LOCUS       NP_001014190             573 aa            linear   ROD 03-APR-2024
DEFINITION  DNA polymerase lambda [Rattus norvegicus].
ACCESSION   NP_001014190 XP_342059
VERSION     NP_001014190.1
DBSOURCE    REFSEQ: accession NM_001014168.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 573)
  AUTHORS   Capp,J.P., Boudsocq,F., Bergoglio,V., Trouche,D., Cazaux,C.,
            Blanco,L., Hoffmann,J.S. and Canitrot,Y.
  TITLE     The R438W polymorphism of human DNA polymerase lambda triggers
            cellular sensitivity to camptothecin by compromising the homologous
            recombination repair pathway
  JOURNAL   Carcinogenesis 31 (10), 1742-1747 (2010)
   PUBMED   20693240
REFERENCE   2  (residues 1 to 573)
  AUTHORS   Lieber,M.R.
  TITLE     The mechanism of double-strand DNA break repair by the
            nonhomologous DNA end-joining pathway
  JOURNAL   Annu Rev Biochem 79, 181-211 (2010)
   PUBMED   20192759
  REMARK    Review article
REFERENCE   3  (residues 1 to 573)
  AUTHORS   Terrados,G., Capp,J.P., Canitrot,Y., Garcia-Diaz,M., Bebenek,K.,
            Kirchhoff,T., Villanueva,A., Boudsocq,F., Bergoglio,V., Cazaux,C.,
            Kunkel,T.A., Hoffmann,J.S. and Blanco,L.
  TITLE     Characterization of a natural mutator variant of human DNA
            polymerase lambda which promotes chromosomal instability by
            compromising NHEJ
  JOURNAL   PLoS One 4 (10), e7290 (2009)
   PUBMED   19806195
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 573)
  AUTHORS   Aoufouchi,S., Flatter,E., Dahan,A., Faili,A., Bertocci,B.,
            Storck,S., Delbos,F., Cocea,L., Gupta,N., Weill,J.C. and
            Reynaud,C.A.
  TITLE     Two novel human and mouse DNA polymerases of the polX family
  JOURNAL   Nucleic Acids Res 28 (18), 3684-3693 (2000)
   PUBMED   10982892
REFERENCE   5  (residues 1 to 573)
  AUTHORS   Garcia-Diaz,M., Dominguez,O., Lopez-Fernandez,L.A., de Lera,L.T.,
            Saniger,M.L., Ruiz,J.F., Parraga,M., Garcia-Ortiz,M.J.,
            Kirchhoff,T., del Mazo,J., Bernad,A. and Blanco,L.
  TITLE     DNA polymerase lambda (Pol lambda), a novel eukaryotic DNA
            polymerase with a potential role in meiosis
  JOURNAL   J Mol Biol 301 (4), 851-867 (2000)
   PUBMED   10966791
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085841.1.
            
            On Apr 20, 2005 this sequence version replaced XP_342059.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085841.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..573
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     Protein         1..573
                     /product="DNA polymerase lambda"
                     /EC_number="2.7.7.7"
                     /note="DNA-directed DNA polymerase lambda; pol Lambda;
                     polymerase (DNA directed), lambda; polymerase (DNA)
                     lambda"
                     /calculated_mol_wt=62270
     Region          40..123
                     /region_name="BRCT_polymerase_lambda"
                     /note="BRCT domain of DNA polymerase lambda and similar
                     proteins; cd17715"
                     /db_xref="CDD:349347"
     Region          126..235
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI3.1)"
     Region          253..571
                     /region_name="NT_POLXc"
                     /note="Nucleotidyltransferase (NT) domain of family X DNA
                     Polymerases; cd00141"
                     /db_xref="CDD:143386"
     Region          263..277
                     /region_name="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q9UGP5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI3.1)"
     Site            order(337,339,341..346,349,370,384,414..415,418,420,
                     422..425,427,470,472,486,488,503..508,511,527)
                     /site_type="active"
                     /db_xref="CDD:143386"
     Site            order(337,339,341..346,349,370,414,418,424..425,427,470,
                     472,486,488,503..508,511)
                     /site_type="other"
                     /note="primer binding site [nucleotide binding]"
                     /db_xref="CDD:143386"
     Region          343..346
                     /region_name="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q9UGP5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI3.1)"
     Site            order(384,414..415,418,420,422..425,427,470,488,503..506,
                     508,511,527)
                     /site_type="other"
                     /note="NTP binding site [chemical binding]"
                     /db_xref="CDD:143386"
     Region          418..427
                     /region_name="Involved in primer binding.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI3.1)"
     Site            order(425,427,488)
                     /site_type="metal-binding"
                     /note="metal binding triad [ion binding]"
                     /db_xref="CDD:143386"
     Region          464..503
                     /region_name="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q9UGP5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5RKI3.1)"
     CDS             1..573
                     /gene="Poll"
                     /coded_by="NM_001014168.1:46..1767"
                     /db_xref="GeneID:361767"
                     /db_xref="RGD:1308053"
ORIGIN      
        1 mdpqgilkaf pkrkkihadp ssnalakipk reagdargwl sslrahimpt gigraraelf
       61 ekqiiqhggq vcsaqapgvt hivvdegmdy eralrllrlp qlppgaqlvk sawlslclqe
      121 kkltdtdgfs lsspkrslne pqpsksgqda sapgtqgvlp rttlslsppc travspppka
      181 ekppktqtql ssedeasdge gpqvssadlq alisghyptp pgedggpdpa pealgkwvca
      241 qpssqkatny nlhiteklev lakaynvqgd kwralgyaka inalksfhkp vssyqeacsi
      301 pgvgrrmaek vmeilesghl rkldhisdsv pvlelfsniw gagtktaqmw yhqgfrsled
      361 irglasltaq qaiglkhydd fldrmpreea aeieqmvrvs aqafnpgllc vacgsfrrgk
      421 vtcgdvdvli thpdgrshqg ifsplldslr qqgfltddlv sqeengqqqk ylgvcrlpga
      481 gqrhrrldii vvpysefaca llyftgsahf nrsmralakt kgmslsehal saavvrnsqg
      541 vkvgagqvlp tptekdvfkl lglpyrepae rdw
//
