LOCUS       NM_001191841            2730 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus patatin-like phospholipase domain containing 1
            (Pnpla1), mRNA.
ACCESSION   NM_001191841 XM_342105
VERSION     NM_001191841.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2730)
  AUTHORS   Grall,A., Guaguere,E., Planchais,S., Grond,S., Bourrat,E.,
            Hausser,I., Hitte,C., Le Gallo,M., Derbois,C., Kim,G.J.,
            Lagoutte,L., Degorce-Rubiales,F., Radner,F.P., Thomas,A., Kury,S.,
            Bensignor,E., Fontaine,J., Pin,D., Zimmermann,R., Zechner,R.,
            Lathrop,M., Galibert,F., Andre,C. and Fischer,J.
  TITLE     PNPLA1 mutations cause autosomal recessive congenital ichthyosis in
            golden retriever dogs and humans
  JOURNAL   Nat Genet 44 (2), 140-147 (2012)
   PUBMED   22246504
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Sep 16, 2022 this sequence version replaced NM_001191841.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.54244.1,
                                           SRR26643294.60787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN14984024, SAMN14984031
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-658               JAXUCZ010000020.1  6919689-6920346
            659-891             JAXUCZ010000020.1  6939801-6940033
            892-957             JAXUCZ010000020.1  6940450-6940515
            958-1167            JAXUCZ010000020.1  6941342-6941551
            1168-1228           JAXUCZ010000020.1  6942283-6942343
            1229-1891           JAXUCZ010000020.1  6945318-6945980
            1892-1976           JAXUCZ010000020.1  6948694-6948778
            1977-2099           JAXUCZ010000020.1  6950339-6950461
            2100-2199           JAXUCZ010000020.1  6951690-6951789
            2200-2730           JAXUCZ010000020.1  6953320-6953850
FEATURES             Location/Qualifiers
     source          1..2730
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2730
                     /gene="Pnpla1"
                     /note="patatin-like phospholipase domain containing 1"
                     /db_xref="GeneID:361812"
                     /db_xref="RGD:1306685"
     exon            1..658
                     /gene="Pnpla1"
                     /inference="alignment:Splign:2.1.0"
     CDS             454..2223
                     /gene="Pnpla1"
                     /EC_number="2.3.1.296"
                     /note="patatin-like phospholipase domain-containing
                     protein 1"
                     /codon_start=1
                     /product="omega-hydroxyceramide transacylase"
                     /protein_id="NP_001178770.1"
                     /db_xref="GeneID:361812"
                     /db_xref="RGD:1306685"
                     /translation="MDEQVFKGDPDTPHSISFSGSGFLSYYQAGAVDALRDLAPRMLD
                     TAHRFAGTSAGAVIAALVICGIEMEEYLRVLNMGLAEVKKFFLGPLSPSCKMVQMMRQ
                     FLYDVLPEDSYKAATGKLHVSLTRVTDGENVVVSEYRSKEELIEALYCSCFVPVYCGF
                     IPPTYRGERYIDGGFTSMQPCAFWTDSITISTFSSQQDICPRDCPAIFHDFRMFNFSF
                     QFSLENITRMTHALFPPDLVILQEYYYRGYDDAVSYLRRLNAAYLDSPSKRVIFPRVE
                     VYCQIEVALGHEPPPTSLQSLPAQRDSPEDCSQTHVQGALKEDRKDSHSPATPSAQTS
                     ESGCKGFEESPVSPTVSSSKQPAVSPLVQAQPGAVVRPADPSDSCPVNVQTPNLEQGV
                     KDDCQPDLATDDQSTNSLLPASLPAADSQESKAGSSVSVASLESAGLLLKSSQGATVA
                     GATAGLPPLSPSTPPAQPPVEDLGPEQPSATGSPASSQLTGSAAPDTGKGAPDKPLLV
                     ASPAADSNTAKKMFRRKQKANATRECFQKNPQSKKPASKLQSAPCPLDFSVLPETVWV
                     TYKPHPNRIQEYSYTEGVSGQNS"
     exon            659..891
                     /gene="Pnpla1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..957
                     /gene="Pnpla1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1167
                     /gene="Pnpla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1228
                     /gene="Pnpla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1891
                     /gene="Pnpla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1976
                     /gene="Pnpla1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2099
                     /gene="Pnpla1"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2199
                     /gene="Pnpla1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2730
                     /gene="Pnpla1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagtcagtg agggaggtac agggagaggc agagattttg caactggatg ctaagggctg
       61 aaaggcgccg cctctgtgga cacggcccag agcagggagc agggaatgcc tcgctccaga
      121 gtgcgcccag gatgggtgga gagcgctgaa gagcctgcgc cccgctgtga gtctagctag
      181 gtcatgaagt cagcatgggg tctgcaggac cacgcccctg cccatgactc tgagaactgt
      241 ctacatttca tccaggacct ggggtccctt atcaggcctt caggggtgtc tctcagcaga
      301 gctcaacagg cccaggcagt ggctggatga accacccgtg ggtgcctggc tgggccggta
      361 cattcccggc tcttgactga cagggaagga gagactgagc caaggcagac aggtgtaggt
      421 ttttcctccg ctgggaggcc agaggcccca aagatggacg aacaggtgtt caaaggagac
      481 ccagacaccc ctcattccat ctccttctcc gggagcgggt tcctgtccta ctaccaggct
      541 ggggccgtgg atgctctgcg agatctggcc cctaggatgc tggacacggc tcatcgcttt
      601 gcagggacgt cagctggcgc cgtgattgca gccttggtca tctgcgggat tgagatggag
      661 gagtacctca gagtgctgaa tatgggtctg gccgaggtga agaagttctt cctaggacct
      721 ctgtctccgt cctgcaagat ggtacaaatg atgcgacagt ttttgtacga cgtgctcccc
      781 gaggactcct acaaggccgc caccgggaag ctccacgtga gcctcacccg ggtcacggac
      841 ggagagaacg tcgtggtttc ggagtaccgg tccaaggagg agctcattga ggctctgtat
      901 tgtagctgct ttgttcctgt ctactgtggc ttcatacccc caacatatcg gggcgagaga
      961 tacatcgacg gcggcttcac aagcatgcag ccctgcgcct tctggacaga ctccatcacc
     1021 atctccacct tcagcagcca gcaggacatc tgtccgaggg actgccccgc catcttccat
     1081 gacttccgaa tgtttaactt ctccttccag ttctccttgg agaatatcac gcgcatgacg
     1141 catgcgctgt tccccccgga cctggtgatc ctgcaggaat attactaccg gggatacgat
     1201 gatgccgtct catacctgcg gaggctgaat gccgcgtacc tcgactctcc cagcaagaga
     1261 gtgatttttc cgagggtaga agtatactgc cagatagagg tcgcccttgg ccatgagccc
     1321 ccacctacga gtctgcagag cctcccagca cagagagaca gccctgagga ctgctcacaa
     1381 acccatgtac agggggctct caaagaggac agaaaggaca gccattcccc agcaacccca
     1441 tcagcgcaga catctgaatc tgggtgcaag gggtttgagg agtcacctgt gtccccaacg
     1501 gtctcttcat ccaagcaacc agctgtgtca ccgttggtcc aagcccagcc gggcgcagta
     1561 gtgaggcccg ctgaccccag tgacagttgc ccagtgaatg ttcaaactcc aaacctggag
     1621 caaggagtga aggatgactg tcagccagac ttggccactg atgaccaaag cacaaacagc
     1681 ctgctccctg catcactccc agctgcagac tcacaggaat caaaggctgg atcctctgtg
     1741 tctgttgcgt cactcgagtc tgctggactg ctgctcaaat cttcccaggg agccacagta
     1801 gccggggcaa cagctggact tccgccccta agtccttcaa cgccacccgc ccagccacct
     1861 gtggaagacc taggcccaga acaaccctca gctacagggt ctcccgcctc atcacagctg
     1921 acaggctcgg cagcaccgga tacggggaag ggagcccccg acaagcctct actggtggcc
     1981 agtcctgctg cagattcaaa cacagcaaaa aagatgttca ggaggaaaca gaaggcaaat
     2041 gccaccagag agtgcttcca gaaaaaccct cagtccaaga agccagctag caaactgcag
     2101 tctgcacctt gtccacttga cttttctgta cttcccgaga cagtctgggt cacctacaaa
     2161 cctcatccca accggattca agaatacagc tacactgagg gcgtgagtgg acagaattcc
     2221 taggctggag caggagaccc cagtgacatg aagcctgggt ccagcctcca cctgaggtct
     2281 tttgggacca ggggagccct cagctaccaa atgctacaga aagtctactc ccccaaggtt
     2341 gggtttcctg gtctgaagag tctcctgctt ccagtcttgc tgcccttcca ccgttctgct
     2401 ctggatggac agacagacat caacgcatac cactcaccat ccttccagga ggagggacac
     2461 aattctgctt ttgtccaatc tggggcaagc atacatcctg actgtacttc ctgcctatgt
     2521 tcctcccacc tacatgtgac cgggcacatc ctgtacagtt ggggcaagca agctgtttac
     2581 agaagtgaaa acaggtggct tgttgtctta catgaaagat atcccccagc attcctggaa
     2641 gttatctgac cttgggcaag tggggcttac aggttaaaaa catctttgtt ttgtaggtct
     2701 cttaagcaca gcaattaaaa cttaaaacgt
//
