LOCUS       NM_013007                974 bp    mRNA    linear   ROD 23-MAR-2024
DEFINITION  Rattus norvegicus prepronociceptin (Pnoc), mRNA.
ACCESSION   NM_013007
VERSION     NM_013007.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 974)
  AUTHORS   Wilson,L., Klausner,M., Chuang,S., Patel,S. and Pratt,W.E.
  TITLE     An examination of the effects of nucleus accumbens core nociceptin
            on appetitive and consummatory motivation for food
  JOURNAL   Behav Brain Res 462, 114895 (2024)
   PUBMED   38316167
  REMARK    GeneRIF: An examination of the effects of nucleus accumbens core
            nociceptin on appetitive and consummatory motivation for food.
REFERENCE   2  (bases 1 to 974)
  AUTHORS   Al Yacoub,O.N., Zhang,Y., Patankar,P.S. and Standifer,K.M.
  TITLE     Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and
            Nociceptin Opioid Peptide Receptor Expression within 24 Hours
  JOURNAL   Int J Mol Sci 25 (3), 1658 (2024)
   PUBMED   38338936
  REMARK    GeneRIF: Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and
            Nociceptin Opioid Peptide Receptor Expression within 24 Hours.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 974)
  AUTHORS   Smith,R.J., Vento,P.J., Chao,Y.S., Good,C.H. and Jhou,T.C.
  TITLE     Gene expression and neurochemical characterization of the
            rostromedial tegmental nucleus (RMTg) in rats and mice
  JOURNAL   Brain Struct Funct 224 (1), 219-238 (2019)
   PUBMED   30302539
  REMARK    GeneRIF: Both Pnoc and FoxP1 were expressed at high levels in the
            rostromedial tegmental nucleus and colocalized strongly with
            previously established RMTg markers.
REFERENCE   4  (bases 1 to 974)
  AUTHORS   Adeghate,E., Saeed,Z., D'Souza,C., Tariq,S., Kalasz,H., Tekes,K.
            and Adeghate,E.A.
  TITLE     Effect of nociceptin on insulin release in normal and diabetic rat
            pancreas
  JOURNAL   Cell Tissue Res 374 (3), 517-529 (2018)
   PUBMED   30112574
  REMARK    GeneRIF: Nociceptin co-localized only with insulin in pancreatic
            beta cells.
REFERENCE   5  (bases 1 to 974)
  AUTHORS   Wille-Bille,A., Miranda-Morales,R.S., Pucci,M., Bellia,F.,
            D'Addario,C. and Pautassi,R.M.
  TITLE     Prenatal ethanol induces an anxiety phenotype and alters expression
            of dynorphin & nociceptin/orphanin FQ genes
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 85, 77-88 (2018)
   PUBMED   29678771
REFERENCE   6  (bases 1 to 974)
  AUTHORS   Chen,X., McClatchy,D.B., Geller,E.B., Liu-Chen,L., Tallarida,R.J.
            and Adler,M.W.
  TITLE     Possible mechanism of hypothermia induced by
            intracerebroventricular injection of orphanin FQ/nociceptin
  JOURNAL   Brain Res 904 (2), 252-258 (2001)
   PUBMED   11406123
  REMARK    GeneRIF: Hypothermia induced by orphanin fq/nociceptin is mediated
            by its own receptor
REFERENCE   7  (bases 1 to 974)
  AUTHORS   Murphy,W.J., Eizirik,E., Johnson,W.E., Zhang,Y.P., Ryder,O.A. and
            O'Brien,S.J.
  TITLE     Molecular phylogenetics and the origins of placental mammals
  JOURNAL   Nature 409 (6820), 614-618 (2001)
   PUBMED   11214319
REFERENCE   8  (bases 1 to 974)
  AUTHORS   Nothacker,H.P., Reinscheid,R.K., Mansour,A., Henningsen,R.A.,
            Ardati,A., Monsma,F.J. Jr., Watson,S.J. and Civelli,O.
  TITLE     Primary structure and tissue distribution of the orphanin FQ
            precursor
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8677-8682 (1996)
   PUBMED   8710930
REFERENCE   9  (bases 1 to 974)
  AUTHORS   Mollereau,C., Simons,M.J., Soularue,P., Liners,F., Vassart,G.,
            Meunier,J.C. and Parmentier,M.
  TITLE     Structure, tissue distribution, and chromosomal localization of the
            prepronociceptin gene
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8666-8670 (1996)
   PUBMED   8710928
REFERENCE   10 (bases 1 to 974)
  AUTHORS   Meunier,J.C., Mollereau,C., Toll,L., Suaudeau,C., Moisand,C.,
            Alvinerie,P., Butour,J.L., Guillemot,J.C., Ferrara,P., Monsarrat,B.
            et al.
  TITLE     Isolation and structure of the endogenous agonist of opioid
            receptor-like ORL1 receptor
  JOURNAL   Nature 377 (6549), 532-535 (1995)
   PUBMED   7566152
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X97375.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X97375.1, U48262.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN12840116, SAMN12840118
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-974               X97375.1           1-974
FEATURES             Location/Qualifiers
     source          1..974
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15p12"
     gene            1..974
                     /gene="Pnoc"
                     /gene_synonym="N23K; Npnc1"
                     /note="prepronociceptin"
                     /db_xref="GeneID:25516"
                     /db_xref="RGD:3362"
     exon            1..150
                     /gene="Pnoc"
                     /gene_synonym="N23K; Npnc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..570
                     /gene="Pnoc"
                     /gene_synonym="N23K; Npnc1"
                     /note="nociceptin; Prepronociceptin (neuropeptide
                     nociceptin) (N23K); orphanin FQ; neuropeptide nociceptin
                     1"
                     /codon_start=1
                     /product="prepronociceptin precursor"
                     /protein_id="NP_037139.1"
                     /db_xref="GeneID:25516"
                     /db_xref="RGD:3362"
                     /translation="MKILFCDVLLLSLLSSVFSSCPEDCLTCQERLHPAPGSFNLKLC
                     ILQCEEKVFPRPLWTLCTKAMASDSEQLSPADPELTSAALYQSKASEMQHLKRMPRVR
                     SVVQARDAEPEADAEPVADEADEVEQKQLQKRFGGFTGARKSARKLANQKRFSEFMRQ
                     YLVLSMQSSQRRRTLHQNGNV"
     exon            151..615
                     /gene="Pnoc"
                     /gene_synonym="N23K; Npnc1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..974
                     /gene="Pnoc"
                     /gene_synonym="N23K; Npnc1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      971
                     /gene="Pnoc"
                     /gene_synonym="N23K; Npnc1"
ORIGIN      
        1 cctcttgctt cccacggctg caccatgaaa atcctgtttt gtgatgtcct gctgctcagc
       61 ctgctctcca gcgtgttcag cagctgtccc gaggactgcc tcacctgcca ggagaggctc
      121 cacccggctc cgggcagctt caacctgaag ctgtgcatcc tccagtgtga agagaaggtc
      181 ttcccccgcc ctctctggac tctttgcacc aaagccatgg ccagtgactc tgagcagctc
      241 agccctgctg atccagagct cacgtccgct gctctttacc agtcgaaagc ctcggagatg
      301 cagcacctga agagaatgcc gcgtgtcagg agtgtggtgc aagcccgaga cgcagagcct
      361 gaggcagatg cagagcctgt cgcagatgag gccgatgagg tggagcagaa gcagctgcag
      421 aaaaggtttg ggggcttcac tggggcccgg aagtcagccc ggaagttggc caaccagaag
      481 cggttcagtg agtttatgag gcagtacctg gtcctgagca tgcagtcaag ccaacgccgg
      541 cgcactctgc accagaatgg taatgtgtag ccagaaggag cccctcccag ctgcaccggc
      601 cactgcaacc catgagcatc caggtgagcc cccgtacagc atgtgtccac accaagacct
      661 gcaggccggg agtcaggatt cctccttccc tgaggcactg aacacccgcg gcacctcccc
      721 acagcatgtc tcaccacaat cctgttgcta catcagagtg tatttttgta attcctccag
      781 ctaacatttt aatggcccca tcttcttgct catcctctgc cctctcgtag ggccaggtga
      841 gaggaacatg aaatcagacc tggggttttg cctcaccact gccataactg gtttgtaaag
      901 gagctgttct ttttgactga ttgtttgaaa caactttctc cattaaactt ctactgagca
      961 aaatggttaa taaa
//
