LOCUS       NM_001011912            2896 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus DNA polymerase mu (Polm), mRNA.
ACCESSION   NM_001011912 XM_223582
VERSION     NM_001011912.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2896)
  AUTHORS   Lieber MR.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   2  (bases 1 to 2896)
  AUTHORS   Lucas D, Lain de Lera T, Gonzalez MA, Ruiz JF, Dominguez O,
            Casanova JC, Martinez-A C, Blanco L and Bernad A.
  TITLE     Polymerase mu is up-regulated during the T cell-dependent immune
            response and its deficiency alters developmental dynamics of spleen
            centroblasts
  JOURNAL   Eur J Immunol 35 (5), 1601-1611 (2005)
   PUBMED   15789338
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081868.1.
            
            On Feb 11, 2005 this sequence version replaced XM_223582.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081868.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2896
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..2896
                     /gene="Polm"
                     /note="DNA polymerase mu"
                     /db_xref="GeneID:289757"
                     /db_xref="RGD:1308247"
     exon            1..443
                     /gene="Polm"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..1740
                     /gene="Polm"
                     /EC_number="2.7.7.7"
                     /note="DNA-directed DNA polymerase mu; polymerase (DNA)
                     mu; polymerase (DNA directed), mu"
                     /codon_start=1
                     /product="DNA-directed DNA/RNA polymerase mu"
                     /protein_id="NP_001011912.1"
                     /db_xref="GeneID:289757"
                     /db_xref="RGD:1308247"
                     /translation="MLPKRRRRVRAGSPHSALASSTPPAARFPGVAIYLAEPRMGRSR
                     RAFLTRLARSKGFRILDVYSSEVTHVVMEETSAKEAICWQKDMNALLPDCPQPALLDI
                     SWFTESMAAGQPVPEEVRHRLEVAEPRKEPPISVTIPAYACQRPSPLTPHNTLLSEAL
                     ETLAEAAGFEGKEGRFLTFYRAASMLKSLPYPVTSLSQLHGLPYFGEHSFRVIQELLE
                     HGTCEEVEQIRCSERHQTMKLFTHIFGVGVKTASRWYQEGLRTLDELREQPQRLTQQQ
                     KAGLQYYQDLSTPVSRAEAEALQQLVEAAMREILPGATVTLTGGFRRGKLQGHDVDFL
                     ITHPEEGQEVGLLPRVMRCLQSQGLVLYHQYHRSHLADSAHILRQRSTMDAFERSFCI
                     LRLPQSQQAALEGPLHPCPTWKAVRVDLVVTPNSQFPFALLGWTGSQFFERELRRFSR
                     QEKGLCLNSHGLFDPERKTFFHATSEEDVFRFLGLKYLPPEQRNA"
     exon            444..624
                     /gene="Polm"
                     /inference="alignment:Splign:2.1.0"
     exon            625..723
                     /gene="Polm"
                     /inference="alignment:Splign:2.1.0"
     exon            724..894
                     /gene="Polm"
                     /inference="alignment:Splign:2.1.0"
     exon            895..966
                     /gene="Polm"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1087
                     /gene="Polm"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1220
                     /gene="Polm"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1323
                     /gene="Polm"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1569
                     /gene="Polm"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..1653
                     /gene="Polm"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..2868
                     /gene="Polm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcctccg aggtctgaga aaccaatggg gctttctccg agagtagttc aaaacagaag
       61 agtcctcggg cattatttgc atagaactgg ggcatccgga gggaatctaa agcatcttag
      121 agggcggctc gtttgcatag agcaaacacc acttcctctc tccgcagtct tcctccctct
      181 ccttccgcct tctttcctga ccctgccttc cttcgttctg cggcctcccg tgcttcctga
      241 gtcggtgtcc agatgcttcc gaagcgacgg cggcgggtgc gagcagggtc cccacacagc
      301 gctttagcct cttccacgcc cccagcggcg cgcttcccgg gtgtagccat ctaccttgcg
      361 gagccgcgaa tgggccgcag ccgccgggcc ttcctcactc gcctggcgcg gtccaaaggc
      421 ttccgcatcc tagatgttta cagctcagag gtgacacatg tggtgatgga ggagacctca
      481 gccaaggagg ccatctgctg gcagaaggac atgaatgctc ttctcccaga ctgcccgcag
      541 ccggctctgc tagatattag ctggtttaca gagagcatgg cagcaggaca gcctgtccct
      601 gaggaggtcc ggcaccgcct ggaggtagct gagcccagga aggaaccccc catctcagtg
      661 acgataccag cttatgcctg tcagcgcccc tcgcctctca caccccataa cactctcctc
      721 tcagaggctc tggagacact ggcggaggca gcgggcttcg aaggcaaaga gggccgtttt
      781 ctcaccttct acagagcagc ctccatgctc aagtccctac cctaccctgt cacatctttg
      841 agccagctgc atggactgcc ttactttggg gaacattcct ttagagtaat ccaggagctg
      901 ctagaacatg gaacgtgtga ggaggtggaa caaatccgtt gctcagaaag gcaccagacc
      961 atgaagctct tcacccacat cttcggggtt ggggtgaaga ctgctagccg gtggtaccag
     1021 gaagggctac gaaccctgga tgagctcaga gagcagcccc agagactgac ccagcagcag
     1081 aaagcagggc tgcagtatta ccaggacctg agcaccccag ttagccgggc agaggccgag
     1141 gctctgcagc agttggtaga ggcagccatg agggagatcc tgcccggagc cactgtcaca
     1201 ctgactggcg gtttccgaag ggggaagtta caaggtcatg acgtggactt ccttatcacc
     1261 caccctgagg agggccaaga agtagggctg ctgcccagag tgatgaggtg ccttcagagc
     1321 cagggacttg tgctgtacca ccagtaccat cgcagccact tagcggactc tgcccacatc
     1381 ctgcggcaga ggtccaccat ggatgctttt gagaggagtt tctgcatctt gcgcttgcca
     1441 cagtcccaac aggcagcttt agaggggccc ctgcatccct gcccaacctg gaaagctgtg
     1501 agggtagatc ttgtggtcac tcccaacagc cagttcccct ttgctcttct tggctggact
     1561 ggctcccagt tttttgagag ggagctacgg cgattcagcc ggcaagagaa ggggctgtgc
     1621 cttaatagcc acgggctgtt tgatcctgag cggaagacat ttttccacgc aacttctgag
     1681 gaagatgttt tcaggttcct gggtctcaag tatcttcctc cagagcagag aaatgcctga
     1741 gatgaaaaat gcctgttggc tgccatacct gtccacgaga agatgagggg ctgtctcttt
     1801 cttgaccagg aatgtttcta gacaggagca ccgccacccc acggcctcac ctgtgcaaat
     1861 gggatttttt attttttacc tcatcggttg agtgtgaccc cgagtcagct cagttttcag
     1921 cctccattct cctcacagtc aggtgctctt agcagttcat gtacatcacg aacctgtggc
     1981 agagtctgaa gtcttggttc tggtccagct gtggttgcag tgtctgctgc agagtacctg
     2041 gttccgtgtg ccagaaaaca gacatatgtc cctgccccgg gcttgggctg atatgggaag
     2101 tataattctg gcaatgaggt gttgcagaag aagcctgcct gagtgccgtg ttgcactagg
     2161 aggtggccta ggtcagcaac atccagtgct ggcagcgcca cccgcagacc tgggtacttg
     2221 taccagactt cataagcagc acagctcagg aattggcccc acaggtgtct tccctcacac
     2281 tcccgcctag gctgagcctg acttgccttt acccacaatc ccttgtgcat ccagagcccc
     2341 agcaatgcct tctgggaggg ctggttccta gaatagactg tagcccagtc tggcagcaga
     2401 gtactaaaac ttagccacat cagggggcag ccacacagtg ttcttcctgt cctgagattg
     2461 tgaggtgcgg gttccctggt cctgtttctt aaagacgtgt cactctgccg ctccggacag
     2521 cgctgcagca gttccaaacc tgcagtcctc actcaggtcc tgtggctctg gtgtttctgt
     2581 cgtctcttct agtctcagct gtactcctcc cttcccccac tttctcagtt cacttctggt
     2641 ccctgtttgc aggctctttg tgaccaactt cttcaccttc tctgagccgg aagcactaaa
     2701 gcgggctggt cacagtgtcc tcatatcccc ttgcccttgc cttactatac acctagtgcc
     2761 cactgtccct gcctccttca ggacctgaca ggtaagggcc tcctagaccc accagcagat
     2821 tagcaagaat tttaaaaatt agcattcaat aaagtggatt cttttggaaa aaaaaaaaaa
     2881 aaaaaaaaaa aaaaaa
//
