LOCUS       NM_017141               1196 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus DNA polymerase beta (Polb), mRNA.
ACCESSION   NM_017141 XM_346492
VERSION     NM_017141.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1196)
  AUTHORS   Whitaker,A.M. and Freudenthal,B.D.
  TITLE     History of DNA polymerase beta X-ray crystallography
  JOURNAL   DNA Repair (Amst) 93, 102928 (2020)
   PUBMED   33087265
  REMARK    GeneRIF: History of DNA polymerase beta X-ray crystallography.
            Review article
REFERENCE   2  (bases 1 to 1196)
  AUTHORS   Wilson,R., Geyer,S.H., Reissig,L., Rose,J., Szumska,D., Hardman,E.,
            Prin,F., McGuire,C., Ramirez-Solis,R., White,J., Galli,A.,
            Tudor,C., Tuck,E., Mazzeo,C.I., Smith,J.C., Robertson,E.,
            Adams,D.J., Mohun,T. and Weninger,W.J.
  TITLE     Highly variable penetrance of abnormal phenotypes in embryonic
            lethal knockout mice
  JOURNAL   Wellcome Open Res 1, 1 (2017)
   PUBMED   27996060
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1196)
  AUTHORS   Gabel,S.A., Smith,C.E., Cuneo,M.J., Mueller,G.A., Kirby,T.W.,
            DeRose,E.F., Krahn,J.M. and London,R.E.
  TITLE     Characterization of the redox transition of the XRCC1 N-terminal
            domain
  JOURNAL   Structure 22 (12), 1754-1763 (2014)
   PUBMED   25456813
REFERENCE   4  (bases 1 to 1196)
  AUTHORS   Szczesny,B., Brunyanszki,A., Olah,G., Mitra,S. and Szabo,C.
  TITLE     Opposing roles of mitochondrial and nuclear PARP1 in the regulation
            of mitochondrial and nuclear DNA integrity: implications for the
            regulation of mitochondrial function
  JOURNAL   Nucleic Acids Res 42 (21), 13161-13173 (2014)
   PUBMED   25378300
REFERENCE   5  (bases 1 to 1196)
  AUTHORS   Senejani,A.G., Liu,Y., Kidane,D., Maher,S.E., Zeiss,C.J.,
            Park,H.J., Kashgarian,M., McNiff,J.M., Zelterman,D., Bothwell,A.L.
            and Sweasy,J.B.
  TITLE     Mutation of POLB causes lupus in mice
  JOURNAL   Cell Rep 6 (1), 1-8 (2014)
   PUBMED   24388753
REFERENCE   6  (bases 1 to 1196)
  AUTHORS   Casas-Finet,J.R., Kumar,A., Karpel,R.L. and Wilson,S.H.
  TITLE     Mammalian DNA polymerase beta: characterization of a 16-kDa
            transdomain fragment containing the nucleic acid-binding activities
            of the native enzyme
  JOURNAL   Biochemistry 31 (42), 10272-10280 (1992)
   PUBMED   1420147
REFERENCE   7  (bases 1 to 1196)
  AUTHORS   Date,T., Tanihara,K., Yamamoto,S., Nomura,N. and Matsukage,A.
  TITLE     Two regions in human DNA polymerase beta mRNA suppress translation
            in Escherichia coli
  JOURNAL   Nucleic Acids Res 20 (18), 4859-4864 (1992)
   PUBMED   1408801
REFERENCE   8  (bases 1 to 1196)
  AUTHORS   Date,T., Yamamoto,S., Tanihara,K., Nishimoto,Y. and Matsukage,A.
  TITLE     Aspartic acid residues at positions 190 and 192 of rat DNA
            polymerase beta are involved in primer binding
  JOURNAL   Biochemistry 30 (21), 5286-5292 (1991)
   PUBMED   2036395
REFERENCE   9  (bases 1 to 1196)
  AUTHORS   Date,T., Yamamoto,S., Tanihara,K., Nishimoto,Y., Liu,N. and
            Matsukage,A.
  TITLE     Site-directed mutagenesis of recombinant rat DNA polymerase beta:
            involvement of arginine-183 in primer recognition
  JOURNAL   Biochemistry 29 (21), 5027-5034 (1990)
   PUBMED   2198936
REFERENCE   10 (bases 1 to 1196)
  AUTHORS   de Recondo,A.M. and Abadiedebat,J.
  TITLE     Regenerating rat liver DNA polymerases: disimilitude or
            relationship between nuclear and cytoplasmic enzymes?
  JOURNAL   Nucleic Acids Res 3 (8), 1823-1837 (1976)
   PUBMED   967678
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098668.1.
            
            On Jun 10, 2007 this sequence version replaced NM_017141.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098668.1, U38801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1196
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..1196
                     /gene="Polb"
                     /note="DNA polymerase beta"
                     /db_xref="GeneID:29240"
                     /db_xref="RGD:3363"
     exon            1..73
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..1020
                     /gene="Polb"
                     /EC_number="2.7.7.7"
                     /EC_number="4.2.99.18"
                     /note="polymerase-beta; DNA pol beta; DNA-directed DNA
                     polymerase beta; polymerase (DNA directed), beta;
                     polymerase (DNA) beta; AP lyase; 5'-dRP lyase;
                     5'-deoxyribose-phosphate lyase"
                     /codon_start=1
                     /product="DNA polymerase beta"
                     /protein_id="NP_058837.2"
                     /db_xref="GeneID:29240"
                     /db_xref="RGD:3363"
                     /translation="MSKRKAPQETLNGGITDMLVELANFEKNVSQAIHKYNAYRKAAS
                     VIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTR
                     VTGIGPSAARKLVDEGIKTLEDLRKNEDKLNHHQRIGLKYFEDFEKRIPREEMLQMQD
                     IVLNEVKKLDPEYIATVCGSFRRGAESSGDMDVLLTHPNFTSESSKQPKLLHRVVEQL
                     QKVRFITDTLSKGETKFMGVCQLPSENDENEYPHRRIDIRLIPKDQYYCGVLYFTGSD
                     IFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEQDIFDYIQWRYREPKDRS
                     E"
     exon            74..131
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     exon            132..198
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     exon            199..273
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     exon            274..332
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     exon            333..382
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     exon            383..434
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     exon            435..489
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     exon            490..562
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     exon            563..633
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     exon            634..720
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     exon            721..785
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     exon            786..925
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1162
                     /gene="Polb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccccggca ccatgagcaa acgcaaggcc ccgcaggaga ccctcaacgg cggcatcacg
       61 gacatgctcg tggaactcgc aaactttgag aagaacgtga gccaggcgat ccacaagtac
      121 aatgcataca gaaaagcagc atctgtgata gcaaagtacc cacacaaaat caagagtgga
      181 gcagaagcta agaaattgcc aggagtagga acaaaaattg ctgaaaagat tgatgaattt
      241 ttagcaactg gaaaattgcg taaactggaa aagattcgtc aggatgatac aagttcatcc
      301 atcaacttcc tgactcgagt tactggcatc gggccatctg ctgcaaggaa gcttgtagat
      361 gaaggaatta aaacattaga agatctcagg aaaaatgaag ataaattgaa ccaccatcag
      421 cgaattgggc tgaaatattt tgaggacttt gaaaagagaa ttcctcgtga ggagatgctg
      481 caaatgcagg acattgttct taatgaagtt aaaaagctgg atcccgagta catcgctaca
      541 gtctgcggca gtttccgaag aggcgcagag tccagtggag atatggacgt tctgctgacc
      601 cacccaaact tcacgtcaga atcaagcaaa cagccaaagt tgttacatcg tgttgtggaa
      661 cagttacaaa aagtccgttt cattacagat actctgtcaa agggtgagac aaagttcatg
      721 ggtgtttgcc agcttcccag cgagaatgat gaaaacgaat atccacacag gagaatcgat
      781 atcaggttga tccccaaaga tcagtactac tgtggtgttc tctacttcac tggaagtgac
      841 atctttaata agaatatgag agcgcatgcc ctggaaaagg gcttcacaat caatgagtac
      901 accatccgcc ccctgggggt cactggggtt gctggggagc cccttccggt ggacagcgag
      961 caggacattt tcgattacat ccagtggcgc taccgggagc ccaaggacag gagtgaatga
     1021 cgcctgcccc accccaggcc tatcccacga ggagtcctaa gttattgctt aacctttgct
     1081 atgtaagggt tgggtgtttt aggtgattgc ctcttctctg tgcttcccat ggactatcgt
     1141 caatgaacct cttgagcagc taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
