LOCUS       NM_001107938            1588 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus RNA polymerase I subunit E (Polr1e), mRNA.
ACCESSION   NM_001107938 XM_001065234 XM_233004
VERSION     NM_001107938.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1588)
  AUTHORS   Chen S, Seiler J, Santiago-Reichelt M, Felbel K, Grummt I and Voit
            R.
  TITLE     Repression of RNA polymerase I upon stress is caused by inhibition
            of RNA-dependent deacetylation of PAF53 by SIRT7
  JOURNAL   Mol Cell 52 (3), 303-313 (2013)
   PUBMED   24207024
REFERENCE   2  (bases 1 to 1588)
  AUTHORS   Vannini A and Cramer P.
  TITLE     Conservation between the RNA polymerase I, II, and III
            transcription initiation machineries
  JOURNAL   Mol Cell 45 (4), 439-446 (2012)
   PUBMED   22365827
  REMARK    Review article
REFERENCE   3  (bases 1 to 1588)
  AUTHORS   Schneider DA.
  TITLE     RNA polymerase I activity is regulated at multiple steps in the
            transcription cycle: recent insights into factors that influence
            transcription elongation
  JOURNAL   Gene 493 (2), 176-184 (2012)
   PUBMED   21893173
  REMARK    Review article
REFERENCE   4  (bases 1 to 1588)
  AUTHORS   Seither P, Iben S, Thiry M and Grummt I.
  TITLE     PAF67, a novel protein that is associated with the
            initiation-competent form of RNA polymerase I
  JOURNAL   Biol Chem 382 (8), 1163-1170 (2001)
   PUBMED   11592397
REFERENCE   5  (bases 1 to 1588)
  AUTHORS   Hanada K, Song CZ, Yamamoto K, Yano K, Maeda Y, Yamaguchi K and
            Muramatsu M.
  TITLE     RNA polymerase I associated factor 53 binds to the nucleolar
            transcription factor UBF and functions in specific rDNA
            transcription
  JOURNAL   EMBO J 15 (9), 2217-2226 (1996)
   PUBMED   8641287
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473962.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_233004.4, XM_001065234.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC158699.1, SRR8487230.22793.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132274, SAMD00132297
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1588
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..1588
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /note="RNA polymerase I subunit E"
                     /db_xref="GeneID:313245"
                     /db_xref="RGD:1565773"
     exon            1..147
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1331
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /note="polymerase (RNA) I associated factor 1; polymerase
                     (RNA) I polypeptide E; polymerase (RNA) I subunit E"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase I subunit RPA49"
                     /protein_id="NP_001101408.1"
                     /db_xref="GeneID:313245"
                     /db_xref="RGD:1565773"
                     /translation="MATPDSPGMDGQTGDTETEVLQSARWQYCGEPDDRQKAVLVQFS
                     NGKLQNPGNMRFTLYNSTDLVNPRQKCHRILAAETDRLSYVGNNFGTGALKCNTLCRH
                     FVGILNKTSGQMEVYDAEVFNMQPLFAEDSIEHGPPLENQNKTFRDKLDSCIEAFGST
                     KQKRSLNSRRMNKVGSESLNFTVAKAAESIIDTKGVSALVSDAMQDDLQNDSLYLPPC
                     HADATKPEDVYRFEDILSPAEYDALESPSEAFRKVMSEDILKMVEENSHCSFIIEMLK
                     SLPADEVQRNRQARSIWFLDALLRFRAQKVIKGKSALGPGIPHIINTKLLKQFTCLTY
                     NNGSLRNLISSSMKAKITAYAIILALHINNFQIDLTVLQRDLKLSEKRMIEIARAMRL
                     KISKRKVSLADGREEDHRLGTLSVPLPPAQTSDRQSKRKKMS"
     exon            148..251
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /inference="alignment:Splign:2.1.0"
     exon            252..328
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /inference="alignment:Splign:2.1.0"
     exon            329..414
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /inference="alignment:Splign:2.1.0"
     exon            415..473
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /inference="alignment:Splign:2.1.0"
     exon            474..618
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /inference="alignment:Splign:2.1.0"
     exon            619..726
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /inference="alignment:Splign:2.1.0"
     exon            727..823
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /inference="alignment:Splign:2.1.0"
     exon            824..957
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1039
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1171
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1588
                     /gene="Polr1e"
                     /gene_synonym="Praf1; RGD1565773"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtccgcgt gtgaaccagc gagctcatgg ctacgccgga ttctcccggg atggatggcc
       61 agactggaga cacggagaca gaggtgctac agagtgcaag atggcagtac tgtggagagc
      121 ccgacgacag gcagaaagct gtgctggtcc aattctccaa tgggaagctg cagaatccag
      181 gcaacatgcg cttcaccttg tacaacagca ccgacttggt aaaccccagg cagaagtgcc
      241 atcggatcct ggccgctgag acagacaggc tctcctatgt tggaaacaat tttgggactg
      301 gcgccctcaa atgcaacact ctttgcagac actttgtggg cattctgaat aagacctctg
      361 gccaaatgga agtctatgat gcggaagtat tcaacatgca gcccctgttt gctgaagact
      421 ctattgagca tgggcctcct ctggagaatc agaacaagac cttcagggac aagttggatt
      481 cttgcattga agcctttgga agcaccaagc agaagcggtc cctgaactcc cggagaatga
      541 acaaagttgg cagcgagtct ttgaatttca cagtagctaa agccgcagag agtatcattg
      601 acacgaaggg cgtgagtgct ttggtcagcg atgccatgca agatgacttg caaaatgact
      661 ccctctacct tcctccctgc catgctgatg ccaccaagcc cgaagacgtg tatagatttg
      721 aagacatcct gtccccggcc gagtatgatg ctcttgaaag cccatccgaa gccttcagaa
      781 aggtcatgtc tgaagacata ctgaagatgg tggaagagaa cagccactgc tccttcatca
      841 tagaaatgct gaagtctttg ccagcagacg aggtgcagcg aaaccggcaa gcccggagca
      901 tttggttcct agatgccctc ctcagattcc gagctcagaa agtgataaaa gggaaaagtg
      961 ccttaggacc tgggatcccg cacatcatca acaccaagct gctgaagcag ttcacctgct
     1021 tgacctacaa caacggcagt ttacggaact taatctcgag ttctatgaag gccaagatca
     1081 ctgcatatgc aatcatcctt gctctgcaca taaataactt ccagattgat ctgacggtgt
     1141 tacagaggga cttgaagctg agtgagaaaa ggatgattga gatagcgaga gccatgaggc
     1201 tgaagatctc caaaagaaag gtgtccctgg cagatggcag ggaagaggat catagactgg
     1261 gcactctgtc cgtcccactg cctccggccc agacctcaga ccgacagtcg aagcggaaaa
     1321 aaatgagcta gacgttttcc acagctactt ctcttcactt cattcttact tttttatttt
     1381 ttgaaaaaga aagtagactg gaccttgtgg tacataccta gaagccaaga actcaggaga
     1441 ctgaggcagg aggattatga attctgggcc tgtctgggat gctgccacgc tccaccacac
     1501 ctgcaaggcc ttactttagc atggttacca tgccgaaagc cagcattcca gttatcagaa
     1561 attaaaacga tggccctggt ttgacttc
//
