LOCUS       NM_001142371            3441 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus polyribonucleotide nucleotidyltransferase 1
            (Pnpt1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001142371 XM_341266
VERSION     NM_001142371.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3441)
  AUTHORS   Pietras,Z., Wojcik,M.A., Borowski,L.S., Szewczyk,M., Kulinski,T.M.,
            Cysewski,D., Stepien,P.P., Dziembowski,A. and Szczesny,R.J.
  TITLE     Dedicated surveillance mechanism controls G-quadruplex forming
            non-coding RNAs in human mitochondria
  JOURNAL   Nat Commun 9 (1), 2558 (2018)
   PUBMED   29967381
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3441)
  AUTHORS   von Ameln,S., Wang,G., Boulouiz,R., Rutherford,M.A., Smith,G.M.,
            Li,Y., Pogoda,H.M., Nurnberg,G., Stiller,B., Volk,A.E., Borck,G.,
            Hong,J.S., Goodyear,R.J., Abidi,O., Nurnberg,P., Hofmann,K.,
            Richardson,G.P., Hammerschmidt,M., Moser,T., Wollnik,B.,
            Koehler,C.M., Teitell,M.A., Barakat,A. and Kubisch,C.
  TITLE     A mutation in PNPT1, encoding mitochondrial-RNA-import protein
            PNPase, causes hereditary hearing loss
  JOURNAL   Am J Hum Genet 91 (5), 919-927 (2012)
   PUBMED   23084290
REFERENCE   3  (bases 1 to 3441)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3441)
  AUTHORS   Wang,G., Chen,H.W., Oktay,Y., Zhang,J., Allen,E.L., Smith,G.M.,
            Fan,K.C., Hong,J.S., French,S.W., McCaffery,J.M., Lightowlers,R.N.,
            Morse,H.C. 3rd, Koehler,C.M. and Teitell,M.A.
  TITLE     PNPASE regulates RNA import into mitochondria
  JOURNAL   Cell 142 (3), 456-467 (2010)
   PUBMED   20691904
REFERENCE   5  (bases 1 to 3441)
  AUTHORS   Das,S.K., Sokhi,U.K., Bhutia,S.K., Azab,B., Su,Z.Z., Sarkar,D. and
            Fisher,P.B.
  TITLE     Human polynucleotide phosphorylase selectively and preferentially
            degrades microRNA-221 in human melanoma cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (26), 11948-11953 (2010)
   PUBMED   20547861
REFERENCE   6  (bases 1 to 3441)
  AUTHORS   Gorchakova,G.A.
  TITLE     [Polynucleotide phosphorylase from rat liver nuclei. Determination
            of the activity and some properties]
  JOURNAL   Biokhimiia 46 (5), 797-801 (1981)
   PUBMED   7295810
REFERENCE   7  (bases 1 to 3441)
  AUTHORS   Fedotov,V.P., Pluzhnikova,G.N., Khoroshutina,E.B., Ianakopulu,E.S.
            and Andrianova,L.E.
  TITLE     [Effect of growth hormone on polynucleotide phosphorylase activity
            in a primary monolayer culture of rat hepatocytes]
  JOURNAL   Biull Eksp Biol Med 90 (12), 692-694 (1980)
   PUBMED   7470604
REFERENCE   8  (bases 1 to 3441)
  AUTHORS   Del'vig,A.A.
  TITLE     [Destruction of mRNA poly-A sequences by polynucleotide
            phosphorylase in rat liver microsomes]
  JOURNAL   Biokhimiia 43 (11), 1983-1988 (1978)
   PUBMED   737213
REFERENCE   9  (bases 1 to 3441)
  AUTHORS   Del vig,A.A., Tarasov,A.P. and Debov,S.S.
  TITLE     [The activity of polynucleotide phosphorylase in polyribosomes of
            regenerating liver of adult rats, liver of newborn rats and in some
            reinoculated tumours]
  JOURNAL   Biokhimiia 41 (12), 2201-2211 (1976)
   PUBMED   191106
REFERENCE   10 (bases 1 to 3441)
  AUTHORS   Del'vig,A.A., Tarasov,A.P. and Debov,S.S.
  TITLE     [Effect of cyclic-3',5'-AMP on rat liver polynucleotide
            phosphorylase activity]
  JOURNAL   Vopr Med Khim 22 (5), 635-639 (1976)
   PUBMED   189502
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Nov 29, 2008 this sequence version replaced XM_341266.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.33710.1,
                                           SRR26643429.47689.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               JAXUCZ010000014.1  107078486-107078656
            172-232             JAXUCZ010000014.1  107080540-107080600
            233-307             JAXUCZ010000014.1  107081309-107081383
            308-413             JAXUCZ010000014.1  107082042-107082147
            414-463             JAXUCZ010000014.1  107082971-107083020
            464-527             JAXUCZ010000014.1  107084131-107084194
            528-575             JAXUCZ010000014.1  107084288-107084335
            576-689             JAXUCZ010000014.1  107085169-107085282
            690-876             JAXUCZ010000014.1  107085427-107085613
            877-928             JAXUCZ010000014.1  107086253-107086304
            929-986             JAXUCZ010000014.1  107086985-107087042
            987-1083            JAXUCZ010000014.1  107088203-107088299
            1084-1186           JAXUCZ010000014.1  107088649-107088751
            1187-1257           JAXUCZ010000014.1  107092400-107092470
            1258-1294           JAXUCZ010000014.1  107093743-107093779
            1295-1361           JAXUCZ010000014.1  107094302-107094368
            1362-1451           JAXUCZ010000014.1  107094453-107094542
            1452-1505           JAXUCZ010000014.1  107095862-107095915
            1506-1612           JAXUCZ010000014.1  107098970-107099076
            1613-1684           JAXUCZ010000014.1  107099877-107099948
            1685-1748           JAXUCZ010000014.1  107100035-107100098
            1749-1832           JAXUCZ010000014.1  107100534-107100617
            1833-1916           JAXUCZ010000014.1  107101225-107101308
            1917-2023           JAXUCZ010000014.1  107102429-107102535
            2024-2079           JAXUCZ010000014.1  107102622-107102677
            2080-2158           JAXUCZ010000014.1  107104716-107104794
            2159-2206           JAXUCZ010000014.1  107105568-107105615
            2207-3441           JAXUCZ010000014.1  107108394-107109628
FEATURES             Location/Qualifiers
     source          1..3441
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q22"
     gene            1..3441
                     /gene="Pnpt1"
                     /note="polyribonucleotide nucleotidyltransferase 1"
                     /db_xref="GeneID:360992"
                     /db_xref="RGD:1307987"
     exon            1..171
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..2365
                     /gene="Pnpt1"
                     /EC_number="2.7.7.8"
                     /codon_start=1
                     /product="polyribonucleotide nucleotidyltransferase 1,
                     mitochondrial"
                     /protein_id="NP_001135843.1"
                     /db_xref="GeneID:360992"
                     /db_xref="RGD:1307987"
                     /translation="MAACRPCCLCLCLRPLSCGPLGRPRRHRALSYLQVRALWSGTRS
                     RAVTVDLGHRKLEISSGKLARFADGCAVVQSGDTAVMVTAVSKTKPSPSQFMPLVVDY
                     RQKAAAAGRIPTNYLRREIGSSDKEILTSRVIDRSIRPLFPAGYFYDTQVLCNLLAVD
                     GINEPDILAINGASAALSLSDIPWNGPVGAVRIGMIDGECVVNPTRKEMSSSTLNLVV
                     AGAPKSQIVMLEASAENILQQDFCHAIKVGVKYTQQIIQSIQQLVKEIGVAKRTPQKI
                     FTPSAEIVKYTHTIAMEKLYAVFTDYEHDKVSRDEAVNKIRLDTEEHLKEKFPEVDQL
                     EIIESFNVVAKEVFRSIILNEYKRCDGRDLTSLRNISCEVDMFKTLHGSALFQRGQTQ
                     VLCTVTFDSLESSIKSDQIITAINGVKDKNFMLHYEFPPYATNETGKVTGVNRRELGH
                     GALAEKALCPVIPKDFPFTIRVTSEVLESNGSSSMASACGGSLALMDAGVPISSAVAG
                     VAVGLVTKSNPEKGEIEDYRLLTDILGIEDYNGDMDFKIAGTNKGITALQADIKLPGV
                     PVKIIMEAIQQATVAKREILQTMSKTISKPRASRKENGPVVETVKVPLSKRAKFIGPG
                     GYHLKKLQAETGVTISQVDEETFSIFAPTPTAMHEARDFITEICRDDQEQQLEFGAVY
                     TATITEIRDTGVMVKLYPNMTAVLLHNSQLDQRKIKHPTALGLEVGQEIQVKYFGRDP
                     ADGRMRLSRKVLQSPATTVLKTLNDRSSIVMGEPISQSSSNSSP"
     exon            172..232
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..307
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            308..413
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..463
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..527
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            528..575
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..689
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..876
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..928
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            929..986
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1083
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1186
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1257
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1294
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1361
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1451
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1505
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1612
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1684
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1748
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1749..1832
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1916
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2023
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2079
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2158
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2206
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..3441
                     /gene="Pnpt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgggtgtc atggcggctt gcaggccgtg ctgcttgtgc ctgtgtctcc gaccgctgag
       61 ctgcggtccc ctcggccggc caaggcggca tcgtgcactc agctatttgc aggtgcgagc
      121 gctgtggagc ggcacccggt ccagagcagt gactgtggac ttgggacaca gaaaattaga
      181 aatatcctct ggaaaactgg caagatttgc tgatggctgt gctgtggtac agtcaggtga
      241 tactgcagta atggtcacag cggtcagcaa aacaaaacct tcaccttccc aattcatgcc
      301 attggtggta gactacagac agaaggctgc tgcagcaggt agaatcccca caaactacct
      361 tagaagagag attggctctt ctgacaaaga gattcttaca agtcgagtaa tagatcgttc
      421 aattcgacct ctctttcctg ctggctattt ttatgatact caggttctct gtaatctgct
      481 agcagtagat ggcatcaatg aacctgatat cttagcaatt aatggcgctt ctgcagctct
      541 ctccttatca gatatccctt ggaatggacc tgttggggca gtacgaatag gaatgatcga
      601 tggagaatgt gtcgttaacc caacaaggaa agaaatgtct tctagcacct taaatttagt
      661 agttgctgga gcacctaaaa gccaaattgt tatgttggaa gcctctgcag aaaacatttt
      721 acagcaggac ttttgccatg ctatcaaagt cggggtgaag tatacgcagc agataattca
      781 gagcatccag cagttggtaa aagaaatcgg tgttgccaag aggacacccc agaagatatt
      841 tactccttct gcagagattg tgaaatacac gcatacaatc gccatggaga aactctatgc
      901 agtttttaca gattatgaac atgataaagt ttccagggat gaagctgtta acaagataag
      961 attagataca gaggaacatc taaaggaaaa atttccagag gttgaccaac ttgaaataat
     1021 agaatccttc aacgttgttg caaaggaggt tttcagaagt attattttga atgaatacaa
     1081 aaggtgtgat ggacgagatc tgacttcact taggaatata agttgcgagg tagatatgtt
     1141 taaaacactt catggatcag cattatttca gagaggacaa acacaggtac tctgtactgt
     1201 tacatttgat tcattagaat ccagtattaa atcagatcaa attataacag ctataaatgg
     1261 ggtaaaagat aaaaatttca tgttgcacta tgagtttcct ccttatgcaa ccaatgaaac
     1321 tggcaaagtt actggtgtaa atagaagaga acttggacat ggtgctcttg ctgagaaagc
     1381 tttgtgtcct gttattccca aagattttcc ttttaccata agagttacat ctgaagttct
     1441 cgagtcaaac gggtcatctt ctatggcatc tgcatgtggt ggaagtttgg cattaatgga
     1501 tgcaggggtc ccaatttcat ctgctgttgc aggtgtagca gtgggattgg ttaccaaaag
     1561 caatccagag aaaggtgaaa tagaagacta tcgtttgcta acagatattc tgggaattga
     1621 agattacaat ggtgacatgg atttcaaaat agctggtaca aataaaggaa taactgcatt
     1681 acaggctgat attaagttac ctggagtacc agttaaaatt ataatggaag ccatccaaca
     1741 agcaacagtg gcaaagaggg aaatattgca gacaatgagc aaaacgattt caaaacctcg
     1801 agcatctagg aaagaaaatg gaccagttgt agaaacagta aaggttccat tatcaaaacg
     1861 agcaaaattc attgggcctg gtggatatca cttaaaaaaa ctccaggctg agacaggtgt
     1921 aacaattagt caggttgatg aagaaacatt ctccatattt gcaccaacac ctactgcaat
     1981 gcatgaggca agagacttca ttacagaaat ttgcagagat gatcaagagc aacaattgga
     2041 atttggagca gtttataccg ctacaataac tgaaatcaga gacacaggag taatggtaaa
     2101 actgtatcca aacatgactg cagtgctact tcataattca caacttgacc aacgaaagat
     2161 taaacatccc actgccctgg gattagaagt tggccaggaa attcaggtca aatactttgg
     2221 ccgtgatcca gctgatggaa gaatgaggct ttcccgtaaa gtacttcagt ctccagctac
     2281 aactgttctc aaaactctaa atgataggag cagcattgta atgggagagc ctatttcaca
     2341 gtcatcatct aactcttccc cttgactcct ttttaaaatg gtattcaatg gtgagattct
     2401 gcagagcaaa atttaatagt cccatttatt gtgtagattt atatataatt taaatataat
     2461 tatttgtatt aaaatgctta tttcatgtgc cttttttatt tcaggagtag cctatatttg
     2521 cttattctta tttgggttat aaatcaataa atatttatta aaagctattt ttaatatctt
     2581 aggaaagatt acctttctgt tcctgtaatt atgaactaat gaaaaataga tcatttatgc
     2641 cttcttaaga actttttttt taataccttc cttctcttca tatatatagt aatggccagt
     2701 ccccttagtt catctctgcc taacaactgt gctcacttac acactagaat tgacattttg
     2761 aaagccagaa cccatttctt caaagcaatt acacatttaa taggtattga ggaactaatt
     2821 tgattcagtt tctaatgatt agttgttcaa attgatcaca agaccaaaaa tacagtgaaa
     2881 tgaatcctat aaatggaatt cttgctagag taatttagtt tttttaatta cctatgtcat
     2941 ataaagacta tgcactcatc agatagaact aggtaattct tcatatgtat ataattggca
     3001 gtgtttggat attcttggtg taagagtagg aggaatcaat caatataaag attattgatg
     3061 taatatctag caataactga taactgtcaa atccattggg ttttttttgt ttgtttgttt
     3121 ttttgttttg tttttattta agacagggtt ggtagaaccc attagaccag gtaggcctgg
     3181 aactgaaatc cacctgtctg acacatcaat ccaaggagta agccaccata cccagctcat
     3241 tgctgtaatt taaaacatgc taatagtcca caaaaagtaa atactacata atttagacta
     3301 tgttcctttt ataagtctta caaaaatgtg gattttttta ttggggctga tataagatat
     3361 taaatatgaa cttacacaag ctaaagatct taaaggtatg tttgtactta aatcaataaa
     3421 cattactctg tgtaaaacag c
//
