LOCUS       NM_001013050            1585 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus DNA polymerase delta 2, accessory subunit
            (Pold2), mRNA.
ACCESSION   NM_001013050 XM_214079
VERSION     NM_001013050.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1585)
  AUTHORS   Baranovskiy,A.G., Lada,A.G., Siebler,H.M., Zhang,Y., Pavlov,Y.I.
            and Tahirov,T.H.
  TITLE     DNA polymerase delta and zeta switch by sharing accessory subunits
            of DNA polymerase delta
  JOURNAL   J Biol Chem 287 (21), 17281-17287 (2012)
   PUBMED   22465957
REFERENCE   2  (bases 1 to 1585)
  AUTHORS   Lehmann,A.R.
  TITLE     DNA polymerases and repair synthesis in NER in human cells
  JOURNAL   DNA Repair (Amst) 10 (7), 730-733 (2011)
   PUBMED   21601536
  REMARK    Review article
REFERENCE   3  (bases 1 to 1585)
  AUTHORS   Li,G.M.
  TITLE     Mechanisms and functions of DNA mismatch repair
  JOURNAL   Cell Res 18 (1), 85-98 (2008)
   PUBMED   18157157
  REMARK    Review article
REFERENCE   4  (bases 1 to 1585)
  AUTHORS   Zhou,J., Ren,K., Liu,X., Xiong,X., Hu,X. and Zhang,J.
  TITLE     A novel PDIP1-related protein, KCTD10, that interacts with
            proliferating cell nuclear antigen and DNA polymerase delta
  JOURNAL   Biochim Biophys Acta 1729 (3), 200-203 (2005)
   PUBMED   15982757
REFERENCE   5  (bases 1 to 1585)
  AUTHORS   Ducoux,M., Urbach,S., Baldacci,G., Hubscher,U., Koundrioukoff,S.,
            Christensen,J. and Hughes,P.
  TITLE     Mediation of proliferating cell nuclear antigen (PCNA)-dependent
            DNA replication through a conserved p21(Cip1)-like PCNA-binding
            motif present in the third subunit of human DNA polymerase delta
  JOURNAL   J Biol Chem 276 (52), 49258-49266 (2001)
   PUBMED   11595739
REFERENCE   6  (bases 1 to 1585)
  AUTHORS   Popanda,O., Flohr,T., Fox,G. and Thielmann,H.W.
  TITLE     A mutation detected in DNA polymerase delta cDNA from Novikoff
            hepatoma cells correlates with abnormal catalytic properties of the
            enzyme
  JOURNAL   J Cancer Res Clin Oncol 125 (11), 598-608 (1999)
   PUBMED   10541966
REFERENCE   7  (bases 1 to 1585)
  AUTHORS   Lopez-Girona,A., Bachs,O. and Agell,N.
  TITLE     Calmodulin is involved in the induction of DNA polymerases alpha
            and delta activities in normal rat kidney cells activated to
            proliferate
  JOURNAL   Biochem Biophys Res Commun 217 (2), 566-574 (1995)
   PUBMED   7503737
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079267.1.
            
            On Apr 20, 2005 this sequence version replaced XM_214079.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079267.1, SRR8487230.66767.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1585
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..1585
                     /gene="Pold2"
                     /note="DNA polymerase delta 2, accessory subunit"
                     /db_xref="GeneID:289758"
                     /db_xref="RGD:1304954"
     exon            1..19
                     /gene="Pold2"
                     /inference="alignment:Splign:2.1.0"
     exon            20..296
                     /gene="Pold2"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1486
                     /gene="Pold2"
                     /EC_number="2.7.7.7"
                     /note="DNA polymerase delta subunit p50; DNA-directed DNA
                     polymerase delta 2; polymerase (DNA directed), delta 2,
                     regulatory subunit; polymerase (DNA directed), delta 2,
                     accessory subunit; polymerase (DNA) delta 2, accessory
                     subunit; DAN polymerase delta 2, accessory subunit"
                     /codon_start=1
                     /product="DNA polymerase delta subunit 2"
                     /protein_id="NP_001013068.1"
                     /db_xref="GeneID:289758"
                     /db_xref="RGD:1304954"
                     /translation="MFSEQAAQRAHTLLSPPSASNATFARVPVATYTNSSQPFRLGER
                     SFNRQYAHIYATRLIQMRPFLVSRAQQHWGSQVEVKKLCELQPGEQCCVVGTLFKAMP
                     LQPSILREISEEHNLIPQPPRSKYIHPDDELVLEDELQRIKLKGTIDVSKLVTGTVLA
                     VFGSVKDDGKFQVEDHCFADLAPQNPVPPLDTDRFVLLVSGLGLGGGGGESLLGTQLL
                     VDVVTGQLGDEGEQCSAAHVSRVILAGNLLSHNTQSRDSINKAKYLTKKTQAASVEAV
                     KMLDEILLQLSASVPVDVMPGEFDPTNYTLPQQPLHPCMFPLATAYATLQLVTNPYQA
                     TIDGVRFLGTSGQNVSDIFRYSSMEDHLEILEWTLRVRHISPTAPDTLGCYPFYKTDP
                     FIFAECPHVYFCGNTPSFGSKVIRGPEDQAVLLVAVPDFSSTQTACLVNLRGLTCQPI
                     SFAGFGAEQDDLEDLGLGP"
     exon            297..418
                     /gene="Pold2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..542
                     /gene="Pold2"
                     /inference="alignment:Splign:2.1.0"
     exon            543..657
                     /gene="Pold2"
                     /inference="alignment:Splign:2.1.0"
     exon            658..856
                     /gene="Pold2"
                     /inference="alignment:Splign:2.1.0"
     exon            857..937
                     /gene="Pold2"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1095
                     /gene="Pold2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1223
                     /gene="Pold2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1325
                     /gene="Pold2"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1562
                     /gene="Pold2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgggatgcgg cgcggcgcgt gataactctt gggcctggac gcaactgctt ggaccaaaca
       61 agccacgagt gccgccatgt tttcagagca ggcagcacag agggcccaca ctctgctctc
      121 cccgccatca gccagcaatg ccacctttgc ccgggtgcct gtggccacgt acaccaactc
      181 ctcacagccc ttccgactgg gagagcgcag ctttaaccga cagtacgccc atatttatgc
      241 cacacgcctt atccagatga gacccttcct ggtgagccgg gcgcagcagc actggggcag
      301 ccaagttgaa gtgaagaagt tgtgtgagct gcagcccggg gagcagtgct gtgtggtggg
      361 cacgctgttc aaagccatgc ctctccaacc ctccatcctg cgggaaatca gcgaggagca
      421 caacctgatc ccccagccgc ctcggagcaa atacatccac ccagatgacg aactggtctt
      481 agaagatgaa ttgcagcgta tcaaactgaa gggcaccatc gatgtgtcaa agttggtcac
      541 aggaacggtc ttggctgtgt ttggctctgt gaaggatgac ggtaagtttc aggttgagga
      601 ccactgcttt gctgacctgg ctccacagaa tcctgtgccc ccacttgaca cagacagatt
      661 tgtgctactg gtgtccggac tgggcctggg cggcggtggc ggggagagcc tcctgggcac
      721 gcagctgctg gtagacgtgg tgacgggaca gcttggggac gaaggggagc agtgcagtgc
      781 tgcccacgtc tctcgagtca tccttgcagg caacctcctc agtcataaca cccagagccg
      841 agattccatc aataaggcca aatacctcac caagaaaacc caggcagcca gtgtggaggc
      901 agtcaaaatg ctggacgaga tcctactgca actcagcgcc tcagtacccg tggatgtgat
      961 gccgggagaa tttgatccaa ccaactatac gctcccacag cagcccctgc acccctgcat
     1021 gttccccctg gccactgcct acgccacact ccagctggtc accaacccat accaagccac
     1081 tattgacgga gtaaggttcc tggggacatc tgggcagaac gtgagcgata tcttccggta
     1141 tagcagcatg gaggaccatt tagagatcct agagtggacc ctgcgagtcc gtcacatcag
     1201 ccccacggcc ccagacaccc tagggtgcta ccccttctac aaaaccgacc cattcatctt
     1261 tgcggaatgc cctcacgtct acttctgcgg caacactccc agctttggct ctaaagtcat
     1321 ccgaggtcct gaggaccagg ccgtgctgtt ggtggccgtt cctgacttca gttccacaca
     1381 gacagcctgc ctggtgaacc tgcgtggcct gacctgccag cctatcagct ttgcaggatt
     1441 tggggcagag caagacgacc tagaagacct ggggctgggt ccctagtgag aggcagctgg
     1501 gtcaggacat cagccttgca atgtgagccc tgtaaataaa acatgaattt ttaccatctg
     1561 aaaaaaaaaa aaaaaaaaaa aaaaa
//
