LOCUS       NM_001401983            1972 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus DNA polymerase delta interacting protein 2
            (Poldip2), mRNA.
ACCESSION   NM_001401983
VERSION     NM_001401983.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1972)
  AUTHORS   Zhu,X., Yan,F., Liu,L. and Huang,Q.
  TITLE     ZEB1 regulates bone metabolism in osteoporotic rats through
            inducing POLDIP2 transcription
  JOURNAL   J Orthop Surg Res 17 (1), 423 (2022)
   PUBMED   36123704
  REMARK    GeneRIF: ZEB1 regulates bone metabolism in osteoporotic rats
            through inducing POLDIP2 transcription.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1972)
  AUTHORS   Gao,M., Lu,W., Shu,Y., Yang,Z., Sun,S., Xu,J., Gan,S., Zhu,S.,
            Qiu,G., Zhuo,F., Xu,S., Wang,Y., Chen,J., Wu,X. and Huang,J.
  TITLE     Poldip2 mediates blood-brain barrier disruption and cerebral edema
            by inducing AQP4 polarity loss in mouse bacterial meningitis model
  JOURNAL   CNS Neurosci Ther 26 (12), 1288-1302 (2020)
   PUBMED   32790044
REFERENCE   3  (bases 1 to 1972)
  AUTHORS   Huff,L.P., Kikuchi,D.S., Faidley,E., Forrester,S.J., Tsai,M.Z.,
            Lassegue,B. and Griendling,K.K.
  TITLE     Polymerase-delta-interacting protein 2 activates the RhoGEF
            epithelial cell transforming sequence 2 in vascular smooth muscle
            cells
  JOURNAL   Am J Physiol Cell Physiol 316 (5), C621-C631 (2019)
   PUBMED   30726115
REFERENCE   4  (bases 1 to 1972)
  AUTHORS   Datla,S.R., L Hilenski,L., Seidel-Rogol,B., Dikalova,A.E.,
            Harousseau,M., Punkova,L., Joseph,G., Taylor,W.R., Lassegue,B. and
            Griendling,K.K.
  TITLE     Poldip2 knockdown inhibits vascular smooth muscle proliferation and
            neointima formation by regulating the expression of PCNA and p21
  JOURNAL   Lab Invest 99 (3), 387-398 (2019)
   PUBMED   30237457
REFERENCE   5  (bases 1 to 1972)
  AUTHORS   Vukelic,S., Xu,Q., Seidel-Rogol,B., Faidley,E.A., Dikalova,A.E.,
            Hilenski,L.L., Jorde,U., Poole,L.B., Lassegue,B., Zhang,G. and
            Griendling,K.K.
  TITLE     NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase delta-Interacting
            Protein 2) Induce Filamentous Actin Oxidation and Promote Its
            Interaction With Vinculin During Integrin-Mediated Cell Adhesion
  JOURNAL   Arterioscler Thromb Vasc Biol 38 (10), 2423-2434 (2018)
   PUBMED   30354218
  REMARK    GeneRIF: Integrin engagement during cell attachment activates
            Poldip2/Nox4 to oxidize actin, which modulates filamentous actin
            assembly and its interaction with vinculin.
REFERENCE   6  (bases 1 to 1972)
  AUTHORS   Bogenhagen,D.F., Rousseau,D. and Burke,S.
  TITLE     The layered structure of human mitochondrial DNA nucleoids
  JOURNAL   J Biol Chem 283 (6), 3665-3675 (2008)
   PUBMED   18063578
REFERENCE   7  (bases 1 to 1972)
  AUTHORS   Klaile,E., Muller,M.M., Kannicht,C., Otto,W., Singer,B.B.,
            Reutter,W., Obrink,B. and Lucka,L.
  TITLE     The cell adhesion receptor carcinoembryonic antigen-related cell
            adhesion molecule 1 regulates nucleocytoplasmic trafficking of DNA
            polymerase delta-interacting protein 38
  JOURNAL   J Biol Chem 282 (36), 26629-26640 (2007)
   PUBMED   17623671
  REMARK    GeneRIF: PDIP38 can shuttle between the cytoplasmic and the nuclear
            compartments and that its subcellular localization is regulated by
            CEACAM1
REFERENCE   8  (bases 1 to 1972)
  AUTHORS   Arakaki,N., Nishihama,T., Kohda,A., Owaki,H., Kuramoto,Y., Abe,R.,
            Kita,T., Suenaga,M., Himeda,T., Kuwajima,M., Shibata,H. and
            Higuti,T.
  TITLE     Regulation of mitochondrial morphology and cell survival by
            Mitogenin I and mitochondrial single-stranded DNA binding protein
  JOURNAL   Biochim Biophys Acta 1760 (9), 1364-1372 (2006)
   PUBMED   16860483
REFERENCE   9  (bases 1 to 1972)
  AUTHORS   Cheng,X., Kanki,T., Fukuoh,A., Ohgaki,K., Takeya,R., Aoki,Y.,
            Hamasaki,N. and Kang,D.
  TITLE     PDIP38 associates with proteins constituting the mitochondrial DNA
            nucleoid
  JOURNAL   J Biochem 138 (6), 673-678 (2005)
   PUBMED   16428295
REFERENCE   10 (bases 1 to 1972)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643293.64527.1,
                                           SRR26643299.44228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               JAXUCZ010000010.1  63905287-63905485
            200-281             JAXUCZ010000010.1  63906816-63906897
            282-379             JAXUCZ010000010.1  63908200-63908297
            380-476             JAXUCZ010000010.1  63910253-63910349
            477-552             JAXUCZ010000010.1  63910511-63910586
            553-660             JAXUCZ010000010.1  63910795-63910902
            661-797             JAXUCZ010000010.1  63910977-63911113
            798-824             JAXUCZ010000010.1  63911828-63911854
            825-950             JAXUCZ010000010.1  63912052-63912177
            951-1030            JAXUCZ010000010.1  63914038-63914117
            1031-1972           JAXUCZ010000010.1  63914714-63915655
FEATURES             Location/Qualifiers
     source          1..1972
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q25"
     gene            1..1972
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /note="DNA polymerase delta interacting protein 2"
                     /db_xref="GeneID:287544"
                     /db_xref="RGD:1307022"
     exon            1..199
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1145
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /note="DNA-directed polymerase delta interacting protein
                     2; polymerase (DNA) delta interacting protein 2;
                     polymerase (DNA-directed), delta interacting protein 2"
                     /codon_start=1
                     /product="polymerase delta-interacting protein 2"
                     /protein_id="NP_001388912.1"
                     /db_xref="GeneID:287544"
                     /db_xref="RGD:1307022"
                     /translation="MAGCVARRALAVGSRWWSRSLATTRGSRPLCAVGGAGALPPVAT
                     ATARRHLSSRNRAEGKVLETVGVFEVPKQNGKYETGQLFLHSVFGYRGVVLFPWQARL
                     YDRDVASAAPEKAENPAGHGSKEVKGKTHTYYQVLIDARDCPHISQRSQTEAVTFLAN
                     HDDSRALYAIPGLDYVSHEDILPYTSTDQVPIQHELFERFLLYDQTKAPPFVARETLR
                     AWQEKNHPWLELSDVHRETTESIRVTVIPFYMGMREAQNSHVYWWRYCIRLENLDSDV
                     VQLRERHWRIFSLSGTLETVRGRGVVGREPVLSKEQPAFQYSSHVSLQASSGHMWGTF
                     RFERPDGSHFDVRIPPFSLESNKDEKTPPSGLHW"
     exon            200..281
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            282..379
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            380..476
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            477..552
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            553..660
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            661..797
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            798..824
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            825..950
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1030
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1972
                     /gene="Poldip2"
                     /gene_synonym="PDIP38"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctgtgtc agcagccgag cgggcgctcg ggcgggacat ggctggctgt gtggcccgac
       61 gggccctagc agtgggcagc cgctggtggt ctcggtcact ggccacgacc cgagggtcga
      121 ggccactgtg tgcggtcggt ggagcagggg cccttccgcc ggtggccaca gcgacggcac
      181 gaaggcatct gtcgtcccga aaccgtgctg agggcaaagt gctggagaca gttggtgtgt
      241 ttgaggtgcc aaaacaaaat ggaaagtatg agacgggaca gctatttctc catagtgttt
      301 ttggctaccg aggggttgtc ctgtttccct ggcaggccag actgtatgac cgggatgtgg
      361 cttctgcagc tccagaaaaa gcagagaacc ctgctggcca tggctctaag gaggtgaaag
      421 gcaaaactca cacttactat caagtgctga ttgatgcccg tgactgccca catatatctc
      481 agagatctca gacagaagct gtgactttct tggctaacca tgatgacagc cgggccctct
      541 atgccatccc aggcttggac tatgtcagcc atgaagacat cctcccctac acctccacgg
      601 atcaggttcc catccagcat gagctctttg agagattcct tctctatgac cagacaaaag
      661 cccctccctt tgtggctcga gagacgctcc gggcctggca agagaagaat cacccatggc
      721 tggagctctc agacgtgcac cgggagacga ccgagagcat ccgtgtcacc gtcatcccct
      781 tctacatggg catgagggaa gcccagaatt cccacgtcta ttggtggcga tactgtatac
      841 gcttggaaaa cttggacagt gacgtggtac agctccggga gcggcactgg cggatattca
      901 gtctctcagg gaccttggaa acagttcgag gacgaggggt ggtgggcagg gaaccggtgt
      961 tatccaagga gcagcctgca ttccagtata gcagccatgt ctctctgcaa gcttccagtg
     1021 ggcacatgtg gggcacattt cgttttgaga gacctgatgg ctcccacttt gatgttcgga
     1081 tcccaccctt ctccttggaa agcaataagg acgagaagac accaccctca ggccttcact
     1141 ggtaggccag ctgaggccct ggttggcccc tacgaacaac agctctcaac ccgtaattgc
     1201 tgcagaactc taaacctctc cctactgtgg gattcttttt tttttttttt ggagagagat
     1261 ggtaactttt cttggaagac ccacataaga ctcctccaag gttggcccct gcccagattc
     1321 tgcttacacc atgttccagc aaaactctgt gttcagtttc cacatgtttc ctggagtgtg
     1381 agatgtggtc aataaagcag tgctcacttg gccaccatgg ccatttttgt cttaggcccc
     1441 cttgctggcc ctataagaac tcttagttgc tttccgtgca aaatttcttc tagggagctg
     1501 ctggctctgc taaggtatgt cttcctcaga ggccggacat ctcctggggg cagtagttaa
     1561 cagtggacag cactggacta agttctcagt ctctttactc tctgcccagt ggagaggagg
     1621 ccagcattta gagttggact gacctgacta taaacacaga ttacccacca gcacccctgg
     1681 cttcactagg cctagagaag agtgaggcaa aaccagtcag gtctcctgga gctgtgggtt
     1741 tctgagaatt gagcaaagtc tgtcaagcat ccagaccaca agtgcaggag tttagccgag
     1801 aagcagctta ggttgtggtc agtgaccaag ccaagccgct ttcggggcta ctttcaggtg
     1861 gacaggagtc agaattgggc tgcatcttgc cccagttctt agggttcctt cacctctgta
     1921 gtcactgtta gaggtccttt cattcttgca ttattaaatc tcagttccag tc
//
