LOCUS       NM_031772               6016 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus RNA polymerase I subunit A (Polr1a), mRNA.
ACCESSION   NM_031772
VERSION     NM_031772.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6016)
  AUTHORS   Sun,X., Chen,H., Deng,Z., Hu,B., Luo,H., Zeng,X., Han,L., Cai,G.
            and Ma,L.
  TITLE     The Warsaw breakage syndrome-related protein DDX11 is required for
            ribosomal RNA synthesis and embryonic development
  JOURNAL   Hum Mol Genet 24 (17), 4901-4915 (2015)
   PUBMED   26089203
REFERENCE   2  (bases 1 to 6016)
  AUTHORS   Bai,B., Moore,H.M. and Laiho,M.
  TITLE     CRM1 and its ribosome export adaptor NMD3 localize to the nucleolus
            and affect rRNA synthesis
  JOURNAL   Nucleus 4 (4), 315-325 (2013)
   PUBMED   23782956
REFERENCE   3  (bases 1 to 6016)
  AUTHORS   Vannini,A. and Cramer,P.
  TITLE     Conservation between the RNA polymerase I, II, and III
            transcription initiation machineries
  JOURNAL   Mol Cell 45 (4), 439-446 (2012)
   PUBMED   22365827
  REMARK    Review article
REFERENCE   4  (bases 1 to 6016)
  AUTHORS   Schneider,D.A.
  TITLE     RNA polymerase I activity is regulated at multiple steps in the
            transcription cycle: recent insights into factors that influence
            transcription elongation
  JOURNAL   Gene 493 (2), 176-184 (2012)
   PUBMED   21893173
  REMARK    Review article
REFERENCE   5  (bases 1 to 6016)
  AUTHORS   Yamamoto,K., Yamamoto,M., Hanada,K., Nogi,Y., Matsuyama,T. and
            Muramatsu,M.
  TITLE     Multiple protein-protein interactions by RNA polymerase
            I-associated factor PAF49 and role of PAF49 in rRNA transcription
  JOURNAL   Mol Cell Biol 24 (14), 6338-6349 (2004)
   PUBMED   15226435
REFERENCE   6  (bases 1 to 6016)
  AUTHORS   Dundr,M., Hoffmann-Rohrer,U., Hu,Q., Grummt,I., Rothblum,L.I.,
            Phair,R.D. and Misteli,T.
  TITLE     A kinetic framework for a mammalian RNA polymerase in vivo
  JOURNAL   Science 298 (5598), 1623-1626 (2002)
   PUBMED   12446911
REFERENCE   7  (bases 1 to 6016)
  AUTHORS   Hannan,R.D., Hempel,W.M., Cavanaugh,A., Arino,T., Dimitrov,S.I.,
            Moss,T. and Rothblum,L.
  TITLE     Affinity purification of mammalian RNA polymerase I. Identification
            of an associated kinase
  JOURNAL   J Biol Chem 273 (2), 1257-1267 (1998)
   PUBMED   9422795
REFERENCE   8  (bases 1 to 6016)
  AUTHORS   Seither,P., Coy,J.F., Pouska,A. and Grummt,I.
  TITLE     Molecular cloning and characterization of the cDNA encoding the
            largest subunit of mouse RNA polymerase I
  JOURNAL   Mol Gen Genet 255 (2), 180-186 (1997)
   PUBMED   9236775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF025425.1 and JAXUCZ010000004.1.
            
            On Dec 2, 2020 this sequence version replaced NM_031772.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF025425.1, SRR26643298.23479.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2617              AF025425.1         8-2624
            2618-2624           JAXUCZ010000004.1  105549691-105549697
            2625-4495           AF025425.1         2632-4502
            4496-5087           JAXUCZ010000004.1  105571681-105572272
            5088-5322           AF025425.1         4504-4738
            5323-5914           JAXUCZ010000004.1  105571681-105572272
            5915-6606           AF025425.1         4740-5431
            6607-7198           JAXUCZ010000004.1  105571681-105572272
FEATURES             Location/Qualifiers
     source          1..6016
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q32"
     gene            1..6016
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /note="RNA polymerase I subunit A"
                     /db_xref="GeneID:83581"
                     /db_xref="RGD:620824"
     exon            1..126
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..5200
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /EC_number="2.7.7.6"
                     /note="DNA-directed RNA polymerase I A; polymerase (RNA) I
                     subunit A; A194; RPA194; RNA polymerase I subunit A1; RNA
                     polymerase I 194 kDa subunit; DNA-directed RNA polymerase
                     I subunit A; polymerase (RNA) I polypeptide A;
                     DNA-directed RNA polymerase I largest subunit; RNA
                     polymerase 1-4"
                     /codon_start=1
                     /product="DNA-directed RNA polymerase I subunit RPA1"
                     /protein_id="NP_113960.2"
                     /db_xref="GeneID:83581"
                     /db_xref="RGD:620824"
                     /translation="MLASKHTPWRRLQGISFGMYSAEELKKLSVKSITNPRYVDSLGN
                     PSADGLYDLALGPADSKEVCSTCVQDFNNCSGHLGHIDLPLTVYNPLLFDKLYLLLRG
                     SCLNCHMLTCPRAAIHLLVCQLKVLDVGALQAVYELERILSRFLEETSDPSAFEIQEE
                     LEEYTSKILQNNLLGSQGAHVKNVCESRSKLVAHFWKTHMAAKRCPHCKTGRSVVRKE
                     HNSKLTITYPAMVHKKSGQKDAELPEGAPAAPGIDEAQMGKRGYLTPSSAQEHLFAIW
                     KNEGFFLNYLFSGLDDIGPESSFNPSMFFLDFIVVPPSRYRPINRLGDQMFTNGQTVN
                     LQAVMKDAVLIRKLLAVMAQEQKLPCEMTEITIDKENDSSGAIDRSFLSLLPGQSLTD
                     KLYNIWIRLQSHVNIVFDSDMDKLMLEKYPGIRQILEKKEGLFRKHMMGKRVDYAARS
                     VICPDMYINTNEIGIPMVFATKLTYPQPVTPWNVQELRQAVINGPNVHPGASMVINED
                     GSRTALSAVDATQREAVAKQLLTPSTGIPKPQGAKVVCRHVKNGDILLLNRQPTLHRP
                     SIQAHRAHILPEEKVLRLHYANCKAYNADFDGDEMNAHFPQSELGRAEAYVLACTDQQ
                     YLVPKDGQPLAGLIQDHMVSGANMTIRGCFFTREQYMELVYRGLTDKVGRVKLFPPAI
                     LKPFPLWTGKQVVSTLLINIIPEDYTPLNLTGKAKIGSKAWVKEKPRPVPDFDPDSMC
                     ESQVIIREGELLCGVLDKAHYGSSAYGLVHCCYEIYGGETSGRVLTCLARLFTAYLQL
                     YRGFTLGVEDILVKPNADVMRQRIIEESTQCGPRAVRAALNLPEAASCDEIQGKWQDA
                     HLGKDQRDFNMIDMKFKEEVNHYSNEINKACMPFGLHRQFPENNLQMMVQSGAKGSTV
                     NTMQISCLLGQIELEGRRPPLMASGKSLPCFEPYEFTPRAGGFVTGRFLTGIRPPEFF
                     FHCMAGREGLVDTAVKTSRSGYLQRCIIKHLEGLVIQYDLTVRDSDGSVVQFLYGEDG
                     LDIPKTQFLQPKQFPFLASNYEVIMKSKHLHEVLSRADPQKVLRHFRAIKKWHHRHSS
                     ALLRKGAFLSFSQKIQAAVKALNLEGKTQNGRSPETQQMLQMWHELDEQSRRKYQKRA
                     APCPDPSLSVWRPDIHFASVSETFEKKIDDYSQEWAAQAEKSHNRSELSLDRLRTLLQ
                     LKWQRSLCDPGEAVGLLAAQSIGEPSTQMTLNTFHFAGRGEMNVTLGIPRLREILMVA
                     SANIKTPMMSVPVFNTKKALRRVKSLKKQLTRVCLGEVLQKVDIQESFCMGEKQNKFR
                     VYELRFQFLPHAYYQQEKCLRPEDILHFMETRFFKLLMEAIKKKNSKASAFRSVNTRR
                     ATQKDLDDTEDSGRNRREEERDEEEEGNIVDAEAEEGDADASDTKRKEKQEEEVDYES
                     EEEGEEEEEEDVQEEENIKGEGAHQTHEPDEEEGSGLEEESSQNPPRRHSRPQGAEAM
                     ERRIQAVRESHSFIEDYQYDTEESLWCQVTVKLPLMKINFDMSSLVVSLAHNAIVYTT
                     KGITRCLLNETINSKNEKEFVLNTEGINLPELFKYSEVLDLRRLYSNDIHAVANTYGI
                     EAALRVIEKEIKDVFAVYGIAVDPRHLSLVADYMCFEGVYKPLNRFGIQSSSSPLQQM
                     TFETSFQFLKQATMMGSHDELKSPSACLVVGKVVKGGTGLFELKQPLR"
     exon            127..331
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            332..481
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            482..589
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            590..675
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            676..779
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            780..887
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            888..993
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1156
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1327
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1450
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1681
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1936
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2128
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2278
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2462
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2545
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2704
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2803
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2804..2956
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3039
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3205
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3206..3427
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3428..3642
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3643..3810
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3811..3946
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            3947..4104
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4105..4231
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4342
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4343..4615
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4616..4816
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4817..4934
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            4935..5099
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
     exon            5100..6016
                     /gene="Polr1a"
                     /gene_synonym="Rpa1; Rpo1-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgactggaa cttctctcgt agggacgaac ctcaaaactg actcggaaga tgctggcctc
       61 caagcacacg ccatggcggc ggcttcaggg catttccttc gggatgtatt cggccgagga
      121 gctcaagaag ttaagtgtta agtccattac aaatcctcgc tatgtggaca gcctgggaaa
      181 cccttcggca gatggcctgt atgatttggc tttgggtcct gcagattcca aagaagtatg
      241 ctctacctgt gtgcaggact tcaacaactg ctccggacac ctgggccaca ttgacctccc
      301 gctcacagtg tacaaccctc tcctcttcga taaactctac ctgctgctgc gaggctcctg
      361 tttaaattgt catatgctga cttgtcctcg ggctgcaatt cacctattgg tctgccagct
      421 gaaggtccta gacgttggag ccctacaagc agtctatgag cttgagcgga ttctcagcag
      481 gtttctggaa gaaacttcgg atccttctgc cttcgaaatt caagaagagt tagaagagta
      541 cacaagcaaa attctgcaga ataacctcct ggggtcccag ggtgcacatg tgaaaaatgt
      601 gtgcgagagc agaagcaaac ttgtcgctca cttctggaag acacacatgg ctgctaagcg
      661 ctgtccacac tgcaagacgg gacggtcagt ggttcgaaag gagcacaata gtaagctaac
      721 aataacatat ccagccatgg tgcacaagaa gtctggccag aaggatgcag aactcccaga
      781 aggagcacca gcagctccag gaattgatga ggctcagatg gggaaacgag gatacttgac
      841 cccaagcagc gcccaagaac atcttttcgc catttggaag aatgaaggat tcttcctgaa
      901 ttatcttttt tcgggattgg atgatattgg cccagagtcc agtttcaacc ccagtatgtt
      961 ctttctagat ttcatcgtgg taccgccatc caggtatcgt cccatcaatc gcctgggtga
     1021 ccagatgttc actaatggcc agacagtgaa tttgcaagcg gtcatgaagg atgcagtttt
     1081 gatccggaaa cttctggcag tgatggccca agaacagaaa ctgccctgtg agatgacaga
     1141 aatcaccata gacaaggaaa atgactcctc gggtgctatc gaccggtcct ttctgagttt
     1201 gcttccagga cagtctctca cagataaact ttacaatatt tggattcgcc tccagagcca
     1261 cgtcaatatt gtgtttgaca gtgacatgga caaactgatg ctggaaaagt accctggcat
     1321 aagacagatc ctcgagaaga aggaaggcct gttccggaag cacatgatgg gaaagcgagt
     1381 ggactacgca gcccgctcgg tcatctgccc agatatgtac atcaacacca atgagatcgg
     1441 gattcccatg gtatttgcca caaaactgac ttacccccag ccagttaccc cctggaacgt
     1501 gcaggaactg agacaggcag tcatcaatgg acccaatgtg cacccaggag cctccatggt
     1561 catcaacgag gatggcagtc gcacagccct gagcgcagtg gatgctacac agcgggaagc
     1621 tgtggccaaa cagctcctga caccgtccac agggatccct aagcctcagg gagcaaaagt
     1681 tgtgtgccgg catgtgaaga atggggacat tctcctcctg aaccgacagc ccaccttgca
     1741 cagaccctcc atccaggccc accgtgccca cattctgcct gaggaaaaag tcctgcgcct
     1801 tcactatgcc aactgcaagg cctacaatgc tgacttcgat ggagacgaga tgaatgccca
     1861 cttcccccag agtgagctgg gccgagctga agcctatgtc ctggcctgca ctgaccagca
     1921 gtatcttgtt cccaaggatg gccagccctt ggcaggactg attcaggatc acatggtgtc
     1981 gggtgcaaac atgaccattc ggggatgctt tttcacccgg gaacagtaca tggagctggt
     2041 gtaccgaggg ctcacagaca aagtgggacg cgtgaagctc tttcctcctg ccatcctgaa
     2101 gcccttcccg ctgtggacag gaaagcaggt cgtgtcgacc ctcctcataa acataatccc
     2161 agaggactac acccccctga atttaactgg aaaggcaaaa atcggcagta aagcctgggt
     2221 gaaggaaaag cctcggcctg ttcctgactt tgaccctgac tccatgtgtg agtcccaggt
     2281 gatcatcagg gaaggggagc tgctctgcgg ggtgctggac aaggcacact atgggagctc
     2341 tgcctacggc ctggtccact gctgctacga gatctatggg ggtgagacca gcggcagggt
     2401 tctcacctgc ttagcccgcc tcttcactgc ctacctacag ctctatcgag gtttcacctt
     2461 gggtgtggaa gacattttgg ttaagccaaa tgcagatgtg atgagacagc gcatcattga
     2521 agaatctacc cagtgtggac cccgggctgt cagggctgcg ttgaacctgc cagaggctgc
     2581 atcatgtgat gagatccagg ggaaatggca ggatgcccat ctgggcaaag accagaggga
     2641 ttttaacatg attgatatga agttcaagga ggaagtgaac cattacagca atgagattaa
     2701 caaggcatgt atgccttttg gcttgcacag acaattccct gaaaacaacc tgcagatgat
     2761 ggtgcagtcg ggagccaaag ggtcgaccgt gaacacgatg caaatctctt gcctgctggg
     2821 ccaaattgag ttggaaggtc ggagaccccc actgatggcg tctggcaagt cactgccctg
     2881 ctttgagcct tacgagttca ccccaagggc tggtggcttt gtcactggaa ggttccttac
     2941 cggtatcagg ccacctgagt tcttcttcca ctgcatggcg gggcgagaag gcctggtgga
     3001 tactgctgtc aagaccagcc gttctggcta tctccaaagg tgtatcatca agcacctgga
     3061 gggtctggtc atccagtacg atctcacggt ccgtgacagt gatggcagtg tggtacagtt
     3121 cctgtatggg gaggatggcc tggacatccc caagacacag ttcctacaac ccaagcagtt
     3181 cccctttctg gccagcaatt atgaggtgat aatgaaatcc aagcatcttc atgaagtttt
     3241 gtctagagca gatccccaga aagtgctccg ccacttcaga gccattaaaa aatggcacca
     3301 caggcattcc agtgccctgc tgagaaaagg cgccttcctg agtttttccc agaagattca
     3361 ggcagctgtg aaagccttga acctagaggg caagacccag aatgggcgca gcccagagac
     3421 ccagcagatg ttacagatgt ggcatgaatt agatgagcag agccgacgga aataccagaa
     3481 gagggctgcc ccgtgtcccg accctagcct ttctgtgtgg cgcccagaca tccacttcgc
     3541 atctgtgtct gaaacatttg aaaaaaagat tgatgactac agtcaggagt gggcagctca
     3601 agcagagaag agtcacaaca gatcagagct ttctcttgac aggctgagaa ccttactgca
     3661 gctcaagtgg cagcgctcac tgtgtgaccc aggcgaggct gttggcctcc tggccgccca
     3721 gagcatcgga gagccctcca cacagatgac actgaacacc ttccactttg caggcagagg
     3781 cgagatgaac gtcaccctgg gcattccaag attgagggag attctcatgg tggccagtgc
     3841 caacatcaaa acacccatga tgagcgtgcc tgtgttcaac accaagaaag cactgaggag
     3901 agtgaagagt ctgaagaagc agctcaccag ggtgtgcctg ggggaggtat tgcagaaagt
     3961 tgacatccag gagtccttct gtatgggaga gaaacagaat aaattccggg tgtatgagct
     4021 ccggtttcag ttcctgccac atgcatatta ccagcaggag aagtgcctga gacccgagga
     4081 catcttgcac ttcatggaaa ccagattctt taagctacta atggaagcta tcaaaaagaa
     4141 gaatagcaaa gcatcagcct tcagaagtgt gaataccagg agagctacac agaaggacct
     4201 cgatgacact gaggactcgg ggaggaatcg gagagaggag gaaagggatg aggaagagga
     4261 ggggaacatt gtggatgctg aagctgagga gggggatgca gatgcttctg acaccaaacg
     4321 caaggagaag caagaagaag aggttgacta tgagagtgag gaagaagggg aggaggaaga
     4381 ggaagaggat gtacaagaag aggagaacat caaaggtgaa ggtgcccacc agacccatga
     4441 gccagatgag gaagaaggtt caggccttga ggaggaatca tcccagaacc ctccccgccg
     4501 ccattccagg cctcagggag ctgaggccat ggaacgccga atccaggctg tacgggagtc
     4561 ccattcgttc attgaggact accagtatga cacagaggag agcctgtggt gccaggtgac
     4621 agtgaagctc ccattgatga agattaattt tgacatgagc tccttggttg tatccttggc
     4681 ccacaatgcc attgtctata cgactaaggg catcactcgg tgtctcctga atgaaacgat
     4741 caacagtaag aatgagaagg agtttgtcct gaacacggag ggaatcaacc tccccgagct
     4801 gttcaagtac tccgaggtgc tggacctgcg ccgcctgtac tccaacgaca tccatgctgt
     4861 ggccaatacg tacggcatcg aggctgcgct gcgggtgata gagaaggaga ttaaggatgt
     4921 gtttgctgtg tacggcattg cggttgatcc tcgccatctc tccctggttg ctgattatat
     4981 gtgttttgag ggtgtttata agccactcaa tcgctttggg atccagtcaa gctcctcccc
     5041 tttgcagcag atgacgtttg aaaccagctt ccagtttctg aaacaggcca ccatgatggg
     5101 atcccatgat gaactgaagt caccttctgc ctgccttgtg gtgggaaagg tcgtcaaagg
     5161 cgggacaggc ctgtttgagc tcaagcagcc cctaagatag cagggttgtt tgcccagcct
     5221 ggaggacctg gaggtgggca cagctgacag ttgagagtga catagcaaag cagtgacctc
     5281 aggctccaga aagcagtggc ctgagctgag ccagcttcac tgagaagagg ctcctcctac
     5341 ctagcctttt ctgcctcagg atcaggaaca acgcacccca ggccctccaa gatggctatg
     5401 gctgacttgt gctccagggg gccccagcca agatcctaac gagagaccta ggactacaca
     5461 gtggcaagat cactgtgggc catgttggct ttgggaatct caggtgccac cattactgtg
     5521 catagctagt agctaaggac acattcctaa gggctcctga agatccagaa aggacatgaa
     5581 acctgcttca tgtacctgtc cctcctgctg cagctactga aggagagtcc tcaaagagcc
     5641 tccacccagg gctgctttcc tgggccagaa tcagtggcac atgtatggct gcttgcacta
     5701 gaccagactg ccccaataga catctctctg ggaccgcagc agctctacct cacagaagcc
     5761 ccaagtttcc cactggggct gttcagcaag gccaagtggc ttgaccttcc tgcccccgca
     5821 ctcagcttgc tgtcagagcc catagtcacc cccagaccct gcacttttgg ggtctttgcc
     5881 atggagtgag actccctgac tggacaggaa aggcagaggc tttataaagc tgggccgttt
     5941 ctatttttgt ccactgttat tccaacatgg gctgagcaat aaacctggct ggaaccagct
     6001 gttagaagac agtcaa
//
