LOCUS       NM_138516               3821 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus DNA polymerase kappa (Polk), mRNA.
ACCESSION   NM_138516 XM_001060864 XM_342178
VERSION     NM_138516.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3821)
  AUTHORS   Xiang Y, Laurent B, Hsu CH, Nachtergaele S, Lu Z, Sheng W, Xu C,
            Chen H, Ouyang J, Wang S, Ling D, Hsu PH, Zou L, Jambhekar A, He C
            and Shi Y.
  TITLE     RNA m6A methylation regulates the ultraviolet-induced DNA damage
            response
  JOURNAL   Nature 543 (7646), 573-576 (2017)
   PUBMED   28297716
  REMARK    Erratum:[Nature. 2017 Nov 29;:. PMID: 29186122]
REFERENCE   2  (bases 1 to 3821)
  AUTHORS   Lehmann AR.
  TITLE     DNA polymerases and repair synthesis in NER in human cells
  JOURNAL   DNA Repair (Amst) 10 (7), 730-733 (2011)
   PUBMED   21601536
  REMARK    Review article
REFERENCE   3  (bases 1 to 3821)
  AUTHORS   Ogi T, Limsirichaikul S, Overmeer RM, Volker M, Takenaka K, Cloney
            R, Nakazawa Y, Niimi A, Miki Y, Jaspers NG, Mullenders LH,
            Yamashita S, Fousteri MI and Lehmann AR.
  TITLE     Three DNA polymerases, recruited by different mechanisms, carry out
            NER repair synthesis in human cells
  JOURNAL   Mol Cell 37 (5), 714-727 (2010)
   PUBMED   20227374
REFERENCE   4  (bases 1 to 3821)
  AUTHORS   Schenten D, Gerlach VL, Guo C, Velasco-Miguel S, Hladik CL, White
            CL, Friedberg EC, Rajewsky K and Esposito G.
  TITLE     DNA polymerase kappa deficiency does not affect somatic
            hypermutation in mice
  JOURNAL   Eur J Immunol 32 (11), 3152-3160 (2002)
   PUBMED   12555660
REFERENCE   5  (bases 1 to 3821)
  AUTHORS   Okochi E, Ichimura S, Sugimura T and Ushijima T.
  TITLE     The absence of Mth1 inactivation and DNA polymerase kappa
            overexpression in rat mammary carcinomas with frequent A:T to C:G
            transversions
  JOURNAL   Jpn J Cancer Res 93 (5), 501-506 (2002)
   PUBMED   12036445
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166778.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_138516.2.
            
            On or before Jun 8, 2008 this sequence version replaced
            XM_342178.3, XM_001060864.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166778.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..3821
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /note="DNA polymerase kappa"
                     /db_xref="GeneID:171525"
                     /db_xref="RGD:620058"
     exon            1..169
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            170..332
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..2756
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /EC_number="2.7.7.7"
                     /note="DNA-directed DNA polymerase kappa; polymerase (DNA
                     directed) kappa; polymerase (DNA) kappa"
                     /codon_start=1
                     /product="DNA polymerase kappa"
                     /protein_id="NP_612525.1"
                     /db_xref="GeneID:171525"
                     /db_xref="RGD:620058"
                     /translation="MDNTKEKNNFKDALLLRMGLNDNKAGMEGLDKEKINKIIMEATK
                     GSRFYGNELKKEKQVNQRIENMMQQKAQITSQQLRKAQLQVDRFAMGLERNRNLNNTI
                     VHVDMDAFYAAVEMRDNPELKEKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLC
                     PQLIIVPPNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQGWPEDKR
                     RYFIKMGNCRKIDTPRQEADELTERERSISPLLFEDSPPDLQPQGSPFQLNSEEQNNP
                     QIAQNPVVFGTSAEEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQI
                     VPSRSAVMDFIKDLPIRKVSGIGKVTEKMLLALGIVTCTELYQQRALLSLLFSESSWH
                     YFLHVALGLGSTDLARDGERKSMSVERTFSEINKTEEQYSLCQELCTELAHDLQKEGL
                     KGRTVTIKLKNVDFEVKTRASTVPSAISTAEDIFAVAKELLRTEVTAGSPQPLRLRLM
                     GVRMSTFSNDDDRKHQQRSIIGFLQAGNQGLSPTGCTADRTDKTELVKPLETSRKKSF
                     FDKKRSERIPNCQDPPRCKIAGEQALQASEPSQALKKMSESFKTSENSNDPQTFICPV
                     CFREQEGISLEAFNEHVDACLDGPSTSENSEMPSYSHASSADIGQQAHRAVPLWEKRG
                     HGDGEITSGDGADLTETEDRSPKAASMDAVGNNHSEGEGYPDSQGKSCPLSPANETVS
                     TLSREDSAQPCTDEVVTGRALVCPVCNLEQETSDLTLFNIHVDICLNKGIIQELRNSE
                     VNSVKQPKGSTRSTDRLQKASGKTKRAGRKTKGSTSKRTKPRDPRHTLDGFFK"
     exon            333..452
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..605
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..737
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            738..891
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1131
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1256
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1423
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1456
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1553
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1725
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..2637
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..2671
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..3797
                     /gene="Polk"
                     /gene_synonym="Dinb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caactagtgt gtgtgtcctg ggcgcgcgaa agactggttg cctaggggaa ccttctgaga
       61 gcaagtgggc ttcttttgac agttgtgtgc cccttcggtc cagcctggct tccgattctg
      121 ccttgcgtgt ttatgacgag cctgcgaatc gggacgtgag aaccctcaga tcacaaggaa
      181 gaaatcgctg cgtttgcatc atggataaca caaaggaaaa gaacaacttc aaagacgccc
      241 ttctgctccg catgggacta aatgataaca aggcaggcat ggaagggttg gataaggaga
      301 aaattaacaa aattatcatg gaagccacaa aggggtccag attttatgga aatgaactca
      361 agaaggagaa gcaagtcaat caacggattg aaaacatgat gcagcaaaag gcgcaaatta
      421 ccagccagca actaaggaag gcccagctac aggttgacag atttgcgatg ggattagaac
      481 ggaaccggaa tttgaacaac accatagttc acgtggacat ggatgctttc tatgcggccg
      541 tagaaatgag ggacaacccg gaactgaagg agaagcccat cgctgtagga tccatgagca
      601 tgctggctac ttcaaattac cacgcaagga ggtttggggt tcgcgcagcc atgccaggat
      661 ttattgccaa gagactctgc ccacaactta ttatagtgcc cccaaacttt gacaagtata
      721 gagctgtgag taaggaggtt aaggagatac tcgctgaata tgatcccaat tttatggcca
      781 tgagtctgga cgaggcctac ttgaatataa cacagcactt acaggaaagg caaggttggc
      841 ctgaggacaa aagaagatat ttcatcaaaa tgggaaactg tagaaaaatt gacacacccc
      901 ggcaggaagc tgatgagctg actgagcggg agcgctccat ctccccactg ctttttgaag
      961 atagccctcc tgatttgcaa ccccaaggaa gtcctttcca actgaactct gaagaacaaa
     1021 acaatcctca aatagcccaa aatccagttg tttttggaac atcagctgag gaagtggtaa
     1081 aggaaattcg cttcagaatt gaacagaaaa caacgctaac agccagcgca ggcatcgccc
     1141 ctaatacaat gttagcaaaa gtgtgcagtg ataagaataa accaaatgga cagtaccaga
     1201 tcgtccccag caggagcgca gtgatggact tcatcaagga cttgcctatt cgaaaggttt
     1261 ctggaatagg aaaagttacg gagaaaatgt tgctggctct cgggattgtt acttgcacag
     1321 aactctacca acagagagcg ttgctttctc tccttttctc ggagtcatcc tggcactatt
     1381 ttcttcatgt tgcactgggc ctgggttcaa cagacctggc gagggatgga gaaaggaaaa
     1441 gtatgagcgt tgaaaggaca tttagtgaga tcaataaaac agaggaacag tacagcttgt
     1501 gccaagaact gtgcactgag ctcgcccacg atctccagaa ggaaggactt aagggcagaa
     1561 ctgtcaccat caagctgaag aatgtggatt ttgaagtaaa aacccgcgca tctacagtac
     1621 cgtccgccat ttctactgca gaggacatat ttgccgttgc caaggagctg ctaaggacag
     1681 aagtcactgc aggctctcca cagcccctgc ggctaagact gatgggtgtt cggatgtcta
     1741 ctttctccaa cgacgatgac aggaagcacc aacaaaggag catcattggc ttcttacaag
     1801 ctggaaacca aggtttgtca cccactgggt gtactgcaga cagaactgac aaaactgagc
     1861 tcgtaaagcc cttagaaacg tctcgtaaga agagtttctt tgataaaaag cgatcagaaa
     1921 ggatcccgaa ctgtcaagac ccacccagat gtaaaatcgc gggtgagcaa gctttacagg
     1981 cctcggaacc atcccaagcg ttgaagaaga tgagcgagag tttcaaaacc tcagagaatt
     2041 caaatgaccc tcagacattt atatgtccag tttgctttag ggagcaagaa ggcatcagtc
     2101 tggaagcctt taatgaacat gtagatgcat gtctcgatgg accgtccacc agtgagaact
     2161 cagagatgcc cagttactca catgcttcgt ctgcggacat tggtcagcag gcacaccgtg
     2221 ctgttccact gtgggagaaa cgggggcatg gagatggaga gatcacctca ggagatggtg
     2281 cagatctaac agagactgaa gacagatcgc cgaaagcagc aagcatggac gctgtaggga
     2341 ataatcacag cgaaggggag ggatatcctg atagtcaggg caagtcctgc cctctgtcac
     2401 ccgcaaacga aactgtcagc acgttaagta gggaagactc tgcccagccc tgtacagatg
     2461 aggtagtgac aggacgagct ctagtttgtc ccgtttgtaa cctagaacaa gagacgtctg
     2521 atctcaccct cttcaacatc cacgtggaca tttgcttaaa taaaggcatc atccaagaac
     2581 tgagaaacag cgaagttaat tcagttaagc aacccaaagg gagcacgaga agcactgaca
     2641 gacttcagaa ggcttcagga aagacaaaaa gggcaggccg gaagacaaag ggctcaacat
     2701 cgaagagaac aaaaccccga gatcccagac acacccttga tggatttttt aaatgaactt
     2761 tgaacatttt atcaacattt ttaattgtag ttattatttt catagtcaat gaatttattt
     2821 ttcctcacct taaatatgtt cctttaagga agacaagtgc aataataata cctcccccac
     2881 gtgacctttt taagaatgta gactgaatat taatatatgt atgtgtgtgt gtatatatat
     2941 atatatatat atatatatat atatatgtac tgggaatgaa atttatataa tcagttggaa
     3001 atcagtcgta ttagagacag cgtaagaagt gaggtcagaa gataatttta taatgagtat
     3061 aaaatattta caaggactct gagccatgtg tagtgacctt agcgtcagct cctcagtgct
     3121 tagccaccgt gttgccgttg atgctattgt acttctcatg agcagatgta attagattta
     3181 gccatgatca ccacgaagaa cttcagctta acagaaaggg tgtgggtatg gctgctccct
     3241 tcaggaagtg atgcacagta ttacctgtgt tcagaggcct ggctcaaacc attgttattt
     3301 gtatcgtctt acttatcaat aagcacttgg ttcgcataaa gaaatgctta gtctgaaact
     3361 caagattgtt tttgtaactc agtactttaa atggcagtat ttaatttctt cccggttata
     3421 tttgctacag atctgcagta aacaagataa gtcccttggt tttcatccac ctctttagga
     3481 caaatagacg gctctgaagc tgcccttgcc gtagctactt ctctgtgccc ctgttaatgg
     3541 ttgtggaaga aagctttgca gcagttcaga ggttgctgca gatgaagtgc cacccacagg
     3601 ttcttatcaa aaagcccttc ctgctactgc tttaagaact gattcctgct ggcttgtggt
     3661 ggctcacgcc tttaatccta gcactgggag gcagaggcag gaggacctcg gagttcaagg
     3721 acagcttggt ctacagagtg agttccagaa agaacagcca gaaccacaca gagaaaccct
     3781 acctcccaaa agaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
