LOCUS       NM_144738               4566 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus patatin-like phospholipase domain containing 7
            (Pnpla7), mRNA.
ACCESSION   NM_144738 XM_001059753 XM_001071589 XM_001071696 XM_001071735
            XM_578102
VERSION     NM_144738.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4566)
  AUTHORS   Heier,C., Kien,B., Huang,F., Eichmann,T.O., Xie,H., Zechner,R. and
            Chang,P.A.
  TITLE     The phospholipase PNPLA7 functions as a lysophosphatidylcholine
            hydrolase and interacts with lipid droplets through its catalytic
            domain
  JOURNAL   J Biol Chem 292 (46), 19087-19098 (2017)
   PUBMED   28887301
REFERENCE   2  (bases 1 to 4566)
  AUTHORS   Chang,P.A., Wang,Z.X., Long,D.X., Qin,W.Z., Wei,C.Y. and Wu,Y.J.
  TITLE     Identification of two novel splicing variants of murine NTE-related
            esterase
  JOURNAL   Gene 497 (2), 164-171 (2012)
   PUBMED   22326266
REFERENCE   3  (bases 1 to 4566)
  AUTHORS   Kienesberger,P.C., Lass,A., Preiss-Landl,K., Wolinski,H.,
            Kohlwein,S.D., Zimmermann,R. and Zechner,R.
  TITLE     Identification of an insulin-regulated lysophospholipase with
            homology to neuropathy target esterase
  JOURNAL   J Biol Chem 283 (9), 5908-5917 (2008)
   PUBMED   18086666
REFERENCE   4  (bases 1 to 4566)
  AUTHORS   Xie,M., Yang,D., Matoney,L. and Yan,B.
  TITLE     Rat NTE-related esterase is a membrane-associated protein,
            hydrolyzes phenyl valerate, and interacts with
            diisopropylfluorophosphate through a serine catalytic machinery
  JOURNAL   Arch Biochem Biophys 416 (2), 137-146 (2003)
   PUBMED   12893290
REFERENCE   5  (bases 1 to 4566)
  AUTHORS   Winrow,C.J., Hemming,M.L., Allen,D.M., Quistad,G.B., Casida,J.E.
            and Barlow,C.
  TITLE     Loss of neuropathy target esterase in mice links organophosphate
            exposure to hyperactivity
  JOURNAL   Nat Genet 33 (4), 477-485 (2003)
   PUBMED   12640454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC091230.1, DN934725.1 and BC083547.1.
            
            On or before Jun 4, 2008 this sequence version replaced
            XM_578102.2, XM_001059753.1, XM_001071735.1, XM_001071589.1,
            XM_001071696.1, NM_144738.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132263 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               BC091230.1         1-432
            433-708             DN934725.1         417-692
            709-3088            BC091230.1         709-3088
            3089-4566           BC083547.1         895-2372
FEATURES             Location/Qualifiers
     source          1..4566
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..4566
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /note="patatin-like phospholipase domain containing 7"
                     /db_xref="GeneID:246246"
                     /db_xref="RGD:708466"
     exon            1..254
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..4274
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /EC_number="3.1.1.5"
                     /note="NTE-related esterase; liver NTE-related protein 1;
                     neuropathy target esterase like 1; patatin-like
                     phospholipase domain-containing protein 7-like"
                     /codon_start=1
                     /product="patatin-like phospholipase domain-containing
                     protein 7"
                     /protein_id="NP_653339.2"
                     /db_xref="GeneID:246246"
                     /db_xref="RGD:708466"
                     /translation="MQKEEDVCPEAGYCLGTALSSWGLHFMEEHSQSTMLMGIGIGVL
                     LTLAFVGLAAFFVYRKVSRFRRAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGN
                     TAAPRQRVRKRTKVLSLAKRILRFKKEYPTLQPKEPPPSLLEADLTEFDVKNSHLPSE
                     VLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGEHVFQPGEPDISIYVVQDGRLEVC
                     IQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSARAAVASTVLWLPAAAF
                     QGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIPLLSVASVAG
                     RAKRQMSYGPEEQLERSPRLSEFNSSDQRSVAVSGPLLKRSCSVPLPPIHGEIDELRQ
                     AQGSGSNTSAFQESQEGATSDLGMAYNRARILPHSEEQLGSSLASKSKKSVVAETSAV
                     FHYSEKPRDEPGPSGRTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTIVSKQ
                     GDQDVNILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANR
                     DCSFLSISKAHFYEIMRKRPDVVLGVAHTVVRRMSSFVRQIDFALDWMEVEAGRAIYR
                     QGDKSDCTYIVLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVEMLTHQARATTVHAVR
                     DSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGSGTGHQLGFNTASSKWD
                     LGNPPGNLSTVAAMPVSEDVPLTAFALELQHALSAIGPVLLLTSDNIKQRLGSAALDS
                     IHEYRLSSWLGQQEDIHRIVLYQADSTLTPWTQRCIRQADCILIVGLGDQEPALGELE
                     QMLESTAVRAQKQLILLHKEEGPAPSRTVEWLNMRSWCSGHLHLCCPRRVFSKRSLPK
                     LVEMYTRIFQRPPDRHSDFSRLARILTGNAIALVLGGGGARGCAQVGILRALAECGIP
                     VDIIGGTSIGAFMGALFAEERSYSQIRIRAKQWAEDMTSMVKTILDLTYPITSMFSGT
                     GFNSSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPP
                     LCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLL
                     WKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGK
                     FDEICEVGYQHGRTVFDIWVRSGVLEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIV
                     SRIEPAKVAAVDDESDYQTEYEEELPAIPKETYADFQSTGIELDSDSECEPSMSQGPH
                     SLTSPKQSQDSFPWLPNQDDQGPRLYRPS"
     exon            255..329
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            330..417
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            418..497
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..589
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..730
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            731..890
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..971
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1100
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1181
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1305
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1437
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1538
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1679
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1757
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1963
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2095
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2219
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            2220..2333
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2403
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2553
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2617
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2786
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            2787..2969
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3088
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3245
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            3246..3362
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            3363..3432
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3549
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3698
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            3699..3851
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            3852..3962
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            3963..4047
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..4151
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
     exon            4152..4538
                     /gene="Pnpla7"
                     /gene_synonym="Nte-related; Ntel; Ntel1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgtgaggctg tttaccggag gcggaagcac acagagaaag cagacgcttc tggaaaacaa
       61 cttgttttgg agcacagagt tctgaagttc cttccaataa gagcgtttgt gtggaaggga
      121 gctggcaaga ctggaactat agttgtcctg ccgtaaaggt tctggaagag cagcttgtct
      181 cagcctgtct ccttttcgcc ctctacattg ttttgctttc agtcatgcag aaagaggaag
      241 atgtctgccc cgaggctggc tactgtttgg ggaccgccct gagctcctgg gggctgcatt
      301 tcatggagga gcattcccag tctaccatgc tgatgggcat tggaataggc gtcctcctta
      361 cgctggcctt cgttggtctc gccgcctttt tcgtgtacag aaaagtgagc agattccgac
      421 gagcagaacc cactcctcag tacagattcc ggaagagaga caaagttatg ttttatggcc
      481 ggaagatcat gaggaaggtg accacactcc cccatacctt ggttgggaat accgctgcac
      541 cccggcagcg agtaaggaag aggaccaaag tgctctcttt ggccaagagg attctgcgct
      601 ttaagaaaga atatcctact ttgcagccaa aagagccccc accctccctg ctcgaggctg
      661 acctcaccga gtttgatgtg aagaactctc atctgccgtc tgaagttttg tacatgttga
      721 agaatgttcg ggttctaggc cactttgaga agccactatt cttggaactt tgtaaacaca
      781 tggtctttgt gcaactgcaa gagggggagc atgtattcca acctggggag cctgacatca
      841 gcatctatgt ggttcaggat ggacggctgg aggtctgcat ccaagatgct gatggcaccg
      901 aggtggtggt caaagaggtc ctgccagggg acagtgtcca cagtctcctc agcattttgg
      961 atgtgatcac tggtcacacg gcaccgtaca aaacagtttc tgcccgtgca gccgttgcat
     1021 ccactgtcct ctggcttcct gcggcagctt ttcaaggagt ttttgagaaa taccctgaaa
     1081 ctctggtgag ggttgtgcag atcatcatgg tacggctgca gcgggtgact ttcctggctc
     1141 tgcacaacta cctggggctg actaccgagc tcttcaaccc tgagagccaa gccatccctc
     1201 tcttgtcagt agcaagtgtg gctggacgag ccaagagaca gatgtcatat ggtccagagg
     1261 agcagcttga gaggtcccca agactgtcgg agttcaacag ctcagatcag aggagcgtgg
     1321 cagtctctgg acctctgctg aagaggagct gctctgtgcc tctgcctccc atccatggcg
     1381 agatagatga gctcaggcag gcccaaggaa gtggctctaa cacttcagcc ttccaagaaa
     1441 gccaggaagg ggccacctca gacctgggga tggcatacaa ccgtgccagg attttgccac
     1501 actcagagga gcaacttggg agctctttgg ccagcaagtc caagaaaagc gttgttgcag
     1561 agacctctgc cgtcttccac tactcggaga agcccaggga tgagcctggg cctagcggga
     1621 ggacagatgc tatcttcagg gctgccacaa aggacctcct aaccctgatg aagctggatg
     1681 acccatccct attggatggc cgggtggcat ttcttcatgt tcctgcaggc accatagtgt
     1741 caaaacaggg agaccaggat gtcaacattt tgtttgtggt ctcggggatg ctgcatgtgt
     1801 accagcaaaa gattgacagc ctggaggaca cttgcctgtt tctcacccat cctggggaga
     1861 tggtggggca actggcagtg ctcactggag agcccctaat gttcaccatc agagccaacc
     1921 gggactgcag ctttctgtcc atctcgaagg cccacttcta tgagatcatg aggaagcggc
     1981 cggatgtcgt cctgggcgtg gcccacacag ttgtgaggag gatgtcgtcc tttgtgcggc
     2041 agattgactt tgcactggac tggatggaag tagaggctgg gcgtgccata tacaggcaag
     2101 gggacaagtc tgactgcaca tacatcgtcc tcagcggcag gctgcggtct gtgatccgaa
     2161 aggatgatgg gaaaaaacgc ctggcagggg agtatggccg aggagacctc gttggtgtgg
     2221 tggagatgct aacccaccag gccagagcaa ccacagtgca tgctgtccgg gactcagaac
     2281 tggctaagct gccagcagga gctctgacgt ctatcaagcg caggtaccca caggttgtaa
     2341 cccgactgat tcatctcttg ggtgagaaga tcttgggcag tctccagcag ggatctggga
     2401 caggtcacca gcttggattt aacacagcaa gcagcaaatg ggacttggga aacccccctg
     2461 gcaacttgtc cacggtggca gcaatgcctg tctctgaaga tgtgccccta actgcctttg
     2521 ccctggagct ccagcatgcc ctcagtgcca ttggtcctgt cctgctgctg accagtgaca
     2581 acatcaaaca acgccttggt tctgctgctc tagacagcat ccatgagtac cggctgtcca
     2641 gctggctggg gcagcaggag gacatccacc ggattgtgct gtatcaagca gacagcacac
     2701 tcacaccctg gacccagcgc tgcattcgtc aggctgactg catcctcatc gtgggcttgg
     2761 gcgatcagga gcccgcactg ggtgagctgg agcagatgtt ggagagcaca gccgtgcgtg
     2821 cccagaagca actgatcttg ctgcacaagg aggagggccc agcaccctcc cgcacagtgg
     2881 agtggctcaa catgcgcagt tggtgttctg gccatttgca cctctgctgc ccgcgtcgtg
     2941 tcttctctaa gaggagcctg cccaaactgg ttgagatgta cacacgcatt ttccaacgac
     3001 caccagaccg tcattccgac ttttcccgcc tggcccggat cctgacaggc aatgccattg
     3061 ccttggtgct tggagggggt ggagccagag ggtgtgccca ggtaggtatc ctcagggcac
     3121 tagcagaatg tggcatcccc gtggacataa tcggagggac atccattggg gctttcatgg
     3181 gcgctctgtt tgctgaggag cgaagctaca gccagatacg gatccgggcc aagcagtggg
     3241 cagaggatat gacatcaatg gtgaagacta tactggacct gacctaccca atcacatcta
     3301 tgttctctgg cactggcttc aacagcagca tcagcaacat cttcaaagac cggcagattg
     3361 aggacctgtg gctcccctac tttgccatca ccaccgacat cacggcctct gccatgcggg
     3421 ttcacacaga tggctctctg tggaggtatg tccgtgcaag catgtccttg tcaggctaca
     3481 tgcccccact ctgtgacccc aaggatggac acctgctgat ggatggcggt tacatcaaca
     3541 atctcccagc ggatgtggca agatccatgg gggcaaaggt tgtgattgcc atcgatgttg
     3601 gcagccggga cgagacggac ctcaccaact acggtgatgc tttgtctgga tggtggctgc
     3661 tttggaaacg ctggaacccc ttggccacaa aagtcaaggt gttgaacatg gcagagattc
     3721 agacacgact ggcctatgta tgctgcgtcc ggcagctgga gatggtgaag aacagcgact
     3781 actgtgagta cctgaggcct cccatcgaca gctaccgaac cctggacttc ggcaagtttg
     3841 atgagatctg tgaagttggg tatcaacatg ggcggacagt atttgacatc tgggtccgga
     3901 gcggggtcct agagaagatg ttgcaggacc agcaggggac aagcaagagg aaggactgtg
     3961 gggtgttcac ctgtcccaat tcctccttca cggacctcgc tgagattgtg tcacggattg
     4021 agccagccaa agtggctgca gtggatgatg agtctgacta tcagacagag tacgaggaag
     4081 agctgccagc catccccaag gaaacctatg ctgacttcca gagcactggg attgagctgg
     4141 actctgactc ggagtgtgaa ccttcgatgt cgcaagggcc ccacagtttg acttccccaa
     4201 aacagtccca ggattccttc ccttggcttc ctaatcaaga tgaccagggg ccaagactgt
     4261 atcgtccttc ctgaccggat taatacaaca caggacctgg gcctcaccct tagactgagg
     4321 ctgcacacac tcgttggagg ctacttcagt tgcctgacaa gatcgaactg ggtggtacac
     4381 ccatctggtt tcttacaggg gcatgggctg tgcattggag tcatgggcct cttctcttcc
     4441 ctggtacccc ttgtatcccc acagcaatac tgaagagcac tgaagcctct gtgaggcttg
     4501 ggagtgtggg attgatatat taataaacgt caatctgaaa aaaaaaaaaa aaaaaaaaaa
     4561 aaaaaa
//
