LOCUS       NM_053528               4547 bp    mRNA    linear   ROD 14-APR-2024
DEFINITION  Rattus norvegicus DNA polymerase gamma, catalytic subunit (Polg),
            mRNA.
ACCESSION   NM_053528 XM_006229410
VERSION     NM_053528.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4547)
  AUTHORS   Loughran,G., Zhdanov,A.V., Mikhaylova,M.S., Rozov,F.N.,
            Datskevich,P.N., Kovalchuk,S.I., Serebryakova,M.V., Kiniry,S.J.,
            Michel,A.M., O'Connor,P.B.F., Papkovsky,D.B., Atkins,J.F.,
            Baranov,P.V., Shatsky,I.N. and Andreev,D.E.
  TITLE     Unusually efficient CUG initiation of an overlapping reading frame
            in POLG mRNA yields novel protein POLGARF
  JOURNAL   Proc Natl Acad Sci U S A 117 (40), 24936-24946 (2020)
   PUBMED   32958672
REFERENCE   2  (bases 1 to 4547)
  AUTHORS   Hynynen,J., Pokka,T., Komulainen-Ebrahim,J., Myllynen,P.,
            Karppa,M., Pylvanen,L., Kalviainen,R., Sokka,A., Jyrkila,A.,
            Lahdetie,J., Haataja,L., Makitalo,A., Ylikotila,P., Eriksson,K.,
            Haapala,P., Ansakorpi,H., Hinttala,R., Vieira,P., Majamaa,K.,
            Rantala,H. and Uusimaa,J.
  TITLE     Variants p.Q1236H and p.E1143G in mitochondrial DNA polymerase
            gamma POLG1 are not associated with increased risk for
            valproate-induced hepatotoxicity or pancreatic toxicity: A
            retrospective cohort study of patients with epilepsy
  JOURNAL   Epilepsia 59 (11), 2125-2136 (2018)
   PUBMED   30255931
REFERENCE   3  (bases 1 to 4547)
  AUTHORS   Siibak,T., Clemente,P., Bratic,A., Bruhn,H., Kauppila,T.E.S.,
            Macao,B., Schober,F.A., Lesko,N., Wibom,R., Naess,K., Nennesmo,I.,
            Wedell,A., Peter,B., Freyer,C., Falkenberg,M. and Wredenberg,A.
  TITLE     A multi-systemic mitochondrial disorder due to a dominant p.Y955H
            disease variant in DNA polymerase gamma
  JOURNAL   Hum Mol Genet 26 (13), 2515-2525 (2017)
   PUBMED   28430993
REFERENCE   4  (bases 1 to 4547)
  AUTHORS   Long,X., Wang,X., Chen,Y., Guo,X., Zhou,F., Fan,Y., Ge,N., Guo,M.,
            Zhang,Z. and Dong,G.
  TITLE     Polymorphisms in POLG were associated with the prognosis and mtDNA
            content in hepatocellular carcinoma patients
  JOURNAL   Bull Cancer 104 (6), 500-507 (2017)
   PUBMED   28457473
REFERENCE   5  (bases 1 to 4547)
  AUTHORS   Bratic,A., Kauppila,T.E., Macao,B., Gronke,S., Siibak,T.,
            Stewart,J.B., Baggio,F., Dols,J., Partridge,L., Falkenberg,M.,
            Wredenberg,A. and Larsson,N.G.
  TITLE     Complementation between polymerase- and exonuclease-deficient
            mitochondrial DNA polymerase mutants in genomically engineered
            flies
  JOURNAL   Nat Commun 6, 8808 (2015)
   PUBMED   26554610
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4547)
  AUTHORS   Van Goethem,G., Dermaut,B., Lofgren,A., Martin,J.J. and Van
            Broeckhoven,C.
  TITLE     Mutation of POLG is associated with progressive external
            ophthalmoplegia characterized by mtDNA deletions
  JOURNAL   Nat Genet 28 (3), 211-212 (2001)
   PUBMED   11431686
REFERENCE   7  (bases 1 to 4547)
  AUTHORS   Lim,S.E., Longley,M.J. and Copeland,W.C.
  TITLE     The mitochondrial p55 accessory subunit of human DNA polymerase
            gamma enhances DNA binding, promotes processive DNA synthesis, and
            confers N-ethylmaleimide resistance
  JOURNAL   J Biol Chem 274 (53), 38197-38203 (1999)
   PUBMED   10608893
REFERENCE   8  (bases 1 to 4547)
  AUTHORS   Ropp,P.A. and Copeland,W.C.
  TITLE     Cloning and characterization of the human mitochondrial DNA
            polymerase, DNA polymerase gamma
  JOURNAL   Genomics 36 (3), 449-458 (1996)
   PUBMED   8884268
REFERENCE   9  (bases 1 to 4547)
  AUTHORS   Jinno,S., Kida,K. and Taguchi,T.
  TITLE     Induction of DNA polymerase beta and gamma in the lungs of
            age-related oxygen tolerant rats
  JOURNAL   Mech Ageing Dev 85 (2-3), 95-107 (1995)
   PUBMED   8786668
REFERENCE   10 (bases 1 to 4547)
  AUTHORS   Lestienne,P.
  TITLE     Evidence for a direct role of the DNA polymerase gamma in the
            replication of the human mitochondrial DNA in vitro
  JOURNAL   Biochem Biophys Res Commun 146 (3), 1146-1153 (1987)
   PUBMED   3619920
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Sep 30, 2022 this sequence version replaced
            XM_006229410.4, NM_053528.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.1830.1,
                                           SRR26643294.2868.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               JAXUCZ010000001.1  142808717-142808838 c
            123-891             JAXUCZ010000001.1  142807228-142807996 c
            892-1087            JAXUCZ010000001.1  142804571-142804766 c
            1088-1252           JAXUCZ010000001.1  142803440-142803604 c
            1253-1399           JAXUCZ010000001.1  142803191-142803337 c
            1400-1479           JAXUCZ010000001.1  142802984-142803063 c
            1480-1662           JAXUCZ010000001.1  142802634-142802816 c
            1663-1811           JAXUCZ010000001.1  142802383-142802531 c
            1812-1938           JAXUCZ010000001.1  142802118-142802244 c
            1939-2175           JAXUCZ010000001.1  142801057-142801293 c
            2176-2293           JAXUCZ010000001.1  142799645-142799762 c
            2294-2371           JAXUCZ010000001.1  142799381-142799458 c
            2372-2479           JAXUCZ010000001.1  142798978-142799085 c
            2480-2640           JAXUCZ010000001.1  142798383-142798543 c
            2641-2694           JAXUCZ010000001.1  142797720-142797773 c
            2695-2812           JAXUCZ010000001.1  142797508-142797625 c
            2813-2948           JAXUCZ010000001.1  142796958-142797093 c
            2949-3195           JAXUCZ010000001.1  142796620-142796866 c
            3196-3318           JAXUCZ010000001.1  142795021-142795143 c
            3319-3487           JAXUCZ010000001.1  142794726-142794894 c
            3488-3696           JAXUCZ010000001.1  142794401-142794609 c
            3697-3857           JAXUCZ010000001.1  142793201-142793361 c
            3858-4547           JAXUCZ010000001.1  142792119-142792808 c
FEATURES             Location/Qualifiers
     source          1..4547
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..4547
                     /gene="Polg"
                     /note="DNA polymerase gamma, catalytic subunit"
                     /db_xref="GeneID:85472"
                     /db_xref="RGD:620057"
     exon            1..122
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            123..891
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..3934
                     /gene="Polg"
                     /EC_number="2.7.7.7"
                     /function="synthesis of mitochondrial DNA"
                     /note="polG-alpha; polymerase (DNA directed), gamma;
                     mitochondrial DNA polymerase catalytic subunit;
                     DNA-directed DNA polymerase gamma; polymerase (DNA) gamma,
                     catalytic subunit; 3'-5' exodeoxyribonuclease;
                     5'-deoxyribose-phosphate lyase"
                     /codon_start=1
                     /product="DNA polymerase subunit gamma-1"
                     /protein_id="NP_445980.2"
                     /db_xref="GeneID:85472"
                     /db_xref="RGD:620057"
                     /translation="MSRLLWKKVAGAKVASGPVPATGRWVSSSVLDPVPSDGQPQSQM
                     PSSENGQLRLNPLHIQMLSRGLHEQIFGCGGDVPDEAAVQRSIEHLRKHGLWGQPTTP
                     LPDVQLRLPRLFGGNLDQHFRLLAQKQSLPYLEAAASLSEAQLPPQPRKWVWAEGWTR
                     YGPEGEAEPVAIPEERALVFDVEVCLAEGTCPTLAVAISPSAWYSWCSRRLVEERYSW
                     TSQLSPADLIPLGVSASASSSTQQDWQEQLVVGHNVSFDRAHIREQYLIQGSRMRFLD
                     TMSMHMAISGLSSFQRSLWMGAKQGKHKTQHPTKRGQKSQKNANGPAISSWDWMDISS
                     ANNLADVHNLYVGGPRLAKEPRELFVKGSMRDIRENFQDLMEYCARDVWATFEVFQQQ
                     LPLFLERCPHPVTLAGMLEMGVSYLPVNQNWERYLTEAQSTYEELQREMKKSLMELAN
                     DACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKTASASKLPIEGAGPFGDPMDQ
                     EDPGPPSEEEELQQNIMAHTRLQQLKSTTDLLPKRPQHLPGHPGWYRKLCPRLDDPAW
                     TPGPSLLSLQMRVTPKLMALTWDGFPLHYSDSHGWGYLVPGRRDNLTELPVSPTEESA
                     AVTCPYRAIESLYRRHCLDQGKQQLETQETDLAEEFLLTDSAMWQTVEELGCLDVEAE
                     ATVESSGLSQPLVPPTACAPKTSQPTYHHGNGPYNDVDIPGCWFFKLPHKDGNNYNVG
                     SPFAKDFLPKMEDGTLQAGPGGARGPRALEINKMISFWRNAHKRISSQMVVWLPRSAL
                     PRAVTRHPSFDEESHYGAILPQVVTAGTITRRAVEPTWLTASNARPDRVGSELKAMVQ
                     APPGYVLVGADVDSQELWIAAVLGDAHFAGMHGCTAFGWMTLQGRKSRGTDLHSKTAA
                     TVGISREHAKVFNYGRIYGAGQSFAERLLMQFNHRLSRQEAADKAQQMYAVTKGLRRY
                     RLSDDGEWLVKQLNVPVDRTEDGWVSLQDLRKIRREASRKSRWKKWEVVTERAWTGGT
                     ESEMFNKLESIAMSDTPRTPVLGCCISRALEPSVVQGEFMTSRVNWVVQSSAVDYLHL
                     MLVAMKWLFEEFAIDGRFCISIHDEVRYLVREEDRYRAALALQITNLLTRCMFAYKLG
                     LNDLPQSVAFFSAVDIDQCLRKEVTMDCKTPSNPTGMERKYGIPQGEALDIYQIIELT
                     KGSLEKRSQPGP"
     exon            892..1087
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1252
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1399
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1479
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1662
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1811
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1938
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2175
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2293
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2371
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            2372..2479
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2640
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2694
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2812
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2948
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            2949..3195
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3318
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3487
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3696
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            3697..3857
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
     exon            3858..4547
                     /gene="Polg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagttgcggc tgctctccag accgcacgcc acccggaggc tgcgtgggcc gcgcgcagcg
       61 gacgccgcgt cgttgccagg gctgtgggct gccgcaggac gggaagcgcg gaacagaccg
      121 aggatttgtg tgaggaaggc aggcatggtg agacctattt cactgacagg aacacagaga
      181 ggggacgtgt ctctctctga gtctttcggc cagtaaaaag cagtcaagct ggagcccaaa
      241 gccaggtgtc ccgactcaca gcggggggct ccctgcacca accatgagcc gcctgctctg
      301 gaagaaggtg gccggcgcca aagtcgcctc agggccagta ccagcaacag gacgctgggt
      361 ctccagctcc gtcctcgacc ccgtccccag cgacgggcag ccgcagtcgc aaatgccctc
      421 ctcagagaat gggcagctgc ggctcaaccc tctgcacatc cagatgctgt cgagaggcct
      481 gcacgagcaa atcttcgggt gcggagggga cgtgcccgac gaggccgcgg tgcagcgcag
      541 catcgagcac ctgcggaagc acgggctctg ggggcagccg accacgccct tgccagacgt
      601 gcagctgcgc ctgccccggc tcttcggggg caacctggac cagcacttcc gcctcctggc
      661 ccagaagcag agcctcccgt acttggaggc ggccgcctcg ttatcggagg cccaattgcc
      721 cccccagccc aggaagtggg tctgggcgga gggctggacc cggtacggcc ccgaggggga
      781 ggccgaaccc gtggccatcc ccgaggagcg ggccctggtg ttcgacgtgg aggtctgctt
      841 ggcagaggga acctgcccca ctttggcggt ggccatatcc ccctcggcct ggtattcctg
      901 gtgcagccgg cggctggtgg aagagcgtta ctcttggacc agccagctgt cgccggctga
      961 cctaatccct ttgggggtct ctgctagtgc cagcagctcc acccagcagg attggcagga
     1021 acagttagtg gtggggcaca atgtttcctt tgaccgagcc catatcaggg agcagtatct
     1081 gattcagggc tcacgcatgc gctttctgga cactatgagc atgcacatgg ctatctcagg
     1141 gctgagcagc ttccagcgca gtctgtggat gggagccaag cagggcaagc acaagaccca
     1201 gcatcctaca aagcgaggtc agaagtccca gaagaatgcg aatggtccag cgatttcatc
     1261 ttgggactgg atggacatca gcagtgctaa taatcttgca gacgtgcaca acctttatgt
     1321 ggggggacct cgcttagcga aggagcctcg ggaactgttc gtcaaaggca gcatgaggga
     1381 tatcagggag aacttccagg atctgatgga gtactgtgct cgtgatgtgt gggccacctt
     1441 tgaggttttc cagcagcagc tgccgctctt cttggagagg tgtccccacc cagtgactct
     1501 ggctggcatg ctggagatgg gtgtctccta cctgcctgtc aaccagaact gggagcggta
     1561 cctgacagaa gcacagagca catatgagga actccagcgg gagatgaaga agtcgctgat
     1621 ggagctggct aatgacgcct gccagttgct ctcaggagag aggtacaaag aagacccttg
     1681 gctctgggac ctagaatggg acttgcagga atttaagcag aaaaaggcaa agaaggtgaa
     1741 gaagacagcc tcagccagca agttgcccat cgagggagct gggccctttg gggatcccat
     1801 ggatcaggaa gatcctggac cacccagtga ggaggaggag cttcagcaaa atataatggc
     1861 ccacacccgt ttacagcagc tgaagagcac cacagacctc ctgcctaagc gaccccaaca
     1921 ccttcctgga caccctgggt ggtaccggaa actctgccct cggctagatg accctgcatg
     1981 gactccgggc cccagcctcc tcagcctgca aatgcgggtc actcctaagc tcatggcact
     2041 gacctgggat ggttttcctc tacactactc agactctcat ggttggggct acctggtgcc
     2101 tgggcggcgg gataatctga ctgagctgcc agtgagcccc actgaggagt cagctgcggt
     2161 gacctgcccc tacagagcca tcgagtcctt gtacaggagg cactgtcttg accagggcaa
     2221 gcagcagctg gagacccagg agacagacct ggctgaggag ttcttgctca cggacagtgc
     2281 catgtggcag acggtagaag aactgggctg cttagatgtg gaggctgagg ccacagtgga
     2341 gagttcaggg ctgagtcagc ccctagttcc gcctactgct tgtgccccca aaaccagcca
     2401 gcccacttat caccatggca acggacctta taatgatgtg gatatccccg gttgctggtt
     2461 tttcaagctg cctcacaagg atggtaacaa ctacaatgtg ggtagtccct ttgccaaaga
     2521 tttcctgccc aagatggaag acggcactct gcaggctggc ccagggggtg ccaggggacc
     2581 tcgtgccctg gaaataaata aaatgatttc tttttggagg aatgctcata aacgcatcag
     2641 ctcccagatg gtggtatggc tccccaggtc agctctgccc cgggctgtga ccaggcaccc
     2701 cagctttgat gaggaaagcc actatggggc catcctgccc caggtggtga ctgctggcac
     2761 catcacccgt cgcgctgtgg agcccacgtg gctcaccgcc agcaatgctc ggcctgaccg
     2821 ggtaggcagt gagttgaaag ccatggtgca ggctccacct ggctatgtcc ttgtgggtgc
     2881 tgatgtggac tcacaggaac tgtggatcgc agccgttctt ggagatgctc actttgctgg
     2941 gatgcatggc tgcacggcct ttggctggat gactcttcag ggcaggaaga gcagaggcac
     3001 tgatctgcac agtaagacag ccgccactgt gggcatcagt cgtgagcacg ccaaagtctt
     3061 caactacggc cgcatctacg gggctgggca gtcctttgcc gagcgcctgc tgatgcagtt
     3121 caaccacagg ctctcaaggc aggaggcagc tgacaaggcc cagcagatgt acgctgtcac
     3181 gaaaggcctg cgccgatacc ggctctcaga tgatggtgaa tggctggtga aacagttaaa
     3241 tgttcctgtg gacaggacag aagacggctg ggtttcccta caagatcttc gaaagatccg
     3301 aagagaagct tcaaggaagt ctcgatggaa gaagtgggag gtagtcactg aacgagcatg
     3361 gacagggggt acggagtcag aaatgtttaa taagctggag agcattgcca tgtctgacac
     3421 accacgcacc ccagtgctgg gctgctgcat cagcagagcc ttggagccct cggttgtcca
     3481 gggagagttt atgaccagtc gtgtgaattg ggtggtacag agctctgctg tggactactt
     3541 acacctcatg cttgtggcca tgaagtggct gtttgaggaa tttgccattg atgggcgctt
     3601 ctgcatcagc atccatgatg aggtgcgcta cctggtacgt gaggaggacc gctaccgtgc
     3661 tgccctggca ctgcagatca ccaatctcct gaccaggtgc atgtttgcct acaagctggg
     3721 tctgaatgac ctgccccagt cagttgcctt tttcagtgca gtagacattg accagtgcct
     3781 caggaaggaa gtgaccatgg actgtaaaac tccttctaac ccaactggga tggaaaggaa
     3841 atacgggatt ccccagggtg aagcactgga tatttaccag ataattgaac tcaccaaagg
     3901 ctccttggaa aaacgaagcc agcctggacc ctagctctgt ctggaggctc tgtatttgct
     3961 cctgtggagc ttcattggcg tggtgcaggc tccttaactc aggctttccc atgtgctttt
     4021 tgcaaaaggc agccattttt ctgtagcagg acctgcccag aagagtcctt ctaacggaag
     4081 gcacagttca gtgtgttcag aacaggacac caacatcagt gcaggctgta tgacaagggg
     4141 tactgttggg cacaaatgaa gcagatgccc caaggtcaca ttaactcagg catttcttcc
     4201 ttctcttctt ggctggttct ctgtcctgct gtgtatgtgc tgatgcagtg ccctggaagg
     4261 aagagtagaa tccttgacaa ccttgctcta aggtgatggg aataaaaaca aacaccaaac
     4321 tcctggatca gtcatgcttt tcctgtctgc ctcccaggca gggattcaga cccccagtcc
     4381 tgagtagagt gtgcctaact cctacttgga catggtgaca gcaacctcag tcacaatgct
     4441 acatgtggcc tttcaaagga gacagggcct acagcacagg gatctaaaga attcatgctc
     4501 agccagctat ccaagttact ttatataaat ttctaatttt gactgtg
//
