LOCUS       NM_021662               3321 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus DNA polymerase delta 1, catalytic subunit
            (Pold1), mRNA.
ACCESSION   NM_021662
VERSION     NM_021662.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3321)
  AUTHORS   Siraj,A.K., Bu,R., Iqbal,K., Parvathareddy,S.K., Masoodi,T.,
            Siraj,N., Al-Rasheed,M., Kong,Y., Ahmed,S.O., Al-Obaisi,K.A.S.,
            Victoria,I.G., Arshad,M., Al-Dayel,F., Abduljabbar,A., Ashari,L.H.
            and Al-Kuraya,K.S.
  TITLE     POLE and POLD1 germline exonuclease domain pathogenic variants, a
            rare event in colorectal cancer from the Middle East
  JOURNAL   Mol Genet Genomic Med 8 (8), e1368 (2020)
   PUBMED   32567205
REFERENCE   2  (bases 1 to 3321)
  AUTHORS   Rosner,G., Gluck,N., Carmi,S., Bercovich,D., Fliss-Issakov,N.,
            Ben-Yehoyada,M., Aharon-Caspi,S., Kellerman,E., Strul,H.,
            Shibolet,O. and Kariv,R.
  TITLE     POLD1 and POLE Gene Mutations in Jewish Cohorts of Early-Onset
            Colorectal Cancer and of Multiple Colorectal Adenomas
  JOURNAL   Dis Colon Rectum 61 (9), 1073-1079 (2018)
   PUBMED   30086056
REFERENCE   3  (bases 1 to 3321)
  AUTHORS   Song,X., Wang,S., Hong,X., Li,X., Zhao,X., Huai,C., Chen,H.,
            Gao,Z., Qian,J., Wang,J., Han,B., Bai,C., Li,Q., Wu,J. and Lu,D.
  TITLE     Single nucleotide polymorphisms of nucleotide excision repair
            pathway are significantly associated with outcomes of
            platinum-based chemotherapy in lung cancer
  JOURNAL   Sci Rep 7 (1), 11785 (2017)
   PUBMED   28924235
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3321)
  AUTHORS   Cazzalini,O., Sommatis,S., Tillhon,M., Dutto,I., Bachi,A., Rapp,A.,
            Nardo,T., Scovassi,A.I., Necchi,D., Cardoso,M.C., Stivala,L.A. and
            Prosperi,E.
  TITLE     CBP and p300 acetylate PCNA to link its degradation with nucleotide
            excision repair synthesis
  JOURNAL   Nucleic Acids Res 42 (13), 8433-8448 (2014)
   PUBMED   24939902
REFERENCE   5  (bases 1 to 3321)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   6  (bases 1 to 3321)
  AUTHORS   Prapurna,D.R. and Rao,K.S.
  TITLE     DNA polymerases delta and epsilon in developing and aging rat brain
  JOURNAL   Int J Dev Neurosci 15 (1), 67-73 (1997)
   PUBMED   9099618
REFERENCE   7  (bases 1 to 3321)
  AUTHORS   Fox,G., Popanda,O. and Thielmann,H.W.
  TITLE     Evidence for reduced copying fidelity of DNA polymerases alpha,
            delta, and epsilon from Novikoff hepatoma cells
  JOURNAL   J Cancer Res Clin Oncol 123 (11-12), 659-668 (1997)
   PUBMED   9620226
REFERENCE   8  (bases 1 to 3321)
  AUTHORS   Lopez-Girona,A., Bachs,O. and Agell,N.
  TITLE     Calmodulin is involved in the induction of DNA polymerases alpha
            and delta activities in normal rat kidney cells activated to
            proliferate
  JOURNAL   Biochem Biophys Res Commun 217 (2), 566-574 (1995)
   PUBMED   7503737
REFERENCE   9  (bases 1 to 3321)
  AUTHORS   Popanda,O. and Thielmann,H.W.
  TITLE     The function of DNA polymerases in DNA repair synthesis of
            ultraviolet-irradiated human fibroblasts
  JOURNAL   Biochim Biophys Acta 1129 (2), 155-160 (1992)
   PUBMED   1730053
REFERENCE   10 (bases 1 to 3321)
  AUTHORS   Nishida,C., Reinhard,P. and Linn,S.
  TITLE     DNA repair synthesis in human fibroblasts requires DNA polymerase
            delta
  JOURNAL   J Biol Chem 263 (1), 501-510 (1988)
   PUBMED   3335506
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ222691.1.
            
            On Aug 31, 2012 this sequence version replaced NM_021662.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ222691.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3321              AJ222691.1         5-3325
FEATURES             Location/Qualifiers
     source          1..3321
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..3321
                     /gene="Pold1"
                     /note="DNA polymerase delta 1, catalytic subunit"
                     /db_xref="GeneID:59294"
                     /db_xref="RGD:621839"
     exon            1..191
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..3313
                     /gene="Pold1"
                     /EC_number="2.7.7.7"
                     /function="DNA polymerization"
                     /note="DNA-directed DNA polymerase delta 1; DNA polymerase
                     delta, catalytic subunit; polymerase (DNA directed), delta
                     1, catalytic subunit; polymerase (DNA) delta 1, catalytic
                     subunit; DAN polymerase delta 1, catalytic subunit; 3'-5'
                     exodeoxyribonuclease"
                     /codon_start=1
                     /product="DNA polymerase delta catalytic subunit"
                     /protein_id="NP_067694.1"
                     /db_xref="GeneID:59294"
                     /db_xref="RGD:621839"
                     /translation="MDGKRRQAPSSGVPPKRACKGLWDEDEPSQFEENLALLEEIEAE
                     NRLQEAEEELQLPPEGIVGGQFSTADIDPRWLRPTPLALDPSTEPLIFQQLEIDHYVG
                     TSPPLPEGPPASRNSVPILRAFGVTDEGFSVCCHIHGFAPYFYTPAPPGFGAEHLSEL
                     QRELNAAISRDQRGGKELSGPAVLAIELCSRESMFGYHGHGPSPFLRITLALPRLMAP
                     ARRLLEQGIRVPGLGTPSFAPYEANVDFEIRFMVDADIVGCNWLELPAGKYVRRAEKK
                     ATLCQLEVDVLWSDVISHPPEGQWQRIAPLRVLSFDIECAGRKGIFPEPERDPVIQIC
                     SLGLRWGEPEPFLRLALTLRPCAPILGAKVQSYEREEDLLQAWATFILAMDPDVITGY
                     NIQNFDLPYLISRAQTLKVDRFPFLGRVTGLRSNIRDSSFQSRQVGRRDSKVVSMVGR
                     VQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSIITDLQNGNEQTRRRLAVYC
                     LKDAFLPLRLLERLMVLVNNVEMARVTGVPLGYLLSRGQQVKVVSQLLRQAMREGLLM
                     PVVKTEGGEDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLRPGAAQ
                     KLGLKPDEFIKTPTGDEFVKASVRKGLLPQILENLLSARKRAKAELAQETDPLRRQVL
                     DGRQLALKVSPNSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVETKYTLENG
                     YDANAKVVYGDTDSVMCRFGVSSVAEAMSLGREAANWVSSHFPSPIRLEFEKVYFPYL
                     LISKKRYAGLLFSSRSDAHDRMDCKGLEAVRRDNCPLVANLVTSSLRRILVDRDPDGA
                     VAHAKDVISDLLCNRIDISQLVITKELTRAAADYAGKQAHVELAERMRKRDPGSAPNL
                     GDRVPYVIIGAAKGVAAYMKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGE
                     GRAESVLLRGDHTRCKTVLTSKVGGLLAFTKRRNSCIGCRSVIDHQGAVCKFCQPRES
                     ELYQKEVSHLNALEERFSRLWTQCQRCQGSLHEDVICTSRDCPIFYMRKKVRKDLEDQ
                     ERLLQRFGPPGPEAW"
     exon            192..305
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..452
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..578
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            579..747
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            748..829
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..959
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1126
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1231
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1372
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1483
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1675
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1764
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1881
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            1882..1995
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2143
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2239
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            2240..2377
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2553
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2706
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2809
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            2810..2942
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            2943..3056
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3109
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..3207
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3321
                     /gene="Pold1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatggatggt aaacggcggc aagcgcccag ctctggggtg cccccaaagc gggcttgcaa
       61 gggcctctgg gatgaagatg agccgtcaca gtttgaggag aacctggcgc tgctggagga
      121 gatagaggcc gagaatcggc tgcaggaggc cgaggaggag ctgcagctgc cccctgaggg
      181 cattgtgggt gggcagtttt ccactgcaga cattgaccca cggtggctgc ggcccacccc
      241 acttgccctg gaccccagca cggagcccct catcttccag cagctggaga ttgaccacta
      301 tgtgggcaca tcacctcccc tgccagaagg accccccgca tctcgtaact cagtgcccat
      361 actgagggcc tttggggtca ccgatgaggg cttctccgtc tgctgccaca tccacggctt
      421 tgccccctac ttctacaccc ctgcacctcc gggttttggg gctgagcacc tgagtgaact
      481 acagcgggag ctgaatgcag ccatcagccg ggaccagcgt ggtggaaagg agctctcggg
      541 gccggcagtg ctagctatag agctgtgctc ccgtgagagc atgtttgggt accatggcca
      601 cggcccttct ccctttctcc gcatcaccct ggcactaccc cgcctgatgg cgccagcccg
      661 ccgcctcctg gaacagggta tccgagtgcc aggcctgggc accccgagct ttgcacccta
      721 tgaagccaat gtggactttg agatccggtt catggtggat gctgacattg tgggatgcaa
      781 ctggttggag ctcccagctg gaaagtacgt tcggagggca gagaagaagg ctacactgtg
      841 tcagctggag gtggatgtgc tgtggtcaga cgtgatcagt cacccaccag aagggcagtg
      901 gcagcgcatc gcacccctgc gtgtgcttag cttcgacatc gagtgcgctg gccgaaaagg
      961 catcttccct gagcctgagc gtgaccccgt gatccagatc tgttctctgg ggctgcgctg
     1021 gggtgagcca gagcccttct tgcgcctagc actcacgctg cggccttgcg cccccatcct
     1081 gggtgccaaa gtacagagct atgaacggga agaagacctg ctccaggcct gggccacttt
     1141 catcctcgcc atggaccctg acgtgatcac cggctacaac attcagaact ttgacctccc
     1201 ctacctcatc tctcgggcac aaaccttaaa ggtggaccga ttccctttcc tgggccgtgt
     1261 gactggtctc cgctccaaca tccgtgactc ctccttccaa tcaaggcagg tgggccggcg
     1321 ggacagtaag gtggtcagca tggtgggtcg cgttcagatg gatatgctgc aggtgctgct
     1381 tcgggagtac aagctccgct cctacacgct caacgctgtg agcttccact tcctgggtga
     1441 gcagaaggag gacgtacagc acagcatcat cactgaccta cagaatggga atgaacagac
     1501 gcgtcgccgc ctggccgtgt actgcctgaa ggatgccttt ctgcctcttc gcctactcga
     1561 gcgccttatg gtgctggtga acaatgtgga gatggcgcgt gtcactggtg taccccttgg
     1621 gtacctgctc agccgaggcc agcaggtcaa ggtcgtgtct cagctgctgc gccaggccat
     1681 gcgcgagggg ctgctgatgc ctgtggtgaa gacggaggga ggtgaggact acacgggagc
     1741 cactgtcatt gagcccctca aagggtacta tgatgtcccc attgccaccc tggacttctc
     1801 ctctctgtac ccatccatca tgatggccca caatctgtgc tacaccacat tgctacggcc
     1861 tggggctgcc cagaagttgg gccttaaacc agatgagttc atcaagacac ccactgggga
     1921 tgagtttgtg aaggcatctg tgcggaaggg cctcctgccc caaatcctgg agaatctgct
     1981 gagtgcccgg aagagggcca aggctgagct ggctcaggag acggaccccc tgcggcgaca
     2041 ggtcttggat ggacggcagc tggcactaaa agtgagtccc aactctgtgt atggcttcac
     2101 tggtgcccag gtgggcaagc tgccgtgttt ggagatctcc cagagtgtca ctgggttcgg
     2161 gcggcagatg attgagaaaa ccaagcagct agtggagacc aagtacactc tggaaaatgg
     2221 ctacgatgct aatgccaagg tggtctacgg tgacactgac tctgtgatgt gccgatttgg
     2281 tgtctcctct gtggctgagg caatgtctct ggggcgggag gctgcaaact gggtatccag
     2341 tcacttccca tcacccatcc ggctggagtt cgagaaggtt tactttccct acctgctcat
     2401 cagcaagaag cgctatgccg gcctactctt ctcctcccgc tctgatgccc atgacagaat
     2461 ggactgcaag ggcctggagg ctgtgcgtag ggacaactgt cccctggtgg ccaaccttgt
     2521 cacatcctct ctgcgcagaa tcctcgtgga tcgggaccct gatggtgcag tagcccatgc
     2581 aaaggatgtc atctcggacc tgctgtgcaa ccgcatagac atctcccaac tggtcatcac
     2641 caaagagttg acccgcgcag cagcagacta cgcgggcaag caggctcatg tggagctggc
     2701 tgagaggatg aggaagcgtg accccggcag tgcgcccaac ttgggcgacc gagtacccta
     2761 cgtgatcatt ggtgctgcca agggtgtggc cgcctacatg aagtcggagg accccctgtt
     2821 tgtgctggag cacagcctgc ccattgatac tcagtactac ctggagcagc agctggccaa
     2881 gccgctattg cgcatctttg agcccattct gggtgagggc cgcgcggagt cagtgctgct
     2941 gcgcggtgac cacacacgct gcaaaaccgt gctcaccagc aaggtgggcg gccttctggc
     3001 cttcaccaag cgccgaaact cttgtattgg ctgccgctcc gtaatcgacc atcaaggagc
     3061 cgtgtgtaag ttctgtcagc cacgggagtc tgagctctat cagaaggagg tgtcacacct
     3121 gaatgccctg gaggaacgtt tctcgcgcct ctggacacag tgccagcgct gccagggcag
     3181 cttgcacgag gatgtcatct gtaccagccg cgactgtccc atcttctaca tgcgcaagaa
     3241 ggtgcgcaag gacctggagg accaggaacg gctgctgcag cgctttggac ctcctggccc
     3301 tgaggcctgg tgacctgaca a
//
