LOCUS       NM_001106766            3745 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus RNA polymerase mitochondrial (Polrmt), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001106766 XM_001074109 XM_216836
VERSION     NM_001106766.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3745)
  AUTHORS   Celestini V, Tezil T, Russo L, Fasano C, Sanese P, Forte G,
            Peserico A, Lepore Signorile M, Longo G, De Rasmo D, Signorile A,
            Gadaleta RM, Scialpi N, Terao M, Garattini E, Cocco T, Villani G,
            Moschetta A, Grossi V and Simone C.
  TITLE     Uncoupling FoxO3A mitochondrial and nuclear functions in cancer
            cells undergoing metabolic stress and chemotherapy
  JOURNAL   Cell Death Dis 9 (2), 231 (2018)
   PUBMED   29445193
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3745)
  AUTHORS   Peserico A, Chiacchiera F, Grossi V, Matrone A, Latorre D,
            Simonatto M, Fusella A, Ryall JG, Finley LW, Haigis MC, Villani G,
            Puri PL, Sartorelli V and Simone C.
  TITLE     A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex
            sensing glucose levels
  JOURNAL   Cell Mol Life Sci 70 (11), 2015-2029 (2013)
   PUBMED   23283301
REFERENCE   3  (bases 1 to 3745)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3745)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 3745)
  AUTHORS   Minczuk M, He J, Duch AM, Ettema TJ, Chlebowski A, Dzionek K,
            Nijtmans LG, Huynen MA and Holt IJ.
  TITLE     TEFM (c17orf42) is necessary for transcription of human mtDNA
  JOURNAL   Nucleic Acids Res 39 (10), 4284-4299 (2011)
   PUBMED   21278163
REFERENCE   6  (bases 1 to 3745)
  AUTHORS   Bogenhagen DF, Rousseau D and Burke S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
REFERENCE   7  (bases 1 to 3745)
  AUTHORS   Wang Z, Cotney J and Shadel GS.
  TITLE     Human mitochondrial ribosomal protein MRPL12 interacts directly
            with mitochondrial RNA polymerase to modulate mitochondrial gene
            expression
  JOURNAL   J Biol Chem 282 (17), 12610-12618 (2007)
   PUBMED   17337445
REFERENCE   8  (bases 1 to 3745)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474029.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_216836.3, XM_001074109.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132264 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3745
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3745
                     /gene="Polrmt"
                     /note="RNA polymerase mitochondrial"
                     /db_xref="GeneID:299604"
                     /db_xref="RGD:1304599"
     exon            1..111
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..3635
                     /gene="Polrmt"
                     /EC_number="2.7.7.6"
                     /note="polymerase (RNA) mitochondrial (DNA directed)"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase, mitochondrial"
                     /protein_id="NP_001100236.1"
                     /db_xref="GeneID:299604"
                     /db_xref="RGD:1304599"
                     /translation="MSALRWTRGAAGLGRVLRSPGPHRPASEEGPLSGLGSSRRRSAA
                     SPREQAVQREWGHAELLEVLEARVRQLRAEGAPEMRVKKVQVDQPPQGRSSRWAQKLE
                     AEKKVKQRHQAKADLQKQPLESRTLHTEPRIRSKKLAGYLHQSKKGAPKSSEEEQLAR
                     VLQAVLAKLGSREAGTPARTKAKAVETHILFLQQKLRTFFECCVCTGQLPLAHHMLVT
                     HHNNQDKQQVLTLDMYNMVLLGWARKGSFRELVYVFIMLTDAGLSPDLHSYAAALQCM
                     GRRDQDAHTIQRCLKQMAEEGFQPQLLFTNLVLEEEDRAALLRAVVKGEPAFCPPPQA
                     SNLVSTPVLLKDFYSKEGPVSYPKLHLPLDTLQDLFYQQLHVELSSSVSVQSVEEAPV
                     MTKEVIEARKTLKALRSKWEVELLRVLRETKAKMGSQAYEGQPTLYPFLCLLSEGEFV
                     SILMQALQVLPAQGEPLFQLAQNLGLQVFNRHLVKQKQVTNHVQKLGQQYSQYLRLLA
                     SDTQVAPCLPREYWDSLGSLETPAQQPWSVPVLLQLGKQLAELLVQAVQMPRSLAARH
                     GAQNFIPVLYHVYSFRSYRQVGILKPHPAFTHLLETAAEPTLTFETTEVPMLCPPLPW
                     TSLHSGAYLLSSTKIMRATEGTTQHQRLLERCPPAQLHGALDALTQLGNCAWRVNGRL
                     LDLVLQIFRDKGCMRLGVPPPRSEAPRPAKHQLPPGSTPVHKSELRKELARCLKAARE
                     MHSLRSEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHLGSDLARALLEFAE
                     GRPLGPRGLDWLKIHLINLTGLRKRDSLRMRLAFADEVMGEILDSADNPLTGQKWWMK
                     ADEPWQTLACCMEVAQAVRSPDPTAYVSHLPVHQDGSCNGLQHYAALGRDSVGAASVN
                     LTPSDLPQDVYREVATQVEELRQQDAKEGLQVAQALEGFVSRKVVKQTVMTVVYGVTR
                     YGGRLQIEKRLRELSDFPQEFVWEASHYLVRQVFKSLQEMFSSTRAIQRWLTESANLI
                     SHAGWPVEWVTPLGIPIIQPYHRESKIQVKGGLQSITFTSSVDDSQKPNTLKQKNGFP
                     PNFIHSLDSSHMMLTALHCYRKGLTFVSVHDCFWTHAADIPMMNEVCREQFVRLHSEP
                     ILEDLAKFLEKRFCSVSKSLKPSELALITKLQETLRSLPETGTFDLGQVIRSTYFFS"
     exon            112..210
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            211..755
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            756..886
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1073
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1223
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1388
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1559
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1781
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..2570
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2693
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            2694..2816
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2996
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3083
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3197
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            3198..3250
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3349
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            3350..3422
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            3423..3514
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            3515..3585
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3745
                     /gene="Polrmt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcactgcg ggcagcaagc ggcatgtcgg cgctccggtg gacccgaggc gcagcggggc
       61 ttggtcgggt tctgcgctcc cctgggcccc accgcccggc ttcggaggaa gggcctctca
      121 gtggcctcgg cagctcaaga aggaggtctg ctgccagtcc ccgtgagcaa gctgtccaga
      181 gggagtgggg ccatgctgaa ctgctggaag tgctggaggc ccgggtgcgg cagctccggg
      241 cggagggcgc tcctgagatg agggtgaaga aggtacaggt ggaccagcct ccgcagggcc
      301 gcagcagccg ctgggcacag aagctggagg ccgagaaaaa ggtgaagcag aggcaccagg
      361 cgaaagctga cctgcagaag caaccactgg agtcccggac ccttcacacg gagccccgga
      421 tccggagcaa gaagctggct ggctacctgc accagagcaa gaagggggcg cccaagagct
      481 cagaggaaga gcagctggcc agggtcctgc aggccgtcct ggcgaagctc ggctcccgtg
      541 aggcagggac cccggccagg acgaaagcca aggcggtaga gacgcacatc ctgttcctcc
      601 agcagaagct tcggactttc ttcgagtgct gcgtgtgcac tggccagctg ccccttgccc
      661 accacatgct ggtcactcac cacaacaacc aagacaagca gcaagtgctc acgctggaca
      721 tgtataacat ggtgctgctc ggctgggccc gcaagggctc cttcagagag ctggtgtatg
      781 tgttcatcat gctgacggac gctggcctct ccccagacct gcactcctat gcagccgcac
      841 tccagtgcat gggacgcagg gaccaggacg cccacaccat ccagaggtgt ctgaagcaga
      901 tggcggaaga aggcttccag ccccagctgc tcttcaccaa cctggtcctg gaagaggagg
      961 accgggccgc gctcctgaga gcagtggtca agggtgagcc tgccttctgc ccaccgccac
     1021 aggcctcgaa cctggtcagc acacccgtgc tgctcaagga cttctatagc aaggagggcc
     1081 cagtgtccta cccaaagctg cacctgcccc tggacaccct gcaggacctt ttctaccagc
     1141 agctgcatgt ggagctgagc tccagtgtct ctgtccagtc agtggaggag gccccagtaa
     1201 tgaccaagga ggtcattgag gcgcggaaga ccctgaaggc actgcgctcg aagtgggagg
     1261 tagagctgct gcgtgtgctg cgggagacca aggccaagat gggcagccag gcctacgaag
     1321 gccagcccac cctctacccg ttcctgtgcc tgctcagcga aggggagttt gtgagcattc
     1381 tgatgcaggc tctgcaggta ctgcctgcac agggtgagcc ccttttccag ttggctcaaa
     1441 acctgggcct tcaggtgttt aatcggcatt tggtgaagca gaagcaggtc accaaccatg
     1501 tgcagaagct ggggcagcaa tactcacagt acctccggct gctggcttcc gacacccagg
     1561 tggcaccctg ccttcctcgg gagtactggg actcgctggg ctcgctggag acccctgcac
     1621 aacagccctg gtcggtgcca gtgctgctac agctcggcaa gcagctggcc gagttgctgg
     1681 tgcaggcagt gcagatgccg cgcagtctgg cggcccggca cggtgctcag aacttcatcc
     1741 cagtgcttta ccatgtctat tccttccgca gctaccgcca ggtgggcatc ctcaagcctc
     1801 accctgcctt cacgcacctg ctggagacgg ccgcagagcc cacgctgacc ttcgagacca
     1861 cggaagtgcc aatgctgtgc ccgccactgc cctggacttc gctgcactct ggtgcctacc
     1921 tgctgagttc caccaaaata atgcgtgcca cggagggtac cacgcaacac cagcgtctac
     1981 tggagcgctg ccctcccgcc cagctgcacg gtgccctgga tgcgctcacg cagctgggga
     2041 actgtgcctg gcgtgtcaat gggcgcctgc tggacttggt gctgcagatc tttagggaca
     2101 agggctgtat gcgcttgggc gtgcctcccc cgcgttccga agcaccacgg ccagccaagc
     2161 atcagctacc acccggctcc acaccagtgc acaagtctga actgcggaag gagctggcgc
     2221 gctgcctcaa ggcggctcga gagatgcaca gtctgcgcag cgaggctctg tatcgcctgt
     2281 cgttggcaca gcacctgcgc gaccgcgtct tctggttgcc acacaacatg gacttccgag
     2341 gccgcactta cccgtgcccg ccgcacttca accacctcgg cagtgaccta gcgcgtgcac
     2401 tgttggagtt cgctgagggc cggccactgg ggccacgtgg tctggactgg ctcaagatac
     2461 acctgatcaa cctgaccggc ctcaggaagc gcgactcgct gcgcatgcgc ctagccttcg
     2521 cagacgaggt catgggggag atcttggact ctgcagacaa ccctttgacg ggccagaagt
     2581 ggtggatgaa agctgacgaa ccctggcaga cgctggcttg ctgcatggag gtggcacaag
     2641 cggtccggtc cccagacccc actgcctacg tttcccacct gccggttcac caggatggtt
     2701 cctgcaatgg cttacagcat tacgccgcac tgggccgaga tagtgtgggt gccgcctcag
     2761 tcaacctaac gccttccgac ctgccccaag atgtgtacag ggaggtggca acacaggtgg
     2821 aggagctccg ccagcaggac gctaaggagg gtctccaggt ggctcaggcg ctggagggct
     2881 tcgtcagccg caaggtggtg aagcagacgg tgatgacggt ggtgtacggg gtcacgcgct
     2941 acggtgggcg cctgcagata gagaagcgcc tgcgtgaact cagcgacttc ccccaggagt
     3001 ttgtctggga agcctcacac tacctcgtgc gccaggtctt caaaagtcta caggagatgt
     3061 tttccagcac ccgggccatt cagcgctggc tgaccgagag tgccaacctc atctctcacg
     3121 cgggctggcc tgtggagtgg gtcacgcccc tgggcatccc catcatacag ccctatcacc
     3181 gggagtccaa gatccaggtg aaagggggcc ttcagagcat caccttcacc agctcagtgg
     3241 atgacagcca gaagcccaac actctgaagc agaaaaatgg cttcccaccc aacttcatcc
     3301 actccctgga ttcctcccac atgatgctga ctgccctaca ctgctacagg aagggcctga
     3361 ctttcgtctc tgtgcacgac tgcttctgga cgcatgccgc tgacatcccc atgatgaacg
     3421 aggtatgccg cgaacagttt gtgcgcctgc acagcgaacc cattctggaa gacctggcta
     3481 agttcctgga gaagcgtttc tgctcggtct ccaagtccct aaagccctcg gagctcgccc
     3541 tgatcaccaa gctgcaggag acactacgat ccttgccaga gacaggtacc ttcgatctgg
     3601 gacaggtgat aagatccacc tacttcttca gctgacccac gccgtgctat tcctaaacct
     3661 gtgcataatg taaataaatg aaagtctatg tctacctatg ccagccgcca ctttctggct
     3721 acacacaaac ccaccaaagc aatga
//
