LOCUS       NM_139326                932 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus proopiomelanocortin (Pomc), mRNA.
ACCESSION   NM_139326
VERSION     NM_139326.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 932)
  AUTHORS   McFadden,T., Gaito,N., Carucci,I., Fletchall,E., Farrell,K. and
            Jarome,T.J.
  TITLE     Controlling hypothalamic DNA methylation at the Pomc promoter does
            not regulate weight gain during the development of obesity
  JOURNAL   PLoS One 18 (4), e0284286 (2023)
   PUBMED   37036864
  REMARK    GeneRIF: Controlling hypothalamic DNA methylation at the Pomc
            promoter does not regulate weight gain during the development of
            obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 932)
  AUTHORS   Zambrano-Zaragoza,J.F., Vazquez-Reyes,A., Duran-Avelar,M.J.,
            Gutierrez-Franco,J., Vibanco-Perez,N., Agraz-Cibrian,J.M.,
            Perez-Cambero,H. and Ayon-Perez,M.F.
  TITLE     Deleted genes associated with obesity in Mexican patients diagnosed
            with nonalcoholic fatty liver disease
  JOURNAL   Ann Hum Genet 86 (5), 237-244 (2022)
   PUBMED   35343586
REFERENCE   3  (bases 1 to 932)
  AUTHORS   Hong,L., Wen,L., Niculescu,M., Zhou,F., Zou,Y., Shen,G., Wang,W.,
            Liu,Y., Chen,Y.H., Wang,F. and Chen,L.
  TITLE     The Interaction Between POMC rs2071345 Polymorphism and Alcohol
            Dependence in Anxiety Symptoms Among Chinese Male Problem Drinkers
  JOURNAL   Front Psychiatry 13, 878960 (2022)
   PUBMED   35592377
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 932)
  AUTHORS   Gangisetty,O., Chaudhary,S., Palagani,A. and Sarkar,D.K.
  TITLE     Transgenerational inheritance of fetal alcohol effects on
            proopiomelanocortin gene expression and methylation, cortisol
            response to stress, and anxiety-like behaviors in offspring for
            three generations in rats: Evidence for male germline transmission
  JOURNAL   PLoS One 17 (2), e0263340 (2022)
   PUBMED   35143549
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 932)
  AUTHORS   Schumacher,R., Rossetti,M.F., Lazzarino,G.P., Canesini,G.,
            Garcia,A.P., Stoker,C., Andreoli,M.F. and Ramos,J.G.
  TITLE     Temporary effects of neonatal overfeeding on homeostatic control of
            food intake involve alterations in POMC promoter methylation in
            male rats
  JOURNAL   Mol Cell Endocrinol 522, 111123 (2021)
   PUBMED   33338550
  REMARK    GeneRIF: Temporary effects of neonatal overfeeding on homeostatic
            control of food intake involve alterations in POMC promoter
            methylation in male rats.
REFERENCE   6  (bases 1 to 932)
  AUTHORS   Wilson,D.B. and Wyatt,D.P.
  TITLE     Adrenocorticotropic cell distribution in adult and embryonic
            pituitaries of the little (lit) mutant mouse
  JOURNAL   Anat Embryol (Berl) 186 (4), 347-353 (1992)
   PUBMED   1329576
REFERENCE   7  (bases 1 to 932)
  AUTHORS   Summers,J.A., Pullan,P.T., Kril,J.J. and Harper,C.G.
  TITLE     Increased central immunoreactive beta-endorphin content in patients
            with Wernicke-Korsakoff syndrome and in alcoholics
  JOURNAL   J Clin Pathol 44 (2), 126-129 (1991)
   PUBMED   1650797
REFERENCE   8  (bases 1 to 932)
  AUTHORS   Hiltz,M.E. and Lipton,J.M.
  TITLE     Antiinflammatory activity of a COOH-terminal fragment of the
            neuropeptide alpha-MSH
  JOURNAL   FASEB J 3 (11), 2282-2284 (1989)
   PUBMED   2550304
REFERENCE   9  (bases 1 to 932)
  AUTHORS   Drouin,J., Chamberland,M., Charron,J., Jeannotte,L. and Nemer,M.
  TITLE     Structure of the rat pro-opiomelanocortin (POMC) gene
  JOURNAL   FEBS Lett 193 (1), 54-58 (1985)
   PUBMED   2998878
REFERENCE   10 (bases 1 to 932)
  AUTHORS   Drouin,J. and Goodman,H.M.
  TITLE     Most of the coding region of rat ACTH beta--LPH precursor gene
            lacks intervening sequences
  JOURNAL   Nature 288 (5791), 610-613 (1980)
   PUBMED   6255341
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 27, 2020 this sequence version replaced NM_139326.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058443.1, CB569820.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                JAXUCZ010000006.1  32659353-32659448
            97-247              JAXUCZ010000006.1  32662593-32662743
            248-932             JAXUCZ010000006.1  32664489-32665173
FEATURES             Location/Qualifiers
     source          1..932
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..932
                     /gene="Pomc"
                     /gene_synonym="ACTH; alphaMSH; Pomc1; Pomc2"
                     /note="proopiomelanocortin"
                     /db_xref="GeneID:24664"
                     /db_xref="RGD:3366"
     exon            1..96
                     /gene="Pomc"
                     /gene_synonym="ACTH; alphaMSH; Pomc1; Pomc2"
                     /inference="alignment:Splign:2.1.0"
     exon            97..247
                     /gene="Pomc"
                     /gene_synonym="ACTH; alphaMSH; Pomc1; Pomc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..823
                     /gene="Pomc"
                     /gene_synonym="ACTH; alphaMSH; Pomc1; Pomc2"
                     /note="pro-opiomelanocortin-alpha;
                     corticotropin-lipotropin; proopiomelanocortin, beta
                     (endorphin, beta); proopoimelanocortin, beta (endorphin,
                     beta); proopiomelanocortin (adrenocorticotropin/
                     beta-lipotropin/ alpha-melanocyte stimulating hormone/
                     beta-melanocyte stimulating hormone/ beta-endorphin);
                     alpha-melanocyte-stimulating hormone; adrenocorticotropic
                     hormone"
                     /codon_start=1
                     /product="pro-opiomelanocortin precursor"
                     /protein_id="NP_647542.1"
                     /db_xref="GeneID:24664"
                     /db_xref="RGD:3366"
                     /translation="MPRFCYSRSGALLLALLLQTSIDVWSWCLESSQCQDLTTESNLL
                     ACIRACRLDLSAETPVFPGNGDEQPLTENPRKYVMGHFRWDRFGPRNSSSAGGSAQRR
                     AEEETAGGDGRPEPSPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNVAENESAEAFPL
                     EFKRELEGEQPDGLEHVLEPDTEKADGPYRVEHFRWGNPPKDKRYGGFMTSEKSQTPL
                     VTLFKNAIIKNAHKKGQ"
     exon            248..932
                     /gene="Pomc"
                     /gene_synonym="ACTH; alphaMSH; Pomc1; Pomc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacgggaggc gacggaggag aaaagaggtt aaggagcagt gactaagaga ggccactgaa
       61 catcttcgtc ctcagagagc tgcctttccg cgacagagcc tcagccacct ggaagatgcc
      121 gagattctgc tacagtcgct caggggccct gctgctggcc ctcctgcttc agacctccat
      181 agacgtgtgg agctggtgcc tggagagcag ccagtgccag gacctcacca cggaaagcaa
      241 cctgctggct tgcatccggg cctgcagact cgacctctcg gcggagacgc ccgtgtttcc
      301 aggcaacgga gatgaacagc ccttgactga aaatccccgg aagtacgtca tgggtcactt
      361 ccgctgggac cgcttcggcc ccagaaacag cagcagtgct ggcggctcag cgcagaggcg
      421 tgcggaggaa gagacggcgg ggggagatgg ccgtccggag ccaagtccac gggagggcaa
      481 gcgctcctac tccatggagc acttccgctg gggcaagccg gtgggcaaga agcggcgccc
      541 tgtgaaggtg taccccaatg tcgccgagaa cgagtcggcc gaggcctttc ccctagagtt
      601 caagagggag ctggaaggcg agcagcctga tggcttggag cacgtcctgg agccggatac
      661 cgagaaggcc gacgggccct atcgggtgga gcacttccgc tggggcaacc cgcccaagga
      721 caagcgctac ggcggcttca tgacctccga gaagagccag acgcccctgg tgacgctctt
      781 caagaacgcc atcatcaaga acgcgcacaa gaagggccag tgagggtgca ggggtcttct
      841 cactccaagg ccccctccct gcatgggcga gagcacctga cctccagcct cttagagtta
      901 cctgtagtta ggaaataaaa cctttcagac tt
//
