LOCUS       NM_031526                945 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus phenylethanolamine-N-methyltransferase (Pnmt),
            mRNA.
ACCESSION   NM_031526 XM_001081395
VERSION     NM_031526.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 945)
  AUTHORS   Nguyen,P., Khurana,S., Peltsch,H., Grandbois,J., Eibl,J.,
            Crispo,J., Ansell,D. and Tai,T.C.
  TITLE     Prenatal glucocorticoid exposure programs adrenal PNMT expression
            and adult hypertension
  JOURNAL   J Endocrinol 227 (2), 117-127 (2015)
   PUBMED   26475702
  REMARK    GeneRIF: These results suggest that increased PNMT gene expression
            via altered transcriptional activity is a possible mechanism by
            which prenatal exposure to elevated levels of glucocorticoids may
            program for hypertension later in life.
REFERENCE   2  (bases 1 to 945)
  AUTHORS   Allen,C.D., Rivier,C.L. and Lee,S.Y.
  TITLE     Adolescent alcohol exposure alters the central brain circuits known
            to regulate the stress response
  JOURNAL   Neuroscience 182, 162-168 (2011)
   PUBMED   21382450
REFERENCE   3  (bases 1 to 945)
  AUTHORS   Bundzikova,J., Pirnik,Z., Lackovicova,L., Mravec,B. and Kiss,A.
  TITLE     Activation of different neuronal phenotypes in the rat brain
            induced by liver ischemia-reperfusion injury: dual Fos/neuropeptide
            immunohistochemistry
  JOURNAL   Cell Mol Neurobiol 31 (2), 293-301 (2011)
   PUBMED   21061149
REFERENCE   4  (bases 1 to 945)
  AUTHORS   Crispo,J.A., Ansell,D.R., Ubriaco,G. and Tai,T.C.
  TITLE     Role of reactive oxygen species in the neural and hormonal
            regulation of the PNMT gene in PC12 cells
  JOURNAL   Oxid Med Cell Longev 2011, 756938 (2011)
   PUBMED   22007271
  REMARK    GeneRIF: Findings demonstrate that CoCl(2)-induced ROS have
            synergistic effects on hormonal and neural activation of the PNMT
            promoter.
REFERENCE   5  (bases 1 to 945)
  AUTHORS   Spasojevic,N., Gavrilovic,L. and Dronjak,S.
  TITLE     Regulation of catecholamine-synthesising enzymes and
            beta-adrenoceptors gene expression in ventricles of stressed rats
  JOURNAL   Physiol Res 60 (Suppl 1), S171-S176 (2011)
   PUBMED   21777029
  REMARK    GeneRIF: Stress elevated PNMT levels in heart ventricles.
REFERENCE   6  (bases 1 to 945)
  AUTHORS   Burke,W.J., Schmitt,C.A., Li,S.W., Gillespie,K.N., Park,D.H. and
            Joh,T.H.
  TITLE     Simultaneous measurement of enzyme activity, protein, mRNA, and
            metabolites in small samples
  JOURNAL   Anal Biochem 230 (2), 345-348 (1995)
   PUBMED   7503429
REFERENCE   7  (bases 1 to 945)
  AUTHORS   Weisberg,E.P., Baruchin,A., Stachowiak,M.K., Stricker,E.M.,
            Zigmond,M.J. and Kaplan,B.B.
  TITLE     Isolation of a rat adrenal cDNA clone encoding phenylethanolamine
            N-methyltransferase and cold-induced alterations in adrenal PNMT
            mRNA and protein
  JOURNAL   Brain Res Mol Brain Res 6 (2-3), 159-166 (1989)
   PUBMED   2575695
REFERENCE   8  (bases 1 to 945)
  AUTHORS   Mezey,E.
  TITLE     Cloning of the rat adrenal medullary
            phenylethanolamine-N-methyltransferase
  JOURNAL   Nucleic Acids Res 17 (5), 2125 (1989)
   PUBMED   2928117
REFERENCE   9  (bases 1 to 945)
  AUTHORS   Burke,W.J., Hanson,D.M. and Chung,H.D.
  TITLE     A highly sensitive assay for phenylethanolamine N-methyltransferase
            in human brain
  JOURNAL   Proc Soc Exp Biol Med 181 (1), 66-70 (1986)
   PUBMED   3945626
REFERENCE   10 (bases 1 to 945)
  AUTHORS   Diaz Borges,J.M., Urbina,M. and Drujan,B.D.
  TITLE     Some properties of phenylethanolamine-N-methyltransferase of rat
            brain
  JOURNAL   Neurochem Res 3 (1), 15-26 (1978)
   PUBMED   683413
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from X75333.1.
            
            [WARNING] On Oct 7, 2024 this sequence was replaced by NM_031526.2.
            
            On Oct 11, 2007 this sequence version replaced XM_001081395.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X14211.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q31"
     gene            1..945
                     /gene="Pnmt"
                     /note="phenylethanolamine-N-methyltransferase"
                     /db_xref="GeneID:24661"
                     /db_xref="RGD:3361"
     exon            1..225
                     /gene="Pnmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..878
                     /gene="Pnmt"
                     /EC_number="2.1.1.28"
                     /note="PNMTase; noradrenaline N-methyltransferase"
                     /codon_start=1
                     /product="phenylethanolamine N-methyltransferase"
                     /protein_id="NP_113714.1"
                     /db_xref="GeneID:24661"
                     /db_xref="RGD:3361"
                     /translation="MDRGSDPKHTAGMDSDSDPGQAEVALAYQRFEPRAYLRNNYAPP
                     RGDLSNPDGVGPWKLRCMAQVFATGEVSGQVLIDIGSGPTIYQLLSACAHFEDITMTD
                     FLEVNRQELGLWLREEPGAFDWSVYSQHVCLIEDKGESWQEKERQLRARVKRVLPIDV
                     HKPQPLGASGLAPLPADALVSAFCLEAVSPDLPSFRQALYHITTLLRPGGNLLFIGAL
                     EESWYLAGEARLSVVPVSEEEVREALVCSGYEVRDLRTYIMPAHLRTGVDDVKGIFFA
                     WAQKIEVQV"
     exon            226..433
                     /gene="Pnmt"
                     /inference="alignment:Splign:2.1.0"
     exon            434..945
                     /gene="Pnmt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 taggcggcct caacaggagc atggaccgtg gctcagaccc gaagcacact gcagggatgg
       61 actctgactc cgaccctggc caggcagagg tcgccttggc ttaccagcgc tttgagcccc
      121 gtgcctacct ccgcaacaac tacgcgcctc ctcgtgggga cctgagcaac cctgatggtg
      181 tggggccttg gaagcttcgc tgcatggcac aagtctttgc caccggtgag gtgtctggac
      241 aggtcctcat tgacatcggc tcaggcccca ccatatacca gctgctcagc gcctgtgccc
      301 acttcgagga catcaccatg acagacttct tggaggtcaa ccggcaggag ctgggactct
      361 ggctgcgaga ggaaccagga gccttcgact ggagtgtgta tagccagcat gtctgcctca
      421 tcgaggacaa gggagagtcc tggcaggaga aagaacgcca gctccgagcg agggtgaagc
      481 gagtcttgcc cattgatgtg cacaagcccc agcccctggg agcttcgggc ctggcacccc
      541 tgcctgctga cgccttggtc tctgccttct gcctggaggc tgtgagcccg gatctcccaa
      601 gcttccggca ggctttgtat catatcacga cgctgctgag gcccgggggt aatctcctct
      661 tcatcggggc cctggaggag tcgtggtacc ttgctgggga ggccaggcta tctgtggttc
      721 cagtgtcaga ggaggaggtg agggaggccc tggtctgtag tggttatgag gtccgagacc
      781 ttcgcaccta catcatgcct gcccacctcc gcacgggtgt ggatgacgtc aagggtatct
      841 tctttgcctg ggcccagaag atagaggtgc aggtgtgagg ctccatttgc ctccctaact
      901 ccttatcacc cgaagtggca cctaataaag taacagtccc cagct
//
