LOCUS       NM_001047114            3097 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus protein-O-mannosyltransferase 2 (Pomt2), mRNA.
ACCESSION   NM_001047114 XM_001058804
VERSION     NM_001047114.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3097)
  AUTHORS   Larsen,I.S.B., Narimatsu,Y., Joshi,H.J., Yang,Z., Harrison,O.J.,
            Brasch,J., Shapiro,L., Honig,B., Vakhrushev,S.Y., Clausen,H. and
            Halim,A.
  TITLE     Mammalian O-mannosylation of cadherins and plexins is independent
            of protein O-mannosyltransferases 1 and 2
  JOURNAL   J Biol Chem 292 (27), 11586-11598 (2017)
   PUBMED   28512129
REFERENCE   2  (bases 1 to 3097)
  AUTHORS   Biancheri,R., Falace,A., Tessa,A., Pedemonte,M., Scapolan,S.,
            Cassandrini,D., Aiello,C., Rossi,A., Broda,P., Zara,F.,
            Santorelli,F.M., Minetti,C. and Bruno,C.
  TITLE     POMT2 gene mutation in limb-girdle muscular dystrophy with
            inflammatory changes
  JOURNAL   Biochem Biophys Res Commun 363 (4), 1033-1037 (2007)
   PUBMED   17923109
REFERENCE   3  (bases 1 to 3097)
  AUTHORS   Bouchet,C., Gonzales,M., Vuillaumier-Barrot,S., Devisme,L.,
            Lebizec,C., Alanio,E., Bazin,A., Bessieres-Grattagliano,B.,
            Bigi,N., Blanchet,P., Bonneau,D., Bonnieres,M., Carles,D.,
            Delahaye,S., Fallet-Bianco,C., Figarella-Branger,D., Gaillard,D.,
            Gasser,B., Guimiot,F., Joubert,M., Laurent,N., Liprandi,A.,
            Loget,P., Marcorelles,P., Martinovic,J., Menez,F., Patrier,S.,
            Pelluard-Nehme,F., Perez,M.J., Rouleau-Dubois,C., Triau,S.,
            Laquerriere,A., Encha-Razavi,F. and Seta,N.
  TITLE     Molecular heterogeneity in fetal forms of type II lissencephaly
  JOURNAL   Hum Mutat 28 (10), 1020-1027 (2007)
   PUBMED   17559086
REFERENCE   4  (bases 1 to 3097)
  AUTHORS   Yanagisawa,A., Bouchet,C., Van den Bergh,P.Y., Cuisset,J.M.,
            Viollet,L., Leturcq,F., Romero,N.B., Quijano-Roy,S., Fardeau,M.,
            Seta,N. and Guicheney,P.
  TITLE     New POMT2 mutations causing congenital muscular dystrophy:
            identification of a founder mutation
  JOURNAL   Neurology 69 (12), 1254-1260 (2007)
   PUBMED   17634419
REFERENCE   5  (bases 1 to 3097)
  AUTHORS   Manya,H., Chiba,A., Margolis,R.U. and Endo,T.
  TITLE     Molecular cloning and characterization of rat Pomt1 and Pomt2
  JOURNAL   Glycobiology 16 (9), 863-873 (2006)
   PUBMED   16704966
REFERENCE   6  (bases 1 to 3097)
  AUTHORS   van Reeuwijk,J., Janssen,M., van den Elzen,C., Beltran-Valero de
            Bernabe,D., Sabatelli,P., Merlini,L., Boon,M., Scheffer,H.,
            Brockington,M., Muntoni,F., Huynen,M.A., Verrips,A., Walsh,C.A.,
            Barth,P.G., Brunner,H.G. and van Bokhoven,H.
  TITLE     POMT2 mutations cause alpha-dystroglycan hypoglycosylation and
            Walker-Warburg syndrome
  JOURNAL   J Med Genet 42 (12), 907-912 (2005)
   PUBMED   15894594
REFERENCE   7  (bases 1 to 3097)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001047114.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB246667.1, SRR26643293.36509.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-729               JAXUCZ010000006.1  112525071-112525799 c
            730-814             JAXUCZ010000006.1  112518986-112519070 c
            815-919             JAXUCZ010000006.1  112517286-112517390 c
            920-1028            JAXUCZ010000006.1  112514470-112514578 c
            1029-1137           JAXUCZ010000006.1  112511875-112511983 c
            1138-1297           JAXUCZ010000006.1  112510149-112510308 c
            1298-1404           JAXUCZ010000006.1  112508696-112508802 c
            1405-1487           JAXUCZ010000006.1  112507576-112507658 c
            1488-1597           JAXUCZ010000006.1  112505905-112506014 c
            1598-1664           JAXUCZ010000006.1  112501656-112501722 c
            1665-1734           JAXUCZ010000006.1  112499672-112499741 c
            1735-1813           JAXUCZ010000006.1  112496503-112496581 c
            1814-1965           JAXUCZ010000006.1  112494853-112495004 c
            1966-2057           JAXUCZ010000006.1  112494335-112494426 c
            2058-2134           JAXUCZ010000006.1  112493473-112493549 c
            2135-2206           JAXUCZ010000006.1  112489309-112489380 c
            2207-2266           JAXUCZ010000006.1  112488943-112489002 c
            2267-2372           JAXUCZ010000006.1  112488751-112488856 c
            2373-2513           JAXUCZ010000006.1  112487878-112488018 c
            2514-2628           JAXUCZ010000006.1  112487583-112487697 c
            2629-3097           JAXUCZ010000006.1  112486416-112486884 c
FEATURES             Location/Qualifiers
     source          1..3097
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..3097
                     /gene="Pomt2"
                     /note="protein-O-mannosyltransferase 2"
                     /db_xref="GeneID:688673"
                     /db_xref="RGD:1586427"
     exon            1..729
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             272..2734
                     /gene="Pomt2"
                     /EC_number="2.4.1.109"
                     /codon_start=1
                     /product="protein O-mannosyl-transferase 2"
                     /protein_id="NP_001040579.1"
                     /db_xref="GeneID:688673"
                     /db_xref="RGD:1586427"
                     /translation="MFYASGRLLAAREATTLYAPPRARGPALRGKRRELQIPWHLETP
                     SYDSLTGQRTRPGVPPARRVILRKGRMPPAIGGGLAGSELRPRRGRSVQQAARAVSRD
                     VVPEAATRKLKRPAWSSRRFQAAGWWATLAVVTLLSFATRFHRLDQPAHICWDETHFG
                     KMGSYYINRTFFFDVHPPLGKMLIGLAGYLSGYDGTFLFQKPGDRYEHHSYMGMRGFC
                     AFLGSWLIPFAYLTVLDLSKSFPAALLTAALLTCDTGCLTLSQYILLDPILMFFIMAA
                     MLSMVKYNSFANRPFSAPWWFWLSLTGISLAGALGVKFVGLFIIVQVGLNTISDLWHL
                     FGDLSLSLVTVGKHLTARILCLIVLPLVLYVTIFAVHVMVLNKSGPGDGFFSSAFQAR
                     LSGNSLHNASIPEHLAYGSVITVKNLRMAIGYLHSHRHLYPEGIGARQQQVTTYLHKD
                     YNNLWIIKKYNTNTDPLDPSFPVEFVRHGDIIRLEHKETTRNLHSHYHEAPLTRKHYQ
                     VTGYGINGTGDSNDFWRIEVVNRKFGNRIKVLRSRIRFIHLVTGCVLGSSGKILPKWG
                     WEQLEVTCNPYLKETSNSIWNIEEHINPKLPNISLDVLQPSFPEILLESHMVMIRGNN
                     GLKPKDNEFTSKPWHWPINYQGLRFSGANDTDFRVYLLGNPVVWWLNLVSLVLYLLTG
                     STIAIAMQRGIQLPAELQGLTKLLLRGGGQLLLGWTLHYFPFFLMGRVLYFHHYFPAM
                     LFSSMLTGLLWDTLLRFCAWALAPSPLGRRIHMVGILSLLLATAYSFYLFHPLAYGMV
                     GPLAQEPESPMAGLRWLESWDF"
     exon            730..814
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            815..919
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1028
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1137
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1297
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1404
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1487
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1597
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1664
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1734
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1813
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1965
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2057
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2134
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2206
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2266
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2372
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2513
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2628
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..3097
                     /gene="Pomt2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgttctc cgcgtttctc aggagcgacc ctcaaccccg gatctgcggc acagaccttc
       61 ccggcttgca tctcgcccgt cggccagcca agaaagtcag ttctcaggac tagaagatga
      121 ctgaggccta gcggggtcca gagagcgaag gttggactag atggcgttcc ctccttcggg
      181 ctggccccgc ccccgcctcc tgagctctgg gagttgtagt tcatgagcgg ccccgagtct
      241 gtctgtcctt cgcgtccctc cgcctcctgc tatgttttac gcctcaggcc gcctcttagc
      301 cgcccgggag gccaccacac tctacgcccc tcccagagcc cggggcccgg cactccgcgg
      361 caaacggagg gaactacaaa tcccatggca cctcgagacg ccctcttacg actccttgac
      421 ggggcagcgg acaagacccg gcgtgcctcc ggcccggagg gtgatcctta gaaaggggag
      481 gatgccgccg gccataggcg gtggcctagc gggctcggag ctgcgtcccc gtaggggccg
      541 cagtgtgcag caggctgcca gagccgtgag ccgagacgtg gtccccgagg ctgcaacgcg
      601 gaaacttaaa cggcctgctt ggagctcgcg gcgcttccag gcggcaggct ggtgggccac
      661 gctggctgtg gtgacgctgc tgtcctttgc cacccgcttt cacaggctgg accagccggc
      721 acatatctgt tgggatgaga ctcactttgg aaaaatggga agttactaca ttaaccgcac
      781 ctttttcttc gatgtgcacc caccactggg aaagatgctg attggccttg ctggctacct
      841 gagtggatat gatggtacct ttttgttcca gaagcctggg gaccgatacg agcaccacag
      901 ctacatgggg atgagagggt tctgtgcttt cctgggttcc tggctgatcc cctttgccta
      961 cctcactgta ctggatctgt ccaagtcctt cccagcagca ctgctcaccg ctgccctgct
     1021 cacctgtgac acgggatgcc tcactctgtc ccagtacatc ctccttgacc ccatcctgat
     1081 gttcttcatc atggctgcca tgctgagcat ggtcaagtac aactccttcg ctaacaggcc
     1141 tttctctgcc ccctggtggt tctggctcag cctgactggc attagtcttg ctggcgcttt
     1201 aggggtcaaa tttgttggcc tctttatcat tgtgcaagtg gggttgaaca ccatctcaga
     1261 cctctggcac ctgtttggag acctcagtct ttcactggtg actgtgggga aacacctgac
     1321 tgctcgcatc ctgtgcctca tagtgctgcc cttggtgctc tatgtgacca tttttgctgt
     1381 tcatgtcatg gtgctgaata aaagtggtcc tggtgatggc ttcttcagtt ctgcctttca
     1441 agcccgactt tcagggaaca gccttcacaa tgcttctatc cctgaacact tggcgtatgg
     1501 ctctgtaatc actgtgaaga acctccggat ggccatcggc taccttcact cccacaggca
     1561 cctctaccct gagggcattg gtgcacgcca gcagcaggtt accacctatt tgcataagga
     1621 ctacaacaac ctgtggatta tcaagaaata caataccaac acagatcctc tagacccttc
     1681 cttcccagtg gagtttgtca gacatgggga catcatacga ctagaacaca aagaaactac
     1741 tcggaacctg cacagtcact atcatgaggc tcccctgacc cggaagcact atcaggtcac
     1801 tggctatggc ataaatggga caggggactc aaatgacttc tggaggattg aagttgtaaa
     1861 tagaaaattt gggaaccgga tcaaggtact gagaagtcga attcgcttca tccatttggt
     1921 tacaggttgt gtcctgggat cttcaggaaa gattctgcct aagtggggct gggagcagtt
     1981 ggaagttact tgtaatccgt acttaaaaga aaccagtaac tccatttgga acatagaaga
     2041 acatatcaat cccaaactgc caaacatcag cctggatgtg ctgcaaccca gttttcctga
     2101 gatcttgctg gagtcccaca tggtcatgat ccggggaaac aatggcctca aacctaagga
     2161 caatgagttt acatccaaac cctggcactg gcctatcaat tatcagggcc tgcgcttctc
     2221 aggggccaat gacacggact tccgagtcta tctgctcggc aaccctgtgg tctggtggct
     2281 caacctggtg agcctcgtcc tctacctcct cacgggcagc accattgcca tcgccatgca
     2341 gagagggata cagctgcctg cagagttgca agggctgacc aagctgctgc tgcgaggagg
     2401 cggccagctg ctcctgggat ggacgctcca ttacttccct ttcttcctga tgggccgcgt
     2461 cctctacttc caccactact tcccagccat gctcttttcc agcatgttga caggtctcct
     2521 gtgggatact cttctgcggt tctgtgcctg ggccttggcc ccttctcccc tgggtaggag
     2581 aatacatatg gtgggaatcc tgagcctgct tctggcaact gcctacagct tctacctctt
     2641 tcaccctctg gcttatggga tggttggtcc cctagcccag gaacctgaga gtccaatggc
     2701 aggactgagg tggctggaat catgggactt ttgaggccac tgccaggacc ccagcctgga
     2761 tccaggtatt gtccagggac acccagctat gaagcctgac cctgggccct tccagcttca
     2821 agggcgctgc ctgagaagcc caaagcattc tgctgccccc caggaccaaa ctctgggaaa
     2881 tgacatggat ttcactaaac actaaaaaga gccacagccc tgtctatagc acctacatgg
     2941 ggctcttgac ctacagcact gcttggtgcc agttcctgtg aaacacaagg aaagccggtg
     3001 tgagtgtcaa gggtacatat gcccaatccc tttggagtgt gtagaccatg taactgtggt
     3061 agccaagtgt cataaattcc aagaatggta caaggct
//
