LOCUS       NP_067694               1103 aa            linear   ROD 27-JUL-2024
DEFINITION  DNA polymerase delta catalytic subunit [Rattus norvegicus].
ACCESSION   NP_067694
VERSION     NP_067694.1
DBSOURCE    REFSEQ: accession NM_021662.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 1103)
  AUTHORS   Siraj,A.K., Bu,R., Iqbal,K., Parvathareddy,S.K., Masoodi,T.,
            Siraj,N., Al-Rasheed,M., Kong,Y., Ahmed,S.O., Al-Obaisi,K.A.S.,
            Victoria,I.G., Arshad,M., Al-Dayel,F., Abduljabbar,A., Ashari,L.H.
            and Al-Kuraya,K.S.
  TITLE     POLE and POLD1 germline exonuclease domain pathogenic variants, a
            rare event in colorectal cancer from the Middle East
  JOURNAL   Mol Genet Genomic Med 8 (8), e1368 (2020)
   PUBMED   32567205
REFERENCE   2  (residues 1 to 1103)
  AUTHORS   Rosner,G., Gluck,N., Carmi,S., Bercovich,D., Fliss-Issakov,N.,
            Ben-Yehoyada,M., Aharon-Caspi,S., Kellerman,E., Strul,H.,
            Shibolet,O. and Kariv,R.
  TITLE     POLD1 and POLE Gene Mutations in Jewish Cohorts of Early-Onset
            Colorectal Cancer and of Multiple Colorectal Adenomas
  JOURNAL   Dis Colon Rectum 61 (9), 1073-1079 (2018)
   PUBMED   30086056
REFERENCE   3  (residues 1 to 1103)
  AUTHORS   Song,X., Wang,S., Hong,X., Li,X., Zhao,X., Huai,C., Chen,H.,
            Gao,Z., Qian,J., Wang,J., Han,B., Bai,C., Li,Q., Wu,J. and Lu,D.
  TITLE     Single nucleotide polymorphisms of nucleotide excision repair
            pathway are significantly associated with outcomes of
            platinum-based chemotherapy in lung cancer
  JOURNAL   Sci Rep 7 (1), 11785 (2017)
   PUBMED   28924235
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1103)
  AUTHORS   Cazzalini,O., Sommatis,S., Tillhon,M., Dutto,I., Bachi,A., Rapp,A.,
            Nardo,T., Scovassi,A.I., Necchi,D., Cardoso,M.C., Stivala,L.A. and
            Prosperi,E.
  TITLE     CBP and p300 acetylate PCNA to link its degradation with nucleotide
            excision repair synthesis
  JOURNAL   Nucleic Acids Res 42 (13), 8433-8448 (2014)
   PUBMED   24939902
REFERENCE   5  (residues 1 to 1103)
  AUTHORS   Grolimund,L., Aeby,E., Hamelin,R., Armand,F., Chiappe,D.,
            Moniatte,M. and Lingner,J.
  TITLE     A quantitative telomeric chromatin isolation protocol identifies
            different telomeric states
  JOURNAL   Nat Commun 4, 2848 (2013)
   PUBMED   24270157
REFERENCE   6  (residues 1 to 1103)
  AUTHORS   Prapurna,D.R. and Rao,K.S.
  TITLE     DNA polymerases delta and epsilon in developing and aging rat brain
  JOURNAL   Int J Dev Neurosci 15 (1), 67-73 (1997)
   PUBMED   9099618
REFERENCE   7  (residues 1 to 1103)
  AUTHORS   Fox,G., Popanda,O. and Thielmann,H.W.
  TITLE     Evidence for reduced copying fidelity of DNA polymerases alpha,
            delta, and epsilon from Novikoff hepatoma cells
  JOURNAL   J Cancer Res Clin Oncol 123 (11-12), 659-668 (1997)
   PUBMED   9620226
REFERENCE   8  (residues 1 to 1103)
  AUTHORS   Lopez-Girona,A., Bachs,O. and Agell,N.
  TITLE     Calmodulin is involved in the induction of DNA polymerases alpha
            and delta activities in normal rat kidney cells activated to
            proliferate
  JOURNAL   Biochem Biophys Res Commun 217 (2), 566-574 (1995)
   PUBMED   7503737
REFERENCE   9  (residues 1 to 1103)
  AUTHORS   Popanda,O. and Thielmann,H.W.
  TITLE     The function of DNA polymerases in DNA repair synthesis of
            ultraviolet-irradiated human fibroblasts
  JOURNAL   Biochim Biophys Acta 1129 (2), 155-160 (1992)
   PUBMED   1730053
REFERENCE   10 (residues 1 to 1103)
  AUTHORS   Nishida,C., Reinhard,P. and Linn,S.
  TITLE     DNA repair synthesis in human fibroblasts requires DNA polymerase
            delta
  JOURNAL   J Biol Chem 263 (1), 501-510 (1988)
   PUBMED   3335506
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ222691.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ222691.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1103
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     Protein         1..1103
                     /product="DNA polymerase delta catalytic subunit"
                     /EC_number="2.7.7.7"
                     /function="DNA polymerization"
                     /note="DNA-directed DNA polymerase delta 1; DNA polymerase
                     delta, catalytic subunit; polymerase (DNA directed), delta
                     1, catalytic subunit; polymerase (DNA) delta 1, catalytic
                     subunit; DAN polymerase delta 1, catalytic subunit; 3'-5'
                     exodeoxyribonuclease"
                     /calculated_mol_wt=123471
     Region          1..27
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O54747.1)"
     Region          4..17
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (O54747.1)"
     Region          80..1096
                     /region_name="PTZ00166"
                     /note="DNA polymerase delta catalytic subunit;
                     Provisional"
                     /db_xref="CDD:240301"
     Region          1054..1072
                     /region_name="CysB motif"
                     /note="propagated from UniProtKB/Swiss-Prot (O54747.1)"
     CDS             1..1103
                     /gene="Pold1"
                     /coded_by="NM_021662.2:2..3313"
                     /db_xref="GeneID:59294"
                     /db_xref="RGD:621839"
ORIGIN      
        1 mdgkrrqaps sgvppkrack glwdedepsq feenlallee ieaenrlqea eeelqlppeg
       61 ivggqfstad idprwlrptp laldpstepl ifqqleidhy vgtspplpeg ppasrnsvpi
      121 lrafgvtdeg fsvcchihgf apyfytpapp gfgaehlsel qrelnaaisr dqrggkelsg
      181 pavlaielcs resmfgyhgh gpspflritl alprlmapar rlleqgirvp glgtpsfapy
      241 eanvdfeirf mvdadivgcn wlelpagkyv rraekkatlc qlevdvlwsd vishppegqw
      301 qriaplrvls fdiecagrkg ifpeperdpv iqicslglrw gepepflrla ltlrpcapil
      361 gakvqsyere edllqawatf ilamdpdvit gyniqnfdlp ylisraqtlk vdrfpflgrv
      421 tglrsnirds sfqsrqvgrr dskvvsmvgr vqmdmlqvll reyklrsytl navsfhflge
      481 qkedvqhsii tdlqngneqt rrrlavyclk daflplrlle rlmvlvnnve marvtgvplg
      541 yllsrgqqvk vvsqllrqam regllmpvvk teggedytga tvieplkgyy dvpiatldfs
      601 slypsimmah nlcyttllrp gaaqklglkp defiktptgd efvkasvrkg llpqilenll
      661 sarkrakael aqetdplrrq vldgrqlalk vspnsvygft gaqvgklpcl eisqsvtgfg
      721 rqmiektkql vetkytleng ydanakvvyg dtdsvmcrfg vssvaeamsl greaanwvss
      781 hfpspirlef ekvyfpylli skkryagllf ssrsdahdrm dckgleavrr dncplvanlv
      841 tsslrrilvd rdpdgavaha kdvisdllcn ridisqlvit keltraaady agkqahvela
      901 ermrkrdpgs apnlgdrvpy viigaakgva aymksedplf vlehslpidt qyyleqqlak
      961 pllrifepil gegraesvll rgdhtrcktv ltskvgglla ftkrrnscig crsvidhqga
     1021 vckfcqpres elyqkevshl naleerfsrl wtqcqrcqgs lhedvictsr dcpifymrkk
     1081 vrkdledqer llqrfgppgp eaw
//
