LOCUS       NM_032077               1322 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus paraoxonase 1 (Pon1), mRNA.
ACCESSION   NM_032077 XM_342639
VERSION     NM_032077.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1322)
  AUTHORS   Kang,T., Qin,X., Lei,Q. and Yang,Q.
  TITLE     BRAP silencing protects against neuronal inflammation, oxidative
            stress and apoptosis in cerebral ischemia-reperfusion injury by
            promoting PON1 expression
  JOURNAL   Environ Toxicol 38 (11), 2645-2655 (2023)
   PUBMED   37647369
  REMARK    GeneRIF: BRAP silencing protects against neuronal inflammation,
            oxidative stress and apoptosis in cerebral ischemia-reperfusion
            injury by promoting PON1 expression.
REFERENCE   2  (bases 1 to 1322)
  AUTHORS   Zhang,L., Dong,W., Ma,Y., Bai,L., Zhang,X., Sun,C., Li,J. and
            Zhang,L.
  TITLE     Pon1 Deficiency Promotes Trem2 Pathway-Mediated Microglial
            Phagocytosis and Inhibits Pro-inflammatory Cytokines Release In
            Vitro and In Vivo
  JOURNAL   Mol Neurobiol 59 (7), 4612-4629 (2022)
   PUBMED   35589918
  REMARK    GeneRIF: Pon1 Deficiency Promotes Trem2 Pathway-Mediated Microglial
            Phagocytosis and Inhibits Pro-inflammatory Cytokines Release In
            Vitro and In Vivo.
REFERENCE   3  (bases 1 to 1322)
  AUTHORS   Wang,T., Dai,L., Shen,S., Yang,Y., Yang,M., Yang,X., Qiu,Y. and
            Wang,W.
  TITLE     Comprehensive Molecular Analyses of a Macrophage-Related Gene
            Signature With Regard to Prognosis, Immune Features, and Biomarkers
            for Immunotherapy in Hepatocellular Carcinoma Based on WGCNA and
            the LASSO Algorithm
  JOURNAL   Front Immunol 13, 843408 (2022)
   PUBMED   35693827
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1322)
  AUTHORS   Decharatchakul,N., Settasatian,C., Settasatian,N., Komanasin,N.,
            Kukongviriyapan,U., Intharapetch,P., Senthong,V. and
            Sawanyawisuth,K.
  TITLE     Association of combined genetic variations in SOD3, GPX3, PON1, and
            GSTT1 with hypertension and severity of coronary artery disease
  JOURNAL   Heart Vessels 35 (7), 918-929 (2020)
   PUBMED   32034489
REFERENCE   5  (bases 1 to 1322)
  AUTHORS   Chen,F., Liu,H., Li,Z., Pei,Y., Wang,H., Zhang,J., Wang,J. and
            Zheng,Z.
  TITLE     Paraoxonase 1 Was Negatively Associated With Intervertebral Disc
            Degeneration
  JOURNAL   Spine (Phila Pa 1976) 44 (18), E1053-E1062 (2019)
   PUBMED   30946296
  REMARK    GeneRIF: Study indicates that low PON1 expression is predictive of
            severe IVDD; PON1 plays an important role of keeping the
            homeostatic balance of intervertebral discs.
REFERENCE   6  (bases 1 to 1322)
  AUTHORS   Shih,D.M., Gu,L., Xia,Y.R., Navab,M., Li,W.F., Hama,S.,
            Castellani,L.W., Furlong,C.E., Costa,L.G., Fogelman,A.M. and
            Lusis,A.J.
  TITLE     Mice lacking serum paraoxonase are susceptible to organophosphate
            toxicity and atherosclerosis
  JOURNAL   Nature 394 (6690), 284-287 (1998)
   PUBMED   9685159
REFERENCE   7  (bases 1 to 1322)
  AUTHORS   Ikeda,Y., Suehiro,T., Inoue,M., Nakauchi,Y., Morita,T., Arii,K.,
            Ito,H., Kumon,Y. and Hashimoto,K.
  TITLE     Serum paraoxonase activity and its relationship to diabetic
            complications in patients with non-insulin-dependent diabetes
            mellitus
  JOURNAL   Metabolism 47 (5), 598-602 (1998)
   PUBMED   9591753
REFERENCE   8  (bases 1 to 1322)
  AUTHORS   Odawara,M., Tachi,Y. and Yamashita,K.
  TITLE     Paraoxonase polymorphism (Gln192-Arg) is associated with coronary
            heart disease in Japanese noninsulin-dependent diabetes mellitus
  JOURNAL   J Clin Endocrinol Metab 82 (7), 2257-2260 (1997)
   PUBMED   9215303
REFERENCE   9  (bases 1 to 1322)
  AUTHORS   Rodrigo,L., Gil,F., Hernandez,A.F., Marina,A., Vazquez,J. and
            Pla,A.
  TITLE     Purification and characterization of paraoxon hydrolase from rat
            liver
  JOURNAL   Biochem J 321 (Pt 3) (Pt 3), 595-601 (1997)
   PUBMED   9032442
REFERENCE   10 (bases 1 to 1322)
  AUTHORS   Sorenson,R.C., Primo-Parmo,S.L., Kuo,C.L., Adkins,S., Lockridge,O.
            and La Du,B.N.
  TITLE     Reconsideration of the catalytic center and mechanism of mammalian
            paraoxonase/arylesterase
  JOURNAL   Proc Natl Acad Sci U S A 92 (16), 7187-7191 (1995)
   PUBMED   7638166
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO570909.1, U94856.1 and CO562983.1.
            
            On Oct 22, 2004 this sequence version replaced XM_342639.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091403.1, FQ209429.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-621               CO570909.1         1-621
            622-1071            U94856.1           580-1029
            1072-1322           CO562983.1         366-616
FEATURES             Location/Qualifiers
     source          1..1322
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..1322
                     /gene="Pon1"
                     /note="paraoxonase 1"
                     /db_xref="GeneID:84024"
                     /db_xref="RGD:620062"
     exon            1..86
                     /gene="Pon1"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1080
                     /gene="Pon1"
                     /EC_number="3.1.1.2"
                     /EC_number="3.1.8.1"
                     /EC_number="3.1.1.81"
                     /note="aromatic esterase 1; serum aryldialkylphosphatase
                     1; PON 1; A-esterase 1"
                     /codon_start=1
                     /product="serum paraoxonase/arylesterase 1"
                     /protein_id="NP_114466.1"
                     /db_xref="GeneID:84024"
                     /db_xref="RGD:620062"
                     /translation="MAKLLGLTLVGLVLALYKNHRSSYQTRLNAFREVTPVDLPNCTL
                     VKGIEAGAEDLEILPNGLTFFSTGLKYPGIKSFDPSKPGKILLMDLNEKEPAVSELAI
                     MGNTLDMSSFNPHGISTFIDEDNTVYLLVVSHPDSSSTVEVFKFQEEERSLLHLKTIT
                     HELLPSINDIAAVGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVRVVAD
                     GFDFANGIGISLDGKYVYIAELLAHKIHVYEKHANWTLTPLKVLSFDTLVDNISVDPV
                     TGDLWVGCHPNGMRIFFYDSENPPGSEVLRIQSILSEDPKVTVVYAENGTVLQGTTVA
                     AVYKGKLLIGTVFHRALCCDL"
     exon            87..157
                     /gene="Pon1"
                     /inference="alignment:Splign:2.1.0"
     exon            158..213
                     /gene="Pon1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..382
                     /gene="Pon1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..509
                     /gene="Pon1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..710
                     /gene="Pon1"
                     /inference="alignment:Splign:2.1.0"
     exon            711..792
                     /gene="Pon1"
                     /inference="alignment:Splign:2.1.0"
     exon            793..921
                     /gene="Pon1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1319
                     /gene="Pon1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgtctcagg acatggcgaa actgctaggg ctcaccctcg tgggactggt gttggcactt
       61 tacaagaacc atcggtcttc ctatcaaaca agattaaatg ctttccgtga agtaacaccg
      121 gtagatcttc ctaactgtac tttagttaaa ggaatcgaag cgggtgctga agacttagag
      181 attctgccta atggactaac tttctttagc acagggttaa agtatcctgg aataaaaagt
      241 ttcgatccca gtaagcctgg aaaaatactt ctgatggact tgaatgagaa ggagccagca
      301 gtgtcagaat tagcaattat gggaaatacg ttggatatgt cttcatttaa ccctcatggg
      361 attagcacat tcatagatga agataacact gtgtacctac tggtggtaag ccacccagac
      421 tcctcgtcca ccgtggaggt gtttaaattt caagaagagg aaagatcact tttgcatctg
      481 aaaaccatca cccatgaact tctgcctagc atcaacgata tagctgctgt tggacctgag
      541 agcttctatg ccacaaatga tcactatttt gctgacccat acttacggtc ctgggaaatg
      601 tacttgggcc tgtcatggtc caatgttgta tactacagtc cagataaagt ccgagtggta
      661 gcagatggat ttgatttcgc taatggcatt ggcatttccc ttgatggcaa gtatgtctat
      721 atcgctgaat tgctggctca caagattcac gtgtatgaaa agcatgctaa ttggacttta
      781 acgccattga aggtcctcag ctttgacacc cttgtggata acatctctgt ggatcctgtg
      841 acaggggacc tctgggttgg atgccatccc aatgggatga ggattttttt ctatgactcg
      901 gagaatcctc ctggctcaga ggtgcttcgg atccagagca ttttatccga agaccccaaa
      961 gtaactgtag tttatgcaga gaatggcacg gtgttgcaag gtacgacagt cgctgctgtg
     1021 tacaaaggaa aactgctgat tggaacggtg ttccacagag ctctttgttg tgacctgtga
     1081 caagctggct acacccacat catggaaagt gaggccatca tttcagccct ttgccatatt
     1141 gtaaggtgcc tatcacagtg atctccgctc accaacgaat gttgacctta atctcagaca
     1201 taagaaggtc tgagaatgtt tcctggcaat agatcctaac tagcaaagat ttcttgagtg
     1261 ttagtttcag actacttaaa gaccccatta cccataaaaa aaaaaatctt tcaccaaaaa
     1321 aa
//
