LOCUS       NM_001109023            2821 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus pinin, desmosome associated protein (Pnn), mRNA.
ACCESSION   NM_001109023 XM_001079732 XM_347237
VERSION     NM_001109023.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2821)
  AUTHORS   Mukda S, Tsai CY, Leu S, Yang JL and Chan SHH.
  TITLE     Pinin protects astrocytes from cell death after acute ischemic
            stroke via maintenance of mitochondrial anti-apoptotic and
            bioenergetics functions
  JOURNAL   J Biomed Sci 26 (1), 43 (2019)
   PUBMED   31167655
  REMARK    GeneRIF: Endogenous Pnn participates in neuroprotection after acute
            ischemic stroke by preserving the viability of astrocytes that
            survived the ischemic challenge via maintenance of mitochondrial
            anti-apoptotic and bioenergetics functions.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2821)
  AUTHORS   Baltz AG, Munschauer M, Schwanhausser B, Vasile A, Murakawa Y,
            Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E,
            Bonneau R, Selbach M, Dieterich C and Landthaler M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 2821)
  AUTHORS   Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein
            C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J and
            Hentze MW.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 2821)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 2821)
  AUTHORS   Leu S and Ouyang P.
  TITLE     Spatial and temporal expression profile of pinin during mouse
            development
  JOURNAL   Gene Expr Patterns 6 (6), 620-631 (2006)
   PUBMED   16427813
REFERENCE   6  (bases 1 to 2821)
  AUTHORS   Tange TO, Shibuya T, Jurica MS and Moore MJ.
  TITLE     Biochemical analysis of the EJC reveals two new factors and a
            stable tetrameric protein core
  JOURNAL   RNA 11 (12), 1869-1883 (2005)
   PUBMED   16314458
REFERENCE   7  (bases 1 to 2821)
  AUTHORS   Tange TO, Nott A and Moore MJ.
  TITLE     The ever-increasing complexities of the exon junction complex
  JOURNAL   Curr Opin Cell Biol 16 (3), 279-284 (2004)
   PUBMED   15145352
  REMARK    Review article
REFERENCE   8  (bases 1 to 2821)
  AUTHORS   Jurica MS, Licklider LJ, Gygi SR, Grigorieff N and Moore MJ.
  TITLE     Purification and characterization of native spliceosomes suitable
            for three-dimensional structural analysis
  JOURNAL   RNA 8 (4), 426-439 (2002)
   PUBMED   11991638
REFERENCE   9  (bases 1 to 2821)
  AUTHORS   Ouyang P and Sugrue SP.
  TITLE     Characterization of pinin, a novel protein associated with the
            desmosome-intermediate filament complex
  JOURNAL   J Cell Biol 135 (4), 1027-1042 (1996)
   PUBMED   8922384
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473947.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001079732.1, XM_347237.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ234501.1, DN948409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2821
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..2821
                     /gene="Pnn"
                     /note="pinin, desmosome associated protein"
                     /db_xref="GeneID:368070"
                     /db_xref="RGD:1597086"
     exon            1..131
                     /gene="Pnn"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2208
                     /gene="Pnn"
                     /codon_start=1
                     /product="pinin"
                     /protein_id="NP_001102493.1"
                     /db_xref="GeneID:368070"
                     /db_xref="RGD:1597086"
                     /translation="MAVAVRALQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARL
                     LALSGPGGGRGRGSLLLRRGFSDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDP
                     EDDDVKKPALQSSVVATSKERTRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQES
                     TVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQL
                     QEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAE
                     QINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEIEEA
                     GEEEKEAGVVHSDAEKDQEEEEQKQETEARMEEETGVREGEKQQDSQPEEVMDVLEMV
                     ESVKNVIAEQEVMETNQVESIEPSENETSKELEPEMEFDVEPDKECKSLSPGKENINS
                     LEVEKESEEKEEKEDKEPEPQPEPVAQPQPPPQPLPQSQPHSQPHSQPHSQPQPALQS
                     QPLSQPEALPLAVLQPPPQVIQEQGNLPPERKDFPVEAIKLPEVPVEPVLTVHSENKS
                     KNKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSS
                     TSGSSSRDSSSSSSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGG
                     SSRDTKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR"
     exon            132..203
                     /gene="Pnn"
                     /inference="alignment:Splign:2.1.0"
     exon            204..272
                     /gene="Pnn"
                     /inference="alignment:Splign:2.1.0"
     exon            273..345
                     /gene="Pnn"
                     /inference="alignment:Splign:2.1.0"
     exon            346..440
                     /gene="Pnn"
                     /inference="alignment:Splign:2.1.0"
     exon            441..516
                     /gene="Pnn"
                     /inference="alignment:Splign:2.1.0"
     exon            517..672
                     /gene="Pnn"
                     /inference="alignment:Splign:2.1.0"
     exon            673..811
                     /gene="Pnn"
                     /inference="alignment:Splign:2.1.0"
     exon            812..2821
                     /gene="Pnn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctgctgca gagagaagat ggcggtcgct gtgagagctt tgcaggagca gctagaaaag
       61 gccaaagaga gcctcaagaa tgtggacgag aatatccgca agctcaccgg gcgggacccg
      121 aatgatgtga ggcccatcca agccagattg ctggcccttt ctggtcctgg tggaggtaga
      181 ggacgaggta gtttattgct aaggcgtgga ttctcagata gtggaggagg acccccagcc
      241 aaacagagag acctggaagg ggcagtcagt aggctgggtg gagagcgtcg gacaagaaga
      301 gaatcacgcc aggaaagtga cccagaagac gatgatgtta aaaagccagc actgcaatct
      361 tctgttgtag ctacctccaa agaacgcaca cgtagagacc ttatccagga tcaaaacatg
      421 gatgaaaagg gaaagcaaag gaaccgacga atatttggct tgttgatggg cactcttcag
      481 aaatttaaac aagaatctac tgttgctact gaacggcaaa agagacgcca agaaattgaa
      541 caaaaacttg aagttcaggc tgaagaagag agaaagcagg ttgaaaatga gaggagagaa
      601 ctgtttgagg agagacgtgc taaacagaca gaactgcggc ttctggaaca gaaggttgag
      661 cttgcacagc tgcaagaaga atggaatgag cataatgcca agataattaa gtatataaga
      721 accaagacaa agccccattt gttctatatt cctggaagaa tgtgtccagc tacccaaaag
      781 ctaatagaag agtcacagag aaaaatgaat gctttatttg aaggtagacg catcgaattt
      841 gcagaacaaa taaataaaat ggaggctagg cctagaagac aatcaatgaa ggaaaaagag
      901 catcaggtgg tgcgtaatga agaacagaag gcggaacaag aagagggtaa ggtggctcag
      961 cgagaggaag agttggagga gacaggtaat cagcacaatg acgtagaaat agaggaggca
     1021 ggagaggaag agaaggaagc aggtgtagtt catagtgatg cagagaagga ccaggaggag
     1081 gaggaacaaa agcaggagac ggaggctagg atggaggagg agactggggt aagagaaggt
     1141 gagaagcagc aggatagtca gccagaagaa gttatggatg tgttagagat ggttgaaagt
     1201 gtcaaaaatg tgattgctga gcaggaggtg atggagacta atcaagttga aagtatagaa
     1261 ccttcagaaa atgaaactag caaggaattg gagccagaga tggaatttga tgttgagcca
     1321 gataaagaat gtaaatctct ttctcctgga aaagagaata ttaattctct ggaagtggaa
     1381 aaggagtctg aggaaaaaga ggaaaaagaa gataaagagc ctgagcccca acctgagcct
     1441 gtggctcagc ctcagccccc acctcagccc ctgccccaga gccagcccca ttctcagccc
     1501 cattctcagc cccattctca gccccaacct gcactccagt cccagcctct cagtcagcct
     1561 gaggctttgc cattggctgt tctgcagcct ccaccccagg ttattcagga gcaagggaat
     1621 ctacctcctg agcggaagga ttttcctgta gaggctataa aactccctga ggtgcctgta
     1681 gagccagtct tgacagtgca ttcagaaaac aaaagcaaaa ataagactag gagcagaagc
     1741 agagggcgag caagaaataa aacgagcaag agtagaagtc gcagcagcag cagcagtagt
     1801 tccagtagca gctctactag tagcagcagt gggagcagct ccagcagtgg cagcagtagt
     1861 agtcgaagca gctccagcag cagctccagc acaagtggga gcagcagcag agacagcagc
     1921 agcagcagta gcagtagcag tgagagtagg agtcgcagta ggggccgagg acataaccga
     1981 gataggaagc acagaaggag cgtggaccgg aagcgaaggg acacttcagg actagaaaga
     2041 agtcacaagt cttcaaaagg tggtagtagt agagatacga aaggatcaaa ggataagaat
     2101 tcccgatctg acagaaaaag gtctatatca gagagtagtc gatcaggcaa aagatcttca
     2161 agaagtgaaa gagaccgaaa atcagacagg aaagacaaaa ggcgttaatg gaagaagcca
     2221 ggcttgctta gcctattctt tgcagcagaa gatttgatga gtaaaaggat taccttgtaa
     2281 agaggatgct gccttaagaa ttgcatgttg taaaaattct ttttggaaaa tacagactgt
     2341 ttgtttacca gacattcttg tactttttgc ataattttgt aagagttatt tatcaaaatt
     2401 atgtgaggtt ccaaaatatg taaaaatgat aataataaaa aaagattaac atcctttgtc
     2461 atctttttta aataccctat tacttttcag tcagaatctg tatattttaa taggtaaatc
     2521 tttaattgtt cctttatgtt ctgtatcata cattgctttt gtagaaataa atatgcatct
     2581 ttcattattt ttgggatgtc cttgttgaca gttgtataat aaatatcttt atatcatttt
     2641 cagtttttgt cacaagatac tgaacatgat taggatgttt ttgaaggttt catcactttg
     2701 atttgcctga aaagttattt tgagttgcca ggtttttaca gctttgatgg ggaatagttc
     2761 ttttaaaaca tttacttatt tcccatttac aatttttaat ctaagcattt ttctgttttt
     2821 g
//
