taccaaagac gcccccctgc taaaaggccc aactatgtta agcttggcac
     2281 actggctcct ttctgttgtc cctgggaaca gctgactcgg gactgggagt ccaggattca
     2341 gacccaagaa gcagctgtta tagattcagt gcctggtgct caagagactg acccaagaag
     2401 gcttggagtg ccttgtgtcc ccaaagagac ctgccagcta tcgaatgagg caagcatagc
     2461 tgaaaaccaa cctaggaagc cggaagttac aggctgtcaa gctcaggcgg ggactgaggt
     2521 ggccctggaa cagaatgcca gtgaggacca cgcagctgcc acaggtagcc agctctgtgt
     2581 tgttcggagt aggaaactac tgaagcaact ctcttcctgg tgtgggccca gttctgaggt
     2641 caggagggct ccctgcagag gccagcaaga actgactaga aaggcttgcc tgtccattct
     2701 ggctgatttc cccagagcgc tggtgtgggt cagcttgtcc ctgctcaaga agggcagccc
     2761 agagccacac accatgatct gtgtcccatc caaggaggac ttgttccagc tcagtcagga
     2821 tcagtgttac catggaccct gcgaatccag acacagcgac ccatttaaaa gcttgattct
     2881 gaaggagaaa gaaaagaaga agaaggagaa gaggcaggat ggggagcagg gggcctccaa
     2941 gggccaggca gcaggggcac ctacagctgg gcaggaggct cggattcagg ggctgtggtc
     3001 aggccccctt ccggggctga cttcacactg ctccaggccc ctcctgggct tcgtgacaca
     3061 tggagatttc tctatggctg ttggctgtgg agaagcctta gggtttgtta gtgtaacagg
     3121 cttgctggaa atgttgtcca gccagtcagc agccatgagg ggcctggtcc tgctgcggcc
     3181 tccgacctcg ctgcaatacc ggtttgctag agttaccatt gaggtgtgaa ttcgagttta
     3241 cacccttaac ctaggtccta actatttttg tcaaattcca aagagagtcc tggccgtctc
     3301 ggtcacctga attaaaatac aatgtggaac tgcttggaaa acaagaatta aaattatata
     3361 attatgtgg
//
