LOCUS       NM_138848               5309 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus podocalyxin-like (Podxl), mRNA.
ACCESSION   NM_138848
VERSION     NM_138848.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5309)
  AUTHORS   Ramdin,S., Naicker,T., Baijnath,S. and Govender,N.
  TITLE     Kidney injury molecule-1 and podocalyxin dysregulation in an
            arginine vasopressin induced rodent model of preeclampsia
  JOURNAL   Eur J Obstet Gynecol Reprod Biol 284, 58-65 (2023)
   PUBMED   36934678
  REMARK    GeneRIF: Kidney injury molecule-1 and podocalyxin dysregulation in
            an arginine vasopressin induced rodent model of preeclampsia.
REFERENCE   2  (bases 1 to 5309)
  AUTHORS   Lu,W., Liu,S., Zhao,Z., Liu,Y. and Li,T.
  TITLE     The effect of connective tissue growth factor on renal fibrosis and
            podocyte injury in hypertensive rats
  JOURNAL   Ren Fail 36 (9), 1420-1427 (2014)
   PUBMED   25003484
  REMARK    GeneRIF: Both the overexpression of CTGF and the loss of
            podocalyxin reflect renal damage in spontaneously hypertensive
            rats. CTGF and PCX may be involved in the mechanisms of podocyte
            injury and apoptosis induced by hypertension
REFERENCE   3  (bases 1 to 5309)
  AUTHORS   Tschernig,T., Pabst,R., Kasper,M., El-Hadi,M. and Singh,B.
  TITLE     Expression of caveolin-1 and podocalyxin in rat lungs challenged
            with 2-kDa macrophage-activating lipopeptide and Flt3L
  JOURNAL   Cell Tissue Res 356 (1), 207-216 (2014)
   PUBMED   24419512
  REMARK    GeneRIF: The immunohistochemical expression of caveolin-1 and
            podocalyxin in lungs from rats challenged with a 2-kDa
            macrophage-activating lipopeptide (MALP-2) and Flt3L, was examined.
REFERENCE   4  (bases 1 to 5309)
  AUTHORS   Hsu,Y.H., Lin,W.L., Hou,Y.T., Pu,Y.S., Shun,C.T., Chen,C.L.,
            Wu,Y.Y., Chen,J.Y., Chen,T.H. and Jou,T.S.
  TITLE     Podocalyxin EBP50 ezrin molecular complex enhances the metastatic
            potential of renal cell carcinoma through recruiting Rac1 guanine
            nucleotide exchange factor ARHGEF7
  JOURNAL   Am J Pathol 176 (6), 3050-3061 (2010)
   PUBMED   20395446
REFERENCE   5  (bases 1 to 5309)
  AUTHORS   Kobayashi,T., Notoya,M., Shinosaki,T. and Kurihara,H.
  TITLE     Cortactin interacts with podocalyxin and mediates morphological
            change of podocytes through its phosphorylation
  JOURNAL   Nephron Exp Nephrol 113 (3), e89-e96 (2009)
   PUBMED   19684413
  REMARK    GeneRIF: cortactin mediates interaction between podocalyxin and
            actin filaments in podocytes and that alteration of this
            interaction may play a role in the process of morphological change
            of podocytes.
REFERENCE   6  (bases 1 to 5309)
  AUTHORS   Economou,C.G., Kitsiou,P.V., Tzinia,A.K., Panagopoulou,E.,
            Marinos,E., Kershaw,D.B., Kerjaschki,D. and Tsilibary,E.C.
  TITLE     Enhanced podocalyxin expression alters the structure of podocyte
            basal surface
  JOURNAL   J Cell Sci 117 (Pt 15), 3281-3294 (2004)
   PUBMED   15226400
  REMARK    GeneRIF: podocalyxin has a role in defining the structure of the
            podocyte basal surface
REFERENCE   7  (bases 1 to 5309)
  AUTHORS   Orlando,R.A., Takeda,T., Zak,B., Schmieder,S., Benoit,V.M.,
            McQuistan,T., Furthmayr,H. and Farquhar,M.G.
  TITLE     The glomerular epithelial cell anti-adhesin podocalyxin associates
            with the actin cytoskeleton through interactions with ezrin
  JOURNAL   J Am Soc Nephrol 12 (8), 1589-1598 (2001)
   PUBMED   11461930
REFERENCE   8  (bases 1 to 5309)
  AUTHORS   Takeda,T., McQuistan,T., Orlando,R.A. and Farquhar,M.G.
  TITLE     Loss of glomerular foot processes is associated with uncoupling of
            podocalyxin from the actin cytoskeleton
  JOURNAL   J Clin Invest 108 (2), 289-301 (2001)
   PUBMED   11457882
REFERENCE   9  (bases 1 to 5309)
  AUTHORS   Takeda,T., Go,W.Y., Orlando,R.A. and Farquhar,M.G.
  TITLE     Expression of podocalyxin inhibits cell-cell adhesion and modifies
            junctional properties in Madin-Darby canine kidney cells
  JOURNAL   Mol Biol Cell 11 (9), 3219-3232 (2000)
   PUBMED   10982412
REFERENCE   10 (bases 1 to 5309)
  AUTHORS   Hara,T., Nakano,Y., Tanaka,M., Tamura,K., Sekiguchi,T.,
            Minehata,K., Copeland,N.G., Jenkins,N.A., Okabe,M., Kogo,H.,
            Mukouyama,Y. and Miyajima,A.
  TITLE     Identification of podocalyxin-like protein 1 as a novel cell
            surface marker for hemangioblasts in the murine
            aorta-gonad-mesonephros region
  JOURNAL   Immunity 11 (5), 567-578 (1999)
   PUBMED   10591182
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF109393.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF109393.1, BC070886.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132262,
                                           SAMD00132263 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5309
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..5309
                     /gene="Podxl"
                     /gene_synonym="PC; PCLP-1; podocalyxin"
                     /note="podocalyxin-like"
                     /db_xref="GeneID:192181"
                     /db_xref="RGD:621878"
     exon            1..228
                     /gene="Podxl"
                     /gene_synonym="PC; PCLP-1; podocalyxin"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1604
                     /gene="Podxl"
                     /gene_synonym="PC; PCLP-1; podocalyxin"
                     /note="podocalyxin-like protein 1"
                     /codon_start=1
                     /product="podocalyxin precursor"
                     /protein_id="NP_620203.1"
                     /db_xref="GeneID:192181"
                     /db_xref="RGD:621878"
                     /translation="MRPTLALSALLLLQLLLLSTPSLSQDNGNKTDTSDITSIDQNQD
                     KPATNQPSNATPKSSVQPPTPTSISTSSPDPKATQSSNSSVTTTSDSTTDRTSSSTST
                     VPTTSNSGQTVSSGGKSSDKITTALPTTLGPVNASSQPTDLNTSTKLPSTPTTNSTAS
                     PHQPVSHSEGQHTTVQSSSASVSSSDNTTLLWILTTSKPTGTSEGTQPIAISTPGITT
                     PVSTPLQPTGSPGGTESVPTTEEFTHSTSSWTPVVSQGPSTPSSTWTSGSYKLKCDPA
                     IKPHEELLILNLTRDSFCKGSPPNERFLELLCHSAKASFKPAEDSCALELAPILDNQA
                     VAVKRIVIETKLSPKAVFELLKDKWDDLTEAGVIDIHLGKEGPPEVNEDRFSLPLIIT
                     IVCMASFLLLVAALYGCCHQRISQRKDQQRLTEELQTVENGYHDNPTLEVMETPSEMQ
                     EKKVVNLNGELGDSWIVPLDNLTKEDLDEEEDTHL"
     exon            229..738
                     /gene="Podxl"
                     /gene_synonym="PC; PCLP-1; podocalyxin"
                     /inference="alignment:Splign:2.1.0"
     exon            739..956
                     /gene="Podxl"
                     /gene_synonym="PC; PCLP-1; podocalyxin"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1028
                     /gene="Podxl"
                     /gene_synonym="PC; PCLP-1; podocalyxin"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1176
                     /gene="Podxl"
                     /gene_synonym="PC; PCLP-1; podocalyxin"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1238
                     /gene="Podxl"
                     /gene_synonym="PC; PCLP-1; podocalyxin"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1406
                     /gene="Podxl"
                     /gene_synonym="PC; PCLP-1; podocalyxin"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..5282
                     /gene="Podxl"
                     /gene_synonym="PC; PCLP-1; podocalyxin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcaggagga gcagccggat agtgactcca gagttcccgg ctgtcgccag gcctccggga
       61 gcggcgccga ctctcccgcg gtccggacgc cggaccctgc gccagagccg cagccacctg
      121 ctccgagtcc ccgggcaagc acaaccatgc gccccactct ggcgctctcc gcgctgctgt
      181 tgctgcagct gctgttactg tcgactccat ctctctccca ggataatgga aataagactg
      241 acacatctga tataactagc attgaccaga accaagacaa accagcgaca aaccagccaa
      301 gcaatgctac acctaaaagc tcagtccaac ctccaacacc gacatctatt tcaacctcct
      361 ccccagaccc caaggccact caaagcagta acagttcagt tacaactacc agtgactcca
      421 ccactgacag gacaagctct tccactagca ctgtccccac tactagcaac agtgggcaga
      481 cagtctcctc tggaggcaag agcagtgaca aaattaccac agccctacca accactttgg
      541 gaccagtcaa cgcctcttct caacctactg acctgaatac ctcgacaaag cttccttcta
      601 cccccacaac aaatagcaca gcaagccctc accagcctgt gagccactct gagggacagc
      661 acaccactgt tcagagcagc tctgcttctg tgtccagctc tgacaacact acgctgttgt
      721 ggatacttac tacatccaaa ccgacaggca cctctgaagg cactcagccc atcgctatct
      781 cgacgccagg catcaccaca ccggtctcca caccactaca gcctacgggg tctccagggg
      841 gaactgagtc ggtgcctacg accgaagaat tcacacactc cacttctagt tggactccag
      901 tggtctctca aggcccgagc acaccctctt ccacctggac gtctgggagt tacaagctaa
      961 aatgtgatcc tgccataaag ccccacgagg aactcctcat tctgaacctc acaagagaca
     1021 gcttttgtaa ggggagccct ccaaatgaaa gattcttgga actgctgtgt cactcagcca
     1081 aagcctcctt caagccagct gaggattcgt gtgctctgga gctggccccc attctagaca
     1141 accaggcggt ggcagtgaag agaatcgtta ttgagacgaa gctttctcct aaggctgtgt
     1201 ttgaactgct gaaggacaaa tgggacgacc tgacagaggc tggagtcatc gacattcatc
     1261 tggggaagga aggacctcca gaagtcaacg aggaccgctt cagccttcct ctcatcatca
     1321 ccatcgtctg catggcatcc ttcctgctcc tcgttgctgc cctctacggc tgctgtcacc
     1381 agcggatctc ccagaggaag gaccaacaac gactcacaga ggagctgcag acagtagaga
     1441 atggttacca tgacaaccca accttggaag tgatggagac tccttctgag atgcaggaga
     1501 agaaggtggt caacctcaac ggggagctgg gagacagttg gatcgtccct ctggacaact
     1561 tgaccaagga ggacctagat gaggaggaag atacacacct ctgatcagtc cgccagccac
     1621 tccgaccgca ccgcagagct ctcgaccacc caaagtgcca tttggacggg ggcggggagg
     1681 ggaggggact tcccacctga agacagaaag attggggagg gagaatggac accgagggtt
     1741 gtctccctcc tccccatccc cacaaggcct taattttccc tttcaagttc aacgaagtca
     1801 cattctgtcc agtttcctca tgtaaaaaaa cctacttgtg cctgagccca gagccgctgg
     1861 aaggcaggaa ggtggagaac accatgcgag aggctctggc gctcctccag gaatggcacc
     1921 cacccatctc ataagtaaga tgaccaaggc cttaagaggt caggtaacct gcacagggcc
     1981 acacggccat ttggtgacaa gggtggtttc cctcggtctg gtgcttcgtt gcatcaagac
     2041 acactactgt gttcatttgt gtccatcccc caaggcacaa gacacacgaa agcgggcagg
     2101 ctagaaagaa aaccaatcct ctatggtctc aaggacaggc cccaaatttc catctcctct
     2161 aacatggcct ctgccagctt gttgaatccc gcttcctatg agtcagtctt tagtcccact
     2221 ctttcccagg gcagggcttt gaacctcttg ggaagatttc cttgcctttg cttagcagga
     2281 ttgggaccta acacacaggc ctcactatct aatggagtct gcctaaaggg tgggtgggca
     2341 ggcagaggaa aaggaagctc aggctgggac gccttcctca tggcagctga ttctgtactg
     2401 acactggcct atcattcaag gcactcccta gaagacactc ccccaaatgt cctctggcct
     2461 tctgctccct ctaggaacaa atctgcagta gctactgaaa gcaagatgtt cctcttttcc
     2521 ttgttcactg ctcagctgag ggggtgactc ctcaaatccg agtgtcacag agcagctgtc
     2581 tagggacaaa catgtcctgg ggttctgacc ggtccttaat tggttcctga ttggcaaatg
     2641 tgtctcagta gacaatcgat ctaacctacc tggcattatt ccacaggaag ctcaggggct
     2701 tttcaagtta ccgagaactt gggtggttgt gttatggtgt gtgttgtgtg tgtgtgcgtg
     2761 tgttgtgtgc atgtgtgttt gtttaattca gctcctaact gccaaaggcc aaagctcaga
     2821 tcctggagac tgttagctca tttcattggt ttgcaccctc ctttgccatg gagaaaggcc
     2881 cagaacatgc agttttaaga ttcttttacc cattctccta gcacggagcc aggtttttgt
     2941 ttccggtgtt ctttgtagca ccccagttgt accatttctg gtggcctctc agggaaacaa
     3001 aaccatgcct aggacccagc acaggagttt tacaggctca gcagagtcaa gcagccatgt
     3061 acaagactgt cgagggcccg gcatagcgat gtttcatctg gttttctgag aaaggggtgg
     3121 gggaccctgt gtggagcttt gaattaggcc tatggtctgg attgttcttg ggcataaatc
     3181 cccatgactg actgtctggt ttgaagcagc ttatttagaa ggggagctag gggacagaca
     3241 ggtgttctct gcctaatccc attgttatag ctgtcacact gagataggct aaggagaaag
     3301 gctgccagaa gtcaagaaag gctctcagtg agtttcacag gagttgaaaa aaaaaacgct
     3361 aacaagaact cacaaacccc ttggcctgca tctctcagat ttgcagggga gggtggggag
     3421 cagtgccaat ttggggggaa attaggttta tttgctcccg gcattaggtt ctgtcctgag
     3481 aggcagccag cattccttct cctttgctac aatcaatggg taaggccatg acagacagca
     3541 catgcgctct ctgcaaactg gtcagattat aaccctacag cctgtcagat atggctgtaa
     3601 cattagacaa cagatactgt gtctaagctg ttggaatagc cttggctctg cccagggtaa
     3661 gcccatagaa actctgccca ggctggccca gtgtcccttc ctgtgcactc aaattgtgta
     3721 gcatttcagt acagcttgag aatctggcct tcacttgctc ttaaccactg ggacatctgt
     3781 tacacaagac atgctgctag tgtctataaa agttatcttc ctgtgtttat tactgggttt
     3841 ttagagctgt ctgtgagttc agaatctcag gcccagtctg agagaaggaa gcggagggga
     3901 cctttagaac cagctgtacc aaagagaaat cagaacttca catttcaggg gcaaaatggc
     3961 ttcccccagc tgcaaaaccc aagggcctga tggttggctg aacaaagcca gccgctcttg
     4021 tgctgcctgc cgtgtgaatg gcgagggaag cagctgagca cagggcacag agcagtctgc
     4081 ctggccgagc aggatccaga ctcatttagg acactcacgc tctctatctt cctgatagag
     4141 agaaccagca ggtgttttac tgttttattg gtttttgttg ttttggtttt ttgggggttt
     4201 tttttttttt tgtgtttttt tgcctacttt ttggacaaca cactggtgaa actttgaaga
     4261 ataagttgaa gttgacaaga cctatgcacg tttttgacaa tgtaaataca agagccacat
     4321 gtttatttta ccctgtactg cttccagagg gtaaactttg ggaaagactt gatagctaag
     4381 cttcccaccc cccattttct gaataagaat gtaaatgtct atttagtaga aatgactttt
     4441 ttaaagaact gaagaatata acaagacagg ctggtaacac gagaatttgc cttgtagata
     4501 ggggatttaa aattttaaaa tactgtcctt gctcctcccc agccaagtct cccatcctgc
     4561 tgcagttcgg gctgaagttt agcatggtct gtgatggtca cgggggaagt ttaggagata
     4621 cagtctttct acaggaaaac acatctgaag ccacaaagaa tctcccgagg gccagagaca
     4681 agatgaaaac atgcatccca gactgcctgc tctgtgctgc atgtttctca agaacaggga
     4741 attaaggact acagctccca ggtacaaggt taatacagga taccatcagt ccttcctcat
     4801 aataaccctg gaagggctag gaggacacaa gggacacaaa cagccatgtg ctgggctctg
     4861 gaatcacatg gtccagatat caataaatat tttgggggct tggttttttt tttcctgtca
     4921 ggaaataatt ttgaaaagtt cctgaggaat gtccagtaga atgaggatca aagggactag
     4981 catagatgaa ggtagagagg gagaagctct gtagtgcagc ctgtgtcact gtcagtcatg
     5041 atccttccct ctcaggtctg cggaaaatcc accactgagc tgggatcact gtttcatggg
     5101 gcttttctgc ttctttgtga atgccaacca gcttgcccag gagattgggg gagtgtatgt
     5161 ggtagtggac aggggtctaa agtacactgg aatttatcga gagactatag ttaactattg
     5221 cattttctta taaagtatat tttggaaaat cgtacaccgt caattaaaat gcttttgtgt
     5281 aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
