LOCUS       NP_001009437             580 aa            linear   ROD 17-OCT-2024
DEFINITION  protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
            [Rattus norvegicus].
ACCESSION   NP_001009437 XP_008764903 XP_236725
VERSION     NP_001009437.1
DBSOURCE    REFSEQ: accession NM_001009437.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 580)
  AUTHORS   Endo,Y., Dong,M., Noguchi,S., Ogawa,M., Hayashi,Y.K., Kuru,S.,
            Sugiyama,K., Nagai,S., Ozasa,S., Nonaka,I. and Nishino,I.
  TITLE     Milder forms of muscular dystrophy associated with POMGNT2
            mutations
  JOURNAL   Neurol Genet 1 (4), e33 (2015)
   PUBMED   27066570
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 580)
  AUTHORS   Nakagawa,N., Yagi,H., Kato,K., Takematsu,H. and Oka,S.
  TITLE     Ectopic clustering of Cajal-Retzius and subplate cells is an
            initial pathological feature in Pomgnt2-knockout mice, a model of
            dystroglycanopathy
  JOURNAL   Sci Rep 5, 11163 (2015)
   PUBMED   26060116
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 580)
  AUTHORS   Yagi,H., Nakagawa,N., Saito,T., Kiyonari,H., Abe,T., Toda,T.,
            Wu,S.W., Khoo,K.H., Oka,S. and Kato,K.
  TITLE     AGO61-dependent GlcNAc modification primes the formation of
            functional glycans on alpha-dystroglycan
  JOURNAL   Sci Rep 3, 3288 (2013)
   PUBMED   24256719
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 580)
  AUTHORS   Yoshida-Moriguchi,T., Willer,T., Anderson,M.E., Venzke,D.,
            Whyte,T., Muntoni,F., Lee,H., Nelson,S.F., Yu,L. and Campbell,K.P.
  TITLE     SGK196 is a glycosylation-specific O-mannose kinase required for
            dystroglycan function
  JOURNAL   Science 341 (6148), 896-899 (2013)
   PUBMED   23929950
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On or before Oct 10, 2024 this sequence version replaced
            XP_008764903.1, XP_236725.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.35148.1,
                                           SRR26643299.37886.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840116 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..580
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     Protein         1..580
                     /product="protein O-linked-mannose
                     beta-1,4-N-acetylglucosaminyltransferase 2"
                     /EC_number="2.4.1.312"
                     /function="contributes to the synthesis of
                     glycoconjugates"
                     /note="glycosyltransferase; glycosyltransferase-like
                     domain-containing protein 2; glycosyltransferase-like
                     domain containing 2"
                     /calculated_mol_wt=66586
     Site            5..25
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5NDF0.1)"
     Site            99
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q5NDF0.1)"
     Site            276
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0007744|PubMed:24090084; propagated from
                     UniProtKB/Swiss-Prot (Q5NDF0.1)"
     Region          <319..391
                     /region_name="Glyco_transf_61"
                     /note="Glycosyltransferase 61; cl15705"
                     /db_xref="CDD:472831"
     Region          493..580
                     /region_name="FN3"
                     /note="Fibronectin type 3 domain; One of three types of
                     internal repeats found in the plasma protein fibronectin.
                     Its tenth fibronectin type III repeat contains an RGD cell
                     recognition sequence in a flexible loop between 2 strands.
                     Approximately 2% of all...; cd00063"
                     /db_xref="CDD:238020"
     Site            order(569..570,572..573)
                     /site_type="active"
                     /note="Cytokine receptor motif [active]"
                     /db_xref="CDD:238020"
     CDS             1..580
                     /gene="Pomgnt2"
                     /gene_synonym="Ago61; Gtdc2; RGD1304827"
                     /coded_by="NM_001009437.2:245..1987"
                     /db_xref="GeneID:316091"
                     /db_xref="RGD:1304827"
ORIGIN      
        1 mhlsavfnal lvsvlaavlw khvrlrehaa tleeelalgq qsldpvpglr idypkalqil
       61 meggthmvct grthtdricr fkwlcysnea eefiffhgns svmlpnlgsr rfqpalldls
      121 tvedhnaqyf nfvelpaaal rfmpkpvfvp dvalianrfn pdnlmhvfhd dllplfytlr
      181 qfpglaqear lffmegwgeg ahfdlyklls pkqpllrsql ktlgrllcfs hafvglskvt
      241 twyqygfvqp qgpkanilvs gneirqftrf mterlnvsha gaplgeeyil vfsrtqnrli
      301 lneaelllel aqefqmktvt vsledhtfad vvrlvsnasm lvsmhgaqlv talflprgat
      361 vvelfpyavn pdhytpyktl atlpgmdlqy vawrnmiren tvthperpwd qggithldra
      421 eqarilqsre vprhlccrnp ewlfriyqdt rvdipslmqs irrvvkgrpg prrqrwaisl
      481 ypgkvrearc qasvqgatea rlsvswqipw nlkylkvrev ryevwlqeqg entyvpymlt
      541 lqnhtfteni kpfttylvwv rcifnrsllg pfadvlvcst
//
