LOCUS       NM_001014168            2320 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DNA polymerase lambda (Poll), mRNA.
ACCESSION   NM_001014168 XM_342058
VERSION     NM_001014168.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2320)
  AUTHORS   Capp,J.P., Boudsocq,F., Bergoglio,V., Trouche,D., Cazaux,C.,
            Blanco,L., Hoffmann,J.S. and Canitrot,Y.
  TITLE     The R438W polymorphism of human DNA polymerase lambda triggers
            cellular sensitivity to camptothecin by compromising the homologous
            recombination repair pathway
  JOURNAL   Carcinogenesis 31 (10), 1742-1747 (2010)
   PUBMED   20693240
REFERENCE   2  (bases 1 to 2320)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   3  (bases 1 to 2320)
  AUTHORS   Terrados,G., Capp,J.P., Canitrot,Y., Garcia-Diaz,M., Bebenek,K.,
            Kirchhoff,T., Villanueva,A., Boudsocq,F., Bergoglio,V., Cazaux,C.,
            Kunkel,T.A., Hoffmann,J.S. and Blanco,L.
  TITLE     Characterization of a natural mutator variant of human DNA
            polymerase lambda which promotes chromosomal instability by
            compromising NHEJ
  JOURNAL   PLoS One 4 (10), e7290 (2009)
   PUBMED   19806195
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2320)
  AUTHORS   Aoufouchi,S., Flatter,E., Dahan,A., Faili,A., Bertocci,B.,
            Storck,S., Delbos,F., Cocea,L., Gupta,N., Weill,J.C. and
            Reynaud,C.A.
  TITLE     Two novel human and mouse DNA polymerases of the polX family
  JOURNAL   Nucleic Acids Res 28 (18), 3684-3693 (2000)
   PUBMED   10982892
REFERENCE   5  (bases 1 to 2320)
  AUTHORS   Garcia-Diaz,M., Dominguez,O., Lopez-Fernandez,L.A., de Lera,L.T.,
            Saniger,M.L., Ruiz,J.F., Parraga,M., Garcia-Ortiz,M.J.,
            Kirchhoff,T., del Mazo,J., Bernad,A. and Blanco,L.
  TITLE     DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA
            polymerase with a potential role in meiosis
  JOURNAL   J Mol Biol 301 (4), 851-867 (2000)
   PUBMED   10966791
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085841.1.
            
            On Apr 20, 2005 this sequence version replaced XM_342058.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..2320
                     /gene="Poll"
                     /note="DNA polymerase lambda"
                     /db_xref="GeneID:361767"
                     /db_xref="RGD:1308053"
     exon            1..20
                     /gene="Poll"
                     /inference="alignment:Splign:2.1.0"
     exon            21..157
                     /gene="Poll"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1767
                     /gene="Poll"
                     /EC_number="2.7.7.7"
                     /note="DNA-directed DNA polymerase lambda; pol Lambda;
                     polymerase (DNA directed), lambda; polymerase (DNA)
                     lambda"
                     /codon_start=1
                     /product="DNA polymerase lambda"
                     /protein_id="NP_001014190.1"
                     /db_xref="GeneID:361767"
                     /db_xref="RGD:1308053"
                     /translation="MDPQGILKAFPKRKKIHADPSSNALAKIPKREAGDARGWLSSLR
                     AHIMPTGIGRARAELFEKQIIQHGGQVCSAQAPGVTHIVVDEGMDYERALRLLRLPQL
                     PPGAQLVKSAWLSLCLQEKKLTDTDGFSLSSPKRSLNEPQPSKSGQDASAPGTQGVLP
                     RTTLSLSPPCTRAVSPPPKAEKPPKTQTQLSSEDEASDGEGPQVSSADLQALISGHYP
                     TPPGEDGGPDPAPEALGKWVCAQPSSQKATNYNLHITEKLEVLAKAYNVQGDKWRALG
                     YAKAINALKSFHKPVSSYQEACSIPGVGRRMAEKVMEILESGHLRKLDHISDSVPVLE
                     LFSNIWGAGTKTAQMWYHQGFRSLEDIRGLASLTAQQAIGLKHYDDFLDRMPREEAAE
                     IEQMVRVSAQAFNPGLLCVACGSFRRGKVTCGDVDVLITHPDGRSHQGIFSPLLDSLR
                     QQGFLTDDLVSQEENGQQQKYLGVCRLPGAGQRHRRLDIIVVPYSEFACALLYFTGSA
                     HFNRSMRALAKTKGMSLSEHALSAAVVRNSQGVKVGAGQVLPTPTEKDVFKLLGLPYR
                     EPAERDW"
     exon            158..452
                     /gene="Poll"
                     /inference="alignment:Splign:2.1.0"
     exon            453..612
                     /gene="Poll"
                     /inference="alignment:Splign:2.1.0"
     exon            613..930
                     /gene="Poll"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1104
                     /gene="Poll"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1233
                     /gene="Poll"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1402
                     /gene="Poll"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..2297
                     /gene="Poll"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgttttcatt ggctcccatg aaaggtccag atccagcgca cttcaatgga cccccagggc
       61 atcctgaagg catttcccaa gcgaaagaaa attcatgcag atccatcatc aaacgcactt
      121 gcaaagattc ccaaaaggga ggcaggagat gctagaggat ggctgagctc cctgagggcc
      181 cacattatgc ccactggcat tgggcgagcc cgggctgaac tctttgagaa gcagattatc
      241 cagcatggtg gccaggtgtg ctctgcccag gccccaggag tcactcacat tgtggtggat
      301 gaaggcatgg actatgaacg ggctctccgg ctcctcagac tgccccagct gccccctggt
      361 gctcagctgg tgaagtcagc ctggctgagc ttgtgtctac aggagaaaaa gctgacagac
      421 acggacggat tcagcctttc cagccctaag aggtccttga atgaaccaca gcccagcaag
      481 tcaggccaag atgcttctgc tcctggcact cagggggttc tacccaggac aacgctctct
      541 ctttcccctc cttgtaccag agctgtatct cctcccccaa aggcagaaaa gccaccaaaa
      601 acccaaaccc agctcagctc agaggatgaa gccagtgatg gggaagggcc ccaggttagc
      661 tcagcagatt tgcaagcctt gatcagtggg cactacccca ctccccctgg ggaagatggt
      721 gggcctgacc cagccccaga agctctgggt aagtgggtct gtgcacagcc ctcaagccag
      781 aaggcaacta attacaacct gcacatcaca gagaagctcg aagtgctggc taaagcctac
      841 aatgtccagg gagacaagtg gagggctctg ggctatgcca aggccatcaa cgccctcaag
      901 agcttccaca agcctgtcag ttcctaccag gaggcctgta gcatcccagg agttggcagg
      961 cgaatggcag agaaggtcat ggagatcctg gagagtgggc atctgcggaa gctggaccac
     1021 atcagcgaca gcgtgcctgt cttagagctc ttctccaaca tctggggagc cgggacgaag
     1081 actgcccaga tgtggtacca tcagggcttc cgaagcctag aagatatccg aggcctggcc
     1141 tccctgaccg ctcagcaggc cattggcttg aagcactatg atgacttcct ggaccgcatg
     1201 cccagggagg aggctgcaga aattgagcag atggtccgag tatcagccca ggccttcaac
     1261 cctgggctgc tgtgtgtggc ctgtggctct ttccgtcgag ggaaggtgac ctgtggggat
     1321 gtagatgtac ttattactca ccccgacggc cggtcccacc agggcatctt cagcccactc
     1381 ctcgacagcc ttcggcagca agggttcctc acagatgact tggtgagcca ggaggagaat
     1441 ggccagcagc agaaatacct gggtgtgtgc cggctcccag gggccgggca gcgccaccgg
     1501 cgactggaca tcatcgtggt gccctacagt gagtttgcct gtgccctgct ctacttcacc
     1561 ggctctgccc acttcaaccg gtccatgaga gctctggcca agaccaaggg catgagcctg
     1621 tcagagcatg cccttagtgc tgctgtggtc cggaacagcc aaggtgtcaa ggtcggggct
     1681 ggacaagtgc tgcccacccc cacagagaag gacgtcttca agctcttagg cctgccctac
     1741 cgagaaccgg ctgaacggga ctggtgacat agggtttggg caagggaagc cacgttggat
     1801 gaactaactg cctcatctgc caccctctta gctttgcctc actctgtccg tcaccacttg
     1861 cccttactga gccaagctag gagctctagg gcctgtagga aagagccagt ctgattgtga
     1921 gcctgccagc tctctcctgg acaggatcat gctgcggtcc cctctgctcc cctctgctcc
     1981 ctgttcaagc acagcaggtg gctggtttca agctggtttc ctgtactgca ggcctggttt
     2041 cctgtactga aggcctgagc ttccctttcc accccaagac tgatgtagac atagggggtc
     2101 aggagaggct gcaggaagag agggaggcag ctgtgggccc agcatcttct tcgggccttc
     2161 acggtagaga aagctatgtg gattccctca cccgcccact tcctgtgcag ctggagctgc
     2221 tgggggtggc ctgcccagac tctgtgagag tggcttctaa gggccctgga gcctaataaa
     2281 gtgcttctga cattcaaaaa aaaaaaaaaa aaaaaaaaaa
//
