LOCUS       NM_001004086            1479 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus paraoxonase 3 (Pon3), mRNA.
ACCESSION   NM_001004086 XM_231437
VERSION     NM_001004086.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1479)
  AUTHORS   Schweikert,E.M., Devarajan,A., Witte,I., Wilgenbus,P., Amort,J.,
            Forstermann,U., Shabazian,A., Grijalva,V., Shih,D.M.,
            Farias-Eisner,R., Teiber,J.F., Reddy,S.T. and Horke,S.
  TITLE     PON3 is upregulated in cancer tissues and protects against
            mitochondrial superoxide-mediated cell death
  JOURNAL   Cell Death Differ 19 (9), 1549-1560 (2012)
   PUBMED   22441669
REFERENCE   2  (bases 1 to 1479)
  AUTHORS   Zhang,C., Peng,W., Wang,M., Zhu,J., Zang,Y., Shi,W., Zhang,J. and
            Qin,J.
  TITLE     Studies on protective effects of human paraoxonases 1 and 3 on
            atherosclerosis in apolipoprotein E knockout mice
  JOURNAL   Gene Ther 17 (5), 626-633 (2010)
   PUBMED   20182519
REFERENCE   3  (bases 1 to 1479)
  AUTHORS   Romani,R., De Medio,G.E., di Tullio,S., Lapalombella,R.,
            Pirisinu,I., Margonato,V., Veicsteinas,A., Marini,M. and Rosi,G.
  TITLE     Modulation of paraoxonase 1 and 3 expression after moderate
            exercise training in the rat
  JOURNAL   J Lipid Res 50 (10), 2036-2045 (2009)
   PUBMED   19091700
  REMARK    GeneRIF: Study documented, for the first time, the presence of PON3
            in rat serum and, notably, found that the upregulation of PON3,
            rather than PON1, appears to be associated with physical training.
REFERENCE   4  (bases 1 to 1479)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   5  (bases 1 to 1479)
  AUTHORS   Rothem,L., Hartman,C., Dahan,A., Lachter,J., Eliakim,R. and
            Shamir,R.
  TITLE     Paraoxonases are associated with intestinal inflammatory diseases
            and intracellularly localized to the endoplasmic reticulum
  JOURNAL   Free Radic Biol Med 43 (5), 730-739 (2007)
   PUBMED   17664137
REFERENCE   6  (bases 1 to 1479)
  AUTHORS   Saeed,M., Siddique,N., Hung,W.Y., Usacheva,E., Liu,E., Sufit,R.L.,
            Heller,S.L., Haines,J.L., Pericak-Vance,M. and Siddique,T.
  TITLE     Paraoxonase cluster polymorphisms are associated with sporadic ALS
  JOURNAL   Neurology 67 (5), 771-776 (2006)
   PUBMED   16822964
REFERENCE   7  (bases 1 to 1479)
  AUTHORS   Erlich,P.M., Lunetta,K.L., Cupples,L.A., Huyck,M., Green,R.C.,
            Baldwin,C.T. and Farrer,L.A.
  CONSRTM   MIRAGE Study Group
  TITLE     Polymorphisms in the PON gene cluster are associated with Alzheimer
            disease
  JOURNAL   Hum Mol Genet 15 (1), 77-85 (2006)
   PUBMED   16319130
REFERENCE   8  (bases 1 to 1479)
  AUTHORS   Draganov,D.I., Teiber,J.F., Speelman,A., Osawa,Y., Sunahara,R. and
            La Du,B.N.
  TITLE     Human paraoxonases (PON1, PON2, and PON3) are lactonases with
            overlapping and distinct substrate specificities
  JOURNAL   J Lipid Res 46 (6), 1239-1247 (2005)
   PUBMED   15772423
REFERENCE   9  (bases 1 to 1479)
  AUTHORS   Rodrigo,L., Gil,F., Hernandez,A.F., Lopez,O. and Pla,A.
  TITLE     Identification of paraoxonase 3 in rat liver microsomes:
            purification and biochemical properties
  JOURNAL   Biochem J 376 (Pt 1), 261-268 (2003)
   PUBMED   12946270
  REMARK    GeneRIF: Purification and characterization of paraoxonase 3 (Pon3)
            from liver microsomes.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079466.1.
            
            On Sep 3, 2004 this sequence version replaced XM_231437.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079466.1, CF110585.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1479
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..1479
                     /gene="Pon3"
                     /note="paraoxonase 3"
                     /db_xref="GeneID:312086"
                     /db_xref="RGD:1302965"
     exon            1..88
                     /gene="Pon3"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1079
                     /gene="Pon3"
                     /EC_number="3.1.1.2"
                     /EC_number="3.1.8.1"
                     /EC_number="3.1.1.81"
                     /codon_start=1
                     /product="serum paraoxonase/lactonase 3"
                     /protein_id="NP_001004086.1"
                     /db_xref="GeneID:312086"
                     /db_xref="RGD:1302965"
                     /translation="MGKLVALTVLGASLALLGERLLNFRERVSTSREIKPTEPQNCHL
                     IEGLENGSEDIDILPSGLAFISTGLKYPGMPSFAPDKPGRIFLMDLNEPYPKAQALEI
                     SDGFDQDSLNPHGISTFIDKDNTVYLYAVNHPHMDSTVEIFKFEEQPRSLVHLKTIKH
                     ELFESVNDIVVLGPEQFYATRDHYFTSHFLVLLEMILDPHWTSVLFYSPKEVKVVAQG
                     FSSANGITVSLDQKYVYVADVTAKNIHIMKKHNNWDLTPVKVIQLGTLVDNLTVDPAT
                     GDILAGCHPNPMKLLIYNPEDPPGSEVLRIQDPLSDNPRVSTLYSNNGSVLQGSTVAS
                     VYHKKMLIGTIFHKALYCEL"
     exon            89..159
                     /gene="Pon3"
                     /inference="alignment:Splign:2.1.0"
     exon            160..215
                     /gene="Pon3"
                     /inference="alignment:Splign:2.1.0"
     exon            216..381
                     /gene="Pon3"
                     /inference="alignment:Splign:2.1.0"
     exon            382..508
                     /gene="Pon3"
                     /inference="alignment:Splign:2.1.0"
     exon            509..709
                     /gene="Pon3"
                     /inference="alignment:Splign:2.1.0"
     exon            710..791
                     /gene="Pon3"
                     /inference="alignment:Splign:2.1.0"
     exon            792..920
                     /gene="Pon3"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1452
                     /gene="Pon3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcccaga caccatgggg aagctagtgg cgctgaccgt gctgggggcc agtttggcct
       61 tactggggga aaggcttctg aattttagag aacgagttag tacctctcga gaaataaagc
      121 ccacagaacc acagaactgc cacttgattg agggacttga gaatggctct gaagatattg
      181 atatacttcc tagtgggctg gcttttatct ccaccggact aaaatatcca ggtatgccaa
      241 gctttgcacc agacaagcca ggaagaatct tcctgatgga tctgaatgag ccatacccaa
      301 aggcacaagc actggaaatc agtgatgggt tcgaccagga ctcactgaat ccccatggga
      361 tcagcacttt catcgacaaa gacaacactg tgtatcttta tgctgtgaat cacccccaca
      421 tggactccac ggtggagata tttaagtttg aagaacaacc gcgttctctc gtccacctga
      481 aaaccataaa acatgagctt ttcgagagtg tgaatgacat tgtggttctt gggccagagc
      541 agttctatgc tacaagagac cactacttta ccagtcattt cttggtactt ctggagatga
      601 tcttggaccc tcactggact tctgttcttt tctacagccc caaagaggtc aaagtagtag
      661 cccaaggatt tagttctgcc aatgggatca cagtctcact agaccagaag tatgtctatg
      721 tagctgatgt aacagctaag aacattcaca taatgaaaaa acacaataat tgggatttaa
      781 ctccagtgaa ggtaattcag ctgggcacct tagtggataa cctgactgtt gatccagcca
      841 ccggagatat tttggcagga tgccatccta accccatgaa gctcttgatc tataacccgg
      901 aggatccccc aggatcagaa gtactacgca tccaggatcc tttgtcagat aacccccggg
      961 tgagcacact gtattcgaac aacggctctg tgcttcaggg cagcaccgtg gcttctgtgt
     1021 atcataaaaa aatgctcata ggcacaatat ttcacaaagc tctctattgt gaactctaga
     1081 tcttcctaaa aatctttata tttgacagaa gtaaaattgt aattgtttga taaggggaac
     1141 tgtaattctt tacaattacc agtgacagta tgtatggctt ttcttatgga gaaaagtaag
     1201 tgagtataga aacttacata cacaaaatca agagtcaggt tagtagcaag gcaaccagaa
     1261 acccaagtgt tctgctacat ttaatatgcc caacattctg tatacgctgt gatgtgtagg
     1321 ctgtgaccat ttaggtttcc cactcacttg aacttgtgcc ccttgttatc tatccagcaa
     1381 tgtcacctcc tacacctgtg atagtctgag gcttctgcag tccatagaaa taaagaagct
     1441 agtggctaac taaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
