LOCUS       NM_053480               2294 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Rattus norvegicus DNA polymerase alpha 2, accessory subunit
            (Pola2), mRNA.
ACCESSION   NM_053480
VERSION     NM_053480.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2294)
  AUTHORS   Baranovskiy,A.G., Lada,A.G., Siebler,H.M., Zhang,Y., Pavlov,Y.I.
            and Tahirov,T.H.
  TITLE     DNA polymerase delta and zeta switch by sharing accessory subunits
            of DNA polymerase delta
  JOURNAL   J Biol Chem 287 (21), 17281-17287 (2012)
   PUBMED   22465957
REFERENCE   2  (bases 1 to 2294)
  AUTHORS   Popanda,O., Flohr,C., Dai,J.C., Hunzicker,A. and Thielmann,H.W.
  TITLE     A mutation in subunit B of the DNA polymerase alpha-primase complex
            from Novikoff hepatoma cells concomitant with a conformational
            change and abnormal catalytic properties of the DNA polymerase
            alpha-primase complex
  JOURNAL   Mol Carcinog 31 (4), 171-183 (2001)
   PUBMED   11536367
REFERENCE   3  (bases 1 to 2294)
  AUTHORS   Mizuno,T., Ito,N., Yokoi,M., Kobayashi,A., Tamai,K., Miyazawa,H.
            and Hanaoka,F.
  TITLE     The second-largest subunit of the mouse DNA polymerase
            alpha-primase complex facilitates both production and nuclear
            translocation of the catalytic subunit of DNA polymerase alpha
  JOURNAL   Mol Cell Biol 18 (6), 3552-3562 (1998)
   PUBMED   9584195
REFERENCE   4  (bases 1 to 2294)
  AUTHORS   Lopez-Girona,A., Bachs,O. and Agell,N.
  TITLE     Calmodulin is involved in the induction of DNA polymerases alpha
            and delta activities in normal rat kidney cells activated to
            proliferate
  JOURNAL   Biochem Biophys Res Commun 217 (2), 566-574 (1995)
   PUBMED   7503737
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097300.1.
            
            On Jun 12, 2005 this sequence version replaced NM_053480.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097300.1, AJ245648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2294
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..2294
                     /gene="Pola2"
                     /note="DNA polymerase alpha 2, accessory subunit"
                     /db_xref="GeneID:85242"
                     /db_xref="RGD:621817"
     exon            1..210
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1934
                     /gene="Pola2"
                     /EC_number="2.7.7.7"
                     /note="DNA-directed DNA polymerase alpha 2; DNA polymerase
                     subunit II; polymerase (DNA directed), alpha 2, accessory
                     subunit; DNA polymerase alpha 70 kDa subunit; DNA
                     polymerase alpha subunit II; polymerase (DNA) alpha 2,
                     accessory subunit"
                     /codon_start=1
                     /product="DNA polymerase alpha subunit B"
                     /protein_id="NP_445932.2"
                     /db_xref="GeneID:85242"
                     /db_xref="RGD:621817"
                     /translation="MAVSTQQLAEELQIFGLDCEDSLLEKLAELCTLYRQTEERMVSE
                     LIAFCTSAGKSCLTGEILSSFEHEVLNKKLSKACHSASKDNRHAGARDIVSIQELIEA
                     EEEEETLLSAYTTPSKGPHKRVSSTPETPLTKRSISTRSPHQLLSPSSFSPSATPSQK
                     YSSRTNRGEVVTTFGSAQGVSWSGRGGSGSISLKVMGYPEPLTSSYKTMFQQLPDIRE
                     VLTCKIEELGSELKEHYKIEAFTPLLVPAQEPVILLGQIGCDSNGRLNSKSVILEGDR
                     EHSSGAQIPVDMSELKDYSLFPGQVVIMEGFNTTGRRLTATKLYEGVPLPFYQPTEEE
                     GDFEQTMVLVACGPYTTSDSITYDPLLDLISTINHDRLDVCILFGPFLDAKHEQVENC
                     KLTSPFEDIFKQCLRTVIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFTFSELPREDK
                     KRVQFVSEPCNLSINGVMFGLTSTDLLFHIGAEEICSSSGTSDRFSRILKHILTQRSY
                     YPLYPPHEDMAIDYENFYTYAQLPVTPDVFIVPSELRYFVKDIFGCVCMNPGRLTKGQ
                     VGGTFGRLYLRRQPKGTDSEGRQGLSVAAQVVRI"
     exon            211..335
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..427
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            428..485
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            486..592
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            593..786
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            787..875
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1031
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1094
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1137
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1262
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1301
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1375
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1484
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1591
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1651
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1778
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..2267
                     /gene="Pola2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttggggtcg tctgagggct taggccaggt ggtcttgtga ccggtccctg tcaccttccc
       61 acaaagtgaa agaataagcc tctgccgggc agatttgagc tgaagtcgga gccctgcggc
      121 aggctcccgg catggccgtg tccacccagc agctggcgga ggagctacag atcttcggcc
      181 tggactgcga ggactccctg ctggagaaat tggcagagct gtgtactctg taccgacaga
      241 ctgaggagag gatggtgagc gagctgatcg ccttctgcac cagcgcaggg aaatcgtgcc
      301 tcactggaga gatcctcagt tcctttgagc acgaggttct gaacaaaaag ctctccaaag
      361 cctgtcacag tgcctccaaa gacaacaggc acgcaggagc cagagatatt gtctccatac
      421 aagagctaat tgaagcagag gaggaagagg agacccttct gagcgcttac accacaccct
      481 ctaagggtcc tcacaagcga gttagcagca ccccagaaac ccccctaacc aaaaggagta
      541 tctctactcg cagcccacac cagcttctct ccccatcgag tttctcccca agtgctaccc
      601 cttcccagaa atacagctcc agaaccaacc ggggagaagt ggtcaccacc tttggctcag
      661 cacagggcgt gtcttggtcc gggagaggag gctctggaag catcagtctg aaggtcatgg
      721 ggtacccaga accactcacc agcagctata aaactatgtt tcagcagctc ccggatattc
      781 gggaagttct gacctgtaag atagaggagc ttggcagcga gctgaaggaa cattacaaga
      841 tcgaggcgtt tacccctctg ctagtcccag cacaggaacc tgtcatcctg ctgggtcaga
      901 ttggctgtga cagcaacggg aggctaaaca gcaagtcagt gatcctcgag ggagaccggg
      961 agcactcctc tggcgctcag attccagtgg acatgtccga actcaaagac tactctctgt
     1021 ttcctgggca ggttgtaatt atggaaggat tcaacaccac tggcaggaga cttactgcca
     1081 ccaaactcta tgagggtgtg ccacttccgt tctatcagcc cactgaagag gagggagatt
     1141 ttgagcagac tatggtgtta gttgcctgtg ggccttatac cacctctgac agcatcacat
     1201 acgaccccct gcttgatctg atcagcacca tcaaccatga ccggctagat gtctgcatcc
     1261 tgttcggccc tttcctggat gctaagcatg aacaagtgga gaactgtaag ttgacaagcc
     1321 cattcgaaga cattttcaag cagtgcctga gaacagttat cgaaggaacg agaagctccg
     1381 gctcccacct tgtctttgtc ccgtctctga gggatgtgca ccacgagcca gtctacccac
     1441 agccaccttt caccttctcc gaactgcctc gagaggacaa gaagcgagtg cagtttgtgt
     1501 cagagccctg caacctctcc ataaatgggg tgatgtttgg tttgacatcc acggacctgc
     1561 tgttccacat tggggccgag gagatctgta gctcctctgg gacttcagac agattcagcc
     1621 gaatcctcaa gcacatcctg acgcagagaa gctactaccc actttaccca ccccacgagg
     1681 acatggccat agactacgag aacttctata cctatgccca gctgccggtc acccctgatg
     1741 ttttcatagt gccatcagag ctgaggtact tcgtgaagga catcttcggc tgtgtctgta
     1801 tgaatcctgg acggctcacc aaaggacaag tgggcggcac ctttggccgc ctctacctca
     1861 ggaggcagcc caagggcacg gacagtgagg ggaggcaggg gctgagtgtg gctgcgcagg
     1921 tggtcagaat ctgagtcttc agcctgggtt gtctggcctc acagacacca agagtccagg
     1981 tacgaccccc tggtgaccaa actgtcaggg tacctgacaa ggatctggcc acaaggtcag
     2041 gacttcaggg ctgcgccatc cgatcgcagc ccccgctgct cctcacccca cgcagcgggg
     2101 ccttgatctg gatcatgctt cttgcctctc tcctgcttca caagataggt gtccagacgt
     2161 gaaccatcta tggagacagc ccgcccagaa aggcaggaaa acattgtgat tttctgtatg
     2221 aagcaaacag cgtgtggaga aataaaaaaa ttttttagta taactgaaaa aaaaaaaaaa
     2281 aaaaaaaaaa aaaa
//
