LOCUS       NM_130820               1786 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus PNMA family member 1 (Pnma1), mRNA.
ACCESSION   NM_130820
VERSION     NM_130820.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Chen,H.L. and D'Mello,S.R.
  TITLE     Induction of neuronal cell death by paraneoplastic Ma1 antigen
  JOURNAL   J Neurosci Res 88 (16), 3508-3519 (2010)
   PUBMED   20936693
  REMARK    GeneRIF: PNMA1 functions to promote neuronal death.  PNMA1-mediated
            apoptosis can be prevented by Bcl2. Although the detailed mechanism
            remains to be delineated, it is likely to involve association of
            proteins with PNMA1 through its BH3-like sequence.
REFERENCE   2  (bases 1 to 1786)
  AUTHORS   Pellkofer,H., Schubart,A.S., Hoftberger,R., Schutze,N., Pagany,M.,
            Schuller,M., Lassmann,H., Hohlfeld,R., Voltz,R. and Linington,C.
  TITLE     Modelling paraneoplastic CNS disease: T-cells specific for the
            onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in
            the rat
  JOURNAL   Brain 127 (Pt 8), 1822-1830 (2004)
   PUBMED   15201193
REFERENCE   3  (bases 1 to 1786)
  AUTHORS   Dalmau,J., Gultekin,S.H., Voltz,R., Hoard,R., DesChamps,T.,
            Balmaceda,C., Batchelor,T., Gerstner,E., Eichen,J., Frennier,J.,
            Posner,J.B. and Rosenfeld,M.R.
  TITLE     Ma1, a novel neuron- and testis-specific protein, is recognized by
            the serum of patients with paraneoplastic neurological disorders
  JOURNAL   Brain 122 (Pt 1), 27-39 (1999)
   PUBMED   10050892
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF335505.1.
            
            On Dec 30, 2008 this sequence version replaced NM_130820.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF335505.1, BC097291.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1786              AF335505.1         17-1802
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..1786
                     /gene="Pnma1"
                     /gene_synonym="MA1"
                     /note="PNMA family member 1"
                     /db_xref="GeneID:170636"
                     /db_xref="RGD:621230"
     exon            1..1786
                     /gene="Pnma1"
                     /gene_synonym="MA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             495..1556
                     /gene="Pnma1"
                     /gene_synonym="MA1"
                     /note="paraneoplastic Ma antigen 1"
                     /codon_start=1
                     /product="paraneoplastic antigen Ma1 homolog"
                     /protein_id="NP_570833.1"
                     /db_xref="GeneID:170636"
                     /db_xref="RGD:621230"
                     /translation="MAMTLLEDWCRGMDVNSQRALLVWGIPVNCDETEIEETLQAAMP
                     QVSYRVLGRMFWREENAKAALLELTGTVDYSLIPREMPGKGGLWKVVFKPPTSDAEFL
                     ERLHLFLAREGWTVQDVARVLGFQNPAPAPGPEMPAEMLNYILDNVIQPLVESIWYKK
                     LTLFSGRDIPGPGEETFDSWLEHSNEVIEEWQVSDIEKRRRLMESLRGPAADVIRILK
                     TNNPAITTAECLKALEQVFGSVESSRDAQVRFLNTYQNPGEKLSSYVIRLEPLLQKVV
                     DKGAIDKDNVNQARLEQVIAGANHSGALRRQLWLTGATEGPAPNLFQLLVQIREEEAK
                     EEEEEAEAALLQLGLEGHF"
ORIGIN      
        1 tgcctccagc ccggttcctc cctccttcgc gcttcctgcc gcctcagtcc ccggtgcttc
       61 gagtgccgcc tctctcggtg tagctgagcc acggcctcga gtaaccctcg gccgcccgcg
      121 ggccagggag aggtgggagg agctgccacg ccccgcgacc gcacccagtc atctccagcc
      181 cgcagccaac cgccttgagc ccaccttcct ccccttctca aagcagtgac gcaaggcaca
      241 gccgcagcca gtccactcct gcccggacca aaagggcgac attcgagtga taggcggagt
      301 gtcccgtggc actgacttgg gacccggaag ggaccagaag gaactctggt gtcttttggt
      361 aattgtggtt gcttgaagct tgtcgccccc tggcctaccg ggggaggaga gcatgttgtc
      421 ctaagcccaa cagcagcacc gtgagccagt ccaagcacag tctgtagaac tggcactctt
      481 aatagttggg cgaaatggct atgacactat tggaagactg gtgcagggga atggatgtga
      541 actctcagag agctctgttg gtctggggga tccctgtgaa ctgtgatgag accgaaatcg
      601 aagagaccct ccaagctgcg atgccccagg tatcctatcg agtactgggg agaatgttct
      661 ggagggaaga aaatgcgaaa gcagccttgt tagagctcac tgggacggtg gattactccc
      721 tgatccccag ggagatgcca ggcaaaggag ggctctggaa agtagtgttt aagcccccca
      781 cttccgacgc ggagtttttg gaaaggctgc acctctttct agctagggaa gggtggacgg
      841 tgcaagatgt tgctcgtgtg cttgggtttc agaaccctgc tccagcccca ggcccggaaa
      901 tgccagcaga gatgctcaac tatattttgg ataatgttat tcaacctctt gttgagtcca
      961 tatggtataa gaagctgact ttgttctccg ggagggacat tcccgggcct ggcgaggaga
     1021 cctttgattc ctggctggag cactcgaatg aagtcataga ggaatggcag gtgtctgata
     1081 tagaaaagag acggcggttg atggagagtt tgcgaggccc ggctgccgat gtcattcgca
     1141 tcctcaagac caacaaccct gctataacca cggcagaatg cctgaaggct cttgagcagg
     1201 tgtttgggag cgtggagagc tctagagatg cacaggtcag atttctgaac acttaccaaa
     1261 acccaggaga aaagttatct tcttacgtta tccgtctgga gcctctgctg caaaaggtag
     1321 tggacaaggg ggccattgat aaagataacg tgaaccaggc tcgcctggaa caggtcatcg
     1381 ctggggccaa ccacagcggg gccctccgaa ggcagttgtg gctgactggg gctacagaag
     1441 ggcctgcacc caacctcttc cagttactgg tgcagattcg agaggaggaa gccaaagagg
     1501 aggaggagga ggccgaggct gcccttttgc agctaggcct agaggggcac ttctgaatcc
     1561 caggactggc caggctgctt ttgatattcc tgtgaagttt tagtaagcct gtcccttaaa
     1621 gtaaacagcc agcctcctcc tgcctttgtt ttgttttctg aggaatggga tgagaaagtc
     1681 aggcccgcat attcctgtag cattcacaga attgtgtaat tagcaggagt aaaggcggtt
     1741 catagtgcta cagtgatgcc agccctcctg gtgacatctc tgacag
//
