LOCUS       NM_022601               2052 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus pyridoxamine 5'-phosphate oxidase (Pnpo), mRNA.
ACCESSION   NM_022601
VERSION     NM_022601.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Kwak,S.E., Kim,J.E., Kim,D.W., Kwon,O.S., Choi,S.Y. and Kang,T.C.
  TITLE     Pyridoxine 5'-phosphate oxidase, not pyridoxal kinase, involves in
            long-term potentiation induction in the rat dentate gyrus
  JOURNAL   Hippocampus 19 (1), 45-56 (2009)
   PUBMED   18680158
  REMARK    GeneRIF: PNPO may play a role in activity-dependent regulation of
            PLP level in the brain, which is involved in LTP induction and
            paired-pulse facilitation but not in enhancement of GABAergic
            inhibition.
REFERENCE   2  (bases 1 to 2052)
  AUTHORS   Okuda,T., Sumiya,T., Iwai,N. and Miyata,T.
  TITLE     Pyridoxine 5'-phosphate oxidase is a candidate gene responsible for
            hypertension in Dahl-S rats
  JOURNAL   Biochem Biophys Res Commun 313 (3), 647-653 (2004)
   PUBMED   14697241
  REMARK    GeneRIF: Pnpo is a candidate gene responsible for hypertension in
            Dahl-S rats
REFERENCE   3  (bases 1 to 2052)
  AUTHORS   Musayev,F.N., Di Salvo,M.L., Ko,T.P., Schirch,V. and Safo,M.K.
  TITLE     Structure and properties of recombinant human pyridoxine
            5'-phosphate oxidase
  JOURNAL   Protein Sci 12 (7), 1455-1463 (2003)
   PUBMED   12824491
REFERENCE   4  (bases 1 to 2052)
  AUTHORS   Ngo,E.O., LePage,G.R., Thanassi,J.W., Meisler,N. and Nutter,L.M.
  TITLE     Absence of pyridoxine-5'-phosphate oxidase (PNPO) activity in
            neoplastic cells: isolation, characterization, and expression of
            PNPO cDNA
  JOURNAL   Biochemistry 37 (21), 7741-7748 (1998)
   PUBMED   9601034
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Mar 28, 2024 this sequence was replaced by
            NM_022601.4.
            
            On Nov 27, 2020 this sequence version replaced NM_022601.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087016.1, U91561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN12840115
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JACYVU010000220.1  38755433-38755702   c
            271-395             JACYVU010000220.1  38754090-38754214   c
            396-495             JACYVU010000220.1  38752662-38752761   c
            496-549             JACYVU010000220.1  38751667-38751720   c
            550-678             JACYVU010000220.1  38751297-38751425   c
            679-749             JACYVU010000220.1  38750917-38750987   c
            750-2052            JACYVU010000220.1  38749442-38750744   c
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..2052
                     /gene="Pnpo"
                     /note="pyridoxamine 5'-phosphate oxidase"
                     /db_xref="GeneID:64533"
                     /db_xref="RGD:621456"
     exon            1..270
                     /gene="Pnpo"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..918
                     /gene="Pnpo"
                     /EC_number="1.4.3.5"
                     /note="pyridoxine 5-phosphate oxidase;
                     pyridoxamine-phosphate oxidase"
                     /codon_start=1
                     /product="pyridoxine-5'-phosphate oxidase"
                     /protein_id="NP_072123.1"
                     /db_xref="GeneID:64533"
                     /db_xref="RGD:621456"
                     /translation="MTCGLLSVTVTFRRPAKWPGYFRHLCCRGAVMDLGPMRKSYRGD
                     REAFEEAHLTSLDPMKQFASWFEEAVQCPDIGEANAMCLATCTRDGKPSARMLLLKGF
                     GKDGFRFFTNYESRKGKELDSNPFASLVFYWEPLNRQVRVEGPVKKLPEKEAENYFHS
                     RPKSSQIGAVVSRQSSVIPDREYLRKKNEELGQLYREQEVPKPEYWGGYILYPQVMEF
                     WQGQTNRLHDRIVFRRGLATGDSPLGPMTHHGEEDWVYERLAP"
     exon            271..395
                     /gene="Pnpo"
                     /inference="alignment:Splign:2.1.0"
     exon            396..495
                     /gene="Pnpo"
                     /inference="alignment:Splign:2.1.0"
     exon            496..549
                     /gene="Pnpo"
                     /inference="alignment:Splign:2.1.0"
     exon            550..678
                     /gene="Pnpo"
                     /inference="alignment:Splign:2.1.0"
     exon            679..749
                     /gene="Pnpo"
                     /inference="alignment:Splign:2.1.0"
     exon            750..2052
                     /gene="Pnpo"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caacttagga cttagtagct tgtctgggcc actggcaaat tcttccttcc caggctagac
       61 acacaggctg agcaattggt tccgaaccca gaggaaccca ggcgacgcta ggtcacgtgg
      121 ccgactgctt acatgacctg cgggctgctg agcgtcactg tgacgttcag gagacctgcg
      181 aagtggcccg gctacttccg tcacctgtgc tgtcggggtg ctgtcatgga cctgggaccg
      241 atgcgcaaga gttaccgcgg ggaccgagag gcatttgagg aggctcatct gacctctctg
      301 gatcccatga agcagtttgc ttcctggttc gaggaggctg ttcaatgtcc agatatagga
      361 gaagccaatg ctatgtgtct ggctacctgc accagagacg gaaaaccctc tgcccgcatg
      421 ctgctgctga agggctttgg caaggatggc ttccgcttct tcactaacta cgagagtcgg
      481 aaggggaaag agctggactc taaccccttt gcctctcttg tcttctattg ggagcccctg
      541 aaccgtcagg tgcgtgtgga aggcccagtg aagaaactgc cggagaagga ggctgagaac
      601 tacttccatt cccggcccaa gagcagccag attggggctg tggtcagtcg ccagagttct
      661 gtgatccccg atcgggagta cctgagaaag aaaaatgagg aactggggca gctctaccgg
      721 gaacaagagg tgcccaagcc agagtactgg ggtggctaca tcctatatcc ccaagtgatg
      781 gagttctggc aaggccaaac caaccgcctg catgaccgta ttgtcttccg tcgaggcctg
      841 gcaacaggag actcccctct gggacccatg acccaccacg gggaggaaga ctgggtgtat
      901 gagagacttg caccttgaca ctggactcca gaatgttggg ggatcatcat agggaagagt
      961 gggggaaggg aaggaaaaaa atggaagcca ggtatacctt ctgtgtgtgt gtgtgtatgt
     1021 gagacattgg gtttaaacct cgctcacact aggtaacact ttaccactga gataaagtcc
     1081 cagcattttt tcttactacc ttttatttta agactaagtt gcttagtctg gccctgaact
     1141 cactgtgtat acatcccaga caagtcttgg ctttgagttc ctcccctcag tcccttgagt
     1201 agcagtatta taggcttgtg ccaccaggcc cagttctagt cctgttttta agaagcccat
     1261 tgcctttgtt tttttttttt ttttttttcc ttcggggctg gggactgaac ccaggacctt
     1321 gcgcttccta ggcaagcgct ctaccactga gccaaatccc caacccgccc attgcctttg
     1381 cctttgttaa cccttctacc tgcatttctc caggactcac cctcaagttc tctgaactcg
     1441 ggatcggttt agtggctgga acagagcgca gtagtgttgt agagagtcac aagtagcaaa
     1501 gagtctcata attattccct tgattttgct cctggtttgg ggggacgccc gtcttgggag
     1561 ctgcagctgg tctaactctg tttccagtaa cagactaatc aggccgcaga tatacaaggg
     1621 ctcgctggct atggaaagga gccagaccat gtttgctgtg actcagacaa accattatat
     1681 gttctggttg gccttgaact tgttactctg gactcctgtc ttcttttgac tttgtggctg
     1741 tgtgctttag cctctgtcac tgacaaaagc ttctcccaag gcaactctgt cctgtgttgt
     1801 tcccccatgt aagcctgggt ccaggaagga cattgaccct gtggccatcg accaggcacc
     1861 ctcacaccta cctcacccct tttgctgaca tgccatggac tgtgacttta ttagtatatg
     1921 tagatgagtt gatgagaagt gttgtacccc atcgctgtta gggggctgtg tgtgcccccc
     1981 ccagactttt gcagtgtgat ctcagctgtc agtcccagtg tacaagtgtg taataaaaac
     2041 ttgtcagccg ta
//
