LOCUS       NM_001106137            2360 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus DNA polymerase iota (Poli), mRNA.
ACCESSION   NM_001106137 XM_001069113 XM_225844
VERSION     NM_001106137.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Dumstorf,C.A., Clark,A.B., Lin,Q., Kissling,G.E., Yuan,T.,
            Kucherlapati,R., McGregor,W.G. and Kunkel,T.A.
  TITLE     Participation of mouse DNA polymerase iota in strand-biased
            mutagenic bypass of UV photoproducts and suppression of skin cancer
  JOURNAL   Proc Natl Acad Sci U S A 103 (48), 18083-18088 (2006)
   PUBMED   17114294
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   McDonald,J.P., Frank,E.G., Plosky,B.S., Rogozin,I.B., Masutani,C.,
            Hanaoka,F., Woodgate,R. and Gearhart,P.J.
  TITLE     129-derived strains of mice are deficient in DNA polymerase iota
            and have normal immunoglobulin hypermutation
  JOURNAL   J Exp Med 198 (4), 635-643 (2003)
   PUBMED   12925679
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473971.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001069113.1, XM_225844.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..2360
                     /gene="Poli"
                     /note="DNA polymerase iota"
                     /db_xref="GeneID:291526"
                     /db_xref="RGD:1305212"
     exon            1..134
                     /gene="Poli"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..2233
                     /gene="Poli"
                     /EC_number="2.7.7.7"
                     /note="polymerase (DNA directed), iota; polymerase (DNA)
                     iota"
                     /codon_start=1
                     /product="DNA polymerase iota"
                     /protein_id="NP_001099607.1"
                     /db_xref="GeneID:291526"
                     /db_xref="RGD:1305212"
                     /translation="MGVEPEEEGGPAEEEDFSRAMEPSDSGAAGGSRAVCDQGAPSRI
                     ASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVR
                     DAKEKCPQLVLVNGEDLSRYREMSYKVTELLEEFSPAVERLGFDENFVDLTEMVEKRL
                     QQLPSDEVPSVTMSGHVYNNQSVNLHSSTHVRLAVGSQIAAEMREAMHNQLGLTGCAG
                     VAPNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEMPGIGYKTAKRLEVLGIN
                     SVHDLQTFPIKTLEKELGISVAQRIRKLSFGEDKSPVTPSGPPQSFSEEDTFKKCSSE
                     VEAKTKIEELLSSLLNRVCHDGRKPHTIRLVIRRYSDKHCNRESRQCPIPSHVIQKLG
                     TGNYDAVPPLMEILMKLFRNMVNVKMAFHLTLLSVCFCNLKALNSAKKGPMDCFLTSS
                     LSTTACSGKRSFKVKDIHMEDSYKEKEANWDCLPSRRIESTRRGESPSDATCFPKEKD
                     TSDLPLQFLPEGVDQEVFTQLPADIQEEILSGKSRENLQGKGSLSCPLHASRGVLSFF
                     STKQTQAGCLSPRDTLLTGKQASAVSPCEPGTSGLSTSSSSHPSCGKDCSYYVDNQLK
                     DERMSQGPTESQGFHFSNTNPAVSVFHSFPNLQSEQLFSTHRTADSHKQTATTSHQGL
                     ENREQDSADEKLTFPSDIDPQVFYELPEEVQRELMAEWKRAGAEFPSVHK"
     exon            135..260
                     /gene="Poli"
                     /inference="alignment:Splign:2.1.0"
     exon            261..425
                     /gene="Poli"
                     /inference="alignment:Splign:2.1.0"
     exon            426..578
                     /gene="Poli"
                     /inference="alignment:Splign:2.1.0"
     exon            579..815
                     /gene="Poli"
                     /inference="alignment:Splign:2.1.0"
     exon            816..994
                     /gene="Poli"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1086
                     /gene="Poli"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1214
                     /gene="Poli"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1420
                     /gene="Poli"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..2360
                     /gene="Poli"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagcagctg cgctgcggtt ggcccgaagg gaagatgggg gtggagccgg aggaggaagg
       61 cggccctgcg gaggaagaag acttttctcg tgccatggag ccctcggact cgggggctgc
      121 gggcggctcg cgggcagttt gcgatcaagg ggcaccatca cgaatcgctt cgtccagagt
      181 catagtacat gtggacctgg attgttttta tgcccaagta gagatgatct ccaatccaga
      241 attaaaggac aaacctttag gtgtgcaaca gaaatacttg gtggttactt gcaactatga
      301 agccaggaaa cttggagtga agaagcttat gaatgtcaga gatgcaaaag aaaagtgtcc
      361 tcagctcgtc ctggtgaatg gagaagactt gagccgctac cgggagatgt cctataaggt
      421 cacagaattg ttggaggaat ttagtccagc tgtggagagg cttggatttg atgaaaattt
      481 tgtggatctg acagaaatgg ttgagaaaag actgcagcag cttccgagtg acgaggttcc
      541 gtcagtgacc atgtccggcc atgtttacaa taaccagtct gtaaacctgc acagcagcac
      601 gcatgtgaga cttgcggttg gatcgcagat tgcagcagag atgcgggaag ccatgcataa
      661 ccagctgggg ctcacaggct gcgctggcgt agcgcctaat aaactattgg caaagttagt
      721 gtctggtgtt tttaaaccaa atcaacagac agtcttatta cctgagagtt gtcagcatct
      781 cattcacagt ttgaaccaca taaaggaaat gcctggtatc ggctataaaa ccgccaagcg
      841 tcttgaagtc ctgggaatca atagtgtgca tgatctccag acctttccaa tcaaaacctt
      901 agaaaaggaa ttgggaattt ctgttgctca gcgcatccgg aagctcagct ttggagagga
      961 caagtcgcct gtaacaccct cagggccacc acagtccttt agtgaagaag atacatttaa
     1021 aaagtgttcc tcagaagtgg aagctaaaac taagattgaa gaattacttt ccagcctttt
     1081 aaacagagta tgccatgatg gaaggaagcc ccatacaata agattagtca tccgtcgata
     1141 ctctgacaaa cactgtaatc gagagagtcg ccagtgccca atcccatctc acgtcattca
     1201 gaagttaggg acaggaaatt atgatgcagt gccgcccctg atggagatcc ttatgaaact
     1261 tttccgaaat atggtaaatg tgaagatggc ctttcacctg acccttctga gtgtgtgctt
     1321 ctgcaacctg aaagccctga acagtgctaa gaaagggcct atggactgct tcctaacgtc
     1381 gtccctgtca acaactgcct gctctggcaa gcggagcttt aaagtgaagg acatccacat
     1441 ggaggactcc tacaaggaga aagaagcaaa ctgggattgt ctcccaagta gaagaatcga
     1501 aagcacgaga aggggggagt ctccatcgga tgccacctgc tttcctaaag aaaaggacac
     1561 gagtgacttg ccactccagt tcctgccaga gggtgttgac caagaagtct tcacgcagct
     1621 tccagcagat attcaagaag aaatcctttc tggaaaatct agagaaaatc ttcaagggaa
     1681 aggaagtttg agttgtccgt tacatgcctc gagaggagta ttgtctttct tttctacaaa
     1741 gcagacgcag gcgggctgct taagtcccag agatactctg ctcactggca agcaggcatc
     1801 ggctgtgtct ccctgtgagc cgggaacgtc ggggttgagt accagtagct cctcccatcc
     1861 atcctgcgga aaggactgct cctattatgt agataatcag ttaaaggacg aacgtatgag
     1921 tcaaggccct acagagtctc agggattcca cttttccaat acgaaccctg ctgtttccgt
     1981 ttttcattca tttccaaatc tgcagagtga acagcttttc tccacacacc gcactgcaga
     2041 cagccacaag cagacagcca ccacctctca ccagggacta gaaaacagag agcaagattc
     2101 tgctgatgaa aagcttactt tcccatcgga cattgatcct caggttttct atgagctacc
     2161 agaagaggtc caaagagaac tgatggccga atggaagaga gctggggcag agttcccctc
     2221 tgtgcacaag taagtgcact caggagaaag ccagggcgtg gccgttccca gattatcttt
     2281 tcataattaa acagtaatat tcaatggtgt agaaatccga tgtaagatgt tatagataag
     2341 gcaaaagtgg atgcaggaag
//
