LOCUS       NM_001134789             808 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus RNA polymerase II, I and III subunit H (Polr2h),
            mRNA.
ACCESSION   NM_001134789 XM_001059014 XM_573313
VERSION     NM_001134789.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 808)
  AUTHORS   Kang X, Hu Y, Li Y, Guo X, Jiang X, Lai L, Xia B and Jin C.
  TITLE     Structural, biochemical, and dynamic characterizations of the hRPB8
            subunit of human RNA polymerases
  JOURNAL   J Biol Chem 281 (26), 18216-18226 (2006)
   PUBMED   16632472
REFERENCE   2  (bases 1 to 808)
  AUTHORS   Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M,
            Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail
            S, Li P and Sutton G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   3  (bases 1 to 808)
  AUTHORS   Shultz MA, Zhang L, Gu YZ, Baker GL, Fannuchi MV, Padua AM, Gurske
            WA, Morin D, Penn SG, Jovanovich SB, Plopper CG and Buckpitt AR.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
REFERENCE   4  (bases 1 to 808)
  AUTHORS   Chu S, Blaisdell CJ, Liu MZ and Zeitlin PL.
  TITLE     Perinatal regulation of the ClC-2 chloride channel in lung is
            mediated by Sp1 and Sp3
  JOURNAL   Am J Physiol 276 (4), L614-L624 (1999)
   PUBMED   10198359
REFERENCE   5  (bases 1 to 808)
  AUTHORS   Kershnar E, Wu SY and Chiang CM.
  TITLE     Immunoaffinity purification and functional characterization of
            human transcription factor IIH and RNA polymerase II from clonal
            cell lines that conditionally express epitope-tagged subunits of
            the multiprotein complexes
  JOURNAL   J Biol Chem 273 (51), 34444-34453 (1998)
   PUBMED   9852112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB758009.1, CB699618.1, CF113682.1 and BQ210721.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_573313.2, XM_001059014.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ222889.1, FM115447.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476, SAMN06680439
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                CB758009.1         12-62
            52-53               CB699618.1         47-48
            54-458              CF113682.1         27-431
            459-808             BQ210721.1         1-350               c
FEATURES             Location/Qualifiers
     source          1..808
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..808
                     /gene="Polr2h"
                     /gene_synonym="RGD1561203; RPB17"
                     /note="RNA polymerase II, I and III subunit H"
                     /db_xref="GeneID:498109"
                     /db_xref="RGD:1561203"
     exon            1..164
                     /gene="Polr2h"
                     /gene_synonym="RGD1561203; RPB17"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..544
                     /gene="Polr2h"
                     /gene_synonym="RGD1561203; RPB17"
                     /EC_number="2.7.7.6"
                     /note="polymerase (RNA) II (DNA directed) polypeptide H;
                     polymerase (RNA) II subunit H; RNA polymerase II subunit
                     H; DNA-directed RNA polymerases I, II, and III subunit
                     RPABC3-like"
                     /codon_start=1
                     /product="DNA-directed RNA polymerases I, II, and III
                     subunit RPABC3"
                     /protein_id="NP_001128261.1"
                     /db_xref="GeneID:498109"
                     /db_xref="RGD:1561203"
                     /translation="MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVN
                     IQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGD
                     ETSTEAATRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMKKLAF"
     exon            165..248
                     /gene="Polr2h"
                     /gene_synonym="RGD1561203; RPB17"
                     /inference="alignment:Splign:2.1.0"
     exon            249..342
                     /gene="Polr2h"
                     /gene_synonym="RGD1561203; RPB17"
                     /inference="alignment:Splign:2.1.0"
     exon            343..426
                     /gene="Polr2h"
                     /gene_synonym="RGD1561203; RPB17"
                     /inference="alignment:Splign:2.1.0"
     exon            427..790
                     /gene="Polr2h"
                     /gene_synonym="RGD1561203; RPB17"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctgtctt cttttctcca cgtgaggggg tgcgcgaatc cccagtggtg gccgcgcgct
       61 cagcacctct gcagctctcg tgcccttcac gatggcgggc atcctgttcg aggatatttt
      121 cgatgtgaaa gacattgacc cagaaggcaa gaaatttgac cgagtatccc gtctgcattg
      181 tgagagtgaa tctttcaaga tggacctcat cttagatgta aacattcaga tttaccctgt
      241 agacttaggt gacaagttcc ggttggttat agctagtact ttgtatgaag atggtacctt
      301 ggatgatggt gaatacaacc ccacagacga caggccttcc agggctgacc agtttgagta
      361 tgtaatgtat gggaaagtgt acaggatcga aggggacgag acctcaacgg aagcagccac
      421 acgtctctct gcgtatgtgt cctatggcgg cctcctcatg aggcttcagg gggacgccaa
      481 caacctgcat ggatttgagg tggactcccg agtctacctg ctgatgaaga agctggcgtt
      541 ctgaacttcc gggaaaccag ccttgccgct tagtcactcg agccacggac attggtcaag
      601 cctgtgcacg agctgtttgc ctgtagaagt gatggtgctc tgtgtcctct gtggtacatc
      661 ttcagcttct ccgaattcag tggaaaaccg accagtctgt aaaaggccaa gtgggagagc
      721 ctagcacgaa cctgaagttg tattattatt attttttttt aattaaagtt tactttttca
      781 gactcttctc aaaaaaaaaa aaaaaaaa
//
