LOCUS       NM_001013082            1782 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus paraoxonase 2 (Pon2), mRNA.
ACCESSION   NM_001013082 XM_216094
VERSION     NM_001013082.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1782)
  AUTHORS   Aguirre-Vidal,Y., Montes,S., Tristan-Lopez,L., Anaya-Ramos,L.,
            Teiber,J., Rios,C., Baron-Flores,V. and Monroy-Noyola,A.
  TITLE     The neuroprotective effect of lovastatin on MPP(+)-induced
            neurotoxicity is not mediated by PON2
  JOURNAL   Neurotoxicology 48, 166-170 (2015)
   PUBMED   25842176
  REMARK    GeneRIF: Lovastatin conferred neuroprotection against
            MPP(+)-induced Parkinson disease but this effect was not associated
            with the induction of PON2 in the rat striatum.
REFERENCE   2  (bases 1 to 1782)
  AUTHORS   Li,X.T., Li,X., Hu,F.F., Shen,H.X., Cao,J.L., Li,Z., Zhang,Z.D. and
            Zhu,B.L.
  TITLE     Association between paraoxonase 2 gene polymorphisms and
            noise-induced hearing loss in the Chinese population
  JOURNAL   J Occup Health 55 (2), 56-65 (2013)
   PUBMED   23327886
REFERENCE   3  (bases 1 to 1782)
  AUTHORS   Hussein,O., Zidan,J., Abu Jabal,K., Shams,I., Szvalb,S.,
            Grozovski,M., Bersudsky,I., Karry,R. and Aviram,M.
  TITLE     Paraoxonase activity and expression is modulated by therapeutics in
            experimental rat nonalcoholic Fatty liver disease
  JOURNAL   Int J Hepatol 2012, 265305 (2012)
   PUBMED   22536512
REFERENCE   4  (bases 1 to 1782)
  AUTHORS   Joo,J.I., Oh,T.S., Kim,D.H., Choi,D.K., Wang,X., Choi,J.W. and
            Yun,J.W.
  TITLE     Differential expression of adipose tissue proteins between
            obesity-susceptible and -resistant rats fed a high-fat diet
  JOURNAL   Proteomics 11 (8), 1429-1448 (2011)
   PUBMED   21365757
REFERENCE   5  (bases 1 to 1782)
  AUTHORS   Giusti,B., Saracini,C., Bolli,P., Magi,A., Martinelli,I.,
            Peyvandi,F., Rasura,M., Volpe,M., Lotta,L.A., Rubattu,S.,
            Mannucci,P.M. and Abbate,R.
  TITLE     Early-onset ischaemic stroke: analysis of 58 polymorphisms in 17
            genes involved in methionine metabolism
  JOURNAL   Thromb Haemost 104 (2), 231-242 (2010)
   PUBMED   20458436
REFERENCE   6  (bases 1 to 1782)
  AUTHORS   Kao,Y., Donaghue,K.C., Chan,A., Bennetts,B.H., Knight,J. and
            Silink,M.
  TITLE     Paraoxonase gene cluster is a genetic marker for early
            microvascular complications in type 1 diabetes
  JOURNAL   Diabet Med 19 (3), 212-215 (2002)
   PUBMED   11918623
REFERENCE   7  (bases 1 to 1782)
  AUTHORS   Janka,Z., Juhasz,A., Rimanoczy,A. A, Boda,K., Marki-Zay,J. and
            Kalman,J.
  TITLE     Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is
            associated with apolipoprotein E4 allele in both Alzheimer's and
            vascular dementias
  JOURNAL   Mol Psychiatry 7 (1), 110-112 (2002)
   PUBMED   11803456
REFERENCE   8  (bases 1 to 1782)
  AUTHORS   Pinizzotto,M., Castillo,E., Fiaux,M., Temler,E., Gaillard,R.C. and
            Ruiz,J.
  TITLE     Paraoxonase2 polymorphisms are associated with nephropathy in Type
            II diabetes
  JOURNAL   Diabetologia 44 (1), 104-107 (2001)
   PUBMED   11206400
REFERENCE   9  (bases 1 to 1782)
  AUTHORS   Mackness,B., Durrington,P.N., Abuashia,B., Boulton,A.J. and
            Mackness,M.I.
  TITLE     Low paraoxonase activity in type II diabetes mellitus complicated
            by retinopathy
  JOURNAL   Clin Sci (Lond) 98 (3), 355-363 (2000)
   PUBMED   10677395
REFERENCE   10 (bases 1 to 1782)
  AUTHORS   Sanghera,D.K., Aston,C.E., Saha,N. and Kamboh,M.I.
  TITLE     DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are
            associated with the risk of coronary heart disease
  JOURNAL   Am J Hum Genet 62 (1), 36-44 (1998)
   PUBMED   9443862
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079462.1.
            
            On Apr 20, 2005 this sequence version replaced XM_216094.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079462.1, CF110230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMEA5760494
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1782
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..1782
                     /gene="Pon2"
                     /note="paraoxonase 2"
                     /db_xref="GeneID:296851"
                     /db_xref="RGD:1309954"
     exon            1..126
                     /gene="Pon2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1117
                     /gene="Pon2"
                     /EC_number="3.1.1.2"
                     /EC_number="3.1.1.81"
                     /note="PON 2; A-esterase 2; aromatic esterase 2; serum
                     aryldialkylphosphatase 2"
                     /codon_start=1
                     /product="serum paraoxonase/arylesterase 2"
                     /protein_id="NP_001013100.1"
                     /db_xref="GeneID:296851"
                     /db_xref="RGD:1309954"
                     /translation="MGRLVALSLLGIGLALLGERFLALRSRLKASREVESVDLPNCRL
                     IKGIETGAEDIDILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRALELRV
                     SWGFDLASFNPHGISTFIDDDDTVYLFVVNHPEFKNTVEIFKFQEEENSLLHLKTIKH
                     ELLPSVNDVIAVGPSHFYATNDHYFSDPFLKYLETYLNLRWANVVYYSPEEVKLVAEG
                     FDSANGINISPDKKYVYVADILAHEIHVLEKQPNMNLTQLKVLQLGTLVDNLSIDPSS
                     GDIWVGCHPNGQKLFVYDPNHPPSSEVLRIQNILSEKPSVTTVYINNGSVLQGSSVAT
                     IYDRKLLVGTLYQRALYCEL"
     exon            127..197
                     /gene="Pon2"
                     /inference="alignment:Splign:2.1.0"
     exon            198..253
                     /gene="Pon2"
                     /inference="alignment:Splign:2.1.0"
     exon            254..419
                     /gene="Pon2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..546
                     /gene="Pon2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..747
                     /gene="Pon2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..829
                     /gene="Pon2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..958
                     /gene="Pon2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1759
                     /gene="Pon2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccggtgca gcccggtcag gcccaaacca gacggcgggc cggtcccgcg ccatgggccg
       61 gctggtggct ctgagtttgc taggcatcgg gctggcgctt ctgggcgagc ggttcttggc
      121 gctcagaagt cgacttaaag cctccagaga agtagaatct gtagaccttc caaactgccg
      181 cctcattaaa ggaattgaaa ctggcgctga ggacattgac attcttccca atggtctggc
      241 attctttagc gtgggcctca agtttccagg acttcacagc tttgcaccag acaaacctgg
      301 agggatactg atgatggatc tcaaagagga gaaaccaaga gcactggagt taagagtcag
      361 ctggggcttt gatttggctt cattcaaccc acatggcatt agcactttca tagatgatga
      421 tgatacagtt tatctctttg ttgtgaacca cccagaattc aagaatacag tggaaatttt
      481 taaatttcaa gaagaagaaa attctctgct gcacctgaaa acaattaaac atgagctcct
      541 tccaagtgtg aatgatgtca tagctgttgg gccctcccac ttctacgcca ccaatgacca
      601 ctacttctcc gaccctttct tgaagtattt ggaaacatac ttgaacctac gttgggcaaa
      661 tgttgtttac tacagtccag aagaagttaa gctggtggca gaaggattcg actcagccaa
      721 cgggatcaac atttcacctg ataaaaagta tgtttacgtt gctgacatat tggctcatga
      781 aatccatgtt ttggaaaaac agcctaatat gaatttaact caactaaagg ttctgcagtt
      841 gggcacgctg gtggacaatt tatctattga tccttcttca ggcgacatct gggtcggctg
      901 tcaccctaac ggccagaagc tcttcgtgta cgacccgaac catcctccct cgtcagaggt
      961 tctccgaatt cagaacattc tatccgagaa gccatcggtg acgacagtgt acatcaacaa
     1021 cgggtctgtc ctccagggta gttctgtggc aaccatatat gacaggaaac ttcttgtagg
     1081 cactttatac cagagagctt tgtactgtga actctaattt gttggcatgt aagtgcaata
     1141 agttttaaca aaataacctt ttgattaatg actaattctg agggtattta accatcagta
     1201 ctgacctagt aagacaccac atacgtagtt ccttttattt caataattcc gattccccac
     1261 aattctgatg cacttttagc gttagaagaa aacgaacttt atttttggtt ttgtttgttt
     1321 gtttgtttgt gttatgccga tccagcgaga aagaagaaag ctgcttttct acgaagtgag
     1381 tgcattttgc acagaggggt ttcacctccg tgccaccaac ctctaggagt ccactgaaac
     1441 agggagtgtt ataaaaatgt cagtggcctc ggtccccatg ctgtgactac tgaatgtgtt
     1501 caagactact gacagatagc atttccatgt tttgtacctc cagctttgtt tactgtttta
     1561 caaattagaa ttgtattaaa ggctaaccaa aatccagggg gttgtttgtg tttgattccc
     1621 aagggagatc ctcagaagga ggccgggggc ggggggattc tgttggacaa gaataaatga
     1681 ccatgttaat ttctcataaa agctgtatgt aaagggactc tttattggaa aaataaaata
     1741 aaacaaccga cttctataaa aaaaaaaaaa aaaaaaaaaa aa
//
