LOCUS       NM_001100652            2935 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Rattus norvegicus protein O-glucosyltransferase 1 (Poglut1), mRNA.
ACCESSION   NM_001100652 XM_001069417 XM_221437
VERSION     NM_001100652.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2935)
  AUTHORS   Takeuchi,H., Schneider,M., Williamson,D.B., Ito,A., Takeuchi,M.,
            Handford,P.A. and Haltiwanger,R.S.
  TITLE     Two novel protein O-glucosyltransferases that modify sites distinct
            from POGLUT1 and affect Notch trafficking and signaling
  JOURNAL   Proc Natl Acad Sci U S A 115 (36), E8395-E8402 (2018)
   PUBMED   30127001
REFERENCE   2  (bases 1 to 2935)
  AUTHORS   Servian-Morilla,E., Takeuchi,H., Lee,T.V., Clarimon,J.,
            Mavillard,F., Area-Gomez,E., Rivas,E., Nieto-Gonzalez,J.L.,
            Rivero,M.C., Cabrera-Serrano,M., Gomez-Sanchez,L.,
            Martinez-Lopez,J.A., Estrada,B., Marquez,C., Morgado,Y.,
            Suarez-Calvet,X., Pita,G., Bigot,A., Gallardo,E.,
            Fernandez-Chacon,R., Hirano,M., Haltiwanger,R.S., Jafar-Nejad,H.
            and Paradas,C.
  TITLE     A POGLUT1 mutation causes a muscular dystrophy with reduced Notch
            signaling and satellite cell loss
  JOURNAL   EMBO Mol Med 8 (11), 1289-1309 (2016)
   PUBMED   27807076
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2935)
  AUTHORS   Ramkumar,N., Harvey,B.M., Lee,J.D., Alcorn,H.L.,
            Silva-Gagliardi,N.F., McGlade,C.J., Bestor,T.H., Wijnholds,J.,
            Haltiwanger,R.S. and Anderson,K.V.
  TITLE     Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse
            Gastrulation through Modification of the Apical Polarity Protein
            CRUMBS2
  JOURNAL   PLoS Genet 11 (10), e1005551 (2015)
   PUBMED   26496195
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2935)
  AUTHORS   Takeuchi,H., Fernandez-Valdivia,R.C., Caswell,D.S., Nita-Lazar,A.,
            Rana,N.A., Garner,T.P., Weldeghiorghis,T.K., Macnaughtan,M.A.,
            Jafar-Nejad,H. and Haltiwanger,R.S.
  TITLE     Rumi functions as both a protein O-glucosyltransferase and a
            protein O-xylosyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 108 (40), 16600-16605 (2011)
   PUBMED   21949356
REFERENCE   5  (bases 1 to 2935)
  AUTHORS   Wu,Z.L., Ethen,C.M., Prather,B., Machacek,M. and Jiang,W.
  TITLE     Universal phosphatase-coupled glycosyltransferase assay
  JOURNAL   Glycobiology 21 (6), 727-733 (2011)
   PUBMED   21081508
REFERENCE   6  (bases 1 to 2935)
  AUTHORS   Fernandez-Valdivia,R., Takeuchi,H., Samarghandi,A., Lopez,M.,
            Leonardi,J., Haltiwanger,R.S. and Jafar-Nejad,H.
  TITLE     Regulation of mammalian Notch signaling and embryonic development
            by the protein O-glucosyltransferase Rumi
  JOURNAL   Development 138 (10), 1925-1934 (2011)
   PUBMED   21490058
REFERENCE   7  (bases 1 to 2935)
  AUTHORS   Teng,Y., Liu,Q., Ma,J., Liu,F., Han,Z., Wang,Y. and Wang,W.
  TITLE     Cloning, expression and characterization of a novel human
            CAP10-like gene hCLP46 from CD34(+) stem/progenitor cells
  JOURNAL   Gene 371 (1), 7-15 (2006)
   PUBMED   16524674
REFERENCE   8  (bases 1 to 2935)
  AUTHORS   Garcia-Garcia,M.J., Eggenschwiler,J.T., Caspary,T., Alcorn,H.L.,
            Wyler,M.R., Huangfu,D., Rakeman,A.S., Lee,J.D., Feinberg,E.H.,
            Timmer,J.R. and Anderson,K.V.
  TITLE     Analysis of mouse embryonic patterning and morphogenesis by forward
            genetics
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5913-5919 (2005)
   PUBMED   15755804
REFERENCE   9  (bases 1 to 2935)
  AUTHORS   Kasarskis,A., Manova,K. and Anderson,K.V.
  TITLE     A phenotype-based screen for embryonic lethal mutations in the
            mouse
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7485-7490 (1998)
   PUBMED   9636176
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM034156.1, BC091408.1 and BQ194157.1.
            
            On or before Dec 18, 2009 this sequence version replaced
            XM_221437.4, XM_001069417.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               FM034156.1         1-228
            229-2910            BC091408.1         1-2682
            2911-2935           BQ194157.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..2935
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q21"
     gene            1..2935
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /note="protein O-glucosyltransferase 1"
                     /db_xref="GeneID:288091"
                     /db_xref="RGD:1306248"
     exon            1..184
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1278
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /EC_number="2.4.2.63"
                     /EC_number="2.4.1.376"
                     /note="KTEL (Lys-Tyr-Glu-Leu) containing 1; protein
                     O-xylosyltransferase; O-glucosyltransferase Rumi homolog"
                     /codon_start=1
                     /product="protein O-glucosyltransferase 1 precursor"
                     /protein_id="NP_001094122.1"
                     /db_xref="GeneID:288091"
                     /db_xref="RGD:1306248"
                     /translation="MERLSGCRLRPWMLLLLLFPVQGRQKDSGSKWKVFIDQINRALE
                     NYEPCSSQNCSCYHGVIEEDLTPFRGGISRKMMAEVVRRRLGTHYQIIKHRLFREDDC
                     MFPSRCSGVEHFILEVIRRLPDMEMVINVRDYPQVPKWMEPTIPVFSFSKTSEYHDIM
                     YPAWTFWEGGPAVWPLYPTGLGRWDLFREDLLRSAAQWPWEKKNSTAYFRGSRTSPER
                     DPLILLSRKNPKLVDAEYTKNQAWKSMKDTLGKPAAKDVHLIDHCKYKYLFNFRGVAA
                     SFRFKHLFLCGSLVFHVGDEWVEFFYPQLKPWVHYIPVKTDLSDVQELLQFVKANDDL
                     AQEIAKRGSQFIINHLQMDDITCYWENLLTEYSKFLSYNVTRRKDYYQIIPRRLKTEL
                     "
     exon            185..275
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /inference="alignment:Splign:2.1.0"
     exon            276..419
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /inference="alignment:Splign:2.1.0"
     exon            420..555
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /inference="alignment:Splign:2.1.0"
     exon            556..677
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /inference="alignment:Splign:2.1.0"
     exon            678..737
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /inference="alignment:Splign:2.1.0"
     exon            738..837
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /inference="alignment:Splign:2.1.0"
     exon            838..896
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1064
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1121
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..2918
                     /gene="Poglut1"
                     /gene_synonym="Ktelc1; RGD1306248"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagggcagt tcccacgtgc cgaggcgtcc gccgccatcc ttctgccggg cggcgcttcc
       61 gccggcgtgc cggtcggaat ccgcagtggt ctgcgggtga tggagcggct gtcgggctgt
      121 aggcttaggc catggatgct gttattgctc ctgttcccgg tgcagggccg ccagaaggac
      181 tcaggctcaa aatggaaagt atttattgac caaattaaca gggctttgga gaattatgaa
      241 ccatgttcaa gtcaaaactg cagctgctat cacggggtca tagaagagga tctgactcct
      301 ttccgaggtg gaatctccag gaagatgatg gccgaggtgg tcagacggag gttaggaacc
      361 cactaccaga tcattaagca cagattattc agggaagacg actgcatgtt tccctccagg
      421 tgtagtggtg tagaacactt tattttggaa gtgatccgtc gcctccctga catggaaatg
      481 gtaatcaatg tccgagacta tcctcaggtt cctaagtgga tggagcctac catccctgtc
      541 ttctccttca gtaagacatc ggagtaccat gatataatgt accctgcgtg gacattttgg
      601 gaagggggtc ctgctgtgtg gccactttat cctacaggtc ttgggcggtg ggacctcttc
      661 agagaagatc tgttaaggtc agcagcacaa tggccatggg aaaagaagaa ttctacagca
      721 tatttccggg gatcaaggac aagccctgaa agagatcctc tcattcttct ctctcggaaa
      781 aatccaaaac tcgttgatgc agaatacacc aaaaaccagg cctggaagtc tatgaaagat
      841 actttgggaa agccagccgc taaggatgtg catcttatag atcactgcaa atacaaatac
      901 ctgtttaatt tccgaggtgt agctgcaagt ttccggttca aacacctctt cttgtgtggc
      961 tcgctggtct tccatgttgg tgatgagtgg gttgagttct tctacccaca gctaaagccc
     1021 tgggttcact acatcccagt caaaacagac ctctccgatg tccaggagct gttgcagttt
     1081 gtgaaagcaa atgatgatct tgctcaggaa attgctaaaa ggggaagcca gttcatcata
     1141 aaccatttgc agatggatga catcacttgt tactgggaga acctcttgac tgaatattcc
     1201 aaattcctgt cctataatgt aacaagaaga aaagattatt atcagatcat tcccagacgt
     1261 ttgaaaactg aactgtagtg tccatcacag gaccagaatc ctgactatgg atctgagatg
     1321 ctctgtggtg aaataccatg atcatgctgc ctataccttg aacacctttg gccgagccaa
     1381 acatccagtt ttccttatca tgttgaagcc agaggaactc ttgagaaaga tctagtacat
     1441 gtataatgag cagaaattta acagctcagc tctttgaatc atgaaataag gatttggaac
     1501 tgcgttctat ctttcatttt cttttgatca ctcacagctt gtgcctcagg tcggctacat
     1561 catcactgtg aacctgactg ggtccatgta agatgctctt tgtcctacta tttggagcag
     1621 accatcgttt ggaactagta ccatacacta gcaattatga agttatttta ggcttgatct
     1681 ctattgcttt attttaatgt agaaatcctt tggagtttgt gaagaaatcc cacagcgatc
     1741 atttcctctg gagtctaagg aaacagtggc tgtgccatga gtgccatcgg aggtctcctt
     1801 tgtaaactca ggaggtttcc acaatgcctc agttgcataa taacttctgc agttggattt
     1861 caaatttcca ttttgtgcct tcatgccctt tttattctct ctaatggaga agaagagaaa
     1921 tttcctagta cattcaggaa gtagtctcat taaagaactg tgcccctgca atgctagcac
     1981 ttctgaggaa gaggcaggaa gatgagttcg tggccaccat cagctgcaca agacttgttc
     2041 aaggagagcc tggctacatg aggtcttgcc tcataaactt gaactcacac acatctttta
     2101 ttttggcatc ttaaattagt agcagcagga ccacctcagt ttgcagagtc gacagtcttc
     2161 atctgtgaac atcagaagtg gcaatttgta gagcatctat cggcttttgc ttttactcct
     2221 gtattaagta ttattggagt acttccttat cccccttctg aaaaaggatg tgtggacaat
     2281 ttatttcaag ttacagctcc agcatcacct ctgaacctca cccccttgag tcggggctcg
     2341 ggccgtactg tgtgccattg tgctgcttcc tagttacttg gcggttcctc ccattgtttt
     2401 gtaagcttgt agatggatga gagtgatgct tccctgctcc tgatgtctcc tttatcagag
     2461 caatgcctca ggcagagtaa tcactgaaca actactgggg gatgagtgag tggggaatgg
     2521 atggatatac tcgtctggct taaccgaatc ctaccttaag ttacctggtt acttgcccca
     2581 gtggggatga gatacattgt acgaaatggg tcagtacaga tcctcacttg ccctctcagg
     2641 tagtgaggag tatctgtttt taaagacaac acaagttcct cagatcttac acttacctgt
     2701 gtacctcact gcaggtggta tgagaatgct gtgtaacaaa cagtttggga agcatatgcc
     2761 tttgaaaaca gtttgtattc tcatactttg aagatgttgt tatcattaat actagctcgg
     2821 tctcaagctt aaccatttgc tcctcgaaaa tgtatttact atagaaaagg ttacaattgt
     2881 tttcaatata actaaatata tgttttgtaa gagttgtaaa aaaaaaaaaa aaaaa
//
