LOCUS       NM_001169108            1696 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DNA polymerase epsilon 2, accessory subunit
            (Pole2), mRNA.
ACCESSION   NM_001169108 XM_001076651 XM_216727
VERSION     NM_001169108.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1696)
  AUTHORS   Baranovskiy,A.G., Lada,A.G., Siebler,H.M., Zhang,Y., Pavlov,Y.I.
            and Tahirov,T.H.
  TITLE     DNA polymerase delta and zeta switch by sharing accessory subunits
            of DNA polymerase delta
  JOURNAL   J Biol Chem 287 (21), 17281-17287 (2012)
   PUBMED   22465957
REFERENCE   2  (bases 1 to 1696)
  AUTHORS   Pospiech,H. and Syvaoja,J.E.
  TITLE     DNA polymerase epsilon - more than a polymerase
  JOURNAL   ScientificWorldJournal 3, 87-104 (2003)
   PUBMED   12806123
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1696)
  AUTHORS   Li,Y., Pursell,Z.F. and Linn,S.
  TITLE     Identification and cloning of two histone fold motif-containing
            subunits of HeLa DNA polymerase epsilon
  JOURNAL   J Biol Chem 275 (30), 23247-23252 (2000)
   PUBMED   10801849
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On or before Dec 16, 2009 this sequence version replaced
            XM_216727.3, XM_001076651.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000006.1  93435269-93435361   c
            94-194              JAXUCZ010000006.1  93433572-93433672   c
            195-270             JAXUCZ010000006.1  93430502-93430577   c
            271-348             JAXUCZ010000006.1  93429779-93429856   c
            349-442             JAXUCZ010000006.1  93429336-93429429   c
            443-517             JAXUCZ010000006.1  93423324-93423398   c
            518-601             JAXUCZ010000006.1  93421536-93421619   c
            602-658             JAXUCZ010000006.1  93420926-93420982   c
            659-707             JAXUCZ010000006.1  93420257-93420305   c
            708-780             JAXUCZ010000006.1  93419636-93419708   c
            781-953             JAXUCZ010000006.1  93418226-93418398   c
            954-1043            JAXUCZ010000006.1  93417743-93417832   c
            1044-1098           JAXUCZ010000006.1  93417356-93417410   c
            1099-1158           JAXUCZ010000006.1  93416323-93416382   c
            1159-1236           JAXUCZ010000006.1  93416161-93416238   c
            1237-1345           JAXUCZ010000006.1  93414712-93414820   c
            1346-1522           JAXUCZ010000006.1  93413173-93413349   c
            1523-1590           JAXUCZ010000006.1  93411943-93412010   c
            1591-1696           JAXUCZ010000006.1  93410758-93410863   c
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1696
                     /gene="Pole2"
                     /note="DNA polymerase epsilon 2, accessory subunit"
                     /db_xref="GeneID:299112"
                     /db_xref="RGD:1311962"
     exon            1..93
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1609
                     /gene="Pole2"
                     /EC_number="2.7.7.7"
                     /note="polymerase (DNA directed), epsilon 2 (p59 subunit);
                     polymerase (DNA directed), epsilon 2, accessory subunit;
                     polymerase (DNA) epsilon 2, accessory subunit"
                     /codon_start=1
                     /product="DNA polymerase epsilon subunit 2"
                     /protein_id="NP_001162579.1"
                     /db_xref="GeneID:299112"
                     /db_xref="RGD:1311962"
                     /translation="MAPERLRSRTVSAFKLRGLLLRSEATKYLTEALQSVTELELEEN
                     LEKIIDAVEKQPLSSNMIERSVVEAAVQECSQSVDETIEHIFNIIGAFDIPHFIYNSE
                     RKKFLPLSMTNHAAPTIFGTARDKAELYRERYTILHQRTHRHELFTPPVIGSHPDESG
                     SKFQLKTIETLLGSTSKVGDVIVLGMITQLKEGKFFLEDPTGTVQLDLSKAQFHSGLY
                     TEACFVLAEGCFEDQVFHANAFGFPPTEPSSTTRAYYGNINFFGGPSNASVKASAKLR
                     QLEEENKDAMFVIVSDVWLDQVQVLEKLHVMFSGYSPAPPTCFILCGNFSSAPYGKNQ
                     VQALKDSLKSLADIICEYPSIHQSSRFVFVPGPEDPGFGSILPRPPLAESITQEFRQR
                     VPFSVFTTNPCRIQYCTQEIIIFREDLVNKMCRNCVRFPSSSLDIPTHFVKTVLSQGH
                     LAPLPLYVSPVYWAYDYTLRVYPVPDLLVIADKYDPFTVTNTECLCINPGSFPRSGFA
                     FKVFYPSSKTVEDSKLQGF"
     exon            94..194
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            195..270
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            271..348
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            349..442
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            443..517
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            518..601
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..658
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..707
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..780
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            781..953
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1043
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1098
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1158
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1236
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1345
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1522
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1590
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1696
                     /gene="Pole2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcggcggtgg cgccaaatct caaacatggc gccggagcgg ctgcggagcc gcacggtctc
       61 agctttcaag cttcggggct tgctgctcag gagtgaagcc actaagtatc tcactgaagc
      121 tctccagtct gtcactgaat tggagctcga ggagaaccta gaaaagatca ttgatgcagt
      181 tgaaaagcag cccttgtcat caaacatgat cgaacgatct gtagtggaag cagctgtcca
      241 ggagtgcagt cagtctgttg atgagactat agaacatatt ttcaatatca ttggagcttt
      301 tgatattcca cattttatat ataattcaga aagaaaaaag tttcttcctc tatcaatgac
      361 taaccatgct gcaccaacca tatttggaac agcaagggac aaagccgagc tgtaccgtga
      421 acgatacacc attttacacc agaggacgca cagacatgaa ttgttcactc ctccagtgat
      481 aggctcacac cccgacgaaa gtggaagcaa attccagctt aaaacaatag aaactttgct
      541 gggtagtacg agtaaagttg gtgacgtgat tgtccttgga atgataaccc agttgaaaga
      601 ggggaagttt ttcctggaag accctactgg aactgtacag ctggacctta gtaaagctca
      661 gttccacagt ggcctataca ctgaggcatg ctttgtgctg gccgaaggtt gctttgaaga
      721 tcaagtgttt catgccaatg cctttggatt tcctcccacg gagccctcta gcaccacaag
      781 ggcatactat ggaaatatta atttttttgg agggccttct aatgcgtcag tgaaggcttc
      841 tgcaaaactg agacagctgg aagaggagaa caaggacgcc atgtttgtga ttgtgtccga
      901 cgtttggttg gatcaagtgc aagtgctgga gaagcttcac gtaatgtttt ctggttattc
      961 ccctgcacct ccgacctgct ttatactgtg cggtaacttt tcatctgcac catatggaaa
     1021 aaatcaagtc caggctttga aagattccct aaaatctttg gcagacataa tatgtgaata
     1081 cccaagtatc caccaaagta gccgttttgt gtttgtgcct ggcccggagg atcctggatt
     1141 tggttctatt ttaccaaggc cgccccttgc tgaaagcatc acacaagaat tcagacaaag
     1201 ggtcccattt tctgttttca ctactaaccc ttgcagaatt cagtattgta cacaagaaat
     1261 aattatcttc cgtgaagact tagtgaataa aatgtgtaga aactgtgtcc gctttcctag
     1321 cagcagtttg gatattccta cccatttcgt aaagactgtc ttatctcagg gacatctggc
     1381 tcctctccct ctttacgtgt cccccgtcta ctgggcatat gactacactt tgagagtgta
     1441 cccagtgccc gatctgctgg tcattgcaga caagtacgat ccgttcaccg tgaccaacac
     1501 cgagtgcctc tgcataaacc ctggctcctt tccaagaagt ggatttgcat ttaaagtttt
     1561 ttacccttcc agtaagacag tagaagacag caaacttcag ggcttttgag acttatgaga
     1621 ctacgtgaat gaactttctt atttttatct tatgtatttt gtaaattaaa ttgtaataaa
     1681 cctatggtaa acctta
//
