LOCUS       NM_001108204            3179 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus DNA polymerase eta (Polh), mRNA.
ACCESSION   NM_001108204 XM_001066743 XM_236934
VERSION     NM_001108204.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3179)
  AUTHORS   Girard E, Eon-Marchais S, Olaso R, Renault AL, Damiola F, Dondon
            MG, Barjhoux L, Goidin D, Meyer V, Le Gal D, Beauvallet J, Mebirouk
            N, Lonjou C, Coignard J, Marcou M, Cavaciuti E, Baulard C, Bihoreau
            MT, Cohen-Haguenauer O, Leroux D, Penet C, Fert-Ferrer S, Colas C,
            Frebourg T, Eisinger F, Adenis C, Fajac A, Gladieff L, Tinat J,
            Floquet A, Chiesa J, Giraud S, Mortemousque I, Soubrier F,
            Audebert-Bellanger S, Limacher JM, Lasset C, Lejeune-Dumoulin S,
            Dreyfus H, Bignon YJ, Longy M, Pujol P, Venat-Bouvet L, Bonadona V,
            Berthet P, Luporsi E, Maugard CM, Nogues C, Delnatte C, Fricker JP,
            Gesta P, Faivre L, Lortholary A, Buecher B, Caron O,
            Gauthier-Villars M, Coupier I, Servant N, Boland A, Mazoyer S,
            Deleuze JF, Stoppa-Lyonnet D, Andrieu N and Lesueur F.
  TITLE     Familial breast cancer and DNA repair genes: Insights into known
            and novel susceptibility genes from the GENESIS study, and
            implications for multigene panel testing
  JOURNAL   Int J Cancer 144 (8), 1962-1974 (2019)
   PUBMED   30303537
REFERENCE   2  (bases 1 to 3179)
  AUTHORS   Kamath-Loeb AS, Lan L, Nakajima S, Yasui A and Loeb LA.
  TITLE     Werner syndrome protein interacts functionally with translesion DNA
            polymerases
  JOURNAL   Proc Natl Acad Sci U S A 104 (25), 10394-10399 (2007)
   PUBMED   17563354
REFERENCE   3  (bases 1 to 3179)
  AUTHORS   Dumstorf CA, Clark AB, Lin Q, Kissling GE, Yuan T, Kucherlapati R,
            McGregor WG and Kunkel TA.
  TITLE     Participation of mouse DNA polymerase iota in strand-biased
            mutagenic bypass of UV photoproducts and suppression of skin cancer
  JOURNAL   Proc Natl Acad Sci U S A 103 (48), 18083-18088 (2006)
   PUBMED   17114294
REFERENCE   4  (bases 1 to 3179)
  AUTHORS   Yamada A, Masutani C, Iwai S and Hanaoka F.
  TITLE     Complementation of defective translesion synthesis and UV light
            sensitivity in xeroderma pigmentosum variant cells by human and
            mouse DNA polymerase eta
  JOURNAL   Nucleic Acids Res 28 (13), 2473-2480 (2000)
   PUBMED   10871396
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473987.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001066743.1, XM_236934.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3179
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..3179
                     /gene="Polh"
                     /note="DNA polymerase eta"
                     /db_xref="GeneID:316235"
                     /db_xref="RGD:1309893"
     exon            1..305
                     /gene="Polh"
                     /inference="alignment:Splign:2.1.0"
     exon            306..447
                     /gene="Polh"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..2380
                     /gene="Polh"
                     /EC_number="2.7.7.7"
                     /note="DNA-directed DNA polymerase eta; polymerase (DNA
                     directed), eta (RAD 30 related); polymerase (DNA) eta"
                     /codon_start=1
                     /product="DNA polymerase eta"
                     /protein_id="NP_001101674.1"
                     /db_xref="GeneID:316235"
                     /db_xref="RGD:1309893"
                     /translation="MAPGQDLVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKG
                     GGIIAVSYEARAFGVTRNMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVEVMEI
                     MSHFAVIERASIDEAYIDLTNAVQERLEKLQGQPVSADLLPSTYIEGLPRGPAVEDTV
                     EKEDIRKQGLLQWLGSLEKDDPTSPDLRLTVGAVIVEEMRAAIERKTGFQCSAGISHN
                     KVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRSLGGKLGASVIDVLGVEYMGD
                     LTQFTEAQLQSHFGEKNGSWLYAMCRGIEHEPVKPRQLPKTIGCSKNFPGKTALATRE
                     QVQWWLLQLALELEERLTKDRTDNGRVATQLVVSIRVEGDKRLSSLRRCCALTRYDAH
                     KMSQDAFATIRNCNTSGVQTEWSPPLTMLFLCATKFSASAPPACTDITVFLSSDSGCQ
                     PKVPAASSGTRTQEPGPAAPTSKEAATSLESFFQKAAKRQRMRETSFVPPKVAVEKSS
                     SKPSLLFQTSGSPGTKSFFKQKSLLLQHTELSNAAAPCPPQASSAVQPSRLPTDRADS
                     RASCEEVCKPVSSKAVSTEVNVAGNSSLAYNSQEMTQRAAEDQVLCEKCDSLVPVWDM
                     PEHLDYHFALELQKSFLQPCTSKPQAVPVSPQGKRNPKSPLASSNKRLRPHGMQTLES
                     FFKPLTH"
     exon            448..582
                     /gene="Polh"
                     /inference="alignment:Splign:2.1.0"
     exon            583..797
                     /gene="Polh"
                     /inference="alignment:Splign:2.1.0"
     exon            798..967
                     /gene="Polh"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1071
                     /gene="Polh"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1191
                     /gene="Polh"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1315
                     /gene="Polh"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1381
                     /gene="Polh"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1551
                     /gene="Polh"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..3179
                     /gene="Polh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagttctgc ggtgcgcagg cgcatcaacc gtctctctca gcgcgcgcgg tgctgaactc
       61 ctaatttccc ctgggcttgc tgtggggcgc aaaccttcag gctctgaagg ctgtttgctc
      121 ggaaggatcc gagggataac tactcggttc tgtgtcacca caggcagtaa gtctctctcg
      181 gaacctactg acctgatcct gggaaggcga cgacctcgtc tagacgctgt cattttcctt
      241 ccagtggact cagcccggaa cccggagcat cgctcttggc agtttgacag gtgtctgtcg
      301 ccttgactaa atggctccag gacaggacct cgtggttgct cttgtagaca tggactgttt
      361 tttcgtacaa gtggaacagc ggcaaaatcc tcatttaagg aataaacctt gtgcagttgt
      421 acagtacaaa tcatggaaag gtggtggaat tattgcagtg agctatgagg cgcgtgcatt
      481 tggcgtgact agaaacatgt gggctgatga tgctaagaag ttatgtccag atcttctgct
      541 ggcacaagtt cgtgagtccc gtgggaaagc taacctcacc aagtaccggg aagctagtgt
      601 tgaagtgatg gagataatgt ctcactttgc tgtgattgaa cgtgccagca tcgatgaggc
      661 ttatatagat ttgaccaatg ctgtgcagga aagacttgaa aagttacaag gtcagcctgt
      721 ctcagcagac ttgttgccaa gcacatacat tgaagggctg ccccgaggcc ccgcggtaga
      781 ggacactgtt gagaaagagg atattcgaaa acaaggctta cttcaatggc ttggttctct
      841 tgagaaagat gatcccacct ctccagacct acggctgacg gtgggtgcgg tgattgtgga
      901 agaaatgaga gcagccatag agaggaagac tggctttcag tgctcagccg ggatttcaca
      961 caataaggtc ctggcaaaac ttgcttgtgg actaaacaag cccaaccgcc aaaccctggt
     1021 ctcacatggg tcagtgccac agctcttcag ccagatgcca atccgtaaaa tccgaagtct
     1081 tggaggaaag cttggggctt ctgtcattga cgtccttggg gtagaataca tgggtgacct
     1141 gacccagttc actgaagccc agctccagag tcattttgga gagaagaatg ggtcttggct
     1201 gtatgccatg tgccgaggca ttgaacacga gccagttaaa cccaggcagt tacctaaaac
     1261 tattggctgt agcaagaact tcccagggaa aacagctctg gctactcggg aacaggtaca
     1321 gtggtggctt ctgcagttag ccctggaact tgaggagaga ctaaccaaag accggactga
     1381 caatggcagg gtggccactc agttggtcgt cagtattcgt gttgaaggag acaagcgtct
     1441 cagcagcctg cgtcggtgct gtgccctcac tcgctatgac gctcacaaga tgagccagga
     1501 cgcatttgct actatcagga actgtaacac atctggagtc cagactgagt ggtcccctcc
     1561 tctcacaatg ctcttcctct gtgctaccaa gttctctgct tccgcccctc cagcctgcac
     1621 ggatatcact gtattcctga gcagtgactc cggttgtcag ccaaaggtgc cagctgccag
     1681 ctcggggacc aggactcagg aacctggccc ggctgcaccc acctctaaag aggcagccac
     1741 atccctagag tctttttttc aaaaggctgc caagaggcag agaatgagag agacttcctt
     1801 tgtacctcct aaggtggccg tggagaagtc atcatccaag ccttcccttc tgttccaaac
     1861 cagcggaagc ccaggaacta agtctttctt caagcagaag agtctgctgc tacagcacac
     1921 agagctgagc aatgctgcag ctccatgccc tccacaggcc agctctgcag tgcaaccaag
     1981 ccgtctcccc acagaccgtg cagacagccg tgcttcttgt gaagaagtgt gcaagccggt
     2041 atcctctaaa gcagtttcta cagaagtgaa tgtggctggg aacagttctt tagcttacaa
     2101 ctcgcaggag atgacccaaa gggcagctga ggaccaagtg ctgtgtgaga agtgtgactc
     2161 cctggtccca gtatgggaca tgccagagca cctggactac cattttgcac tggagttgca
     2221 gaagtctttt ttgcagcctt gtacttcaaa accccaggct gtccccgtgt ctcctcaggg
     2281 caaaagaaat cccaagagtc ctttggcttc cagtaataaa cgccttaggc cccacggcat
     2341 gcagacactg gaatcatttt ttaagccatt gacacattag tgctgccctc gggcttgcag
     2401 gagaacttta ctgttttatt tctaagagat ggaaccacgt tggttactca agggaactat
     2461 gaaattttaa tacattattt ttttcttttt tccaatggga ttctgatcct gttgctgatc
     2521 aaaacgtttt taatctttag ggagatacag tgtcataaaa ggtataaggg accatggcaa
     2581 actccctcag cttcgagcta tcgcactttc ctccctataa tattgactaa ggactaaaca
     2641 tcatatattt aggggtgtaa cgcaaaagat tgaaacagaa aaggggaaaa atggggctgg
     2701 acatatggct cacttgttta ggacagcatg tgcggggccc catgttcact tcccagttta
     2761 aagtaaggac tatcaagatg ggcaagtact aatggctgaa gcaacggatt cagcagtctt
     2821 cctcagccat gcaggccttg ggattaaatc tcttaggcct ctctgataaa ttacatgact
     2881 gaattatgta tgaatcaggt agtaggttta atgggtagga aagtagcaca cacatctccc
     2941 ctacataaat acaaatcaac ttactcagta attgggtctc taagatgaga ttcagtggtt
     3001 aggaggaacc atccttgcct tggatcttag tgtgtagctt cttcctagat ttatagtttc
     3061 ttaacggcaa gaactcctgc agtgcattac atggaatatg ttcttgatgt tgtttgaatg
     3121 tgtgtaataa aaaactatag atctacctgc ccatagagac aacaagaatg tactctgag
//
