LOCUS       NM_053479               5321 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus DNA polymerase alpha 1, catalytic subunit
            (Pola1), mRNA.
ACCESSION   NM_053479 XM_001064735 XM_242396
VERSION     NM_053479.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5321)
  AUTHORS   Van Esch,H., Colnaghi,R., Freson,K., Starokadomskyy,P., Zankl,A.,
            Backx,L., Abramowicz,I., Outwin,E., Rohena,L., Faulkner,C.,
            Leong,G.M., Newbury-Ecob,R.A., Challis,R.C., Ounap,K., Jaeken,J.,
            Seuntjens,E., Devriendt,K., Burstein,E., Low,K.J. and O'Driscoll,M.
  TITLE     Defective DNA Polymerase alpha-Primase Leads to X-Linked
            Intellectual Disability Associated with Severe Growth Retardation,
            Microcephaly, and Hypogonadism
  JOURNAL   Am J Hum Genet 104 (5), 957-967 (2019)
   PUBMED   31006512
REFERENCE   2  (bases 1 to 5321)
  AUTHORS   Starokadomskyy,P., Gemelli,T., Rios,J.J., Xing,C., Wang,R.C.,
            Li,H., Pokatayev,V., Dozmorov,I., Khan,S., Miyata,N., Fraile,G.,
            Raj,P., Xu,Z., Xu,Z., Ma,L., Lin,Z., Wang,H., Yang,Y.,
            Ben-Amitai,D., Orenstein,N., Mussaffi,H., Baselga,E., Tadini,G.,
            Grunebaum,E., Sarajlija,A., Krzewski,K., Wakeland,E.K., Yan,N., de
            la Morena,M.T., Zinn,A.R. and Burstein,E.
  TITLE     DNA polymerase-alpha regulates the activation of type I interferons
            through cytosolic RNA:DNA synthesis
  JOURNAL   Nat Immunol 17 (5), 495-504 (2016)
   PUBMED   27019227
REFERENCE   3  (bases 1 to 5321)
  AUTHORS   Baranovskiy,A.G., Lada,A.G., Siebler,H.M., Zhang,Y., Pavlov,Y.I.
            and Tahirov,T.H.
  TITLE     DNA polymerase delta and zeta switch by sharing accessory subunits
            of DNA polymerase delta
  JOURNAL   J Biol Chem 287 (21), 17281-17287 (2012)
   PUBMED   22465957
REFERENCE   4  (bases 1 to 5321)
  AUTHORS   Rytkonen,A.K., Vaara,M., Nethanel,T., Kaufmann,G., Sormunen,R.,
            Laara,E., Nasheuer,H.P., Rahmeh,A., Lee,M.Y., Syvaoja,J.E. and
            Pospiech,H.
  TITLE     Distinctive activities of DNA polymerases during human DNA
            replication
  JOURNAL   FEBS J 273 (13), 2984-3001 (2006)
   PUBMED   16762037
REFERENCE   5  (bases 1 to 5321)
  AUTHORS   En-Nia,A., Yilmaz,E., Klinge,U., Lovett,D.H., Stefanidis,I. and
            Mertens,P.R.
  TITLE     Transcription factor YB-1 mediates DNA polymerase alpha gene
            expression
  JOURNAL   J Biol Chem 280 (9), 7702-7711 (2005)
   PUBMED   15615704
  REMARK    GeneRIF: YB-1 mediates DNA polymerase alpha gene expression
REFERENCE   6  (bases 1 to 5321)
  AUTHORS   Coverley,D., Kenny,M.K., Lane,D.P. and Wood,R.D.
  TITLE     A role for the human single-stranded DNA binding protein HSSB/RPA
            in an early stage of nucleotide excision repair
  JOURNAL   Nucleic Acids Res 20 (15), 3873-3880 (1992)
   PUBMED   1508673
REFERENCE   7  (bases 1 to 5321)
  AUTHORS   Popanda,O. and Thielmann,H.W.
  TITLE     The function of DNA polymerases in DNA repair synthesis of
            ultraviolet-irradiated human fibroblasts
  JOURNAL   Biochim Biophys Acta 1129 (2), 155-160 (1992)
   PUBMED   1730053
REFERENCE   8  (bases 1 to 5321)
  AUTHORS   Martelli,A.M., Cocco,L. and Manzoli,F.A.
  TITLE     On the association of DNA polymerase alpha activity with the
            nuclear matrix in HeLa cells
  JOURNAL   Cell Biol Int Rep 15 (2), 131-140 (1991)
   PUBMED   1903085
REFERENCE   9  (bases 1 to 5321)
  AUTHORS   Matsumoto,T., Eki,T. and Hurwitz,J.
  TITLE     Studies on the initiation and elongation reactions in the simian
            virus 40 DNA replication system
  JOURNAL   Proc Natl Acad Sci U S A 87 (24), 9712-9716 (1990)
   PUBMED   2175912
REFERENCE   10 (bases 1 to 5321)
  AUTHORS   Fisher,P.A. and Korn,D.
  TITLE     DNA polymerase-alpha. Purification and structural characterization
            of the near homogeneous enzyme from human KB cells
  JOURNAL   J Biol Chem 252 (18), 6528-6535 (1977)
   PUBMED   893425
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ011605.1, FM076387.1, CN543332.1 and AI511322.1.
            
            On or before May 21, 2010 this sequence version replaced
            XM_001064735.2, XM_242396.6.
            
            Sequence Note: This RefSeq record was created from transcripts from
            several strains because no full length transcript from a single
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ011605.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4362              AJ011605.1         1-4362
            4363-4719           FM076387.1         146-502
            4720-5301           CN543332.1         16-597              c
            5302-5321           AI511322.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..5321
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq22"
     gene            1..5321
                     /gene="Pola1"
                     /note="DNA polymerase alpha 1, catalytic subunit"
                     /db_xref="GeneID:85241"
                     /db_xref="RGD:621816"
     exon            1..53
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..4417
                     /gene="Pola1"
                     /EC_number="2.7.7.7"
                     /note="DNA polymerase alpha catalytic subunit p180; DNA
                     polymerase alpha subunit I; polymerase (DNA directed),
                     alpha 1, catalytic subunit; polymerase (DNA) alpha 1,
                     catalytic subunit"
                     /codon_start=1
                     /product="DNA polymerase alpha catalytic subunit"
                     /protein_id="NP_445931.1"
                     /db_xref="GeneID:85241"
                     /db_xref="RGD:621816"
                     /translation="MAPVHGDDCKLETSAVSDSGSFVASRARREKKSKKGRQEALERL
                     KKAKAGEKYKYEVEDLTSVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFD
                     DDLEDDALDTCGEGSDGKAHRKDRKDVKKPSVTKPNNIKAMFIASAGKKTTDKTVDLS
                     KDDLLGDILQDLNTETPQIAPPPVLIPKKKRSTGASPNPFSVHTATAVPSGKIASPVS
                     RKEPPLTPVPLKRAEFAGDLAQPECPEDEQESGVIEFEDGDFDEPMDTEEVDEEEPVT
                     AKIWDQESEPVEGVKHEADPETGTTSFLDSFLPDVSCWDIDQKDENSFLLQEVQVDSN
                     HLPLVKGADDEQVFQFYWLDAYEDPYNQPGVVFLFGKVWVESAKTHVSCCVMVKNIER
                     TLYFLPREMKIDLNTGKETATPITMKDVYEEFDSKISAKYKIMKFKSKIVEKNYAFEI
                     PDVPEKSEYLEVRYSAEVPQLPQNLKGETFSHVFGTNTSSLELFLMNRKIKGPCWLEV
                     KNPQLLNQPISWCKFEAMALKPDLVNVIKDVSPPPLVVMSFSMKTMQNVQNHQHEIIA
                     MAALVHHNFPLDKAPPKPPFQTHFCVVSKPKDCIFPCAFKEVIKKKNMEVEVAATERT
                     LLGFFLAKVHKLDPDILVGHNICGFELEVLLQRINECKVPFWSKIGRLRRSNMPKLGS
                     RSGFGERNATCGRMICDVEISVKELIHCKSYHLSELVQQILKTERIVIPTENIRNMYS
                     EPSHLLYLLEHIWKDARFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFL
                     LLHAFYENNYIVPDKQIFRKPQQKPGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKV
                     GFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASETLKATEDEEQEQIPELPDPNLD
                     MGILPREIRKLVERRKQVKQLMKQQDLNPDLVLQYDIRQKALKLTANSMYGCLGFSYS
                     RFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGN
                     KVKNEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDIVR
                     RDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKAL
                     TKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLPATQRAYAPEQ
                     LQKQDNLAIDTQYYLAQQIHPVVARICEPIDGIDAVLIALWLGLDSTQFRVHQYHKDE
                     ENDALLGGPAQLTDEEKYKDCEKFKCLCPSCGTENIYDNVFEGSGMDMEPSLNRCSNI
                     DCKASPATFMVQLSNKLIMDIRRCIKKYYDGWLICEEPTCRNRIRRLPLHFSRNGPLC
                     PACMKAVLRPEYSDKSLYTQLCFYRYIFDADCALEKLPEHEKDKLKKQFFTPRVLQDY
                     RKVKNIAEHFLSWSGYSEVNLSKLFANYAGKN"
     exon            54..178
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            179..275
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..356
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            357..472
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..535
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..628
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            629..716
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..921
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1100
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1213
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1330
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1405
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1544
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1699
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1784
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1846
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1936
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2053
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2229
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2359
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            2360..2479
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2579
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2704
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2854
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..2977
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3010
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3103
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            3104..3309
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3442
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            3443..3574
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3749
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            3750..3928
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            3929..4060
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            4061..4177
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            4178..4271
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
     exon            4272..5305
                     /gene="Pola1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctatcggacc atggcgcctg ttcacggaga cgactgcaaa ctggaaacaa gcgctgtgtc
       61 agattcaggg agttttgtag cttctcgagc acgtcgagaa aaaaaatcaa agaaaggacg
      121 ccaagaagct ttagagcgac tgaaaaaggc taaagctggt gagaagtaca agtatgaagt
      181 tgaggacctc acaagtgttt atgaagaagt tgatgaagag cagtattcaa aactggttca
      241 ggcacgtcag gatgatgact ggatcgtgga tgacgacggt ataggctatg tggaagacgg
      301 tagagagatt tttgatgacg accttgaaga tgatgcactt gacacctgtg gggaaggaag
      361 tgatggcaaa gcacacagaa aggacaggaa ggatgtaaag aaaccttcag tgacaaaacc
      421 aaacaatatc aaggcaatgt tcattgctag tgctgggaag aaaaccacag ataaaacagt
      481 tgacttgtcc aaggatgatc tgctaggtga cattctacag gatctgaaca ctgagacacc
      541 tcaaatagct ccaccgccag tattgatacc aaagaaaaaa agatctactg gagcttcacc
      601 gaatcctttc tctgtgcaca ccgccacggc agttccttca ggaaaaattg cttcccctgt
      661 ctccagaaag gagcctccat taactcctgt tcctcttaaa cgtgctgaat ttgctggcga
      721 tctggctcag ccagagtgtc cagaagatga gcaggagtca ggggttatag agtttgaaga
      781 tggcgacttt gatgagccca tggacacaga ggaagtagat gaggaggagc ctgtgactgc
      841 caagatttgg gaccaagaga gtgagccagt ggaaggggtg aagcatgagg cagatcctga
      901 gacgggaacc acatctttct tagacagttt tctcccagat gtttcttgtt gggacattga
      961 tcagaaggac gaaaacagtt tcttacttca agaagttcaa gtggactcca atcatctccc
     1021 gttggtaaaa ggggcagatg atgaacaagt ctttcagttt tattggctgg atgcttatga
     1081 agatccatac aaccaaccag gtgtggtttt tctgtttggc aaagtatggg tcgaatcagc
     1141 caaaacccat gtgagctgtt gtgttatggt gaaaaatatt gagcgaacac tctacttcct
     1201 tccccgtgaa atgaaaattg acctaaacac agggaaagaa acagcaactc caattacaat
     1261 gaaggatgtt tatgaagaat ttgattcaaa aatttcagca aaatataaaa taatgaagtt
     1321 caagtccaag atagtggaaa agaactatgc ttttgagata cctgatgttc cagaaaaatc
     1381 tgagtacttg gaagttagat actcggcaga agtgccacag cttccacaga atttaaaagg
     1441 agaaacattt tctcatgtat ttggaactaa cacgtctagc ttggaactgt tcttgatgaa
     1501 tagaaagatc aaaggaccct gttggcttga agtaaaaaat ccacaactct tgaatcaacc
     1561 aatcagttgg tgtaaatttg aggcaatggc tttgaaacca gacttggtga atgtaattaa
     1621 ggatgtcagt cctcctccac ttgtggtgat gtctttcagc atgaagacaa tgcaaaatgt
     1681 acagaaccat caacacgaga tcattgctat ggcagcgctg gttcatcaca atttcccatt
     1741 agataaagca cctccaaaac ctccctttca gacgcatttc tgtgttgtgt ctaaaccaaa
     1801 ggactgtatt ttcccatgcg ctttcaaaga agtcattaag aaaaagaata tggaggttga
     1861 ggttgctgca acagaaagaa ctttgctagg atttttcctt gcaaaagttc acaaacttga
     1921 ccctgatatt ctcgtgggtc ataatatttg tggttttgaa ctagaagtgc tactgcaaag
     1981 aattaatgag tgcaaggttc ctttctggtc caagataggt cggctgagga gatccaacat
     2041 gccaaaactt gggagccgga gtggatttgg tgaaagaaat gctacctgtg gtcgaatgat
     2101 atgtgatgtg gaaatttcag taaaagaatt gattcattgt aaaagttacc atttgtctga
     2161 acttgttcag cagattctga aaactgagag gattgtaatt ccaacagaaa atatacgaaa
     2221 catgtatagt gaaccttctc atctgttgta cctgttggaa cacatctgga aagatgccag
     2281 attcattttg cagatcatgt gtgagctaaa tgttcttcca ttagcattgc agatcactaa
     2341 catcgctggg aacattatgt ctaggacact gatgggtgga cgatctgagc gaaacgagtt
     2401 tttgttgctt catgcatttt atgaaaacaa ctatattgtg cctgacaagc agattttcag
     2461 aaaacctcag caaaaaccgg gagatgaaga tgaagaaatt gatggggata ccaataaata
     2521 taagaaagga cgcaagaaag cagcttatgc tggaggcttg gttttggacc ccaaagttgg
     2581 tttttatgac aagttcattt tgctcctgga tttcaacagt ttatatcctt ccatcattca
     2641 ggaatttaac atttgtttta caacagtgca aagagttgct tcagagacac tgaaagctac
     2701 agaggatgag gaacaagaac agattccaga gttgccagat ccaaacttag atatgggcat
     2761 tttgcccaga gagatccgga aactggtaga gcggagaaaa caagtgaaac agctaatgaa
     2821 acagcaagat ttaaatccag accttgttct tcagtatgat atccgacaga aggctttgaa
     2881 gctcacagcg aacagtatgt atggttgcct gggattttcg tacagcagat tttatgctaa
     2941 accgctggct gccttggtga catacaaagg aagggagatt ttgatgcaca cgaaagagat
     3001 ggtacagaag atgaatcttg aagttattta tggagacaca gattcaatta tgataaatac
     3061 caatagcacc aacctggaag aagtctttaa gttgggaaac aaggtaaaaa atgaagtgaa
     3121 taaattgtac aaactgcttg aaatagacat tgatggtgtt ttcaagtctc tgctattgct
     3181 gaagaaaaag aaatatgctg ctctagttgt cgaaccaaca tccgatggga attacatcac
     3241 caagcaggaa ctgaaaggat tggatatagt tagaagggac tggtgtgatc ttgccaagga
     3301 caccggaaac tttgtcattg gccagattct ttctgatcaa agtcgggaca ccattgtgga
     3361 aaacattcag aagaggttaa tagaaattgg agaaaatgtg ctaaacggca gtgtcccagt
     3421 gagccagttt gaaattaaca aggcattgac aaaggatccc caggattacc ctgataaaaa
     3481 aagtctacct catgtacatg ttgcactgtg gataaattct caaggaggca ggaaggtgaa
     3541 agctggcgat acagtgtcat atgttatctg tcaggatggg tcaaacctcc ctgcaactca
     3601 gagggcctat gcacccgagc aattgcagaa acaggacaat ttagccatcg acacccagta
     3661 ctacttggcc cagcagatcc accctgttgt ggctcgaatc tgtgagccaa tagatggaat
     3721 tgatgctgta ctcattgcat tatggctagg acttgactcc actcaattta gagttcatca
     3781 gtatcacaaa gatgaagaga atgatgctct ccttggtggt ccagcacagc taactgatga
     3841 agagaaatac aaggattgtg aaaaattcaa atgcctttgt ccttcatgtg gaactgaaaa
     3901 tatttatgat aatgtctttg aaggctcggg aatggatatg gagcccagct tgaatcgttg
     3961 cagtaatatt gattgtaagg cttcaccagc gacctttatg gtacagttga gcaacaaatt
     4021 gatcatggac attagacgtt gcattaaaaa gtactatgat ggctggttga tatgtgagga
     4081 gccaacttgt cgcaatcgca ttcgtcgtct tccccttcat ttctcccgaa atgggcctct
     4141 gtgtccagcc tgcatgaaag ctgtgctcag accagagtat tctgacaagt ccctgtacac
     4201 ccagctgtgc ttttaccggt acatttttga tgcggactgt gcactggaaa aacttcctga
     4261 acacgagaaa gataaattga agaagcagtt tttcactccc agagttcttc aggactacag
     4321 aaaagtcaag aacatagcag aacacttctt gtcctggagt ggctactctg aagtaaacct
     4381 cagcaagctc ttcgccaatt atgctgggaa gaactgagcg agccaggagc aagcacggag
     4441 gccaggtgct gaatgtgagc ttctgaggcc gccacctgcc ctaactgctt caccagtagc
     4501 ttgcttttct tttgaggatt gcatgctgtg ttgatgtaga tgtggaccag gatgggagtg
     4561 taaaaatact taacttgcca aatagttttc atagtactat gtgcaaccaa accctttcct
     4621 aagtacccaa agacctatta tcttattggg gactggattt ctgcagagca gaaattacta
     4681 ctttaattga gagtacctga gacataagtg accttcattt taccctgggg ctgtatcaga
     4741 ggcaccccta aaagagttct atggggtttt gtggaggtcc taacattttg ctttttcaca
     4801 tgtcaattaa acccagactg tgtccatata cttgttcagc tactggctac aagcttggct
     4861 gatttcagcg ctgtctttca tataagtgct gcaggtggcg ggggtgggtg gtgatggtgg
     4921 agggatttag aaagtttgca cttactaaat acaaagagca agtttgctta ttgaattgtt
     4981 cagagttcaa cactgaccag atgtttcata tgcacattcc ttatgttgtc cctttacata
     5041 gaatgttcaa agtggaggtt tataaaatag gaaagcattt ttaaatactt tgtcctgaca
     5101 tttcacaaaa attatggcgg ggctctggtg ggaggcagcc gacaggaccc agtgcttgct
     5161 gtctcatcag ttcttcataa cagtgctcac tttgaagcca taaactctat tttaatacct
     5221 taaagactta tctatttgtc tttttataaa gaaaaaaatg gattgtgttc tgtgcttaag
     5281 aataaagttt tctaaaggaa acccaaaaaa aaaaaaaaaa a
//
