LOCUS       NM_001282324            2759 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus patatin-like phospholipase domain containing 3
            (Pnpla3), mRNA.
ACCESSION   NM_001282324 XR_085887 XR_086307
VERSION     NM_001282324.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Alptekin,I.M., Cakiroglu,F.P., Kiremitci,S., Recber,T. and
            Nemutlu,E.
  TITLE     Inulin may prevent steatosis by suppressing cannabinoid receptor-1
            and patatin-like phospholipase-3 expression in liver
  JOURNAL   Nutrition 103-104, 111742 (2022)
   PUBMED   35908495
  REMARK    GeneRIF: Inulin may prevent steatosis by suppressing cannabinoid
            receptor-1 and patatin-like phospholipase-3 expression in liver.
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Machado,C.M., Leite,N.C., Franca,P.H., Cardoso,C.R., Salles,G.F.
            and Villela-Nogueira,C.A.
  TITLE     PNPLA3 gene polymorphism in Brazilian patients with type 2
            diabetes: A prognostic marker beyond liver disease?
  JOURNAL   Nutr Metab Cardiovasc Dis 29 (9), 965-971 (2019)
   PUBMED   31377187
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Jimenez-Sousa,M.A., Gomez-Moreno,A.Z., Pineda-Tenor,D.,
            Sanchez-Ruano,J.J., Fernandez-Rodriguez,A., Artaza-Varasa,T.,
            Gomez-Sanz,A., Martin-Vicente,M., Vazquez-Moron,S. and Resino,S.
  TITLE     PNPLA3 rs738409 polymorphism is associated with liver fibrosis
            progression in patients with chronic hepatitis C: A repeated
            measures study
  JOURNAL   J Clin Virol 103, 71-74 (2018)
   PUBMED   29674183
REFERENCE   4  (bases 1 to 2759)
  AUTHORS   Restrepo,R.J., Lim,R.W., Korthuis,R.J. and Shukla,S.D.
  TITLE     Binge alcohol alters PNPLA3 levels in liver through epigenetic
            mechanism involving histone H3 acetylation
  JOURNAL   Alcohol 60, 77-82 (2017)
   PUBMED   28433418
  REMARK    GeneRIF: Histone acetylation plays a role in the modulation of
            PNPLA3 levels in the liver exposed to binge ethanol drinking.
REFERENCE   5  (bases 1 to 2759)
  AUTHORS   Edelman,D., Kalia,H., Delio,M., Alani,M., Krishnamurthy,K., Abd,M.,
            Auton,A., Wang,T., Wolkoff,A.W. and Morrow,B.E.
  TITLE     Genetic analysis of nonalcoholic fatty liver disease within a
            Caribbean-Hispanic population
  JOURNAL   Mol Genet Genomic Med 3 (6), 558-569 (2015)
   PUBMED   26740948
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2759)
  AUTHORS   Calvo,R.M. and Obregon,M.J.
  TITLE     Tri-iodothyronine upregulates adiponutrin mRNA expression in rat
            and human adipocytes
  JOURNAL   Mol Cell Endocrinol 311 (1-2), 39-46 (2009)
   PUBMED   19619606
  REMARK    GeneRIF: PNPLA3 mRNA expression is upregulated by tri-iodothyronine
            in adipocytes in vitro, in humans and rats, and in vivo in rat
            white adipose tissue.
REFERENCE   7  (bases 1 to 2759)
  AUTHORS   Caimari,A., Oliver,P. and Palou,A.
  TITLE     Regulation of adiponutrin expression by feeding conditions in rats
            is altered in the obese state
  JOURNAL   Obesity (Silver Spring) 15 (3), 591-599 (2007)
   PUBMED   17372308
  REMARK    GeneRIF: Adiponutrin expression is highly regulated by feeding
            conditions in the different adipose tissue depots, but this
            regulation is impaired in obese rats.
REFERENCE   8  (bases 1 to 2759)
  AUTHORS   Jenkins,C.M., Mancuso,D.J., Yan,W., Sims,H.F., Gibson,B. and
            Gross,R.W.
  TITLE     Identification, cloning, expression, and purification of three
            novel human calcium-independent phospholipase A2 family members
            possessing triacylglycerol lipase and acylglycerol transacylase
            activities
  JOURNAL   J Biol Chem 279 (47), 48968-48975 (2004)
   PUBMED   15364929
REFERENCE   9  (bases 1 to 2759)
  AUTHORS   Polson,D.A. and Thompson,M.P.
  TITLE     Adiponutrin mRNA expression in white adipose tissue is rapidly
            induced by meal-feeding a high-sucrose diet
  JOURNAL   Biochem Biophys Res Commun 301 (2), 261-266 (2003)
   PUBMED   12565853
  REMARK    GeneRIF: Data suggest that adiponutrin could be involved in overall
            energy homeostasis, as is leptin.
REFERENCE   10 (bases 1 to 2759)
  AUTHORS   Baulande,S., Lasnier,F., Lucas,M. and Pairault,J.
  TITLE     Adiponutrin, a transmembrane protein corresponding to a novel
            dietary- and obesity-linked mRNA specifically expressed in the
            adipose lineage
  JOURNAL   J Biol Chem 276 (36), 33336-33344 (2001)
   PUBMED   11431482
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC161881.1, FM043479.1 and FM042237.1.
            
            On or before Aug 30, 2013 this sequence version replaced
            XR_086307.2, XR_085887.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132278,
                              SAMD00132282 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               BC161881.1         1-233
            234-1960            BC161881.1         552-2278
            1961-2255           FM043479.1         322-616
            2256-2759           FM042237.1         76-579
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2759
                     /gene="Pnpla3"
                     /gene_synonym="Adpn"
                     /note="patatin-like phospholipase domain containing 3"
                     /db_xref="GeneID:362972"
                     /db_xref="RGD:1595843"
     exon            1..233
                     /gene="Pnpla3"
                     /gene_synonym="Adpn"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1324
                     /gene="Pnpla3"
                     /gene_synonym="Adpn"
                     /EC_number="3.1.1.3"
                     /note="adiponutrin; patatin-like phospholipase
                     domain-containing protein 3"
                     /codon_start=1
                     /product="1-acylglycerol-3-phosphate O-acyltransferase
                     PNPLA3"
                     /protein_id="NP_001269253.1"
                     /db_xref="GeneID:362972"
                     /db_xref="RGD:1595843"
                     /translation="MYDPERRWSLSFAGCGFLGFYHIGATLCLSERAPHILREARTFF
                     GCSAGALHAVTFVCSLPLDHIMEILMDLVRKARSRNIGTLHPFFNINKCVRDGLQETL
                     PDNVHQIISGKVYISLTRVSDGENVLVSEFHSKDEVVDALVCSCFIPLFSGLIPPSFR
                     GERYVDGGVSDNVPVLDAKTTITVSPFYGEHDICPKVKSTNFLQVNITNLSLRLCTGN
                     LHLLTRALFPSDVKVMGELCFQGYLDAFRFLEENGICNGPQRSLSLSLEKEMAPETMI
                     PCLENGHLVAGNKVPVSCVCLTAVPSDESIWEMLSPKLSTALTEAIKDRGGYLNKVCN
                     LLPIRILSYILLPCTLPVESAIAAVHRLVMWLPDIHEDIQWLQWATSQVCARMTMCLL
                     PSTRSRASKDNHQTLKHGYHPSLHKPQGSSAGL"
     exon            234..466
                     /gene="Pnpla3"
                     /gene_synonym="Adpn"
                     /inference="alignment:Splign:2.1.0"
     exon            467..532
                     /gene="Pnpla3"
                     /gene_synonym="Adpn"
                     /inference="alignment:Splign:2.1.0"
     exon            533..742
                     /gene="Pnpla3"
                     /gene_synonym="Adpn"
                     /inference="alignment:Splign:2.1.0"
     exon            743..803
                     /gene="Pnpla3"
                     /gene_synonym="Adpn"
                     /inference="alignment:Splign:2.1.0"
     exon            804..995
                     /gene="Pnpla3"
                     /gene_synonym="Adpn"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1128
                     /gene="Pnpla3"
                     /gene_synonym="Adpn"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1233
                     /gene="Pnpla3"
                     /gene_synonym="Adpn"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..2759
                     /gene="Pnpla3"
                     /gene_synonym="Adpn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggagcag aattgagctg catcgccttc cggagcctcc agcgccatgt acgacccaga
       61 gcgccgctgg agcctgtcgt tcgcaggctg cggcttccta ggcttctacc acatcggggc
      121 tacgctatgt ctgagcgagc gcgctccgca catcctccgc gaagcgcgca ctttcttcgg
      181 ctgctcggcc ggtgcactgc acgcggtcac cttcgtgtgc agtctccctc tcgatcacat
      241 catggagatc ctcatggacc tcgtgcggaa agccaggagc cgcaacatcg gcaccctcca
      301 cccgttcttc aacattaaca agtgcgtcag agacggcctt caggagaccc tcccagacaa
      361 cgtccaccag atcatttctg gcaaggttta catctcactc accagagtgt ccgatgggga
      421 gaacgtgctg gtgtctgagt tccattccaa agacgaagtg gtggatgccc tggtgtgctc
      481 ctgcttcatt cctctcttct ctggcctaat ccctccttcc ttccgaggtg agcggtacgt
      541 ggatggagga gtgagtgaca acgtccctgt gctggacgcc aaaaccacca tcacggtgtc
      601 ccctttctat ggtgagcatg acatctgtcc caaagtgaag tccaccaact tcctccaggt
      661 gaatatcacc aacctcagtc ttcgtctctg cactgggaac cttcatcttc tgaccagagc
      721 actcttccca tctgatgtga aggtgatggg agagctgtgc tttcaagggt acctggacgc
      781 cttccggttc ctggaagaga acggcatctg taatgggcca cagcgcagcc tgagtctgtc
      841 cttggagaag gaaatggcgc cagaaaccat gataccctgc ttggaaaatg gccaccttgt
      901 agcagggaac aaggtgccag taagctgtgt atgccttaca gctgtgccgt cggatgagag
      961 catctgggag atgctgtccc ccaagctcag cacagctctg actgaagcga ttaaagacag
     1021 ggggggctac ctgaacaaag tctgcaacct cctgcccatt aggatcctgt cctacatctt
     1081 gctgccctgc actctgcccg tggagtcggc catcgctgca gtccacaggc tggtgatgtg
     1141 gctccctgat atccatgaag atatccagtg gctacagtgg gcaacatccc aggtgtgtgc
     1201 ccgaatgacc atgtgcctgc tcccctctac cagatccaga gcatccaagg ataaccatca
     1261 aacactcaag catggatatc acccatctct ccacaaaccc caaggcagct ctgccggttt
     1321 gtaaattgct ggtctccgtg cttccgatga acttgggcat tctccctgtg gatggttcca
     1381 ggagaggcca tagctgaagg cactctgcct tccaccccaa gtccagtttg acctttatct
     1441 agagcaacag tgtctagatg ataggtgggt ggggggtgct gtctctctgt ttccctctgg
     1501 gaagggttct gttaactttt ggaggcagct aggaaatttc tctccaggag ctgagcctgt
     1561 gcagctgccc ccttggtgct gtgtggtaac ctcattgcct gtgaccctag gatcatagga
     1621 tctgggctaa ataggtagtt catagaaacc aaagacaata atttggtgtt tagaaaacta
     1681 cttttggtct gggtgaagtc tggtgcttga gagttagtgc agagagaacg gtcaaaccgt
     1741 ctctcagcct gtggatctat ggggattcca agggcttcag tgtttggaaa cggcaatcca
     1801 aacgggcaat cttgtgcaat cttggaagga gaactgttca ggaagtgtga tgggatgagc
     1861 tgtggctgtc tctgaaaagg gcctaccata taacttatta ctttcaagga tacctttggc
     1921 tcttactaaa atagtttata aagcatttta tagaaacaca ccagggaatg cgtggtgaac
     1981 tacatgtatg atcagtgaac tgtgactaga attaacctta aaatctcttg tatgtggggc
     2041 cagagcaaca caggtgggaa acgcagcgga cctctgcctc ctcggcctca acatgaactt
     2101 ggcttgcttt ctccaccgtc tccaaatctt tgtatagtca tcgaccatta ccacctctcc
     2161 tttcccatct actacagcag ccttaatggg gataagtacc cccttttctc aggtgtccga
     2221 ataagctgtg ggtgtggcct gtgtttcctg taattctgag gttagattgg aacataagca
     2281 agcagacaaa caagcagaca aacaaacaag gttctactca tattcctaag cagtgacagt
     2341 gaaggcatgt gtctcccatg cctgagtctc ctagggtcct agtgagctct gggttcatgc
     2401 aagcacttcc ggaggaattg caccctccat ggaacacata atctccactg ggttgatcct
     2461 gattggataa gaaaggatct cggggagaga atgtggttcc agaggcaaag tgtctaggct
     2521 acacagaaaa ggtaagactg tccccaaggg aagaaaacaa actgggagct ggggtccagc
     2581 tcaattgtta agagtgcttc tctagtatgc gtgaagccca gagtccaatc tcagtaccag
     2641 atacacggta caggcagtga catatgcctg taatcccaac cctcaagcag tagaggcaag
     2701 aggatcagaa gttcatggtc atccttgact acttatactt agggagttgg aggtcagcc
//
