LOCUS       NM_001109614            1082 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus RNA polymerase II, I and III subunit E (Polr2e),
            mRNA.
ACCESSION   NM_001109614 XM_001076333
VERSION     NM_001109614.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1082)
  AUTHORS   Knutson,B.A. and Hahn,S.
  TITLE     TFIIB-related factors in RNA polymerase I transcription
  JOURNAL   Biochim Biophys Acta 1829 (3-4), 265-273 (2013)
   PUBMED   22960599
  REMARK    Review article
REFERENCE   2  (bases 1 to 1082)
  AUTHORS   Vannini,A. and Cramer,P.
  TITLE     Conservation between the RNA polymerase I, II, and III
            transcription initiation machineries
  JOURNAL   Mol Cell 45 (4), 439-446 (2012)
   PUBMED   22365827
  REMARK    Review article
REFERENCE   3  (bases 1 to 1082)
  AUTHORS   Schneider,D.A.
  TITLE     RNA polymerase I activity is regulated at multiple steps in the
            transcription cycle: recent insights into factors that influence
            transcription elongation
  JOURNAL   Gene 493 (2), 176-184 (2012)
   PUBMED   21893173
  REMARK    Review article
REFERENCE   4  (bases 1 to 1082)
  AUTHORS   Dumay-Odelot,H., Durrieu-Gaillard,S., Da Silva,D., Roeder,R.G. and
            Teichmann,M.
  TITLE     Cell growth- and differentiation-dependent regulation of RNA
            polymerase III transcription
  JOURNAL   Cell Cycle 9 (18), 3687-3699 (2010)
   PUBMED   20890107
  REMARK    Review article
REFERENCE   5  (bases 1 to 1082)
  AUTHORS   Hu,P., Wu,S., Sun,Y., Yuan,C.C., Kobayashi,R., Myers,M.P. and
            Hernandez,N.
  TITLE     Characterization of human RNA polymerase III identifies orthologues
            for Saccharomyces cerevisiae RNA polymerase III subunits
  JOURNAL   Mol Cell Biol 22 (22), 8044-8055 (2002)
   PUBMED   12391170
REFERENCE   6  (bases 1 to 1082)
  AUTHORS   Kershnar,E., Wu,S.Y. and Chiang,C.M.
  TITLE     Immunoaffinity purification and functional characterization of
            human transcription factor IIH and RNA polymerase II from clonal
            cell lines that conditionally express epitope-tagged subunits of
            the multiprotein complexes
  JOURNAL   J Biol Chem 273 (51), 34444-34453 (1998)
   PUBMED   9852112
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474029.1.
            
            On Oct 4, 2007 this sequence version replaced XM_001076333.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ234550.1, FQ222796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1082
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..1082
                     /gene="Polr2e"
                     /note="RNA polymerase II, I and III subunit E"
                     /db_xref="GeneID:690966"
                     /db_xref="RGD:1589817"
     exon            1..133
                     /gene="Polr2e"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..709
                     /gene="Polr2e"
                     /EC_number="2.7.7.6"
                     /note="DNA-directed RNA polymerase II subunit E;
                     polymerase (RNA) II subunit E; RNA polymerases I, II, and
                     III subunit ABC1; RPB5 homolog; polymerase (RNA) II (DNA
                     directed) polypeptide E, 25kDa"
                     /codon_start=1
                     /product="DNA-directed RNA polymerases I, II, and III
                     subunit RPABC1"
                     /protein_id="NP_001103084.1"
                     /db_xref="GeneID:690966"
                     /db_xref="RGD:1589817"
                     /translation="MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQF
                     GDKPSEGRPRRTDLTVLVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRA
                     LIVVQQGMTPSAKQSLVDMAPKYVLEQFLQQELLINITEHELVPEHVVMTKEEVTELL
                     ARYKLRESQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ"
     exon            134..308
                     /gene="Polr2e"
                     /inference="alignment:Splign:2.1.0"
     exon            309..505
                     /gene="Polr2e"
                     /inference="alignment:Splign:2.1.0"
     exon            506..564
                     /gene="Polr2e"
                     /inference="alignment:Splign:2.1.0"
     exon            565..643
                     /gene="Polr2e"
                     /inference="alignment:Splign:2.1.0"
     exon            644..715
                     /gene="Polr2e"
                     /inference="alignment:Splign:2.1.0"
     exon            716..1082
                     /gene="Polr2e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttatgctgtc ccgcgcaggc tcagtcctgg taggtctacg agcgcgcgtg cagagttgtt
       61 tgtgaagtgc gacaacatgg acgacgagga ggaaacgtat cggctgtgga agatccgcaa
      121 gactatcatg cagctgtgtc atgaccgagg ctacctggtg acccaggatg agctggacca
      181 gacacttgaa gagttcaagg cacagtttgg ggacaagccc agcgaaggac ggccgaggcg
      241 cacagacctc accgtgctgg tggcccacaa cgatgatccc acagaccaga tgtttgtctt
      301 cttcccagag gagcccaagg tgggcatcaa gaccatcaag gtgtactgcc agcgcatgca
      361 ggaggagaac atcacacggg cgctgatcgt ggtgcagcag ggcatgacac cctccgccaa
      421 gcagtccctg gtagacatgg cccctaagta cgtgctagaa cagtttctac agcaggagct
      481 gctcatcaat atcacagaac atgagctagt ccctgagcac gtggtcatga ccaaggagga
      541 ggtgacggaa ctgctggcgc gatacaagct ccgtgagagc cagctgccca ggatccaggc
      601 tggggacccg gtggcacggt acttcgggat caagcgaggg caggttgtga agattatccg
      661 ccccagtgag acagccggcc ggtacatcac ctaccgcctg gtgcagtagc tgcaggggaa
      721 atctagtact ctggagactg aagcaggagg attgctgcaa ttgaaggcaa gtttgtggac
      781 tcttcggtgt tgggagagtc tcttctggaa aactgtggaa aagagtccgc gcggcacagt
      841 gcgcagggag accccaggaa ccttctgctc tgcccttcac agctcaccag caacctcaca
      901 gaggaccagg ccagagccgc tgctcccatg agccccagcg tgtgggtcat ggctttcatc
      961 ctgcaggatg agcaacttca gagcttcagc cccaccccca ctcctcgccc tgaggtcact
     1021 gctctgttaa gagttctcca tgactccccg gagaattaaa agctactttg ggataagtta
     1081 ct
//
